IMP

Process View

Homo sapiens

11 genes annotated in human

regulation of synaptic transmission

Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of synaptic transmission"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of synaptic transmission" (in gray)

Name	Description	Probability	Func Analog Organism
DLG4	discs, large homolog 4 (Drosophila)	0.996	Mouse Rat
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.954	Human
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.923
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.869
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.823	Human
GSK3B	glycogen synthase kinase 3 beta	0.722	Rat
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.675	Mouse Rat
SNAP25	synaptosomal-associated protein, 25kDa	0.573	Mouse Fly
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.528	Fly
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.475	Fly
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.428	Human
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.408	Mouse Rat
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.323	Mouse
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.257	Mouse
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.237
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.212
CRHR1	corticotropin releasing hormone receptor 1	0.203	Rat
EPS15	epidermal growth factor receptor pathway substrate 15	0.191
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.179
ADORA2A	adenosine A2a receptor	0.177	Mouse Rat
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.173	Fly
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.172
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.170
PUM2	pumilio homolog 2 (Drosophila)	0.151	Fly
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.125
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.123	Mouse
SPRR2A	small proline-rich protein 2A	0.120
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.115
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.114
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.113
DRD2	dopamine receptor D2	0.107	Mouse Rat
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.106
NSF	N-ethylmaleimide-sensitive factor	0.103	Fly
NGF	nerve growth factor (beta polypeptide)	0.103	Mouse
ANAPC4	anaphase promoting complex subunit 4	0.091
DNM1	dynamin 1	0.085	Fly
ARRB1	arrestin, beta 1	0.081
SNAP23	synaptosomal-associated protein, 23kDa	0.077	Fly
SMAD2	SMAD family member 2	0.070
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.068
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.068	Human
NCOA3	nuclear receptor coactivator 3	0.066
LRRK2	leucine-rich repeat kinase 2	0.062
ACTL6B	actin-like 6B	0.062
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.059	Fly
PSEN1	presenilin 1	0.059	Mouse
VIM	vimentin	0.059
KALRN	kalirin, RhoGEF kinase	0.058
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.056	Human Mouse
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.055
PRKCG	protein kinase C, gamma	0.055
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.054
BMI1	BMI1 polycomb ring finger oncogene	0.052
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.051
STX1A	syntaxin 1A (brain)	0.048	Human Mouse Rat
EGR3	early growth response 3	0.047
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.047	Fly
APP	amyloid beta (A4) precursor protein	0.046
TPBG	trophoblast glycoprotein	0.046
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.042	Human Rat
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.041
C1QA	complement component 1, q subcomponent, A chain	0.040	Human
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.039
PLAU	plasminogen activator, urokinase	0.039
C1QC	complement component 1, q subcomponent, C chain	0.037	Human
DLG2	discs, large homolog 2 (Drosophila)	0.037
HDAC4	histone deacetylase 4	0.036
SOX10	SRY (sex determining region Y)-box 10	0.036
LAT	linker for activation of T cells	0.036
ACTN2	actinin, alpha 2	0.035
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.035	Rat
STX5	syntaxin 5	0.035
EGR2	early growth response 2	0.033	Rat
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.033
S100A1	S100 calcium binding protein A1	0.033
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.033
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.033
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.030
ADAM15	ADAM metallopeptidase domain 15	0.030
RET	ret proto-oncogene	0.029
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.029
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.029
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.028
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	0.028	Rat
MAPK1	mitogen-activated protein kinase 1	0.027	Fly
EGR1	early growth response 1	0.026	Rat
PRKCA	protein kinase C, alpha	0.026
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.025
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.025
CRH	corticotropin releasing hormone	0.025	Rat
ACHE	acetylcholinesterase	0.025
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.024	Mouse Rat
TOR1A	torsin family 1, member A (torsin A)	0.024
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.023
APC	adenomatous polyposis coli	0.023
OCRL	oculocerebrorenal syndrome of Lowe	0.022
NOS1	nitric oxide synthase 1 (neuronal)	0.022	Mouse Rat
SEZ6L	seizure related 6 homolog (mouse)-like	0.022
ACCN2	amiloride-sensitive cation channel 2, neuronal	0.022	Mouse
KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	0.022
ITSN1	intersectin 1 (SH3 domain protein)	0.021
EGFR	epidermal growth factor receptor	0.021
