IMP

Process View

Homo sapiens

16 genes annotated in human

protein heterooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein heterooligomerization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein heterooligomerization" (in gray)

Name	Description	Probability	Func Analog Organism
S100A6	S100 calcium binding protein A6	0.999	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.961
HBA2	hemoglobin, alpha 2	0.957
ANXA1	annexin A1	0.940	Human
EGFR	epidermal growth factor receptor	0.922
HBB	hemoglobin, beta	0.876
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.862
SEPT2	septin 2	0.827	Human
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.814
S100A11	S100 calcium binding protein A11	0.781	Human
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.717
IGF1R	insulin-like growth factor 1 receptor	0.709	Human Rat
RIPK2	receptor-interacting serine-threonine kinase 2	0.703	Human
S100A8	S100 calcium binding protein A8	0.677	Human
S100A9	S100 calcium binding protein A9	0.619	Human
INSR	insulin receptor	0.611
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.509
HBG2	hemoglobin, gamma G	0.487	Rat
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.460
S100B	S100 calcium binding protein B	0.436	Human
LGALS1	lectin, galactoside-binding, soluble, 1	0.428
BIRC3	baculoviral IAP repeat containing 3	0.403	Rat
S100A10	S100 calcium binding protein A10	0.401
COL6A1	collagen, type VI, alpha 1	0.380
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.354
STK11	serine/threonine kinase 11	0.341
FKBP4	FK506 binding protein 4, 59kDa	0.332
ILK	integrin-linked kinase	0.318	Rat
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.304	Rat
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.297
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.282	Rat
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.275
ANXA2	annexin A2	0.255
ADRB1	adrenergic, beta-1-, receptor	0.231
KCNIP2	Kv channel interacting protein 2	0.219	Rat
TRAF1	TNF receptor-associated factor 1	0.202
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.197
SMN1	survival of motor neuron 1, telomeric	0.193
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.186
S100A4	S100 calcium binding protein A4	0.173	Human
NLRC4	NLR family, CARD domain containing 4	0.141
S100A1	S100 calcium binding protein A1	0.132	Human
COL1A1	collagen, type I, alpha 1	0.109	Mouse
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.105	Fly
COL3A1	collagen, type III, alpha 1	0.094
TRADD	TNFRSF1A-associated via death domain	0.093
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.092	Fly
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.077	Rat
AKAP1	A kinase (PRKA) anchor protein 1	0.076
AREG	amphiregulin	0.071
CCL3	chemokine (C-C motif) ligand 3	0.068
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.065
IRS1	insulin receptor substrate 1	0.064	Rat
TMSB10	thymosin beta 10	0.058
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.056
NCK2	NCK adaptor protein 2	0.053
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.050
LGALS3	lectin, galactoside-binding, soluble, 3	0.050
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.049	Rat
COL6A2	collagen, type VI, alpha 2	0.048
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.047
TRAF2	TNF receptor-associated factor 2	0.047
TSC1	tuberous sclerosis 1	0.047
FADD	Fas (TNFRSF6)-associated via death domain	0.045
PRKAG1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.042	Rat
COL5A1	collagen, type V, alpha 1	0.042
BIRC2	baculoviral IAP repeat containing 2	0.041
VIM	vimentin	0.040
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.038
SEPT6	septin 6	0.038	Human
SEPT7	septin 7	0.038
EMP3	epithelial membrane protein 3	0.038
COL18A1	collagen, type XVIII, alpha 1	0.037
CTNNBIP1	catenin, beta interacting protein 1	0.036
GRB10	growth factor receptor-bound protein 10	0.035
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.034
MAPK1	mitogen-activated protein kinase 1	0.032
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.031
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.030
NMT2	N-myristoyltransferase 2	0.030
TRAF3	TNF receptor-associated factor 3	0.029
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.028
SEPT5	septin 5	0.028
DLG4	discs, large homolog 4 (Drosophila)	0.027
VCAM1	vascular cell adhesion molecule 1	0.027
SMAD4	SMAD family member 4	0.025
SMAD3	SMAD family member 3	0.024
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	0.024
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.023
PRKCE	protein kinase C, epsilon	0.023
RRAS	related RAS viral (r-ras) oncogene homolog	0.022
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.021
COL1A2	collagen, type I, alpha 2	0.021	Mouse
RPS27L	ribosomal protein S27-like	0.021
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.021
HBD	hemoglobin, delta	0.021
KIF5B	kinesin family member 5B	0.020
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.020
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.020
IRS2	insulin receptor substrate 2	0.019
PCOLCE	procollagen C-endopeptidase enhancer	0.018
NPC2	Niemann-Pick disease, type C2	0.018
KCNIP1	Kv channel interacting protein 1	0.018
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.018
ANXA5	annexin A5	0.018	Human
RIPK3	receptor-interacting serine-threonine kinase 3	0.018
WDYHV1	WDYHV motif containing 1	0.017
CFLAR	CASP8 and FADD-like apoptosis regulator	0.017
CD63	CD63 molecule	0.017
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.017
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.017
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.017
ZFYVE9	zinc finger, FYVE domain containing 9	0.017
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.017
FN1	fibronectin 1	0.016
SEPT11	septin 11	0.016
HBZ	hemoglobin, zeta	0.016	Human
MYL9	myosin, light chain 9, regulatory	0.015
AKAP2	A kinase (PRKA) anchor protein 2	0.015
SH3GL1	SH3-domain GRB2-like 1	0.015
NOD2	nucleotide-binding oligomerization domain containing 2	0.014
CSNK1D	casein kinase 1, delta	0.014
COL4A1	collagen, type IV, alpha 1	0.014
TNF	tumor necrosis factor	0.014
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.014
PARVA	parvin, alpha	0.014	Rat
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.014
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.014
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.013
BGN	biglycan	0.013
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.013
CSTA	cystatin A (stefin A)	0.013
PEA15	phosphoprotein enriched in astrocytes 15	0.013
S100P	S100 calcium binding protein P	0.013	Human
MYCBP	c-myc binding protein	0.013
DSCAML1	Down syndrome cell adhesion molecule like 1	0.013
BTRC	beta-transducin repeat containing	0.012
S100A2	S100 calcium binding protein A2	0.012	Human
GHR	growth hormone receptor	0.012
KIF23	kinesin family member 23	0.012
PPHLN1	periphilin 1	0.012
TIMP1	TIMP metallopeptidase inhibitor 1	0.012
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.012
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.011
FBLN2	fibulin 2	0.011
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.011
LIMS1	LIM and senescent cell antigen-like domains 1	0.011	Rat
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.011
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.011
PF4	platelet factor 4	0.011
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.011
GORAB	golgin, RAB6-interacting	0.011
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.011
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.010
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.010
MRC2	mannose receptor, C type 2	0.010