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Danio rerio

13 genes annotated in zebrafish

negative regulation of cell fate commitment

Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cell fate commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
gli1	GLI-Kruppel family member 1	0.683
fgf17	fibroblast growth factor 17	0.582
hmx4	H6 family homeobox 4	0.546
wnt5b	wingless-type MMTV integration site family, member 5b	0.522	Zebrafish
bmp2b	bone morphogenetic protein 2b	0.522
sfrp1a	secreted frizzled-related protein 1a	0.499
wnt8b	wingless-type MMTV integration site family, member 8b	0.484
bmp4	bone morphogenetic protein 4	0.435
wnt4a	wingless-type MMTV integration site family, member 4a	0.359	Zebrafish
wnt10a	wingless-type MMTV integration site family, member 10a	0.357	Zebrafish
dkk1b	dickkopf 1b	0.313
wnt11r	wingless-type MMTV integration site family, member 11, related	0.289	Zebrafish
tbx1	T-box 1	0.266
twist1b	twist1b	0.263
notch2	notch homolog 2	0.261
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.236	Zebrafish
wnt9a	wingless-type MMTV integration site family, member 9A	0.224	Zebrafish
bmp2a	bone morphogenetic protein 2a	0.219	Zebrafish
tbx20	T-box 20	0.172
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.164
gata4	GATA-binding protein 4	0.140
msxc	muscle segment homeobox C	0.136
twist3	twist3	0.135
oep	one-eyed pinhead	0.133
gbx2	gastrulation brain homeo box 2	0.129
dharma	dharma	0.121
nkx6.1	NK6 transcription factor related, locus 1 (Drosophila)	0.120
tbx5a	T-box 5a	0.120
her5	hairy-related 5	0.119
fgf10a	fibroblast growth factor 10a	0.118
wnt11	wingless-type MMTV integration site family, member 11	0.117	Zebrafish
fzd7a	frizzled homolog 7a	0.108
notch3	notch homolog 3	0.108
hoxd11a	homeo box D11a	0.106
six4b	sine oculis homeobox homolog 4b	0.105
hnf1ba	HNF1 homeobox Ba	0.104
pcdh8	protocadherin 8	0.102
foxa3	forkhead box A3	0.096
mespb	mesoderm posterior b	0.093	Mouse
jag1b	jagged 1b	0.087
slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.086
tagln2	transgelin 2	0.084
pdlim7	PDZ and LIM domain 7	0.074
flh	floating head	0.072
wif1	wnt inhibitory factor 1	0.066
wnt1	wingless-type MMTV integration site family, member 1	0.065	Zebrafish Fly
fgf3	fibroblast growth factor 3	0.061
ndr2	nodal-related 2	0.061
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.058
dusp6	dual specificity phosphatase 6	0.057
sox17	SRY-box containing gene 17	0.056	Mouse
hoxa11a	homeo box A11a	0.055
spry4	sprouty (Drosophila) homolog 4	0.054
tbx6	T-box gene 6	0.053
foxd5	forkhead box D5	0.052
wnt10b	wingless-type MMTV integration site family, member 10b	0.052	Zebrafish
meis3	myeloid ecotropic viral integration site 3	0.052
msxb	muscle segment homeobox B	0.052
dmrta2	doublesex and mab-3 related transcription factor like family A2	0.052
hapln3	hyaluronan and proteoglycan link protein 3	0.050
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.050	Zebrafish
neo1	neogenin 1	0.048
axin1	axin 1	0.047
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.046
rest	RE1-silencing transcription factor	0.045
lef1	lymphocyte enhancer binding factor 1	0.044
chd	chordin	0.044
tbx18	T-box 18	0.044
gdnf	glial cell derived neurotrophic factor	0.042
frem3	Fras1 related extracellular matrix 3	0.042
col2a1a	collagen type II, alpha-1a	0.040
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.040
hoxb5a	homeo box B5a	0.040
hoxd13a	homeo box D13a	0.040
gata6	GATA-binding protein 6	0.040
ef1	ETS-related factor1	0.039
etv5b	ets variant 5b	0.038
hhip	hedgehog interacting protein	0.038
lama5	laminin, alpha 5	0.037
perp	PERP, TP53 apoptosis effector	0.036
cdh1	cadherin 1, epithelial	0.036
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.036
mapk6	mitogen-activated protein kinase 6	0.035
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.035
wnt3	wingless-type MMTV integration site family, member 3	0.034	Zebrafish
rx1	retinal homeobox gene 1	0.034
waca	WW domain containing adaptor with coiled-coil a	0.032
hoxd10a	homeo box D10a	0.032
osr2	odd-skipped related 2 (Drosophila)	0.032
epha4b	eph receptor A4b	0.031
sox11b	SRY-box containing gene 11b	0.031
hmx3	homeo box (H6 family) 3	0.031
jag2	jagged 2	0.030
gata2a	GATA-binding protein 2a	0.029
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.029
wnt2	wingless-type MMTV integration site family member 2	0.029	Zebrafish
hoxa13b	homeo box A13b	0.028
fli1a	friend leukemia integration 1a	0.028
mespa	mesoderm posterior a	0.028	Mouse
tgfb3	transforming growth factor, beta 3	0.027
etv2	ets variant gene 2	0.027
sox32	SRY-box containing gene 32	0.027	Mouse
