IMP

Process View

Homo sapiens

27 genes annotated in human

type i interferon production

The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "type i interferon production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "type i interferon production" (in gray)

Name	Description	Probability	Func Analog Organism
MYD88	myeloid differentiation primary response gene (88)	0.936	Mouse
IRAK1	interleukin-1 receptor-associated kinase 1	0.924
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.905
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.809
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.803
TBK1	TANK-binding kinase 1	0.748
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.577	Mouse
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.567
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.523	Human
IRF7	interferon regulatory factor 7	0.469
PILRA	paired immunoglobin-like type 2 receptor alpha	0.465
STAT2	signal transducer and activator of transcription 2, 113kDa	0.412
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.369	Human
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.348	Human
MAVS	mitochondrial antiviral signaling protein	0.282
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.280	Human
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.261
STAT1	signal transducer and activator of transcription 1, 91kDa	0.244
IRAK2	interleukin-1 receptor-associated kinase 2	0.213
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.192
CYLD	cylindromatosis (turban tumor syndrome)	0.189
CHUK	conserved helix-loop-helix ubiquitous kinase	0.181	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.167
SP110	SP110 nuclear body protein	0.149
PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.146
PIAS4	protein inhibitor of activated STAT, 4	0.141
IRF3	interferon regulatory factor 3	0.124	Human Mouse
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.122
CD33	CD33 molecule	0.118
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.117	Human
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.115
NLRC4	NLR family, CARD domain containing 4	0.103
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.099
TRIM5	tripartite motif containing 5	0.096	Human
RANBP3	RAN binding protein 3	0.090
ZNF263	zinc finger protein 263	0.088
TRAF6	TNF receptor-associated factor 6	0.085
PTAFR	platelet-activating factor receptor	0.082
MED15	mediator complex subunit 15	0.080
BIRC3	baculoviral IAP repeat containing 3	0.079
TMEM173	transmembrane protein 173	0.070
TLR4	toll-like receptor 4	0.067	Human Mouse
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.063
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.063
KAT2B	K(lysine) acetyltransferase 2B	0.059
NLRP3	NLR family, pyrin domain containing 3	0.054
IRF8	interferon regulatory factor 8	0.052	Human
TLR2	toll-like receptor 2	0.051
ZNF473	zinc finger protein 473	0.051
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.050
TRIM25	tripartite motif containing 25	0.048
NLRC5	NLR family, CARD domain containing 5	0.048
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.047
POLR3E	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	0.046
TRIM26	tripartite motif containing 26	0.045
TRIM21	tripartite motif containing 21	0.045	Human
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.043
MEFV	Mediterranean fever	0.040
DTX3L	deltex 3-like (Drosophila)	0.040
TNRC6B	trinucleotide repeat containing 6B	0.040
TRAF2	TNF receptor-associated factor 2	0.039
IRAK3	interleukin-1 receptor-associated kinase 3	0.038
IRAK4	interleukin-1 receptor-associated kinase 4	0.036
CREBBP	CREB binding protein	0.036
TRIM39	tripartite motif containing 39	0.035	Human
CD86	CD86 molecule	0.035
ADAR	adenosine deaminase, RNA-specific	0.035
HK3	hexokinase 3 (white cell)	0.032
TRAF3	TNF receptor-associated factor 3	0.032	Mouse
CCR1	chemokine (C-C motif) receptor 1	0.031
TICAM2	toll-like receptor adaptor molecule 2	0.030
POLR1C	polymerase (RNA) I polypeptide C, 30kDa	0.029
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.027
SIGLEC7	sialic acid binding Ig-like lectin 7	0.026
PML	promyelocytic leukemia	0.026
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.025
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.025
TRIM17	tripartite motif containing 17	0.025	Human
SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.023
NOD2	nucleotide-binding oligomerization domain containing 2	0.022
