IMP
Process View
negative regulation of mammary gland epithelial cell proliferation
Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of mammary gland epithelial cell proliferation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Trp53 | transformation related protein 53 | 0.972 | ||
| Apc | adenomatosis polyposis coli | 0.855 | ||
| Brca1 | breast cancer 1 | 0.848 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.587 | ||
| Slit3 | slit homolog 3 (Drosophila) | 0.496 | ||
| Hr | hairless | 0.412 | ||
| Kit | kit oncogene | 0.369 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.315 | ||
| Rb1 | retinoblastoma 1 | 0.203 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.201 | ||
| Pten | phosphatase and tensin homolog | 0.183 | ||
| Slit2 | slit homolog 2 (Drosophila) | 0.181 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.171 | ||
| Robo2 | roundabout homolog 2 (Drosophila) | 0.157 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.149 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.148 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.147 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.142 | ||
| Hmx3 | H6 homeobox 3 | 0.122 | ||
| Trp63 | transformation related protein 63 | 0.121 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.110 | ||
| Socs1 | suppressor of cytokine signaling 1 | 0.084 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.079 | ||
| Espn | espin | 0.078 | ||
| Runx1 | runt related transcription factor 1 | 0.075 | ||
| Tomm40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | 0.072 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.072 | ||
| Efnb2 | ephrin B2 | 0.071 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.071 | ||
| Etv4 | ets variant gene 4 (E1A enhancer binding protein, E1AF) | 0.070 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.069 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.069 | ||
| Sox4 | SRY-box containing gene 4 | 0.067 | ||
| Ccnd1 | cyclin D1 | 0.063 | ||
| Rara | retinoic acid receptor, alpha | 0.060 | ||
| Ptch1 | patched homolog 1 | 0.059 | ||
| Etv1 | ets variant gene 1 | 0.054 | Mouse | |
| Brca2 | breast cancer 2 | 0.052 | Human | |
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.052 | ||
| Ifng | interferon gamma | 0.052 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.052 | ||
| Samm50 | sorting and assembly machinery component 50 homolog (S. cerevisiae) | 0.049 | ||
| Gbx2 | gastrulation brain homeobox 2 | 0.049 | ||
| Braf | Braf transforming gene | 0.047 | ||
| Atr | ataxia telangiectasia and Rad3 related | 0.047 | ||
| Psmd3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.047 | ||
| Ntf3 | neurotrophin 3 | 0.046 | ||
| Hoxa1 | homeobox A1 | 0.045 | ||
| Krt14 | keratin 14 | 0.043 | ||
| Prdm1 | PR domain containing 1, with ZNF domain | 0.043 | ||
| Zfp42 | zinc finger protein 42 | 0.042 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.041 | ||
| Pou4f3 | POU domain, class 4, transcription factor 3 | 0.041 | ||
| Nf1 | neurofibromatosis 1 | 0.041 | ||
| Foxn1 | forkhead box N1 | 0.041 | ||
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.040 | ||
| Shh | sonic hedgehog | 0.035 | ||
| Lats1 | large tumor suppressor | 0.035 | ||
| Kitl | kit ligand | 0.034 | ||
| Tsc1 | tuberous sclerosis 1 | 0.034 | ||
| Irx4 | Iroquois related homeobox 4 (Drosophila) | 0.034 | ||
| Sox2 | SRY-box containing gene 2 | 0.033 | ||
| Tcf4 | transcription factor 4 | 0.033 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.033 | ||
| Egr1 | early growth response 1 | 0.032 | ||
| Phf13 | PHD finger protein 13 | 0.032 | ||
| Efna4 | ephrin A4 | 0.032 | ||
| Mtx1 | metaxin 1 | 0.031 | ||
| Thbs1 | thrombospondin 1 | 0.030 | ||
| Wwox | WW domain-containing oxidoreductase | 0.029 | ||
| Crebbp | CREB binding protein | 0.029 | ||
| Sfn | stratifin | 0.029 | ||
| Cntrob | centrobin, centrosomal BRCA2 interacting protein | 0.028 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.028 | ||
