IMP

Process View

Mus musculus

4 genes annotated in mouse

cranial nerve formation

The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cranial nerve formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cranial nerve formation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.989
Ednra	endothelin receptor type A	0.978
Eya1	eyes absent 1 homolog (Drosophila)	0.974
Hoxa1	homeobox A1	0.970	Human
Dlx5	distal-less homeobox 5	0.952	Zebrafish
Pax3	paired box gene 3	0.935
Tcfap2a	transcription factor AP-2, alpha	0.933
Gli3	GLI-Kruppel family member GLI3	0.931
Msx1	homeobox, msh-like 1	0.929
Fgfr2	fibroblast growth factor receptor 2	0.926
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.915
Pax2	paired box gene 2	0.911
Prrx1	paired related homeobox 1	0.896	Mouse
Foxc2	forkhead box C2	0.892
Foxc1	forkhead box C1	0.882
Bmp7	bone morphogenetic protein 7	0.878
Tbx1	T-box 1	0.866
Chrd	chordin	0.850
Foxg1	forkhead box G1	0.766
Msx2	homeobox, msh-like 2	0.644
Bmp4	bone morphogenetic protein 4	0.620
Sox9	SRY-box containing gene 9	0.576
Fgfr1	fibroblast growth factor receptor 1	0.537	Zebrafish
Hand2	heart and neural crest derivatives expressed transcript 2	0.523
Zeb1	zinc finger E-box binding homeobox 1	0.477
Hand1	heart and neural crest derivatives expressed transcript 1	0.459
Jag1	jagged 1	0.418
Isl1	ISL1 transcription factor, LIM/homeodomain	0.402
Fgf10	fibroblast growth factor 10	0.383
Vangl2	vang-like 2 (van gogh, Drosophila)	0.369
Gbx2	gastrulation brain homeobox 2	0.363
Fgf3	fibroblast growth factor 3	0.350
Otx2	orthodenticle homolog 2 (Drosophila)	0.329
Ntf3	neurotrophin 3	0.324
Hoxa3	homeobox A3	0.321
Tgfb2	transforming growth factor, beta 2	0.321
Ret	ret proto-oncogene	0.315
Fgf8	fibroblast growth factor 8	0.305
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.295
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.290
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.277
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.253
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.243
Gli2	GLI-Kruppel family member GLI2	0.201	Zebrafish
Smo	smoothened homolog (Drosophila)	0.191
Tbx10	T-box 10	0.183
Pitx2	paired-like homeodomain transcription factor 2	0.178
Rarg	retinoic acid receptor, gamma	0.174
Prrx2	paired related homeobox 2	0.170	Mouse
Efnb2	ephrin B2	0.166
Rarb	retinoic acid receptor, beta	0.150
Runx2	runt related transcription factor 2	0.145
Lef1	lymphoid enhancer binding factor 1	0.140
Alx1	ALX homeobox 1	0.139
Chd7	chromodomain helicase DNA binding protein 7	0.125
Fgfr3	fibroblast growth factor receptor 3	0.122
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.113
Bmp2	bone morphogenetic protein 2	0.112
Dusp1	dual specificity phosphatase 1	0.101
Gsc	goosecoid homeobox	0.099
Lrp6	low density lipoprotein receptor-related protein 6	0.097
Alx4	aristaless-like homeobox 4	0.092
Sox11	SRY-box containing gene 11	0.090
Rara	retinoic acid receptor, alpha	0.080
Nrg1	neuregulin 1	0.080
Bdnf	brain derived neurotrophic factor	0.077
Pax6	paired box gene 6	0.077
Hoxa2	homeobox A2	0.077
Gna13	guanine nucleotide binding protein, alpha 13	0.071
Rhob	ras homolog gene family, member B	0.069
Pbx1	pre B-cell leukemia transcription factor 1	0.066
Tgfbr2	transforming growth factor, beta receptor II	0.063
Jun	Jun oncogene	0.061
Rbms1	RNA binding motif, single stranded interacting protein 1	0.058
Hoxd3	homeobox D3	0.055
Hoxb3	homeobox B3	0.054
