IMP

Process View

Mus musculus

20 genes annotated in mouse

negative regulation of dna binding

Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of dna binding"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of dna binding" (in gray)

Name	Description	Probability	Func Analog Organism
Otx2	orthodenticle homolog 2 (Drosophila)	0.995
Neurod1	neurogenic differentiation 1	0.943	Mouse
Gata4	GATA binding protein 4	0.927
Pax6	paired box gene 6	0.898
Hand2	heart and neural crest derivatives expressed transcript 2	0.874
Pitx2	paired-like homeodomain transcription factor 2	0.804
Sox2	SRY-box containing gene 2	0.757
Id3	inhibitor of DNA binding 3	0.754	Mouse Fly
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.729
Neurog2	neurogenin 2	0.706	Mouse
Mstn	myostatin	0.640
Tcf4	transcription factor 4	0.623
Id1	inhibitor of DNA binding 1	0.606
Emx2	empty spiracles homolog 2 (Drosophila)	0.598
Tcf3	transcription factor 3	0.595
Emx1	empty spiracles homolog 1 (Drosophila)	0.549
Fgf8	fibroblast growth factor 8	0.519
Cry2	cryptochrome 2 (photolyase-like)	0.508
En1	engrailed 1	0.470
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.454
Pou4f2	POU domain, class 4, transcription factor 2	0.383
Clock	circadian locomotor output cycles kaput	0.361
Lhx3	LIM homeobox protein 3	0.358	Mouse
Pax3	paired box gene 3	0.351
Kiss1	KiSS-1 metastasis-suppressor	0.336
Hand1	heart and neural crest derivatives expressed transcript 1	0.328	Mouse
Foxc1	forkhead box C1	0.318
Neurod4	neurogenic differentiation 4	0.312	Mouse
Msx1	homeobox, msh-like 1	0.293
Onecut1	one cut domain, family member 1	0.286
Shh	sonic hedgehog	0.263
Nhlh1	nescient helix loop helix 1	0.227	Mouse
Isl1	ISL1 transcription factor, LIM/homeodomain	0.207	Mouse
Gli2	GLI-Kruppel family member GLI2	0.206
Tcfap2a	transcription factor AP-2, alpha	0.191
Gata6	GATA binding protein 6	0.184
Ntf3	neurotrophin 3	0.176
Foxc2	forkhead box C2	0.152
Hes5	hairy and enhancer of split 5 (Drosophila)	0.129
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.124
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.112
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.108
Srrm4	serine/arginine repetitive matrix 4	0.108
Mecom	MDS1 and EVI1 complex locus	0.100
Epor	erythropoietin receptor	0.094
Zic2	zinc finger protein of the cerebellum 2	0.091
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.091
Fst	follistatin	0.089
Insm1	insulinoma-associated 1	0.086
Ldb1	LIM domain binding 1	0.079
Ptf1a	pancreas specific transcription factor, 1a	0.077	Mouse
Sox4	SRY-box containing gene 4	0.075
Dlx2	distal-less homeobox 2	0.075
Olig2	oligodendrocyte transcription factor 2	0.070
Zfpm2	zinc finger protein, multitype 2	0.069
Smad6	MAD homolog 6 (Drosophila)	0.068
Tef	thyrotroph embryonic factor	0.065
Hes1	hairy and enhancer of split 1 (Drosophila)	0.064
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.064	Human Mouse
Cdh23	cadherin 23 (otocadherin)	0.057
Lhx4	LIM homeobox protein 4	0.057	Mouse
Gbx2	gastrulation brain homeobox 2	0.056
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.055
Ldb2	LIM domain binding 2	0.055
Lhx9	LIM homeobox protein 9	0.055	Mouse
Prox1	prospero-related homeobox 1	0.051
Gsc	goosecoid homeobox	0.050
Pou4f3	POU domain, class 4, transcription factor 3	0.048
Zic1	zinc finger protein of the cerebellum 1	0.048
Neurog3	neurogenin 3	0.047	Mouse
Pou3f2	POU domain, class 3, transcription factor 2	0.046
Ush1g	Usher syndrome 1G homolog (human)	0.045
Tbx3	T-box 3	0.044
Per2	period homolog 2 (Drosophila)	0.044
Usp2	ubiquitin specific peptidase 2	0.043
Csnk1e	casein kinase 1, epsilon	0.043
Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.042
Mab21l2	mab-21-like 2 (C. elegans)	0.040
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.040
Mesp1	mesoderm posterior 1	0.040
Socs1	suppressor of cytokine signaling 1	0.039
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.039
