IMP

Process View

Mus musculus

15 genes annotated in mouse

epithelial cell maturation

GO:0002070

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "epithelial cell maturation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "epithelial cell maturation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.993
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.976	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.971
Tcfap2a	transcription factor AP-2, alpha	0.905
Sall4	sal-like 4 (Drosophila)	0.824
Eya1	eyes absent 1 homolog (Drosophila)	0.730
Msx1	homeobox, msh-like 1	0.693
Hoxa1	homeobox A1	0.684
Pitx2	paired-like homeodomain transcription factor 2	0.661
Pax6	paired box gene 6	0.643
Hoxb5	homeobox B5	0.637	Mouse
Fgf8	fibroblast growth factor 8	0.634
Hoxa10	homeobox A10	0.597
Hoxd11	homeobox D11	0.548
Hoxd3	homeobox D3	0.531
Gli3	GLI-Kruppel family member GLI3	0.530
Hoxa9	homeobox A9	0.514
Hoxc5	homeobox C5	0.509	Mouse
Egfr	epidermal growth factor receptor	0.467
Hand2	heart and neural crest derivatives expressed transcript 2	0.452
Msx2	homeobox, msh-like 2	0.417
Otx2	orthodenticle homolog 2 (Drosophila)	0.402
Hoxa5	homeobox A5	0.401
Foxa2	forkhead box A2	0.392	Mouse
Hoxb6	homeobox B6	0.357	Mouse
Lepr	leptin receptor	0.337
Hoxd9	homeobox D9	0.334
Dlx5	distal-less homeobox 5	0.328
Pou5f1	POU domain, class 5, transcription factor 1	0.275
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.264
Sox2	SRY-box containing gene 2	0.258
Tbx1	T-box 1	0.257
Esrrb	estrogen related receptor, beta	0.255	Mouse
Pax3	paired box gene 3	0.240
Sox9	SRY-box containing gene 9	0.235
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.235	Mouse
Hoxa2	homeobox A2	0.235
Fgf10	fibroblast growth factor 10	0.228
Tcfap2c	transcription factor AP-2, gamma	0.223
Lhx5	LIM homeobox protein 5	0.218
Uncx	UNC homeobox	0.214
Pax2	paired box gene 2	0.213
Sall1	sal-like 1 (Drosophila)	0.211
Hmx3	H6 homeobox 3	0.210
Hoxc8	homeobox C8	0.204	Mouse
Foxc1	forkhead box C1	0.204	Mouse
Hoxb4	homeobox B4	0.189	Mouse
Pbx1	pre B-cell leukemia transcription factor 1	0.185
Sall3	sal-like 3 (Drosophila)	0.182
Hoxd10	homeobox D10	0.168
Pitx1	paired-like homeodomain transcription factor 1	0.163
Tbx15	T-box 15	0.158
Hoxb8	homeobox B8	0.154	Mouse
Hoxb9	homeobox B9	0.147
Dlx1	distal-less homeobox 1	0.144
Nog	noggin	0.141
Alx4	aristaless-like homeobox 4	0.136
Gsc	goosecoid homeobox	0.131
Hoxb3	homeobox B3	0.125
Nanog	Nanog homeobox	0.124
Hoxd4	homeobox D4	0.119	Mouse
Hmx1	H6 homeobox 1	0.116
Tbx3	T-box 3	0.113
Hand1	heart and neural crest derivatives expressed transcript 1	0.112
Sox7	SRY-box containing gene 7	0.109
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.108
Tcfcp2l1	transcription factor CP2-like 1	0.104
Hoxd8	homeobox D8	0.101	Mouse
Foxn1	forkhead box N1	0.100
Foxd1	forkhead box D1	0.100	Mouse
Fgf3	fibroblast growth factor 3	0.091
Pax8	paired box gene 8	0.088
Vegfa	vascular endothelial growth factor A	0.087
Neurog1	neurogenin 1	0.086
Rdh10	retinol dehydrogenase 10 (all-trans)	0.084
Apc	adenomatosis polyposis coli	0.081
Gbx2	gastrulation brain homeobox 2	0.078
Foxa1	forkhead box A1	0.078
Nkx2-1	NK2 homeobox 1	0.077
Meox2	mesenchyme homeobox 2	0.076
Prrx1	paired related homeobox 1	0.075
Bnc1	basonuclin 1	0.074
Hoxb7	homeobox B7	0.073	Mouse
Bmp4	bone morphogenetic protein 4	0.073
Foxd2	forkhead box D2	0.072	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.071
Hoxa4	homeobox A4	0.070	Mouse
Hoxd13	homeobox D13	0.070	Mouse
Tbx5	T-box 5	0.069
Gdnf	glial cell line derived neurotrophic factor	0.069
Sox3	SRY-box containing gene 3	0.068
Twist2	twist homolog 2 (Drosophila)	0.066
Pax7	paired box gene 7	0.066
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.061
Hoxa3	homeobox A3	0.061
Otx1	orthodenticle homolog 1 (Drosophila)	0.061
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.061