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.053
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.053
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.050
Tbx15	T-box 15	0.049
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.047
Ndn	necdin	0.043
Lhx1	LIM homeobox protein 1	0.041
Alx3	aristaless-like homeobox 3	0.041
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.041
Gata3	GATA binding protein 3	0.040
Acvr1	activin A receptor, type 1	0.038
Sox2	SRY-box containing gene 2	0.038
Ptch1	patched homolog 1	0.037
Sox10	SRY-box containing gene 10	0.036
Tuba1b	tubulin, alpha 1B	0.035
Wnt3a	wingless-related MMTV integration site 3A	0.035
Efna4	ephrin A4	0.035
Hoxd11	homeobox D11	0.034
Col2a1	collagen, type II, alpha 1	0.033
T	brachyury	0.033
Nog	noggin	0.033
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.033
Hmx2	H6 homeobox 2	0.032
Lmx1a	LIM homeobox transcription factor 1 alpha	0.032
Hoxa11	homeobox A11	0.032
Hoxd13	homeobox D13	0.031
Dlx2	distal-less homeobox 2	0.030
Igl	immunoglobulin lambda chain complex	0.029
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.029
Twist2	twist homolog 2 (Drosophila)	0.026
Meox2	mesenchyme homeobox 2	0.026
Btg2	B-cell translocation gene 2, anti-proliferative	0.026
Trp63	transformation related protein 63	0.025
Pax9	paired box gene 9	0.025	Mouse
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.025
Fgf15	fibroblast growth factor 15	0.025
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.025
Sox4	SRY-box containing gene 4	0.025
Vti1a	vesicle transport through interaction with t-SNAREs homolog 1A (yeast)	0.025
Twist1	twist homolog 1 (Drosophila)	0.024
Mcl1	myeloid cell leukemia sequence 1	0.024
Pou4f3	POU domain, class 4, transcription factor 3	0.024
Hoxc4	homeobox C4	0.024
Fbln1	fibulin 1	0.023
Tshz1	teashirt zinc finger family member 1	0.023
Cyld	cylindromatosis (turban tumor syndrome)	0.023
Ptk7	PTK7 protein tyrosine kinase 7	0.022
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.022
Igh	immunoglobulin heavy chain complex	0.022
Fos	FBJ osteosarcoma oncogene	0.022
Ctgf	connective tissue growth factor	0.021
Ntf5	neurotrophin 5	0.021
Klf7	Kruppel-like factor 7 (ubiquitous)	0.021	Zebrafish
Egr2	early growth response 2	0.021
Fgf9	fibroblast growth factor 9	0.021
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.020
Nkx3-2	NK3 homeobox 2	0.020
Hoxa5	homeobox A5	0.020
Disp1	dispatched homolog 1 (Drosophila)	0.019
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.019
Hoxb1	homeobox B1	0.018
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.018
Dll1	delta-like 1 (Drosophila)	0.018
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.018
Psen1	presenilin 1	0.018
Foxd1	forkhead box D1	0.018
Crabp2	cellular retinoic acid binding protein II	0.018
Igf1r	insulin-like growth factor I receptor	0.017
Rxra	retinoid X receptor alpha	0.017
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.017
Phox2b	paired-like homeobox 2b	0.017	Mouse
Mecom	MDS1 and EVI1 complex locus	0.017
Hoxc5	homeobox C5	0.017
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.016
Hmx1	H6 homeobox 1	0.016
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.016
Hoxb4	homeobox B4	0.016
Hhat	hedgehog acyltransferase	0.016
Apaf1	apoptotic peptidase activating factor 1	0.015
Hoxb2	homeobox B2	0.015
Cldn8	claudin 8	0.015
Hoxd9	homeobox D9	0.015
Mn1	meningioma 1	0.015
Sfrp2	secreted frizzled-related protein 2	0.015
Nkx2-1	NK2 homeobox 1	0.015
