IMP

Process View

Mus musculus

1 genes annotated in mouse

negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.999
Fgfr2	fibroblast growth factor receptor 2	0.999
Pitx2	paired-like homeodomain transcription factor 2	0.998
Tbx3	T-box 3	0.998	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.978
Tbx5	T-box 5	0.967	Mouse
Foxc1	forkhead box C1	0.966
Chd7	chromodomain helicase DNA binding protein 7	0.959
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.956
Foxg1	forkhead box G1	0.931
Hoxa1	homeobox A1	0.930
Gli3	GLI-Kruppel family member GLI3	0.923
Foxc2	forkhead box C2	0.920
Sox9	SRY-box containing gene 9	0.888
Pax2	paired box gene 2	0.888
Bmp4	bone morphogenetic protein 4	0.873
Eya1	eyes absent 1 homolog (Drosophila)	0.850
Tcfap2a	transcription factor AP-2, alpha	0.834
Pitx1	paired-like homeodomain transcription factor 1	0.829
Vangl2	vang-like 2 (van gogh, Drosophila)	0.823
Pax3	paired box gene 3	0.796
Prrx1	paired related homeobox 1	0.779
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.692
Otx2	orthodenticle homolog 2 (Drosophila)	0.668
Msx1	homeobox, msh-like 1	0.652
Dlx5	distal-less homeobox 5	0.632
Fgfr3	fibroblast growth factor receptor 3	0.617
Jag1	jagged 1	0.608
Scn5a	sodium channel, voltage-gated, type V, alpha	0.574
Hand1	heart and neural crest derivatives expressed transcript 1	0.567
Gbx2	gastrulation brain homeobox 2	0.497
Rarb	retinoic acid receptor, beta	0.479
Runx2	runt related transcription factor 2	0.459
Alx1	ALX homeobox 1	0.447
Hand2	heart and neural crest derivatives expressed transcript 2	0.433
Fgf10	fibroblast growth factor 10	0.398
Fgf8	fibroblast growth factor 8	0.398
Zeb1	zinc finger E-box binding homeobox 1	0.396
Lef1	lymphoid enhancer binding factor 1	0.391
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.352
Tbx4	T-box 4	0.348	Mouse
Sall4	sal-like 4 (Drosophila)	0.335
Bmp7	bone morphogenetic protein 7	0.319
Efnb2	ephrin B2	0.310
Chrd	chordin	0.303
Rarg	retinoic acid receptor, gamma	0.280
Lrp6	low density lipoprotein receptor-related protein 6	0.279
Hoxa3	homeobox A3	0.268
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.267
Tbx1	T-box 1	0.230	Mouse
Sox2	SRY-box containing gene 2	0.209
Smo	smoothened homolog (Drosophila)	0.206
Ednra	endothelin receptor type A	0.199
Gata3	GATA binding protein 3	0.182
Zic3	zinc finger protein of the cerebellum 3	0.174
Sox11	SRY-box containing gene 11	0.173
Lmx1a	LIM homeobox transcription factor 1 alpha	0.160
Rxra	retinoid X receptor alpha	0.144
Pax9	paired box gene 9	0.139
Fgfr1	fibroblast growth factor receptor 1	0.137
Gli2	GLI-Kruppel family member GLI2	0.136
Gsc	goosecoid homeobox	0.130
Wt1	Wilms tumor 1 homolog	0.120
Tcf21	transcription factor 21	0.115
Msx2	homeobox, msh-like 2	0.114
Tgfb2	transforming growth factor, beta 2	0.109
Smad6	MAD homolog 6 (Drosophila)	0.101
Ighmbp2	immunoglobulin mu binding protein 2	0.100
Isl1	ISL1 transcription factor, LIM/homeodomain	0.100
Trp63	transformation related protein 63	0.099
Bmp5	bone morphogenetic protein 5	0.097
Vegfa	vascular endothelial growth factor A	0.092
Lrp5	low density lipoprotein receptor-related protein 5	0.090
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.084
