IMP
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regulation of natural killer cell mediated cytotoxicity
Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.
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Click on a gene's description to view its network relationships with genes known to be involved in "regulation of natural killer cell mediated cytotoxicity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| B2M | beta-2-microglobulin | 1.000 | ||
| HLA-A | major histocompatibility complex, class I, A | 1.000 | ||
| HLA-C | major histocompatibility complex, class I, C | 1.000 | Human | |
| HLA-B | major histocompatibility complex, class I, B | 1.000 | ||
| HLA-G | major histocompatibility complex, class I, G | 1.000 | Human | |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 1.000 | Rat | |
| HLA-F | major histocompatibility complex, class I, F | 0.999 | Human | |
| HLA-E | major histocompatibility complex, class I, E | 0.998 | ||
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.993 | Human | |
| TAPBP | TAP binding protein (tapasin) | 0.990 | ||
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.984 | ||
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 0.981 | ||
| LILRB1 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 0.906 | ||
| PILRA | paired immunoglobin-like type 2 receptor alpha | 0.895 | ||
| IL2RB | interleukin 2 receptor, beta | 0.805 | ||
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.623 | ||
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.595 | ||
| ITM2B | integral membrane protein 2B | 0.495 | ||
| LILRB3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 0.474 | Human | |
| TAP2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 0.473 | Rat | |
| LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | 0.461 | Human | |
| GBA | glucosidase, beta, acid | 0.408 | ||
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 0.344 | ||
| SIGLEC7 | sialic acid binding Ig-like lectin 7 | 0.248 | ||
| PTAFR | platelet-activating factor receptor | 0.235 | ||
| HK3 | hexokinase 3 (white cell) | 0.234 | ||
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.208 | ||
| LILRA1 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 | 0.207 | Human | |
| IL23A | interleukin 23, alpha subunit p19 | 0.198 | ||
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.175 | ||
| IFNG | interferon, gamma | 0.174 | ||
| ARRB2 | arrestin, beta 2 | 0.166 | ||
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.132 | ||
| GNLY | granulysin | 0.127 | ||
| INSR | insulin receptor | 0.119 | ||
| PRF1 | perforin 1 (pore forming protein) | 0.111 | ||
| KLRC3 | killer cell lectin-like receptor subfamily C, member 3 | 0.106 | Human | |
| KLRC2 | killer cell lectin-like receptor subfamily C, member 2 | 0.105 | Human | |
| PVRL2 | poliovirus receptor-related 2 (herpesvirus entry mediator B) | 0.089 | ||
| CD33 | CD33 molecule | 0.073 | ||
| BTN3A1 | butyrophilin, subfamily 3, member A1 | 0.073 | ||
| PGCP | plasma glutamate carboxypeptidase | 0.070 | ||
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.066 | ||
| NKG7 | natural killer cell group 7 sequence | 0.055 | ||
| HEXB | hexosaminidase B (beta polypeptide) | 0.054 | ||
| CMKLR1 | chemokine-like receptor 1 | 0.050 | ||
| IL18RAP | interleukin 18 receptor accessory protein | 0.048 | ||
| NCSTN | nicastrin | 0.046 | ||
| CXCR6 | chemokine (C-X-C motif) receptor 6 | 0.045 | ||
| PIK3R5 | phosphoinositide-3-kinase, regulatory subunit 5 | 0.043 | ||
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.042 | ||
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.042 | ||
| KLRG1 | killer cell lectin-like receptor subfamily G, member 1 | 0.042 | Human | |
| STAP2 | signal transducing adaptor family member 2 | 0.042 | ||
| HCST | hematopoietic cell signal transducer | 0.041 | ||
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 0.040 | ||
| CCL5 | chemokine (C-C motif) ligand 5 | 0.038 | ||
| SIGLEC9 | sialic acid binding Ig-like lectin 9 | 0.037 | ||
| PSAP | prosaposin | 0.037 | ||
| KIR3DL2 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 | 0.036 | ||
| CCL4 | chemokine (C-C motif) ligand 4 | 0.036 | ||
| MAPK10 | mitogen-activated protein kinase 10 | 0.036 | ||
| KLRC4 | killer cell lectin-like receptor subfamily C, member 4 | 0.035 | Human | |
| CD160 | CD160 molecule | 0.035 | ||
| RAB14 | RAB14, member RAS oncogene family | 0.035 | ||
| TJP1 | tight junction protein 1 (zona occludens 1) | 0.035 | ||
| XCL2 | chemokine (C motif) ligand 2 | 0.034 | ||
| ARRB1 | arrestin, beta 1 | 0.034 | Human | |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.033 | ||
| KLRF1 | killer cell lectin-like receptor subfamily F, member 1 | 0.033 | ||
| FPR2 | formyl peptide receptor 2 | 0.033 | ||
| EPOR | erythropoietin receptor | 0.033 | ||
| HFE | hemochromatosis | 0.032 | Human | |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.032 | ||
| CD84 | CD84 molecule | 0.032 | ||
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.032 | ||
| IL12A | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 0.031 | ||
| AOAH | acyloxyacyl hydrolase (neutrophil) | 0.031 | ||
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.031 | ||
| CD226 | CD226 molecule | 0.030 | ||
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.030 | Human | |