Hmx3	H6 homeobox 3	0.015
Wnt5a	wingless-related MMTV integration site 5A	0.015
Fgfrl1	fibroblast growth factor receptor-like 1	0.015
Bmper	BMP-binding endothelial regulator	0.014
Col17a1	collagen, type XVII, alpha 1	0.014
Hoxb13	homeobox B13	0.014
Nrtn	neurturin	0.014
Myog	myogenin	0.014
En1	engrailed 1	0.014
Gucy2d	guanylate cyclase 2d	0.014
Krt14	keratin 14	0.014
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.014
Pea15a	phosphoprotein enriched in astrocytes 15A	0.014
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.014
Fyn	Fyn proto-oncogene	0.014
Camk2d	calcium/calmodulin-dependent protein kinase II, delta	0.013
Ids	iduronate 2-sulfatase	0.013
Praf2	PRA1 domain family 2	0.013
Spna2	spectrin alpha 2	0.013
Mef2a	myocyte enhancer factor 2A	0.013
Hdac6	histone deacetylase 6	0.013
Uncx	UNC homeobox	0.013
Pkp1	plakophilin 1	0.012
Fbn2	fibrillin 2	0.012
Krt16	keratin 16	0.012
Klf6	Kruppel-like factor 6	0.012	Zebrafish
Nrk	Nik related kinase	0.012
Bcl10	B-cell leukemia/lymphoma 10	0.012
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.012
Col9a1	collagen, type IX, alpha 1	0.012
Spnb2	spectrin beta 2	0.012
Rem1	rad and gem related GTP binding protein 1	0.012
Emx2	empty spiracles homolog 2 (Drosophila)	0.012
Klf4	Kruppel-like factor 4 (gut)	0.012
Cldn4	claudin 4	0.012
Actg1	actin, gamma, cytoplasmic 1	0.012
Irf2bp2	interferon regulatory factor 2 binding protein 2	0.012
Ctnnb1	catenin (cadherin associated protein), beta 1	0.012
Add1	adducin 1 (alpha)	0.012
Gdnf	glial cell line derived neurotrophic factor	0.012
Capn6	calpain 6	0.012
Hoxa9	homeobox A9	0.011
Stra6	stimulated by retinoic acid gene 6	0.011
Aqp6	aquaporin 6	0.011
Col11a1	collagen, type XI, alpha 1	0.011
Gjb5	gap junction protein, beta 5	0.011
Dlx6	distal-less homeobox 6	0.011
Usp22	ubiquitin specific peptidase 22	0.011
Tmem54	transmembrane protein 54	0.011
Ier3	immediate early response 3	0.011
Pef1	penta-EF hand domain containing 1	0.011
Pou4f2	POU domain, class 4, transcription factor 2	0.011
Pitpnc1	phosphatidylinositol transfer protein, cytoplasmic 1	0.011
Hoxd8	homeobox D8	0.011
Krt36	keratin 36	0.011
Mafb	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.011
Krt15	keratin 15	0.011
Osta	organic solute transporter alpha	0.011
Gsx2	GS homeobox 2	0.011
Tshr	thyroid stimulating hormone receptor	0.011
Adh6a	alcohol dehydrogenase 6A (class V)	0.011
Klc1	kinesin light chain 1	0.011
Efs	embryonal Fyn-associated substrate	0.011
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.011
Tbx3	T-box 3	0.011
Calm1	calmodulin 1	0.011
Hoxb9	homeobox B9	0.011
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.011
Hoxd4	homeobox D4	0.011
Fgf18	fibroblast growth factor 18	0.011
Sfn	stratifin	0.011
Crabp1	cellular retinoic acid binding protein I	0.011
Cldn7	claudin 7	0.011
S100a14	S100 calcium binding protein A14	0.011
Csnk1e	casein kinase 1, epsilon	0.011
Ets2	E26 avian leukemia oncogene 2, 3' domain	0.010
Cdx2	caudal type homeobox 2	0.010
Nxf7	nuclear RNA export factor 7	0.010
Evl	Ena-vasodilator stimulated phosphoprotein	0.010
Osr2	odd-skipped related 2 (Drosophila)	0.010
Akt3	thymoma viral proto-oncogene 3	0.010
Prph	peripherin	0.010
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.010
Has2	hyaluronan synthase 2	0.010
Wnt6	wingless-related MMTV integration site 6	0.010
Tex13	testis expressed gene 13	0.010
Hoxa7	homeobox A7	0.010
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.010