| Hoxb3 | homeobox B3 | 0.028 | ||
| Nf2 | neurofibromatosis 2 | 0.027 | ||
| Ptk7 | PTK7 protein tyrosine kinase 7 | 0.025 | ||
| Gdnf | glial cell line derived neurotrophic factor | 0.025 | ||
| Zic2 | zinc finger protein of the cerebellum 2 | 0.025 | ||
| Dll1 | delta-like 1 (Drosophila) | 0.024 | ||
| Foxp1 | forkhead box P1 | 0.024 | ||
| Ptf1a | pancreas specific transcription factor, 1a | 0.023 | ||
| Ltb | lymphotoxin B | 0.023 | ||
| Stk11 | serine/threonine kinase 11 | 0.023 | ||
| Smad4 | MAD homolog 4 (Drosophila) | 0.022 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.022 | ||
| Trp73 | transformation related protein 73 | 0.021 | ||
| Ncs1 | neuronal calcium sensor 1 | 0.021 | ||
| F2rl1 | coagulation factor II (thrombin) receptor-like 1 | 0.021 | ||
| Pax8 | paired box gene 8 | 0.021 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.021 | ||
| Smad7 | MAD homolog 7 (Drosophila) | 0.020 | ||
| Ahr | aryl-hydrocarbon receptor | 0.020 | ||
| Padi3 | peptidyl arginine deiminase, type III | 0.020 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.020 | ||
| Nbn | nibrin | 0.020 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.019 | ||
| Rhob | ras homolog gene family, member B | 0.019 | ||
| Msx2 | homeobox, msh-like 2 | 0.019 | ||
| Uqcrc1 | ubiquinol-cytochrome c reductase core protein 1 | 0.019 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.019 | ||
| Dus1l | dihydrouridine synthase 1-like (S. cerevisiae) | 0.018 | ||
| Fli1 | Friend leukemia integration 1 | 0.017 | ||
| Sema5b | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 0.017 | ||
| Cdx1 | caudal type homeobox 1 | 0.017 | ||
| Mis18bp1 | MIS18 binding protein 1 | 0.017 | ||
| Celf4 | CUGBP, Elav-like family member 4 | 0.017 | ||
| Psg17 | pregnancy specific glycoprotein 17 | 0.017 | ||
| Jun | Jun oncogene | 0.017 | ||
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.017 | ||
| Zfp57 | zinc finger protein 57 | 0.017 | ||
| Rcor2 | REST corepressor 2 | 0.017 | ||
| Hoxd1 | homeobox D1 | 0.017 | ||
| Il23a | interleukin 23, alpha subunit p19 | 0.016 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.016 | ||
| Hoxc9 | homeobox C9 | 0.016 | ||
| Klf6 | Kruppel-like factor 6 | 0.016 | ||
| Mrpl34 | mitochondrial ribosomal protein L34 | 0.016 | ||
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.016 | ||
| Kctd12 | potassium channel tetramerisation domain containing 12 | 0.016 | ||
| E2f1 | E2F transcription factor 1 | 0.016 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.016 | ||
| Mapre2 | microtubule-associated protein, RP/EB family, member 2 | 0.016 | ||
| Foxd3 | forkhead box D3 | 0.016 | ||
| Phlda2 | pleckstrin homology-like domain, family A, member 2 | 0.015 | ||
| Pus1 | pseudouridine synthase 1 | 0.015 | ||
| Sox11 | SRY-box containing gene 11 | 0.015 | ||
| 2310046K01Rik | RIKEN cDNA 2310046K01 gene | 0.015 | ||
| 5730559C18Rik | RIKEN cDNA 5730559C18 gene | 0.015 | ||
| Pax6 | paired box gene 6 | 0.015 | ||
| Gem | GTP binding protein (gene overexpressed in skeletal muscle) | 0.015 | ||
| Il11 | interleukin 11 | 0.014 | ||
| Hmga2 | high mobility group AT-hook 2 | 0.014 | ||
| Klf4 | Kruppel-like factor 4 (gut) | 0.014 | ||
| Mrpl12 | mitochondrial ribosomal protein L12 | 0.014 | ||
| Lsm4 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.014 | ||
| Apex1 | apurinic/apyrimidinic endonuclease 1 | 0.014 | ||
| 1300001I01Rik | RIKEN cDNA 1300001I01 gene | 0.014 | ||
| Tcf7 | transcription factor 7, T-cell specific | 0.014 | ||
| Vasp | vasodilator-stimulated phosphoprotein | 0.014 | ||
| Elf3 | E74-like factor 3 | 0.014 | ||
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.014 | ||
| Fos | FBJ osteosarcoma oncogene | 0.014 | ||
| Zfp36l1 | zinc finger protein 36, C3H type-like 1 | 0.014 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.014 | ||
| Hdac1 | histone deacetylase 1 | 0.014 | ||
| Cldn4 | claudin 4 | 0.014 | ||
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.014 | ||
