IMP
Process View
double strand break repair via single strand annealing
Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "double strand break repair via single strand annealing"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| BRCA1 | breast cancer 1, early onset | 1.000 | ||
| WRN | Werner syndrome, RecQ helicase-like | 0.995 | ||
| MUS81 | MUS81 endonuclease homolog (S. cerevisiae) | 0.988 | ||
| H2AFX | H2A histone family, member X | 0.985 | ||
| RAD51 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 0.972 | ||
| NBN | nibrin | 0.972 | ||
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.963 | ||
| EME1 | essential meiotic endonuclease 1 homolog 1 (S. pombe) | 0.925 | ||
| MSH6 | mutS homolog 6 (E. coli) | 0.915 | ||
| TERF2 | telomeric repeat binding factor 2 | 0.911 | ||
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.895 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.861 | ||
| MSH2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 0.848 | ||
| BRCA2 | breast cancer 2, early onset | 0.771 | ||
| RPA1 | replication protein A1, 70kDa | 0.768 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.763 | ||
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 0.618 | ||
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.609 | ||
| ERCC4 | excision repair cross-complementing rodent repair deficiency, complementation group 4 | 0.603 | ||
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.603 | ||
| MLH1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 0.523 | ||
| TOP3A | topoisomerase (DNA) III alpha | 0.368 | ||
| C20orf94 | chromosome 20 open reading frame 94 | 0.366 | ||
| ATM | ataxia telangiectasia mutated | 0.341 | ||
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.246 | ||
| BLM | Bloom syndrome, RecQ helicase-like | 0.165 | Fly | |
| TP53 | tumor protein p53 | 0.164 | ||
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | 0.152 | ||
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.152 | ||
| PALB2 | partner and localizer of BRCA2 | 0.146 | ||
| RBL1 | retinoblastoma-like 1 (p107) | 0.140 | ||
| BARD1 | BRCA1 associated RING domain 1 | 0.135 | ||
| PLK1 | polo-like kinase 1 | 0.106 | ||
| RAD18 | RAD18 homolog (S. cerevisiae) | 0.105 | ||
| PSMB2 | proteasome (prosome, macropain) subunit, beta type, 2 | 0.103 | ||
| EXO1 | exonuclease 1 | 0.086 | ||
| MSH3 | mutS homolog 3 (E. coli) | 0.086 | ||
| RPA2 | replication protein A2, 32kDa | 0.066 | ||
| FANCA | Fanconi anemia, complementation group A | 0.064 | ||
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | 0.064 | ||
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.054 | ||
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.053 | ||
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | 0.053 | ||
| RIF1 | RAP1 interacting factor homolog (yeast) | 0.050 | ||
| RMI1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) | 0.045 | ||
| RB1 | retinoblastoma 1 | 0.036 | ||
| CLSPN | claspin | 0.034 | ||
| SMC1A | structural maintenance of chromosomes 1A | 0.031 | ||
| SLC25A13 | solute carrier family 25, member 13 (citrin) | 0.031 | ||
| TTI1 | Tel2 interacting protein 1 homolog (S. pombe) | 0.031 | ||
| RAD51L3 | RAD51-like 3 (S. cerevisiae) | 0.030 | ||
| TP53BP1 | tumor protein p53 binding protein 1 | 0.029 | ||
| CUX1 | cut-like homeobox 1 | 0.025 | ||
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 0.024 | ||
| THAP11 | THAP domain containing 11 | 0.024 | ||
| RFC1 | replication factor C (activator 1) 1, 145kDa | 0.020 | ||
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.019 | ||
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.019 | ||
| CTBP1 | C-terminal binding protein 1 | 0.017 | ||
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.015 | ||
| DUSP10 | dual specificity phosphatase 10 | 0.015 | ||
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.014 | ||
| E2F3 | E2F transcription factor 3 | 0.013 | ||
| ATR | ataxia telangiectasia and Rad3 related | 0.013 | Fly | |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.012 | ||
| DCLRE1B | DNA cross-link repair 1B | 0.012 | ||
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | 0.012 | ||
| POMP | proteasome maturation protein | 0.012 | ||
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.011 | ||
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | 0.011 | ||
| PSMA1 | proteasome (prosome, macropain) subunit, alpha type, 1 | 0.011 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.011 | ||
| ORC2 | origin recognition complex, subunit 2 | 0.011 | ||
| DCLRE1C | DNA cross-link repair 1C | 0.010 | ||
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.010 |