| NLRP3 | NLR family, pyrin domain containing 3 | 0.029 | ||
| TXK | TXK tyrosine kinase | 0.029 | ||
| LILRA3 | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 | 0.028 | Human | |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.028 | ||
| FTH1 | ferritin, heavy polypeptide 1 | 0.028 | ||
| HCP5 | HLA complex P5 | 0.026 | ||
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | 0.026 | ||
| TBX21 | T-box 21 | 0.026 | ||
| EMR1 | egf-like module containing, mucin-like, hormone receptor-like 1 | 0.026 | ||
| SIRPB1 | signal-regulatory protein beta 1 | 0.025 | ||
| NPC2 | Niemann-Pick disease, type C2 | 0.025 | ||
| PYHIN1 | pyrin and HIN domain family, member 1 | 0.025 | ||
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.024 | ||
| KIR2DL2 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 and killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 | 0.023 | ||
| KIR3DL1 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | 0.023 | ||
| TAPBPL | TAP binding protein-like | 0.022 | ||
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 0.021 | ||
| LILRB4 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 | 0.021 | Human | |
| CTSW | cathepsin W | 0.021 | ||
| GPR171 | G protein-coupled receptor 171 | 0.021 | ||
| TPP1 | tripeptidyl peptidase I | 0.020 | ||
| KIR2DL5A | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A | 0.020 | ||
| IL16 | interleukin 16 (lymphocyte chemoattractant factor) | 0.020 | ||
| CCR5 | chemokine (C-C motif) receptor 5 | 0.020 | ||
| CD300C | CD300c molecule | 0.020 | ||
| IFITM2 | interferon induced transmembrane protein 2 (1-8D) | 0.019 | ||
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.018 | ||
| BIN2 | bridging integrator 2 | 0.018 | ||
| CD86 | CD86 molecule | 0.018 | ||
| CLEC10A | C-type lectin domain family 10, member A | 0.018 | ||
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.018 | ||
| TREM1 | triggering receptor expressed on myeloid cells 1 | 0.018 | ||
| LAIR2 | leukocyte-associated immunoglobulin-like receptor 2 | 0.017 | Human | |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.017 | ||
| KIR2DL3 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 | 0.017 | ||
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 0.017 | ||
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.017 | ||
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 0.017 | ||
| CD2 | CD2 molecule | 0.016 | ||
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.016 | ||
| GRN | granulin | 0.016 | ||
| CD8A | CD8a molecule | 0.016 | ||
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.016 | Mouse | |
| TYMP | thymidine phosphorylase | 0.016 | ||
| CLEC5A | C-type lectin domain family 5, member A | 0.015 | ||
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.015 | ||
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.015 | ||
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.014 | ||
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.014 | ||
| ICOS | inducible T-cell co-stimulator | 0.014 | ||
| IL12RB1 | interleukin 12 receptor, beta 1 | 0.014 | ||
| CCR1 | chemokine (C-C motif) receptor 1 | 0.014 | ||
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.014 | ||
| CD300A | CD300a molecule | 0.014 | ||
| CR1 | complement component (3b/4b) receptor 1 (Knops blood group) | 0.013 | ||
| KLRC1 | killer cell lectin-like receptor subfamily C, member 1 | 0.013 | Human | |
| LILRA5 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 | 0.013 | Human | |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.013 | ||
| CD96 | CD96 molecule | 0.013 | ||
| SYNRG | synergin, gamma | 0.013 | ||
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.013 | ||
| GGA2 | golgi-associated, gamma adaptin ear containing, ARF binding protein 2 | 0.013 | ||
| TXNDC3 | thioredoxin domain containing 3 (spermatozoa) | 0.013 | ||
| SLAMF7 | SLAM family member 7 | 0.013 | ||
| CD80 | CD80 molecule | 0.013 | ||
| IGSF6 | immunoglobulin superfamily, member 6 | 0.012 | ||
| KIR3DS1 | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 | 0.012 | ||
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.012 | ||
| BCR | breakpoint cluster region | 0.012 | ||
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 0.012 | ||
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 0.012 | ||
| TRD@ | T cell receptor delta locus | 0.012 | ||
| CASP5 | caspase 5, apoptosis-related cysteine peptidase | 0.012 | ||
| NOD2 | nucleotide-binding oligomerization domain containing 2 | 0.012 | ||
| GRB10 | growth factor receptor-bound protein 10 | 0.012 | ||
| LEPROT | leptin receptor overlapping transcript | 0.012 | ||
| IRF1 | interferon regulatory factor 1 | 0.011 | ||
| CD101 | CD101 molecule | 0.011 | ||
| SIGLEC10 | sialic acid binding Ig-like lectin 10 | 0.011 | ||
| FPR3 | formyl peptide receptor 3 | 0.011 | ||
| KIR2DL1 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 | 0.011 | ||
| SKAP1 | src kinase associated phosphoprotein 1 | 0.011 | ||
| RAB5C | RAB5C, member RAS oncogene family | 0.011 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.011 | ||
| IL32 | interleukin 32 | 0.011 | ||
| GM2A | GM2 ganglioside activator | 0.011 | ||
| SH2D2A | SH2 domain containing 2A | 0.010 | ||
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.010 |