| Vax1 | ventral anterior homeobox containing gene 1 | 0.013 | ||
| Klf7 | Kruppel-like factor 7 (ubiquitous) | 0.013 | ||
| Eif2b4 | eukaryotic translation initiation factor 2B, subunit 4 delta | 0.013 | ||
| Dusp6 | dual specificity phosphatase 6 | 0.013 | ||
| Ttc16 | tetratricopeptide repeat domain 16 | 0.013 | ||
| Neurod1 | neurogenic differentiation 1 | 0.013 | ||
| Mecr | mitochondrial trans-2-enoyl-CoA reductase | 0.013 | ||
| 4933415F23Rik | RIKEN cDNA 4933415F23 gene | 0.013 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.013 | ||
| Phb | prohibitin | 0.012 | ||
| Map4k4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.012 | ||
| Wnt16 | wingless-related MMTV integration site 16 | 0.012 | ||
| Aif1l | allograft inflammatory factor 1-like | 0.012 | ||
| Mrpl4 | mitochondrial ribosomal protein L4 | 0.012 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.012 | ||
| Ccdc92 | coiled-coil domain containing 92 | 0.012 | ||
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.012 | ||
| Tbx1 | T-box 1 | 0.012 | ||
| Ier5 | immediate early response 5 | 0.012 | ||
| Rxra | retinoid X receptor alpha | 0.012 | ||
| Mdfi | MyoD family inhibitor | 0.012 | ||
| Myo6 | myosin VI | 0.012 | ||
| Klf5 | Kruppel-like factor 5 | 0.012 | ||
| Elk3 | ELK3, member of ETS oncogene family | 0.012 | ||
| Fam43a | family with sequence similarity 43, member A | 0.012 | ||
| Tulp2 | tubby-like protein 2 | 0.012 | ||
| Egr2 | early growth response 2 | 0.012 | ||
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.012 | ||
| Hoxa4 | homeobox A4 | 0.012 | ||
| Cdk6 | cyclin-dependent kinase 6 | 0.012 | ||
| Mcl1 | myeloid cell leukemia sequence 1 | 0.012 | ||
| Acr | acrosin prepropeptide | 0.012 | ||
| Spnb2 | spectrin beta 2 | 0.012 | ||
| Nr2f1 | nuclear receptor subfamily 2, group F, member 1 | 0.012 | ||
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.012 | ||
| Icam4 | intercellular adhesion molecule 4, Landsteiner-Wiener blood group | 0.012 | ||
| En1 | engrailed 1 | 0.012 | ||
| Tcfap2c | transcription factor AP-2, gamma | 0.012 | ||
| Ldha | lactate dehydrogenase A | 0.011 | ||
| Ar | androgen receptor | 0.011 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.011 | ||
| Hoxb6 | homeobox B6 | 0.011 | ||
| Fancd2 | Fanconi anemia, complementation group D2 | 0.011 | ||
| Rint1 | RAD50 interactor 1 | 0.011 | ||
| Foxo3 | forkhead box O3 | 0.011 | ||
| Ptch2 | patched homolog 2 | 0.011 | ||
| Cs | citrate synthase | 0.011 | ||
| Hoxb2 | homeobox B2 | 0.011 | ||
| Atad3a | ATPase family, AAA domain containing 3A | 0.011 | ||
| Nedd9 | neural precursor cell expressed, developmentally down-regulated gene 9 | 0.011 | ||
| Frmd6 | FERM domain containing 6 | 0.011 | ||
| Tacstd2 | tumor-associated calcium signal transducer 2 | 0.011 | ||
| Fyn | Fyn proto-oncogene | 0.011 | ||
| Alcam | activated leukocyte cell adhesion molecule | 0.011 | ||
| Smad1 | MAD homolog 1 (Drosophila) | 0.011 | ||
| Ighmbp2 | immunoglobulin mu binding protein 2 | 0.011 | ||
| Cd93 | CD93 antigen | 0.011 | ||
| Npc1 | Niemann Pick type C1 | 0.011 | ||
| Prkd2 | protein kinase D2 | 0.011 | ||
| Eif2ak3 | eukaryotic translation initiation factor 2 alpha kinase 3 | 0.011 | ||
| Epha2 | Eph receptor A2 | 0.011 | ||
| Dusp1 | dual specificity phosphatase 1 | 0.011 | ||
| Hoxa7 | homeobox A7 | 0.011 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.010 | ||
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.010 | ||
| Pla2g10 | phospholipase A2, group X | 0.010 | ||
| Stra8 | stimulated by retinoic acid gene 8 | 0.010 | ||
| Mll1 | myeloid/lymphoid or mixed-lineage leukemia 1 | 0.010 | ||
| Ret | ret proto-oncogene | 0.010 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.010 | ||
| Rad51l1 | RAD51-like 1 (S. cerevisiae) | 0.010 | ||
| Ybx2 | Y box protein 2 | 0.010 | ||
| Tcfap2a | transcription factor AP-2, alpha | 0.010 | ||
| Rbms1 | RNA binding motif, single stranded interacting protein 1 | 0.010 |