Hoxc6	homeobox C6	0.061	Mouse
Isl1	ISL1 transcription factor, LIM/homeodomain	0.060
Lhx1	LIM homeobox protein 1	0.059
Hoxc4	homeobox C4	0.058	Mouse
Trp63	transformation related protein 63	0.057
Hoxb13	homeobox B13	0.057
Neurog2	neurogenin 2	0.057
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.056
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.052
Adra2b	adrenergic receptor, alpha 2b	0.052
Fam164c	family with sequence similarity 164, member C	0.052
Lmx1a	LIM homeobox transcription factor 1 alpha	0.051
Dlx6	distal-less homeobox 6	0.051
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.051
Ar	androgen receptor	0.051
Lmx1b	LIM homeobox transcription factor 1 beta	0.051
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.050
Pax9	paired box gene 9	0.050
Pthlh	parathyroid hormone-like peptide	0.050
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.048
Hoxa13	homeobox A13	0.048	Mouse
Sox1	SRY-box containing gene 1	0.048
Cldn8	claudin 8	0.048
Emx2	empty spiracles homolog 2 (Drosophila)	0.047
Nppc	natriuretic peptide type C	0.046
Jag1	jagged 1	0.046
Gjb4	gap junction protein, beta 4	0.046	Mouse
Barx2	BarH-like homeobox 2	0.045
Fgf15	fibroblast growth factor 15	0.045
Pou3f3	POU domain, class 3, transcription factor 3	0.045
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.044	Zebrafish
Zfpm2	zinc finger protein, multitype 2	0.044
Zic1	zinc finger protein of the cerebellum 1	0.043
Irx3	Iroquois related homeobox 3 (Drosophila)	0.043
Tcfap2b	transcription factor AP-2 beta	0.043
Pcdh12	protocadherin 12	0.042
Alx1	ALX homeobox 1	0.041
Wt1	Wilms tumor 1 homolog	0.041
Gpr50	G-protein-coupled receptor 50	0.041
Cdx1	caudal type homeobox 1	0.041
Adcyap1	adenylate cyclase activating polypeptide 1	0.040
Myog	myogenin	0.040
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.039
Pou3f4	POU domain, class 3, transcription factor 4	0.039
Tcf15	transcription factor 15	0.039
Foxg1	forkhead box G1	0.039	Mouse
Rxra	retinoid X receptor alpha	0.038
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.038
Meis1	Meis homeobox 1	0.038
Tgfb2	transforming growth factor, beta 2	0.038
Csf3	colony stimulating factor 3 (granulocyte)	0.037
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.037
Gli1	GLI-Kruppel family member GLI1	0.036
Lhx9	LIM homeobox protein 9	0.036
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.036
Hes5	hairy and enhancer of split 5 (Drosophila)	0.036
Shox2	short stature homeobox 2	0.035
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.034
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.033	Mouse
Pou3f2	POU domain, class 3, transcription factor 2	0.032
Rax	retina and anterior neural fold homeobox	0.031
Hoxa7	homeobox A7	0.031	Mouse
Espn	espin	0.031
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.031
Wnt7a	wingless-related MMTV integration site 7A	0.031
Krt15	keratin 15	0.030
Dlx2	distal-less homeobox 2	0.030
Myf5	myogenic factor 5	0.030
Gjb6	gap junction protein, beta 6	0.030	Mouse
Nkx6-1	NK6 homeobox 1	0.030
Hoxc9	homeobox C9	0.030
Vsx2	visual system homeobox 2	0.029
Dhh	desert hedgehog	0.029
Wnt1	wingless-related MMTV integration site 1	0.029
Ighmbp2	immunoglobulin mu binding protein 2	0.029
Gipc3	GIPC PDZ domain containing family, member 3	0.028
Slc26a4	solute carrier family 26, member 4	0.028
Pitx3	paired-like homeodomain transcription factor 3	0.027
Hmx2	H6 homeobox 2	0.027
Foxe3	forkhead box E3	0.027	Mouse
Wnt6	wingless-related MMTV integration site 6	0.027
Hes2	hairy and enhancer of split 2 (Drosophila)	0.027
Hes1	hairy and enhancer of split 1 (Drosophila)	0.027
Pax1	paired box gene 1	0.026
Tbx2	T-box 2	0.026
Ebf3	early B-cell factor 3	0.026
Tlx3	T-cell leukemia, homeobox 3	0.026
En1	engrailed 1	0.026
Zfp185	zinc finger protein 185	0.026
Pou4f2	POU domain, class 4, transcription factor 2	0.026
Amhr2	anti-Mullerian hormone type 2 receptor	0.026
