IMP

Process View

Mus musculus

4 genes annotated in mouse

immune response inhibiting signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "immune response inhibiting signal transduction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "immune response inhibiting signal transduction" (in gray)

Name	Description	Probability	Func Analog Organism
Ptprc	protein tyrosine phosphatase, receptor type, C	0.953
Slamf1	signaling lymphocytic activation molecule family member 1	0.933
Cd28	CD28 antigen	0.898
Ikzf1	IKAROS family zinc finger 1	0.852
Rag1	recombination activating gene 1	0.761
Inpp5d	inositol polyphosphate-5-phosphatase D	0.675
Fyn	Fyn proto-oncogene	0.477	Mouse
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.442
Il2rg	interleukin 2 receptor, gamma chain	0.426
Cd19	CD19 antigen	0.426
Cd247	CD247 antigen	0.404
Plcg2	phospholipase C, gamma 2	0.362
Icos	inducible T-cell co-stimulator	0.285
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.270
Was	Wiskott-Aldrich syndrome homolog (human)	0.235
Tcra	T-cell receptor alpha chain	0.232
Blnk	B-cell linker	0.209
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.197
Cd40	CD40 antigen	0.163
Ptpre	protein tyrosine phosphatase, receptor type, E	0.151
Il2rb	interleukin 2 receptor, beta chain	0.143
Hcls1	hematopoietic cell specific Lyn substrate 1	0.143
Tnf	tumor necrosis factor	0.132
Fyb	FYN binding protein	0.120
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.119
Ccr6	chemokine (C-C motif) receptor 6	0.109
Cbl	Casitas B-lineage lymphoma	0.108
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.101
Fas	Fas (TNF receptor superfamily member 6)	0.096
Foxp3	forkhead box P3	0.088
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.081
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.079
Lat	linker for activation of T cells	0.076
Sh2d1b1	SH2 domain protein 1B1	0.067
Skap2	src family associated phosphoprotein 2	0.058
Cd8a	CD8 antigen, alpha chain	0.058
Wipf1	WAS/WASL interacting protein family, member 1	0.057
Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	0.056
Ptpra	protein tyrosine phosphatase, receptor type, A	0.056
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.055
Il4	interleukin 4	0.055
Cd244	CD244 natural killer cell receptor 2B4	0.055
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.051
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.051
Dok2	docking protein 2	0.050
Pou2af1	POU domain, class 2, associating factor 1	0.049
Il2	interleukin 2	0.049
Ncr1	natural cytotoxicity triggering receptor 1	0.048
Sfpi1	SFFV proviral integration 1	0.047
Cd22	CD22 antigen	0.047
Hck	hemopoietic cell kinase	0.045	Mouse
Card11	caspase recruitment domain family, member 11	0.044
Ifnar1	interferon (alpha and beta) receptor 1	0.044	Mouse
Zap70	zeta-chain (TCR) associated protein kinase	0.043
Itgb2	integrin beta 2	0.042
Sykb	spleen tyrosine kinase	0.042
Ifng	interferon gamma	0.041
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.036
Ifnar2	interferon (alpha and beta) receptor 2	0.036
Dok1	docking protein 1	0.035
Lyz2	lysozyme 2	0.035
Il10	interleukin 10	0.034
Foxn1	forkhead box N1	0.033
Cd72	CD72 antigen	0.033
Cd84	CD84 antigen	0.033
Itk	IL2-inducible T-cell kinase	0.030
Irf1	interferon regulatory factor 1	0.030
Ptk2	PTK2 protein tyrosine kinase 2	0.030
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.027
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.027
Prkce	protein kinase C, epsilon	0.027
Cr2	complement receptor 2	0.027
Ikzf3	IKAROS family zinc finger 3	0.026
Batf	basic leucine zipper transcription factor, ATF-like	0.026
Il21r	interleukin 21 receptor	0.026
Cd180	CD180 antigen	0.026
Khdrbs1	KH domain containing, RNA binding, signal transduction associated 1	0.025
Hcst	hematopoietic cell signal transducer	0.025
Clnk	cytokine-dependent hematopoietic cell linker	0.024
Tmod3	tropomodulin 3	0.024
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.023
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.023
Ltb	lymphotoxin B	0.023
B2m	beta-2 microglobulin	0.023
Ccr7	chemokine (C-C motif) receptor 7	0.022
Mcoln2	mucolipin 2	0.022
Grb2	growth factor receptor bound protein 2	0.022
Cd4	CD4 antigen	0.022
Fcgr1	Fc receptor, IgG, high affinity I	0.021
Rasa1	RAS p21 protein activator 1	0.021
Il15	interleukin 15	0.020
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.020
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.019
Myd88	myeloid differentiation primary response gene 88	0.019
Sell	selectin, lymphocyte	0.018
Dynlt1b	dynein light chain Tctex-type 1D	0.018
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.018
Jak1	Janus kinase 1	0.017
Il7r	interleukin 7 receptor	0.017
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.017
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.017
Fpr1	formyl peptide receptor 1	0.017
Il27ra	interleukin 27 receptor, alpha	0.016
Ifngr1	interferon gamma receptor 1	0.016
Map1lc3b	microtubule-associated protein 1 light chain 3 beta	0.016
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.015
Il1a	interleukin 1 alpha	0.015
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	0.015
Mrc1	mannose receptor, C type 1	0.014
Itgax	integrin alpha X	0.014
Lta	lymphotoxin A	0.014
Map4k1	mitogen-activated protein kinase kinase kinase kinase 1	0.014
Irf8	interferon regulatory factor 8	0.014
Rasal3	RAS protein activator like 3	0.014
Cd160	CD160 antigen	0.014
Birc3	baculoviral IAP repeat-containing 3	0.013
Cd2	CD2 antigen	0.013
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.013
Il18rap	interleukin 18 receptor accessory protein	0.013
Jak3	Janus kinase 3	0.013
Cd79b	CD79B antigen	0.013
Rptn	repetin	0.013
Csf1	colony stimulating factor 1 (macrophage)	0.012
Itgal	integrin alpha L	0.012
Lcp1	lymphocyte cytosolic protein 1	0.012
Stat4	signal transducer and activator of transcription 4	0.012
Lck	lymphocyte protein tyrosine kinase	0.012	Mouse
Tnip1	TNFAIP3 interacting protein 1	0.012
Ctsw	cathepsin W	0.012
Gzmb	granzyme B	0.012
Rasgrp1	RAS guanyl releasing protein 1	0.012
Sh2d1a	SH2 domain protein 1A	0.012	Mouse
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.012
Laptm5	lysosomal-associated protein transmembrane 5	0.012
Cxcr5	chemokine (C-X-C motif) receptor 5	0.011
Cnr2	cannabinoid receptor 2 (macrophage)	0.011
Sbf2	SET binding factor 2	0.011
Gna15	guanine nucleotide binding protein, alpha 15	0.011
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.011
Sla	src-like adaptor	0.011
Cxcr3	chemokine (C-X-C motif) receptor 3	0.011
Bcl3	B-cell leukemia/lymphoma 3	0.011
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.011
P2rx4	purinergic receptor P2X, ligand-gated ion channel 4	0.011
Tlr6	toll-like receptor 6	0.011
Cd86	CD86 antigen	0.011
Cdcp1	CUB domain containing protein 1	0.011
Man2b1	mannosidase 2, alpha B1	0.011
Plek	pleckstrin	0.011
Wnt7b	wingless-related MMTV integration site 7B	0.010
Runx1	runt related transcription factor 1	0.010