IMP

Process View

Mus musculus

12 genes annotated in mouse

Multi-species View

interleukin 6 biosynthetic process

GO:0042226

The chemical reactions and pathways resulting in the formation of interleukin-6.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 6 biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "interleukin 6 biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
Il10	interleukin 10	0.996	Mouse
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.928
Tlr4	toll-like receptor 4	0.918	Mouse
Tnf	tumor necrosis factor	0.910
Myd88	myeloid differentiation primary response gene 88	0.784
Ccl2	chemokine (C-C motif) ligand 2	0.629
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.576
Mmp9	matrix metallopeptidase 9	0.571
Birc3	baculoviral IAP repeat-containing 3	0.379
Il6	interleukin 6	0.341
Ccr2	chemokine (C-C motif) receptor 2	0.318
Nlrp3	NLR family, pyrin domain containing 3	0.256
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.245
Tcra	T-cell receptor alpha chain	0.236
Il1b	interleukin 1 beta	0.236
Ptgs2	prostaglandin-endoperoxide synthase 2	0.211
Irak4	interleukin-1 receptor-associated kinase 4	0.180
Il1r1	interleukin 1 receptor, type I	0.154
Cd40	CD40 antigen	0.153
Ifng	interferon gamma	0.142
Tlr2	toll-like receptor 2	0.118	Mouse
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.117
Mavs	mitochondrial antiviral signaling protein	0.111
Igh	immunoglobulin heavy chain complex	0.100
Nos2	nitric oxide synthase 2, inducible	0.083
Noto	notochord homolog (Xenopus laevis)	0.075
Siglec5	sialic acid binding Ig-like lectin 5	0.071
Foxp3	forkhead box P3	0.068
Ikbkg	inhibitor of kappaB kinase gamma	0.066
Cd44	CD44 antigen	0.059
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.059
Csf1	colony stimulating factor 1 (macrophage)	0.059
Il1rn	interleukin 1 receptor antagonist	0.054	Mouse
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.053
Ncoa3	nuclear receptor coactivator 3	0.052
Ldlr	low density lipoprotein receptor	0.051
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.050
Ticam1	toll-like receptor adaptor molecule 1	0.047
Il1a	interleukin 1 alpha	0.041	Mouse
Cxcl2	chemokine (C-X-C motif) ligand 2	0.039
Mefv	Mediterranean fever	0.038
Lif	leukemia inhibitory factor	0.038
Rag1	recombination activating gene 1	0.038
Stat3	signal transducer and activator of transcription 3	0.033
Lyz2	lysozyme 2	0.033
Irg1	immunoresponsive gene 1	0.032
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.032
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.029
Ccr5	chemokine (C-C motif) receptor 5	0.029
Kif19a	kinesin family member 19A	0.028
Il1f9	interleukin 1 family, member 9	0.028
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.027	Mouse
Foxo1	forkhead box O1	0.025
Igf1	insulin-like growth factor 1	0.025
Card11	caspase recruitment domain family, member 11	0.024	Mouse
Vdr	vitamin D receptor	0.024
Spp1	secreted phosphoprotein 1	0.023
Irak3	interleukin-1 receptor-associated kinase 3	0.022
Traf6	TNF receptor-associated factor 6	0.022
Fas	Fas (TNF receptor superfamily member 6)	0.020
Il4	interleukin 4	0.020
Dok2	docking protein 2	0.018
Prf1	perforin 1 (pore forming protein)	0.017
Irak1	interleukin-1 receptor-associated kinase 1	0.017
Btk	Bruton agammaglobulinemia tyrosine kinase	0.017
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.016
Pthlh	parathyroid hormone-like peptide	0.016
Fpr1	formyl peptide receptor 1	0.016
Cd14	CD14 antigen	0.015
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.015
Cxcl1	chemokine (C-X-C motif) ligand 1	0.015
Cd19	CD19 antigen	0.015
Foxa2	forkhead box A2	0.014
Cd33	CD33 antigen	0.014
Ccr1	chemokine (C-C motif) receptor 1	0.014
Sharpin	SHANK-associated RH domain interacting protein	0.014
Wisp2	WNT1 inducible signaling pathway protein 2	0.014
Ltbr	lymphotoxin B receptor	0.014
Clec4e	C-type lectin domain family 4, member e	0.014
Fasl	Fas ligand (TNF superfamily, member 6)	0.014
Col1a1	collagen, type I, alpha 1	0.013
Abca3	ATP-binding cassette, sub-family A (ABC1), member 3	0.013
Slpi	secretory leukocyte peptidase inhibitor	0.013
Sykb	spleen tyrosine kinase	0.013
Tgfb1	transforming growth factor, beta 1	0.013
Il22	interleukin 22	0.013	Mouse
Pparg	peroxisome proliferator activated receptor gamma	0.013
Ccl7	chemokine (C-C motif) ligand 7	0.012
Dyx1c1	dyslexia susceptibility 1 candidate 1 homolog (human)	0.012
Ccl4	chemokine (C-C motif) ligand 4	0.012
Cd300ld	CD300 molecule-like family member d	0.012
Ticam2	toll-like receptor adaptor molecule 2	0.012
Mmp8	matrix metallopeptidase 8	0.012
Vangl1	vang-like 1 (van gogh, Drosophila)	0.011
Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.011
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.011
Clec4n	C-type lectin domain family 4, member n	0.011
Cxcl5	chemokine (C-X-C motif) ligand 5	0.011
Siglece	sialic acid binding Ig-like lectin E	0.011
Traf3ip2	TRAF3 interacting protein 2	0.010
Msr1	macrophage scavenger receptor 1	0.010
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.010
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.010