IMP

Process View

Homo sapiens

4 genes annotated in human

immune response inhibiting cell surface receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "immune response inhibiting cell surface receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "immune response inhibiting cell surface receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
HLA-A	major histocompatibility complex, class I, A	1.000	Human
HLA-C	major histocompatibility complex, class I, C	1.000	Human
HLA-G	major histocompatibility complex, class I, G	1.000
B2M	beta-2-microglobulin	1.000
HLA-B	major histocompatibility complex, class I, B	1.000
HLA-F	major histocompatibility complex, class I, F	1.000	Human
HLA-E	major histocompatibility complex, class I, E	1.000	Human
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	1.000
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	1.000
PILRA	paired immunoglobin-like type 2 receptor alpha	0.999
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.999
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.997	Human
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.993
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.984
TAPBP	TAP binding protein (tapasin)	0.981
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.957	Human
HK3	hexokinase 3 (white cell)	0.906
SIGLEC7	sialic acid binding Ig-like lectin 7	0.798
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.714
PTAFR	platelet-activating factor receptor	0.629
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.611
CD84	CD84 molecule	0.586
TYMP	thymidine phosphorylase	0.289
CD33	CD33 molecule	0.258
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.237	Human
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.192
HFE	hemochromatosis	0.175	Human
AOAH	acyloxyacyl hydrolase (neutrophil)	0.155
SIRPB1	signal-regulatory protein beta 1	0.138
SIGLEC9	sialic acid binding Ig-like lectin 9	0.120
NLRP3	NLR family, pyrin domain containing 3	0.118
TAPBPL	TAP binding protein-like	0.110
CD300C	CD300c molecule	0.107
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.094
BTN3A1	butyrophilin, subfamily 3, member A1	0.079
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.079	Human
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.071
HCP5	HLA complex P5	0.071
TREM1	triggering receptor expressed on myeloid cells 1	0.069
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.063	Human
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.062
FPR2	formyl peptide receptor 2	0.060
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.059
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.057
VSIG4	V-set and immunoglobulin domain containing 4	0.052
CST3	cystatin C	0.048
CMKLR1	chemokine-like receptor 1	0.048
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.048
ASGR2	asialoglycoprotein receptor 2	0.048
MARCO	macrophage receptor with collagenous structure	0.045
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.045
PECAM1	platelet/endothelial cell adhesion molecule	0.045
CD300A	CD300a molecule	0.043
SIGLEC5	sialic acid binding Ig-like lectin 5	0.043
GRB7	growth factor receptor-bound protein 7	0.042
KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	0.040
CSK	c-src tyrosine kinase	0.040
KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	0.040
FCAR	Fc fragment of IgA, receptor for	0.039	Human
CD86	CD86 molecule	0.037
FTL	ferritin, light polypeptide	0.036
CYTH4	cytohesin 4	0.035
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.034
NOD2	nucleotide-binding oligomerization domain containing 2	0.034
SH3BP2	SH3-domain binding protein 2	0.034
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.034
KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 and killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	0.034
PGCP	plasma glutamate carboxypeptidase	0.033
BTN3A2	butyrophilin, subfamily 3, member A2	0.032
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.032
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.031
DPEP2	dipeptidase 2	0.028
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.028
TPP1	tripeptidyl peptidase I	0.028
BIN2	bridging integrator 2	0.027
CCR1	chemokine (C-C motif) receptor 1	0.026
SIGLEC10	sialic acid binding Ig-like lectin 10	0.025
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.025	Human
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.025
APOBR	apolipoprotein B receptor	0.024
ADPRH	ADP-ribosylarginine hydrolase	0.024
TLR8	toll-like receptor 8	0.024
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.024
CFP	complement factor properdin	0.024
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.023
EPOR	erythropoietin receptor	0.023
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.023
FOLR3	folate receptor 3 (gamma)	0.022
SLC15A3	solute carrier family 15, member 3	0.022
S100A12	S100 calcium binding protein A12	0.021
BTN3A3	butyrophilin, subfamily 3, member A3	0.021
BEST1	bestrophin 1	0.021
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.020
SIRPA	signal-regulatory protein alpha	0.020
AQP9	aquaporin 9	0.020
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.019
LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	0.019
C1orf38	chromosome 1 open reading frame 38	0.019
SLAMF1	signaling lymphocytic activation molecule family member 1	0.019
KIR2DL4	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	0.019	Human
TCIRG1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	0.018
TLR6	toll-like receptor 6	0.018
P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	0.018
EMR3	egf-like module containing, mucin-like, hormone receptor-like 3	0.018
KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	0.018
OASL	2'-5'-oligoadenylate synthetase-like	0.018
BATF2	basic leucine zipper transcription factor, ATF-like 2	0.017
C2	complement component 2	0.017
GNLY	granulysin	0.017
CLEC5A	C-type lectin domain family 5, member A	0.016
P2RX7	purinergic receptor P2X, ligand-gated ion channel, 7	0.016
TXNDC3	thioredoxin domain containing 3 (spermatozoa)	0.016
FFAR2	free fatty acid receptor 2	0.015
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.015
BPI	bactericidal/permeability-increasing protein	0.015
FPR3	formyl peptide receptor 3	0.015
IFITM1	interferon induced transmembrane protein 1 (9-27)	0.015
HAMP	hepcidin antimicrobial peptide	0.014
IGSF6	immunoglobulin superfamily, member 6	0.014
RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	0.014
TFEB	transcription factor EB	0.014
GPR132	G protein-coupled receptor 132	0.014
GPR77	G protein-coupled receptor 77	0.014
TBXAS1	thromboxane A synthase 1 (platelet)	0.014
CD163	CD163 molecule	0.014
RPGRIP1	retinitis pigmentosa GTPase regulator interacting protein 1	0.013
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.013
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.013
CD101	CD101 molecule	0.013
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.013
PRSS23	protease, serine, 23	0.013
CD72	CD72 molecule	0.012
CD68	CD68 molecule	0.012
RNASE3	ribonuclease, RNase A family, 3	0.012
FPR1	formyl peptide receptor 1	0.012
HP	haptoglobin	0.012
HOXD8	homeobox D8	0.012
BTN2A1	butyrophilin, subfamily 2, member A1	0.012
NLRC5	NLR family, CARD domain containing 5	0.012
KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	0.012
APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.012
RIN3	Ras and Rab interactor 3	0.012
CD22	CD22 molecule	0.012
ITM2B	integral membrane protein 2B	0.012
ISG20	interferon stimulated exonuclease gene 20kDa	0.012
PSAP	prosaposin	0.012
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.012
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.012
ARG1	arginase, liver	0.011
TF	transferrin	0.011
PDCD1LG2	programmed cell death 1 ligand 2	0.011
CXCR1	chemokine (C-X-C motif) receptor 1	0.011
MYO1G	myosin IG	0.011
ACPP	acid phosphatase, prostate	0.011
CD160	CD160 molecule	0.011
IL10	interleukin 10	0.010
IL1RN	interleukin 1 receptor antagonist	0.010
CD14	CD14 molecule	0.010
CCL24	chemokine (C-C motif) ligand 24	0.010
RENBP	renin binding protein	0.010