Gli3	GLI-Kruppel family member GLI3	0.038
Sox11	SRY-box containing gene 11	0.038	Rat
Wfikkn1	WAP, FS, Ig, KU, and NTR-containing protein 1	0.038
Hoxd13	homeobox D13	0.037
Snai1	snail homolog 1 (Drosophila)	0.037
Gpr50	G-protein-coupled receptor 50	0.036
Isl2	insulin related protein 2 (islet 2)	0.036	Mouse
Zic3	zinc finger protein of the cerebellum 3	0.035
Tbx20	T-box 20	0.034
Lef1	lymphoid enhancer binding factor 1	0.033	Human
Sqstm1	sequestosome 1	0.033
Gas1	growth arrest specific 1	0.033
Gdf11	growth differentiation factor 11	0.033
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.032
Inca1	inhibitor of CDK, cyclin A1 interacting protein 1	0.032
Epha3	Eph receptor A3	0.032
Uncx	UNC homeobox	0.032
Pitx1	paired-like homeodomain transcription factor 1	0.031
Pax7	paired box gene 7	0.031
Efna2	ephrin A2	0.030
Pou2f2	POU domain, class 2, transcription factor 2	0.030
Ebf3	early B-cell factor 3	0.030
En2	engrailed 2	0.030
Per1	period homolog 1 (Drosophila)	0.029	Mouse
Zeb1	zinc finger E-box binding homeobox 1	0.029
Pax2	paired box gene 2	0.028
Fos	FBJ osteosarcoma oncogene	0.028
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.028
Apaf1	apoptotic peptidase activating factor 1	0.026
Tgfb2	transforming growth factor, beta 2	0.026
Rb1	retinoblastoma 1	0.026
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.026
Prop1	paired like homeodomain factor 1	0.025
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.025
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.025
Tlx3	T-cell leukemia, homeobox 3	0.024
Pitx3	paired-like homeodomain transcription factor 3	0.024
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.024
Hif1a	hypoxia inducible factor 1, alpha subunit	0.024
Nodal	nodal	0.024
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.024
Foxa2	forkhead box A2	0.023
Il2rg	interleukin 2 receptor, gamma chain	0.023
Ssbp2	single-stranded DNA binding protein 2	0.023
Foxg1	forkhead box G1	0.023
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.023
Barhl1	BarH-like 1 (Drosophila)	0.022
Ebf2	early B-cell factor 2	0.022
Disp1	dispatched homolog 1 (Drosophila)	0.022
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.022
Foxd2	forkhead box D2	0.022
Hmx1	H6 homeobox 1	0.022
Ssbp3	single-stranded DNA binding protein 3	0.021
Tulp1	tubby like protein 1	0.021
Irx4	Iroquois related homeobox 4 (Drosophila)	0.021
Nfia	nuclear factor I/A	0.021
Sox9	SRY-box containing gene 9	0.020
Igfbpl1	insulin-like growth factor binding protein-like 1	0.020
Lmx1b	LIM homeobox transcription factor 1 beta	0.020	Mouse
Lhx5	LIM homeobox protein 5	0.020	Mouse
Tcf7	transcription factor 7, T-cell specific	0.020
Bnc1	basonuclin 1	0.019
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.019
Mapk8	mitogen-activated protein kinase 8	0.018
Bmp7	bone morphogenetic protein 7	0.018
Lmo1	LIM domain only 1	0.018
Myf5	myogenic factor 5	0.018
Adra2b	adrenergic receptor, alpha 2b	0.018
Pten	phosphatase and tensin homolog	0.018
Evx1	even skipped homeotic gene 1 homolog	0.018
Tbx2	T-box 2	0.018
Otp	orthopedia homolog (Drosophila)	0.018
Hoxa4	homeobox A4	0.018
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.018
Fgf15	fibroblast growth factor 15	0.017
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.017
Pax9	paired box gene 9	0.017
Tbx5	T-box 5	0.017
Shox2	short stature homeobox 2	0.016
Axin2	axin2	0.016
Myog	myogenin	0.016
Arx	aristaless related homeobox	0.016
Thra	thyroid hormone receptor alpha	0.016
Hrc	histidine rich calcium binding protein	0.016
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.016
Meis2	Meis homeobox 2	0.016
Socs3	suppressor of cytokine signaling 3	0.015
Evx2	even skipped homeotic gene 2 homolog	0.015
Nr2c2	nuclear receptor subfamily 2, group C, member 2	0.015
Pygo1	pygopus 1	0.015
Sh2b1	SH2B adaptor protein 1	0.015
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.015
Gdnf	glial cell line derived neurotrophic factor	0.015
