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Mus musculus

10 genes annotated in mouse

cardiac cell fate commitment

The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac cell fate commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cardiac cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Fgf8	fibroblast growth factor 8	0.994
Otx2	orthodenticle homolog 2 (Drosophila)	0.993
Gli3	GLI-Kruppel family member GLI3	0.987
Pax3	paired box gene 3	0.985
Vangl2	vang-like 2 (van gogh, Drosophila)	0.981
Pitx2	paired-like homeodomain transcription factor 2	0.974
Pax2	paired box gene 2	0.966
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.965
Sox9	SRY-box containing gene 9	0.956	Mouse
Tbx3	T-box 3	0.946
Fgfr2	fibroblast growth factor receptor 2	0.946
Lhx1	LIM homeobox protein 1	0.933	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.932	Fly
Gata4	GATA binding protein 4	0.924	Fly
Foxc1	forkhead box C1	0.908
Hand1	heart and neural crest derivatives expressed transcript 1	0.894
Hand2	heart and neural crest derivatives expressed transcript 2	0.887
Sox2	SRY-box containing gene 2	0.825	Mouse
Gli2	GLI-Kruppel family member GLI2	0.820
Pou5f1	POU domain, class 5, transcription factor 1	0.742	Human
Pax6	paired box gene 6	0.698
Emx1	empty spiracles homolog 1 (Drosophila)	0.683
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.662
Pitx1	paired-like homeodomain transcription factor 1	0.658
Foxc2	forkhead box C2	0.627
Emx2	empty spiracles homolog 2 (Drosophila)	0.624
Fgfr1	fibroblast growth factor receptor 1	0.618
Alx4	aristaless-like homeobox 4	0.602
Tcfap2a	transcription factor AP-2, alpha	0.583
Isl1	ISL1 transcription factor, LIM/homeodomain	0.560
Pten	phosphatase and tensin homolog	0.547
Bmp4	bone morphogenetic protein 4	0.543
Wnt3a	wingless-related MMTV integration site 3A	0.513
Wt1	Wilms tumor 1 homolog	0.501
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.453
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.420
Meox2	mesenchyme homeobox 2	0.370
Notch1	Notch gene homolog 1 (Drosophila)	0.340	Fly
Tgfb2	transforming growth factor, beta 2	0.323
Lmx1a	LIM homeobox transcription factor 1 alpha	0.311	Mouse
Rxra	retinoid X receptor alpha	0.300
Gata6	GATA binding protein 6	0.286	Fly
Hoxa1	homeobox A1	0.275
Nog	noggin	0.252
Chd7	chromodomain helicase DNA binding protein 7	0.223
Fgf10	fibroblast growth factor 10	0.221
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.218
Robo1	roundabout homolog 1 (Drosophila)	0.211	Fly
Pou3f3	POU domain, class 3, transcription factor 3	0.200
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.193
Sox11	SRY-box containing gene 11	0.190	Mouse
Dll4	delta-like 4 (Drosophila)	0.190
Lhx9	LIM homeobox protein 9	0.189	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.183
Msx1	homeobox, msh-like 1	0.176
Rarg	retinoic acid receptor, gamma	0.173
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.172
Hoxd13	homeobox D13	0.164
Tbx1	T-box 1	0.158	Mouse
Hoxa13	homeobox A13	0.158
Nodal	nodal	0.153
Vegfa	vascular endothelial growth factor A	0.146
Vangl1	vang-like 1 (van gogh, Drosophila)	0.141
Sall4	sal-like 4 (Drosophila)	0.139
Jag1	jagged 1	0.135
She	src homology 2 domain-containing transforming protein E	0.134
Wnt6	wingless-related MMTV integration site 6	0.132	Mouse
Foxg1	forkhead box G1	0.125
Pax8	paired box gene 8	0.123
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.120
En1	engrailed 1	0.119
Alx3	aristaless-like homeobox 3	0.118
Lmx1b	LIM homeobox transcription factor 1 beta	0.116	Mouse
Prrx1	paired related homeobox 1	0.113
Fgfr3	fibroblast growth factor receptor 3	0.111
Otx1	orthodenticle homolog 1 (Drosophila)	0.110
Gbx2	gastrulation brain homeobox 2	0.106
Mesp1	mesoderm posterior 1	0.103
Smad6	MAD homolog 6 (Drosophila)	0.099
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.094
Apc	adenomatosis polyposis coli	0.092
Gdnf	glial cell line derived neurotrophic factor	0.089
Cldn5	claudin 5	0.089
Rara	retinoic acid receptor, alpha	0.089
Lef1	lymphoid enhancer binding factor 1	0.084
Dlx5	distal-less homeobox 5	0.082
Hes1	hairy and enhancer of split 1 (Drosophila)	0.080
