IMP

Process View

Mus musculus

9 genes annotated in mouse

type i interferon biosynthetic process

The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "type i interferon biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "type i interferon biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
Tlr4	toll-like receptor 4	0.868
Ticam1	toll-like receptor adaptor molecule 1	0.832
Stat1	signal transducer and activator of transcription 1	0.812
Ikbkg	inhibitor of kappaB kinase gamma	0.743
Ikbkb	inhibitor of kappaB kinase beta	0.730	Mouse
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.592
Myd88	myeloid differentiation primary response gene 88	0.531
Chuk	conserved helix-loop-helix ubiquitous kinase	0.486	Mouse
Ifnar2	interferon (alpha and beta) receptor 2	0.276
Ccr2	chemokine (C-C motif) receptor 2	0.259
Cblb	Casitas B-lineage lymphoma b	0.131
Unc93b1	unc-93 homolog B1 (C. elegans)	0.128
Birc3	baculoviral IAP repeat-containing 3	0.121
Sfpi1	SFFV proviral integration 1	0.118
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.097
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.071
Irf1	interferon regulatory factor 1	0.058	Mouse
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.052
Ccl2	chemokine (C-C motif) ligand 2	0.051
Irak4	interleukin-1 receptor-associated kinase 4	0.050
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.047
Tnf	tumor necrosis factor	0.046
Stat2	signal transducer and activator of transcription 2	0.045
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.044
Traf6	TNF receptor-associated factor 6	0.043
Ifngr1	interferon gamma receptor 1	0.043
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.042
Stat6	signal transducer and activator of transcription 6	0.041
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.041
Ifnar1	interferon (alpha and beta) receptor 1	0.039
Irf5	interferon regulatory factor 5	0.038	Mouse
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.032
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.032
Uba7	ubiquitin-like modifier activating enzyme 7	0.031
Usp18	ubiquitin specific peptidase 18	0.031
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.029
Lyz2	lysozyme 2	0.028
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.028
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.026
Il1r1	interleukin 1 receptor, type I	0.026
Sykb	spleen tyrosine kinase	0.025
Stat3	signal transducer and activator of transcription 3	0.025
Tor3a	torsin family 3, member A	0.025
Irf8	interferon regulatory factor 8	0.024	Mouse
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.023
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.023
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.023
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.022
Tlr2	toll-like receptor 2	0.021	Mouse
Mavs	mitochondrial antiviral signaling protein	0.020
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.018
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.018
Rnf31	ring finger protein 31	0.018
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.018
Dock2	dedicator of cyto-kinesis 2	0.018
Fas	Fas (TNF receptor superfamily member 6)	0.018
Isg15	ISG15 ubiquitin-like modifier	0.018
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.017
Sfn	stratifin	0.016
Mmp9	matrix metallopeptidase 9	0.016
Igtp	interferon gamma induced GTPase	0.015
Tank	TRAF family member-associated Nf-kappa B activator	0.015
Irgm1	immunity-related GTPase family M member 1	0.014
Rtp4	receptor transporter protein 4	0.014
Parp10	poly (ADP-ribose) polymerase family, member 10	0.014
Gbp3	guanylate binding protein 3	0.014
C3	complement component 3	0.014
Rsad2	radical S-adenosyl methionine domain containing 2	0.014
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.014
Parp14	poly (ADP-ribose) polymerase family, member 14	0.014
Itga4	integrin alpha 4	0.013
Tlr5	toll-like receptor 5	0.013	Mouse
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.013
Mx2	myxovirus (influenza virus) resistance 2	0.013
Pyhin1	pyrin and HIN domain family, member 1	0.013
Cxcl10	chemokine (C-X-C motif) ligand 10	0.013
Vav1	vav 1 oncogene	0.013
Cd14	CD14 antigen	0.012
Il10ra	interleukin 10 receptor, alpha	0.012
Ikzf1	IKAROS family zinc finger 1	0.012
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.012
Irf7	interferon regulatory factor 7	0.012
Irgm2	immunity-related GTPase family M member 2	0.011
Pml	promyelocytic leukemia	0.011
Spp1	secreted phosphoprotein 1	0.011
Ncoa3	nuclear receptor coactivator 3	0.010
Sp100	nuclear antigen Sp100	0.010
Irf4	interferon regulatory factor 4	0.010	Mouse
Tgfb1	transforming growth factor, beta 1	0.010
Irak1	interleukin-1 receptor-associated kinase 1	0.010
Trim21	tripartite motif-containing 21	0.010