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.015
Tcf15	transcription factor 15	0.015	Mouse
Myb	myeloblastosis oncogene	0.015
Edaradd	EDAR (ectodysplasin-A receptor)-associated death domain	0.015
Sox21	SRY-box containing gene 21	0.015
Bsg	basigin	0.014
BC024139	cDNA sequence BC024139	0.014
Olig3	oligodendrocyte transcription factor 3	0.014
Id2	inhibitor of DNA binding 2	0.014
Efnb3	ephrin B3	0.014
Uba7	ubiquitin-like modifier activating enzyme 7	0.014
Nfix	nuclear factor I/X	0.014
Fgf6	fibroblast growth factor 6	0.014
Lmo2	LIM domain only 2	0.014
Bdnf	brain derived neurotrophic factor	0.014
Nrk	Nik related kinase	0.014
Wnt6	wingless-related MMTV integration site 6	0.014
Col25a1	collagen, type XXV, alpha 1	0.014
Irx5	Iroquois related homeobox 5 (Drosophila)	0.014
Irx1	Iroquois related homeobox 1 (Drosophila)	0.014
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.014
Msi1	Musashi homolog 1(Drosophila)	0.014
Rras	Harvey rat sarcoma oncogene, subgroup R	0.013
Hrh2	histamine receptor H2	0.013
Tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.013
Lgr5	leucine rich repeat containing G protein coupled receptor 5	0.013
Zic4	zinc finger protein of the cerebellum 4	0.013
Hoxa1	homeobox A1	0.013
Pole	polymerase (DNA directed), epsilon	0.013
Vgll2	vestigial like 2 homolog (Drosophila)	0.013
Prph2	peripherin 2	0.013
Tbx1	T-box 1	0.013
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.013
Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.013
Hoxc6	homeobox C6	0.013
Cry1	cryptochrome 1 (photolyase-like)	0.013
Bhlhe22	basic helix-loop-helix family, member e22	0.013
Bhlha9	basic helix-loop-helix family, member a9	0.013
Ptch1	patched homolog 1	0.013
Dab1	disabled homolog 1 (Drosophila)	0.013
Rxra	retinoid X receptor alpha	0.012
Adamts7	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7	0.012
Ehmt1	euchromatic histone methyltransferase 1	0.012
Dmbx1	diencephalon/mesencephalon homeobox 1	0.012
T	brachyury	0.012
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.012
Dbh	dopamine beta hydroxylase	0.012
Fev	FEV (ETS oncogene family)	0.012
Irs2	insulin receptor substrate 2	0.012
Prokr2	prokineticin receptor 2	0.012
Nxph4	neurexophilin 4	0.012
Foxf1a	forkhead box F1a	0.012
Foxe3	forkhead box E3	0.012
Llgl1	lethal giant larvae homolog 1 (Drosophila)	0.012
Espn	espin	0.012
Rhoh	ras homolog gene family, member H	0.012
Vangl2	vang-like 2 (van gogh, Drosophila)	0.012
Scrt2	scratch homolog 2, zinc finger protein (Drosophila)	0.012
D0H4S114	DNA segment, human D4S114	0.012
Hoxd12	homeobox D12	0.012
Sim2	single-minded homolog 2 (Drosophila)	0.011
Ctnnb1	catenin (cadherin associated protein), beta 1	0.011
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.011
Nkx6-1	NK6 homeobox 1	0.011
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
Foxp2	forkhead box P2	0.011
Coro1b	coronin, actin binding protein 1B	0.011
Acvr2b	activin receptor IIB	0.011
Sox1	SRY-box containing gene 1	0.011
Vsx2	visual system homeobox 2	0.011
Mecp2	methyl CpG binding protein 2	0.011
Clspn	claspin homolog (Xenopus laevis)	0.011
Hoxd3	homeobox D3	0.011
Hoxa11	homeobox A11	0.011
Mndal	myeloid nuclear differentiation antigen like	0.011
Auts2	autism susceptibility candidate 2	0.011
Psmd14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.011
Asb10	ankyrin repeat and SOCS box-containing 10	0.010
Alox12	arachidonate 12-lipoxygenase	0.010
Cxcr3	chemokine (C-X-C motif) receptor 3	0.010
Twist2	twist homolog 2 (Drosophila)	0.010
Trim62	tripartite motif-containing 62	0.010
Gja1	gap junction protein, alpha 1	0.010
Mycl1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	0.010
Dpf1	D4, zinc and double PHD fingers family 1	0.010
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.010
Hmga2	high mobility group AT-hook 2	0.010
Lrp6	low density lipoprotein receptor-related protein 6	0.010
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.010