CACNG2	calcium channel, voltage-dependent, gamma subunit 2	0.021
RIMS1	regulating synaptic membrane exocytosis 1	0.021	Mouse Rat Worm
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.020
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.020
ARHGAP1	Rho GTPase activating protein 1	0.020
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.020
DPP6	dipeptidyl-peptidase 6	0.020
RXRA	retinoid X receptor, alpha	0.020
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.019
SYN2	synapsin II	0.019
OPTN	optineurin	0.018
ALAS1	aminolevulinate, delta-, synthase 1	0.018
GRIK1	glutamate receptor, ionotropic, kainate 1	0.018	Mouse Rat
ADRBK1	adrenergic, beta, receptor kinase 1	0.018
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.018
TOB1	transducer of ERBB2, 1	0.018
TMEM59L	transmembrane protein 59-like	0.018
WBP11	WW domain binding protein 11	0.017
MYOD1	myogenic differentiation 1	0.017
NRXN1	neurexin 1	0.017	Mouse Fly
ESR1	estrogen receptor 1	0.017
NLGN1	neuroligin 1	0.017	Mouse Rat
PLAUR	plasminogen activator, urokinase receptor	0.017
DDN	dendrin	0.017
PCDHA4	protocadherin alpha 4	0.017
GRM7	glutamate receptor, metabotropic 7	0.017
SFN	stratifin	0.017	Human
MAPT	microtubule-associated protein tau	0.017
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.017
DNM2	dynamin 2	0.017	Fly
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.016
MAP2K1	mitogen-activated protein kinase kinase 1	0.016
STK4	serine/threonine kinase 4	0.016
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.016	Rat
CRMP1	collapsin response mediator protein 1	0.016
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.016	Mouse
TBR1	T-box, brain, 1	0.016
EEA1	early endosome antigen 1	0.016
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.016	Human
GAB2	GRB2-associated binding protein 2	0.016
HIPK2	homeodomain interacting protein kinase 2	0.016
DUSP23	dual specificity phosphatase 23	0.016
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.016
CCK	cholecystokinin	0.016
FBXO7	F-box protein 7	0.015
BSN	bassoon (presynaptic cytomatrix protein)	0.015
RPH3A	rabphilin 3A homolog (mouse)	0.015
STMN2	stathmin-like 2	0.015
AKAP11	A kinase (PRKA) anchor protein 11	0.015
RAB3A	RAB3A, member RAS oncogene family	0.014	Human Mouse
GAB1	GRB2-associated binding protein 1	0.014
CADM3	cell adhesion molecule 3	0.014
MAST1	microtubule associated serine/threonine kinase 1	0.014
KCNC1	potassium voltage-gated channel, Shaw-related subfamily, member 1	0.014
PDE4DIP	phosphodiesterase 4D interacting protein	0.014
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.013
PTPRN	protein tyrosine phosphatase, receptor type, N	0.013
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.013	Rat
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.013	Rat Fly
ADNP	activity-dependent neuroprotector homeobox	0.013	Rat
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.013
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.013
BDNF	brain-derived neurotrophic factor	0.013
GRIK3	glutamate receptor, ionotropic, kainate 3	0.013	Human Rat
SH3RF1	SH3 domain containing ring finger 1	0.013
ADAM11	ADAM metallopeptidase domain 11	0.013
AGER	advanced glycosylation end product-specific receptor	0.012
UBQLN1	ubiquilin 1	0.012
CCKBR	cholecystokinin B receptor	0.012	Rat
ADORA1	adenosine A1 receptor	0.012	Mouse Rat
KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.012	Worm
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.012
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.012
CA10	carbonic anhydrase X	0.012
SRCIN1	SRC kinase signaling inhibitor 1	0.012
ATP8	ATP synthase F0 subunit 8	0.012
NELL1	NEL-like 1 (chicken)	0.012
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.012
KIAA1045	KIAA1045	0.012
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.012
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.011
ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.011
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.011
KCNH1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.011
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.011
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.011
CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.011
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.011
EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	0.011
MYO16	myosin XVI	0.011
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.011	Mouse Rat Fly
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.011	Mouse
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.011
GRIA3	glutamate receptor, ionotrophic, AMPA 3	0.011	Human
FEZF2	FEZ family zinc finger 2	0.011
RGS2	regulator of G-protein signaling 2, 24kDa	0.011
SLC7A10	solute carrier family 7, (neutral amino acid transporter, y+ system) member 10	0.011
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.010
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.010
MKL1	megakaryoblastic leukemia (translocation) 1	0.010
RIMS2	regulating synaptic membrane exocytosis 2	0.010	Worm
MEOX2	mesenchyme homeobox 2	0.010
NUMB	numb homolog (Drosophila)	0.010
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.010
SLC8A2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.010
RNF11	ring finger protein 11	0.010
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.010
CACNB4	calcium channel, voltage-dependent, beta 4 subunit	0.010
RAB10	RAB10, member RAS oncogene family	0.010
NEUROD2	neurogenic differentiation 2	0.010	Mouse
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.010
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.010
NCAN	neurocan	0.010