Pou5f1	POU domain, class 5, transcription factor 1	0.084
Wnt5a	wingless-related MMTV integration site 5A	0.076
Wnt3a	wingless-related MMTV integration site 3A	0.074
Myf5	myogenic factor 5	0.074
Otx1	orthodenticle homolog 1 (Drosophila)	0.073
Prrx2	paired related homeobox 2	0.068
Mn1	meningioma 1	0.068
Hoxb3	homeobox B3	0.068
Emx2	empty spiracles homolog 2 (Drosophila)	0.063
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.063
Hoxa2	homeobox A2	0.063
Satb2	special AT-rich sequence binding protein 2	0.063
Sall1	sal-like 1 (Drosophila)	0.060
Dlx2	distal-less homeobox 2	0.059
Meox2	mesenchyme homeobox 2	0.057
Nanog	Nanog homeobox	0.056
Gata4	GATA binding protein 4	0.055
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.055
Noto	notochord homolog (Xenopus laevis)	0.047
Twist2	twist homolog 2 (Drosophila)	0.044
Ptch1	patched homolog 1	0.044
Dll4	delta-like 4 (Drosophila)	0.044
Gata6	GATA binding protein 6	0.043
Hoxd1	homeobox D1	0.043
Hoxa13	homeobox A13	0.042
Irx3	Iroquois related homeobox 3 (Drosophila)	0.041
Ntf3	neurotrophin 3	0.040
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.039
Rybp	RING1 and YY1 binding protein	0.038
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.038
Lhx1	LIM homeobox protein 1	0.037
Mecom	MDS1 and EVI1 complex locus	0.036
Gja5	gap junction protein, alpha 5	0.036
Rara	retinoic acid receptor, alpha	0.036
Col13a1	collagen, type XIII, alpha 1	0.036
Fgfrl1	fibroblast growth factor receptor-like 1	0.036
Hoxd3	homeobox D3	0.035
Pou4f2	POU domain, class 4, transcription factor 2	0.035
Rnf2	ring finger protein 2	0.035
Cxadr	coxsackie virus and adenovirus receptor	0.032
Zfp503	zinc finger protein 503	0.031
Pbx1	pre B-cell leukemia transcription factor 1	0.031
Nog	noggin	0.030
Hoxa10	homeobox A10	0.029
Prdm6	PR domain containing 6	0.028
Bmp2	bone morphogenetic protein 2	0.028
Hmx2	H6 homeobox 2	0.028
Alx4	aristaless-like homeobox 4	0.027
Ltbp1	latent transforming growth factor beta binding protein 1	0.027
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.026
Hmx3	H6 homeobox 3	0.026
Nkx3-2	NK3 homeobox 2	0.026
Tbx20	T-box 20	0.025	Mouse
Lhx9	LIM homeobox protein 9	0.025
Nodal	nodal	0.024
Hoxb4	homeobox B4	0.023
Ptk7	PTK7 protein tyrosine kinase 7	0.023
Gata2	GATA binding protein 2	0.023
Hoxa11	homeobox A11	0.023
Prdm1	PR domain containing 1, with ZNF domain	0.022
Bmper	BMP-binding endothelial regulator	0.022
Hoxd11	homeobox D11	0.022
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.022
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.021
Osr1	odd-skipped related 1 (Drosophila)	0.021
Gja1	gap junction protein, alpha 1	0.020
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.020
Vstm2b	V-set and transmembrane domain containing 2B	0.020
Mks1	Meckel syndrome, type 1	0.020
Foxf1a	forkhead box F1a	0.019
Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	0.019
Ripply3	ripply3 homolog (zebrafish)	0.019
Irx5	Iroquois related homeobox 5 (Drosophila)	0.018
Slc12a2	solute carrier family 12, member 2	0.017
Hoxb2	homeobox B2	0.016
Tbx2	T-box 2	0.016	Mouse
Msc	musculin	0.016
Egfr	epidermal growth factor receptor	0.016
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.016
