IMP

Process View

Homo sapiens

11 genes annotated in human

cell maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell maturation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cell maturation" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	0.952	Fly
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.716	Fly
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.620	Fly
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.593	Fly
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.566	Fly
CDK2	cyclin-dependent kinase 2	0.279
TP53	tumor protein p53	0.149
RUNX1	runt-related transcription factor 1	0.139
TAL1	T-cell acute lymphocytic leukemia 1	0.093	Mouse
CUL1	cullin 1	0.093	Fly
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.093
RB1	retinoblastoma 1	0.089	Mouse
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.087	Fly
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.087
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.086	Fly
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.077	Fly
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.065
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.064
PPARA	peroxisome proliferator-activated receptor alpha	0.064	Human
RING1	ring finger protein 1	0.062
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.059	Fly
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.056	Fly
HIPK2	homeodomain interacting protein kinase 2	0.055
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.049
CCNA2	cyclin A2	0.049
NCOR2	nuclear receptor corepressor 2	0.047
SKP2	S-phase kinase-associated protein 2 (p45)	0.045
GSK3B	glycogen synthase kinase 3 beta	0.043	Mouse
RHOA	ras homolog gene family, member A	0.042
PLXNB1	plexin B1	0.041
CCNB1	cyclin B1	0.039	Rat Worm
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.037
OCRL	oculocerebrorenal syndrome of Lowe	0.036
RBL1	retinoblastoma-like 1 (p107)	0.034
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.034
ESR1	estrogen receptor 1	0.031
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.030
FBXW11	F-box and WD repeat domain containing 11	0.030	Fly
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.029
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.025
USP11	ubiquitin specific peptidase 11	0.023
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.023	Fly
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.022
PCGF2	polycomb group ring finger 2	0.022
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.022	Fly
PRKCZ	protein kinase C, zeta	0.022
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.021
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.021
JUN	jun proto-oncogene	0.021
SYK	spleen tyrosine kinase	0.021
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.021	Mouse
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.021
E2F1	E2F transcription factor 1	0.021
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.021
RBL2	retinoblastoma-like 2 (p130)	0.020
BMI1	BMI1 polycomb ring finger oncogene	0.020
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.020	Fly
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.019
RAD21	RAD21 homolog (S. pombe)	0.019
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.019
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.019	Human
NCOR1	nuclear receptor corepressor 1	0.018
LAT	linker for activation of T cells	0.018
EIF4A3	eukaryotic translation initiation factor 4A3	0.017	Fly
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.016
BTRC	beta-transducin repeat containing	0.016	Fly
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.016	Fly
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.016
WEE1	WEE1 homolog (S. pombe)	0.015
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.015
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.015	Fly
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.015
EGR1	early growth response 1	0.015	Worm
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.014
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.014
CDK1	cyclin-dependent kinase 1	0.014	Worm
SNAP25	synaptosomal-associated protein, 25kDa	0.014
ARRB1	arrestin, beta 1	0.014
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.014
MAPK6	mitogen-activated protein kinase 6	0.014
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.014
COX17	COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)	0.014
PCGF3	polycomb group ring finger 3	0.013
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.013	Fly
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.013
EZR	ezrin	0.013	Fly
FGFR1	fibroblast growth factor receptor 1	0.013	Mouse
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.013
TFDP1	transcription factor Dp-1	0.013
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.012
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.012
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.012
NRP1	neuropilin 1	0.012
BMPR1A	bone morphogenetic protein receptor, type IA	0.012
CSNK2B	casein kinase 2, beta polypeptide	0.012
HDAC4	histone deacetylase 4	0.012
MEOX2	mesenchyme homeobox 2	0.011
BRCA2	breast cancer 2, early onset	0.011	Mouse
GDA	guanine deaminase	0.011
CAV1	caveolin 1, caveolae protein, 22kDa	0.011
EGR3	early growth response 3	0.011	Worm
GAS6	growth arrest-specific 6	0.011
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.011
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.011
YAP1	Yes-associated protein 1	0.011
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.011
SKP1	S-phase kinase-associated protein 1	0.011	Fly
FBXL12	F-box and leucine-rich repeat protein 12	0.011
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.011
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.011
ZNF746	zinc finger protein 746	0.011
ZMYND11	zinc finger, MYND-type containing 11	0.010
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.010	Fly
MIB1	mindbomb homolog 1 (Drosophila)	0.010
CBX4	chromobox homolog 4	0.010	Fly
ITSN1	intersectin 1 (SH3 domain protein)	0.010
RNF2	ring finger protein 2	0.010
ATF2	activating transcription factor 2	0.010
CTCF	CCCTC-binding factor (zinc finger protein)	0.010
SCHIP1	schwannomin interacting protein 1	0.010