Fzd8	frizzled homolog 8 (Drosophila)	0.026
Lhx3	LIM homeobox protein 3	0.026
Gata6	GATA binding protein 6	0.025
Aplnr	apelin receptor	0.025
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.025
Alx3	aristaless-like homeobox 3	0.025
Mep1a	meprin 1 alpha	0.025
Foxd3	forkhead box D3	0.025	Mouse
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.025
Ly6g6d	lymphocyte antigen 6 complex, locus G6D	0.024
Neurod4	neurogenic differentiation 4	0.024
Foxh1	forkhead box H1	0.024
Prrx2	paired related homeobox 2	0.024
Phlda2	pleckstrin homology-like domain, family A, member 2	0.024
Hoxd12	homeobox D12	0.024
Zic2	zinc finger protein of the cerebellum 2	0.024
Scn5a	sodium channel, voltage-gated, type V, alpha	0.024
Zfp503	zinc finger protein 503	0.024
Foxf2	forkhead box F2	0.024
Krt17	keratin 17	0.023
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.023
Ghr	growth hormone receptor	0.023
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.022
Zic4	zinc finger protein of the cerebellum 4	0.022
Tlx2	T-cell leukemia, homeobox 2	0.021
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.021
Runx2	runt related transcription factor 2	0.021
Lgals12	lectin, galactose binding, soluble 12	0.021
Rarg	retinoic acid receptor, gamma	0.020
Clcnka	chloride channel Ka	0.020
Matn3	matrilin 3	0.020
Tgm3	transglutaminase 3, E polypeptide	0.020
Zfp771	zinc finger protein 771	0.020
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.019
Smad6	MAD homolog 6 (Drosophila)	0.019
Tcf21	transcription factor 21	0.019
Mesp1	mesoderm posterior 1	0.019
Dsc1	desmocollin 1	0.019
Neurod1	neurogenic differentiation 1	0.019
Evx1	even skipped homeotic gene 1 homolog	0.019
Col11a1	collagen, type XI, alpha 1	0.018
Ggnbp1	gametogenetin binding protein 1	0.018
Fgf4	fibroblast growth factor 4	0.018
Col22a1	collagen, type XXII, alpha 1	0.018
She	src homology 2 domain-containing transforming protein E	0.018
Degs2	degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase	0.018
Rem1	rad and gem related GTP binding protein 1	0.018
Ihh	Indian hedgehog	0.017
Ctf1	cardiotrophin 1	0.017
Krt35	keratin 35	0.017
Efna4	ephrin A4	0.017
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.017	Mouse
Hs3st3a1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.017
Sim2	single-minded homolog 2 (Drosophila)	0.017	Mouse
Mnx1	motor neuron and pancreas homeobox 1	0.017
Gli2	GLI-Kruppel family member GLI2	0.017
Nrtn	neurturin	0.017
Foxc2	forkhead box C2	0.017	Mouse
Ehf	ets homologous factor	0.017
Insm1	insulinoma-associated 1	0.017
Irx1	Iroquois related homeobox 1 (Drosophila)	0.017
Krt34	keratin 34	0.017
Vax1	ventral anterior homeobox containing gene 1	0.016
Cldn4	claudin 4	0.016
Adam17	a disintegrin and metallopeptidase domain 17	0.016
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.016
Krt14	keratin 14	0.016
Fgf17	fibroblast growth factor 17	0.016
Pou4f3	POU domain, class 4, transcription factor 3	0.016
Cdh3	cadherin 3	0.016
Ntf3	neurotrophin 3	0.016
Npr3	natriuretic peptide receptor 3	0.016
Gata4	GATA binding protein 4	0.015
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.015
Sim1	single-minded homolog 1 (Drosophila)	0.015	Mouse
Zbtb7c	zinc finger and BTB domain containing 7C	0.015
Wnt3	wingless-related MMTV integration site 3	0.015
Krtap3-3	keratin associated protein 3-3	0.015
5730559C18Rik	RIKEN cDNA 5730559C18 gene	0.015
Dach1	dachshund 1 (Drosophila)	0.015
Npas1	neuronal PAS domain protein 1	0.015	Mouse
Egln1	EGL nine homolog 1 (C. elegans)	0.015
Dsc3	desmocollin 3	0.015
Efna2	ephrin A2	0.015
Nkx3-2	NK3 homeobox 2	0.015
Rarb	retinoic acid receptor, beta	0.015
Tgfbr3	transforming growth factor, beta receptor III	0.015
Cldn2	claudin 2	0.015
Eya4	eyes absent 4 homolog (Drosophila)	0.015
Foxi3	forkhead box I3	0.015
Irx2	Iroquois related homeobox 2 (Drosophila)	0.014