Sall3	sal-like 3 (Drosophila)	0.075
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.068
Egr2	early growth response 2	0.063	Mouse
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.063
Atoh7	atonal homolog 7 (Drosophila)	0.062
Ntf3	neurotrophin 3	0.061
Sox3	SRY-box containing gene 3	0.061	Mouse
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.060	Mouse
Zeb1	zinc finger E-box binding homeobox 1	0.058
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.058
Arx	aristaless related homeobox	0.057
Amhr2	anti-Mullerian hormone type 2 receptor	0.055
Tcf15	transcription factor 15	0.053
Aplnr	apelin receptor	0.052
Tbx5	T-box 5	0.051	Mouse
Egfl7	EGF-like domain 7	0.051
Lhx3	LIM homeobox protein 3	0.050	Mouse
Hoxa2	homeobox A2	0.048
Hoxd11	homeobox D11	0.048
Pcdh12	protocadherin 12	0.047
Sox4	SRY-box containing gene 4	0.047	Mouse
Gja5	gap junction protein, alpha 5	0.046
Rarb	retinoic acid receptor, beta	0.046
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.045	Human
Wnt4	wingless-related MMTV integration site 4	0.042	Mouse
Phox2b	paired-like homeobox 2b	0.042
Fgf4	fibroblast growth factor 4	0.042
Ret	ret proto-oncogene	0.040
Rasip1	Ras interacting protein 1	0.040
Nkx6-1	NK6 homeobox 1	0.040
Kdr	kinase insert domain protein receptor	0.039
Cdh5	cadherin 5	0.039
Trp63	transformation related protein 63	0.037
Foxb1	forkhead box B1	0.037
Ptprb	protein tyrosine phosphatase, receptor type, B	0.037
Smad7	MAD homolog 7 (Drosophila)	0.037
Zic1	zinc finger protein of the cerebellum 1	0.036
Btbd17	BTB (POZ) domain containing 17	0.036
Scn5a	sodium channel, voltage-gated, type V, alpha	0.035
Zic2	zinc finger protein of the cerebellum 2	0.034
Foxf1a	forkhead box F1a	0.034
Ptf1a	pancreas specific transcription factor, 1a	0.033
Sox1	SRY-box containing gene 1	0.033
Zfpm2	zinc finger protein, multitype 2	0.033
Foxa2	forkhead box A2	0.032
Pou3f1	POU domain, class 3, transcription factor 1	0.032
Msx2	homeobox, msh-like 2	0.032
Hoxa4	homeobox A4	0.032
Slit3	slit homolog 3 (Drosophila)	0.031
Insm1	insulinoma-associated 1	0.031
Pou4f2	POU domain, class 4, transcription factor 2	0.031
Efnb2	ephrin B2	0.031
Notch2	Notch gene homolog 2 (Drosophila)	0.030	Fly
Lhx5	LIM homeobox protein 5	0.030	Mouse
Dll1	delta-like 1 (Drosophila)	0.030
Tbx2	T-box 2	0.030	Mouse
Slit2	slit homolog 2 (Drosophila)	0.029
Chrd	chordin	0.029
Barx1	BarH-like homeobox 1	0.029
Adra2b	adrenergic receptor, alpha 2b	0.028
Notch3	Notch gene homolog 3 (Drosophila)	0.028	Fly
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.028
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.028	Fly
Col2a1	collagen, type II, alpha 1	0.027
Vax1	ventral anterior homeobox containing gene 1	0.027
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.025	Mouse
Slit1	slit homolog 1 (Drosophila)	0.025
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.024
Nkx2-1	NK2 homeobox 1	0.024	Mouse
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.024
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.024
Col13a1	collagen, type XIII, alpha 1	0.024
Pou3f4	POU domain, class 3, transcription factor 4	0.023
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.023
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.023
Wnt9b	wingless-type MMTV integration site 9B	0.023	Mouse
Zfp651	zinc finger protein 651	0.023
Lama5	laminin, alpha 5	0.022
Smo	smoothened homolog (Drosophila)	0.022
Gsc	goosecoid homeobox	0.022
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.022
Foxe3	forkhead box E3	0.022
Nkx3-2	NK3 homeobox 2	0.022	Mouse
Neurog2	neurogenin 2	0.022
T	brachyury	0.022	Mouse
Bmp2	bone morphogenetic protein 2	0.022
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.021
Zic3	zinc finger protein of the cerebellum 3	0.021
Tcf21	transcription factor 21	0.021
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.021
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.021
Flt4	FMS-like tyrosine kinase 4	0.021
Gli1	GLI-Kruppel family member GLI1	0.021
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.020
Fgf15	fibroblast growth factor 15	0.020
Ldb2	LIM domain binding 2	0.019