Efna1	ephrin A1	0.016
Gata5	GATA binding protein 5	0.016
Shox2	short stature homeobox 2	0.016
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.016
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.015
Irx4	Iroquois related homeobox 4 (Drosophila)	0.015
Gimap7	GTPase, IMAP family member 7	0.015
Zic1	zinc finger protein of the cerebellum 1	0.015
Acvr2b	activin receptor IIB	0.015
Zfpm2	zinc finger protein, multitype 2	0.015
Foxa1	forkhead box A1	0.015
Foxi1	forkhead box I1	0.014
Foxi3	forkhead box I3	0.014
Runx3	runt related transcription factor 3	0.014
Sox4	SRY-box containing gene 4	0.014
Sorbs3	sorbin and SH3 domain containing 3	0.014
Nkx2-1	NK2 homeobox 1	0.014
Fign	fidgetin	0.013
Zic2	zinc finger protein of the cerebellum 2	0.013
Foxf2	forkhead box F2	0.013
Axin2	axin2	0.013
Zfp318	zinc finger protein 318	0.013
Tal1	T-cell acute lymphocytic leukemia 1	0.013
Cd274	CD274 antigen	0.013
Alx3	aristaless-like homeobox 3	0.013
Nckap5l	NCK-associated protein 5-like	0.013
Olig3	oligodendrocyte transcription factor 3	0.013
Sox17	SRY-box containing gene 17	0.013
Ptgfr	prostaglandin F receptor	0.013
Hoxa4	homeobox A4	0.012
Npr3	natriuretic peptide receptor 3	0.012
Tcfcp2l1	transcription factor CP2-like 1	0.012
Mmp15	matrix metallopeptidase 15	0.012
Ece1	endothelin converting enzyme 1	0.012
En1	engrailed 1	0.012
Tcf7	transcription factor 7, T-cell specific	0.012
Ryr2	ryanodine receptor 2, cardiac	0.012
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.012
Ctnnb1	catenin (cadherin associated protein), beta 1	0.012
Thsd1	thrombospondin, type I, domain 1	0.012
S1pr4	sphingosine-1-phosphate receptor 4	0.011
Atoh8	atonal homolog 8 (Drosophila)	0.011
BC020535	cDNA sequence BC020535	0.011
Nkg7	natural killer cell group 7 sequence	0.011
Hoxa5	homeobox A5	0.011
Fam89a	family with sequence similarity 89, member A	0.011
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.011
Lrp4	low density lipoprotein receptor-related protein 4	0.011
Apc	adenomatosis polyposis coli	0.011
Rdh10	retinol dehydrogenase 10 (all-trans)	0.011
Bcl2	B-cell leukemia/lymphoma 2	0.011
Nos3	nitric oxide synthase 3, endothelial cell	0.011
Eomes	eomesodermin homolog (Xenopus laevis)	0.011	Mouse
Fev	FEV (ETS oncogene family)	0.011
Cd5	CD5 antigen	0.011
Pou3f3	POU domain, class 3, transcription factor 3	0.011
Hic2	hypermethylated in cancer 2	0.011
Tbx6	T-box 6	0.011	Mouse
Ifng	interferon gamma	0.011
Dnahc11	dynein, axonemal, heavy chain 11	0.011
Wdr19	WD repeat domain 19	0.011
Hhip	Hedgehog-interacting protein	0.011
Fzd6	frizzled homolog 6 (Drosophila)	0.010
Hoxb5	homeobox B5	0.010
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.010
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.010
Kremen2	kringle containing transmembrane protein 2	0.010
Asb10	ankyrin repeat and SOCS box-containing 10	0.010
Wnt9b	wingless-type MMTV integration site 9B	0.010
Foxh1	forkhead box H1	0.010
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.010
Hoxb6	homeobox B6	0.010
Cd28	CD28 antigen	0.010
Rag2	recombination activating gene 2	0.010
Meox1	mesenchyme homeobox 1	0.010
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.010