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.014
Hoxb2	homeobox B2	0.014
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.014
Insr	insulin receptor	0.014
Scarb2	scavenger receptor class B, member 2	0.014
Fut2	fucosyltransferase 2	0.014
Upk3b	uroplakin 3B	0.014
Myom2	myomesin 2	0.014
Hoxa11	homeobox A11	0.014
Wnt2b	wingless related MMTV integration site 2b	0.014
Onecut1	one cut domain, family member 1	0.014
Mll2	myeloid/lymphoid or mixed-lineage leukemia 2	0.014
Hoxb1	homeobox B1	0.014
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.014
F12	coagulation factor XII (Hageman factor)	0.014
Sox18	SRY-box containing gene 18	0.014
Emx1	empty spiracles homolog 1 (Drosophila)	0.014
Foxq1	forkhead box Q1	0.014	Mouse
Vhl	von Hippel-Lindau tumor suppressor	0.014
Gata3	GATA binding protein 3	0.013
S100a14	S100 calcium binding protein A14	0.013
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.013
Atoh1	atonal homolog 1 (Drosophila)	0.013
Aqp3	aquaporin 3	0.013
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.013
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.013
Irx4	Iroquois related homeobox 4 (Drosophila)	0.013
Phox2b	paired-like homeobox 2b	0.013
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.013
Hoxc10	homeobox C10	0.013
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.013
Sox21	SRY-box containing gene 21	0.013
Cnga3	cyclic nucleotide gated channel alpha 3	0.013
Ovol1	OVO homolog-like 1 (Drosophila)	0.013
Cer1	cerberus 1 homolog (Xenopus laevis)	0.013
Tjp1	tight junction protein 1	0.013
Btbd17	BTB (POZ) domain containing 17	0.013
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.012
Bmp7	bone morphogenetic protein 7	0.012
Klf5	Kruppel-like factor 5	0.012
Cnr1	cannabinoid receptor 1 (brain)	0.012
Lrp2	low density lipoprotein receptor-related protein 2	0.012
Foxb1	forkhead box B1	0.012
Elf5	E74-like factor 5	0.012
Otp	orthopedia homolog (Drosophila)	0.012
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.012
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.012
Flg	filaggrin	0.012
Gja5	gap junction protein, alpha 5	0.012	Mouse
Zfp316	zinc finger protein 316	0.012
Avpr1a	arginine vasopressin receptor 1A	0.012
Hmga2	high mobility group AT-hook 2	0.012
Tnni1	troponin I, skeletal, slow 1	0.012
Lgals7	lectin, galactose binding, soluble 7	0.011
Irx5	Iroquois related homeobox 5 (Drosophila)	0.011
Lif	leukemia inhibitory factor	0.011
Aif1l	allograft inflammatory factor 1-like	0.011
Wnt5b	wingless-related MMTV integration site 5B	0.011
Srrm4	serine/arginine repetitive matrix 4	0.011
Mdfi	MyoD family inhibitor	0.011
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.011
Gjb3	gap junction protein, beta 3	0.011	Mouse
Kcnk3	potassium channel, subfamily K, member 3	0.011
Fam84a	family with sequence similarity 84, member A	0.011
Ntn1	netrin 1	0.011
Musk	muscle, skeletal, receptor tyrosine kinase	0.011
Prph	peripherin	0.011
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.011
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.011
Dmrt3	doublesex and mab-3 related transcription factor 3	0.011
Fzd7	frizzled homolog 7 (Drosophila)	0.011
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.011
Atp6v0a4	ATPase, H+ transporting, lysosomal V0 subunit A4	0.011
Rhcg	Rhesus blood group-associated C glycoprotein	0.011
Mlph	melanophilin	0.011
Car12	carbonic anyhydrase 12	0.011
Miox	myo-inositol oxygenase	0.011
En2	engrailed 2	0.010
Msi1	Musashi homolog 1(Drosophila)	0.010
Cldn3	claudin 3	0.010
Atoh7	atonal homolog 7 (Drosophila)	0.010
Cav1	caveolin 1, caveolae protein	0.010
Tal2	T-cell acute lymphocytic leukemia 2	0.010
Foxl1	forkhead box L1	0.010
Glra1	glycine receptor, alpha 1 subunit	0.010
G6pc2	glucose-6-phosphatase, catalytic, 2	0.010
Skor1	SKI family transcriptional corepressor 1	0.010
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.010