Sox13	SRY-box containing gene 13	0.019
Psen1	presenilin 1	0.019
Osr1	odd-skipped related 1 (Drosophila)	0.019
Npr3	natriuretic peptide receptor 3	0.019
Trp53	transformation related protein 53	0.019
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.019	Fly
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.019
Pitx3	paired-like homeodomain transcription factor 3	0.019
Bdnf	brain derived neurotrophic factor	0.019
Kcnk3	potassium channel, subfamily K, member 3	0.019
Wnt10b	wingless related MMTV integration site 10b	0.019	Mouse
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.018
Dlx1	distal-less homeobox 1	0.018
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.018
Wnt9a	wingless-type MMTV integration site 9A	0.017	Mouse
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.017
Ighmbp2	immunoglobulin mu binding protein 2	0.017
Prox1	prospero-related homeobox 1	0.017
Kiss1	KiSS-1 metastasis-suppressor	0.017
Hoxa10	homeobox A10	0.017
Dbx1	developing brain homeobox 1	0.016
Esr1	estrogen receptor 1 (alpha)	0.016
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.016
Tlx3	T-cell leukemia, homeobox 3	0.016
Avp	arginine vasopressin	0.016
Nanog	Nanog homeobox	0.016
Fgf18	fibroblast growth factor 18	0.016
Msx3	homeobox, msh-like 3	0.016
Neurog3	neurogenin 3	0.016
Hoxd12	homeobox D12	0.016	Fly
Otp	orthopedia homolog (Drosophila)	0.015
Hes5	hairy and enhancer of split 5 (Drosophila)	0.015
Dmrt3	doublesex and mab-3 related transcription factor 3	0.015
Lrp5	low density lipoprotein receptor-related protein 5	0.015
Hoxb13	homeobox B13	0.015
Hoxa3	homeobox A3	0.015
Pthlh	parathyroid hormone-like peptide	0.015
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.015	Fly
Evx2	even skipped homeotic gene 2 homolog	0.015
Dlx2	distal-less homeobox 2	0.015
Hoxa11	homeobox A11	0.015
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.015	Fly
Hoxc6	homeobox C6	0.015
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.014	Mouse
Nes	nestin	0.014
Hoxc9	homeobox C9	0.014
Smad1	MAD homolog 1 (Drosophila)	0.014
Cux2	cut-like homeobox 2	0.014
Tsks	testis-specific serine kinase substrate	0.014
Cer1	cerberus 1 homolog (Xenopus laevis)	0.014
Robo3	roundabout homolog 3 (Drosophila)	0.014	Fly
Fgf17	fibroblast growth factor 17	0.014
Tcfcp2l1	transcription factor CP2-like 1	0.014
Foxe1	forkhead box E1	0.013
Tbx20	T-box 20	0.013	Mouse
Pax1	paired box gene 1	0.013
Npas1	neuronal PAS domain protein 1	0.013
Cdx2	caudal type homeobox 2	0.013
Sall1	sal-like 1 (Drosophila)	0.013
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.013
Lhx6	LIM homeobox protein 6	0.012	Mouse
Zfp503	zinc finger protein 503	0.012
Cdx1	caudal type homeobox 1	0.012
Phox2a	paired-like homeobox 2a	0.012
Lrp6	low density lipoprotein receptor-related protein 6	0.012
Gja1	gap junction protein, alpha 1	0.012
Alx1	ALX homeobox 1	0.012
Wnt11	wingless-related MMTV integration site 11	0.012	Mouse
Dlx6	distal-less homeobox 6	0.012
Hoxd1	homeobox D1	0.012
Prop1	paired like homeodomain factor 1	0.011
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.011	Mouse
Gja4	gap junction protein, alpha 4	0.011
Nfib	nuclear factor I/B	0.011
Gas1	growth arrest specific 1	0.011
Nkd1	naked cuticle 1 homolog (Drosophila)	0.011
Ptch1	patched homolog 1	0.011
Robo2	roundabout homolog 2 (Drosophila)	0.011	Fly
Hhex	hematopoietically expressed homeobox	0.011
Fos	FBJ osteosarcoma oncogene	0.011
Nobox	NOBOX oogenesis homeobox	0.011
Cxadr	coxsackie virus and adenovirus receptor	0.011
Pbx1	pre B-cell leukemia transcription factor 1	0.011
Bcl2	B-cell leukemia/lymphoma 2	0.011
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.011
Foxh1	forkhead box H1	0.011
Evx1	even skipped homeotic gene 1 homolog	0.011
Wnt2b	wingless related MMTV integration site 2b	0.010	Mouse
Hmx1	H6 homeobox 1	0.010
Pdx1	pancreatic and duodenal homeobox 1	0.010
Lepr	leptin receptor	0.010
Tlx2	T-cell leukemia, homeobox 2	0.010
Foxd2	forkhead box D2	0.010
Sox7	SRY-box containing gene 7	0.010	Mouse
Etv2	ets variant gene 2	0.010
Wnt7a	wingless-related MMTV integration site 7A	0.010	Mouse
Fgfr4	fibroblast growth factor receptor 4	0.010