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.022
POLR3H	polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)	0.022
PPP3CB	protein phosphatase 3, catalytic subunit, beta isozyme	0.021
ZNFX1	zinc finger, NFX1-type containing 1	0.021
TANK	TRAF family member-associated NFKB activator	0.020
TRIM32	tripartite motif containing 32	0.020
RTP4	receptor (chemosensory) transporter protein 4	0.020
FKBP5	FK506 binding protein 5	0.020
VNN2	vanin 2	0.020
FADD	Fas (TNFRSF6)-associated via death domain	0.020
C19orf66	chromosome 19 open reading frame 66	0.020
MR1	major histocompatibility complex, class I-related	0.019
CYTH4	cytohesin 4	0.019
TRIM8	tripartite motif containing 8	0.019
HCK	hemopoietic cell kinase	0.019
IL4R	interleukin 4 receptor	0.018
TLR8	toll-like receptor 8	0.018
HERC5	hect domain and RLD 5	0.018
TADA3	transcriptional adaptor 3	0.018
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.018
JAK2	Janus kinase 2	0.018
SPOP	speckle-type POZ protein	0.017
BIN2	bridging integrator 2	0.017
IGSF6	immunoglobulin superfamily, member 6	0.017
LY86	lymphocyte antigen 86	0.017
FKBP4	FK506 binding protein 4, 59kDa	0.016
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.016
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.016
TYMP	thymidine phosphorylase	0.016
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.015
AOAH	acyloxyacyl hydrolase (neutrophil)	0.015
BATF	basic leucine zipper transcription factor, ATF-like	0.015
BTK	Bruton agammaglobulinemia tyrosine kinase	0.015
CYBB	cytochrome b-245, beta polypeptide	0.015
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.015
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.015
TNRC6C	trinucleotide repeat containing 6C	0.015
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.015
CD300C	CD300c molecule	0.014
PARP12	poly (ADP-ribose) polymerase family, member 12	0.014	Human
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.014
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.014
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.014
STAP2	signal transducing adaptor family member 2	0.014
TFEC	transcription factor EC	0.014
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.013
C5orf56	chromosome 5 open reading frame 56	0.013
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.013	Human
POLR3D	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	0.013
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.013
IRF2BP2	interferon regulatory factor 2 binding protein 2	0.013
ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	0.013
TLR6	toll-like receptor 6	0.013	Human
IFIH1	interferon induced with helicase C domain 1	0.013
BAX	BCL2-associated X protein	0.013
CFLAR	CASP8 and FADD-like apoptosis regulator	0.013
TRIM52	tripartite motif containing 52	0.013
CD180	CD180 molecule	0.012	Human
SAMD9L	sterile alpha motif domain containing 9-like	0.012
UBA7	ubiquitin-like modifier activating enzyme 7	0.012
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.012
CTSS	cathepsin S	0.012
TNIP1	TNFAIP3 interacting protein 1	0.012
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.012
IL15	interleukin 15	0.012
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.012	Human
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.012
PELI3	pellino homolog 3 (Drosophila)	0.012	Mouse
FAS	Fas (TNF receptor superfamily, member 6)	0.012
SLC15A3	solute carrier family 15, member 3	0.012
EPOR	erythropoietin receptor	0.012
IRF5	interferon regulatory factor 5	0.012	Human
P2RY13	purinergic receptor P2Y, G-protein coupled, 13	0.012
TRIM35	tripartite motif containing 35	0.011
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.011
SP100	SP100 nuclear antigen	0.011
PARP14	poly (ADP-ribose) polymerase family, member 14	0.011
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.011
BRAP	BRCA1 associated protein	0.011
SREBF1	sterol regulatory element binding transcription factor 1	0.011
TNRC6A	trinucleotide repeat containing 6A	0.011
TICAM1	toll-like receptor adaptor molecule 1	0.011	Mouse
CD28	CD28 molecule	0.010
MCOLN1	mucolipin 1	0.010
SIGLEC10	sialic acid binding Ig-like lectin 10	0.010
PLEK	pleckstrin	0.010
KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.010
PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	0.010
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.010
TLR1	toll-like receptor 1	0.010	Human
DOCK8	dedicator of cytokinesis 8	0.010