sfrp1b	secreted frizzled-related protein 1b	0.026
tll1	tolloid-like 1	0.026
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.026
og9x	OG9 homeobox gene	0.026
zgc:77051	zgc:77051	0.025
hgfa	hepatocyte growth factor a	0.025
fgfr2	fibroblast growth factor receptor 2	0.025	Zebrafish
pcdh10b	protocadherin 10b	0.024
wnt9b	wingless-type MMTV integration site family, member 9B	0.024	Zebrafish
fn1	fibronectin 1	0.024
drl	draculin	0.024
nkx2.5	NK2 transcription factor related 5	0.024
lft1	lefty1	0.024
fbln1	fibulin 1	0.023
krt4	keratin 4	0.023
klf4a	Kruppel-like transcription factor 4a	0.023
atoh1a	atonal homolog 1a	0.023
lhx1b	LIM homeobox 1b	0.023
wnt3a	wingless-type MMTV integration site family, member 3A	0.022	Human Zebrafish
fgf8b	fibroblast growth factor 8 b	0.022	Zebrafish
ptch1	patched 1	0.022
fibin	fin bud initiation factor	0.022
foxh1	forkhead box H1	0.021
map2k4b	mitogen-activated protein kinase kinase 4b	0.021
grem2	gremlin 2, cysteine knot superfamily	0.021
gpr126	G protein-coupled receptor 126	0.021
wnt4b	wingless-type MMTV integration site family, member 4b	0.021	Zebrafish
map2k7	mitogen-activated protein kinase kinase 7	0.021
sfrp2	secreted frizzled-related protein 2	0.021	Mouse
oprk1	opioid receptor, kappa 1	0.020
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.020
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.020	Zebrafish
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.020
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.020
pea3	ETS-domain transcription factor pea3	0.020
ppm1d	protein phosphatase 1D magnesium-dependent, delta isoform	0.020
mib	mind bomb	0.019
chd7	chromodomain helicase DNA binding protein 7	0.019
sptb	spectrin, beta, erythrocytic	0.019
uts2a	urotensin 2, alpha	0.019
dspa	desmoplakin a	0.019
osr1	odd-skipped related 1 (Drosophila)	0.018
egr2b	early growth response 2b	0.018
kif7	kinesin family member 7	0.018
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.018
si:ch211-173o4.2	si:ch211-173o4.2	0.018
hhex	hematopoietically expressed homeobox	0.018
eng1a	engrailed 1a	0.018
map2k4a	mitogen-activated protein kinase kinase 4a	0.018
grem1a	gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)	0.018
acvr2b	activin receptor IIb	0.018
nog1	noggin 1	0.017
mxtx2	mix-type homeobox gene 2	0.017
buc	bucky ball	0.017
kal1b	Kallmann syndrome 1b sequence	0.017
her6	hairy-related 6	0.017
fzd5	frizzled homolog 5	0.016
stm	starmaker	0.016
lhx2b	LIM homeobox 2b	0.016
fgf24	fibroblast growth factor 24	0.016
atoh1b	atonal homolog 1b	0.016
pbx4	pre-B-cell leukemia transcription factor 4	0.016
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.015
notch1b	notch homolog 1b	0.015
bmp7b	bone morphogenetic protein 7b	0.015	Zebrafish
mc5rb	melanocortin 5b receptor	0.015
vax2	ventral anterior homeobox 2	0.015
hoxa10b	homeo box A10b	0.015
tp63	tumor protein p63	0.015
zbtb4	zinc finger and BTB domain containing 4	0.015
zgc:92360	zgc:92360	0.015
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.015
zgc:162270	zgc:162270	0.015
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.015
spaw	southpaw	0.014
krt5	keratin 5	0.014
sim1a	single-minded homolog 1a (Drosophila)	0.014
mesp2	mesoderm posterior 2 homolog (mouse)	0.014
fgfrl1b	fibroblast growth factor receptor-like 1b	0.014
sema3h	semaphorin 3h	0.014
hand2	heart and neural crest derivatives expressed transcript 2	0.014
zgc:66100	zgc:66100	0.014
foxd3	forkhead box D3	0.014
jun	jun proto-oncogene	0.013
boc	brother of CDO	0.013
cdh2	cadherin 2, neuronal	0.013
sdprb	serum deprivation response b	0.013
runx3	runt-related transcription factor 3	0.013
angptl2	angiopoietin-like 2	0.013
cmn	calymmin	0.013
hoxc11a	homeo box C11a	0.013
dbx1a	developing brain homeobox 1a	0.013
evx2	even-skipped homeobox 2	0.013
eif4e1b	eukaryotic translation initiation factor 4e 1b	0.013
mapk7	mitogen-activated protein kinase 7	0.013
klf2a	Kruppel-like factor 2a	0.013
igf3	insulin-like growth factor 3	0.013
tfeb	transcription factor EB	0.013
rx2	retinal homeobox gene 2	0.013
wnt16	wingless-type MMTV integration site family, member 16	0.013
nkd2	naked cuticle homolog 2 and naked 2a	0.013
tcf21	transcription factor 21	0.012
si:dkey-273o13.1	si:dkey-273o13.1	0.012
bmp3	bone morphogenetic protein 3	0.012	Zebrafish
fli1b	friend leukemia integration 1b	0.012
and1	actinodin1	0.012
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.012
opn1mw4	opsin 1 (cone pigments), medium-wave-sensitive, 4	0.012
fzd8b	frizzled homolog 8b	0.012
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.012
foxg1a	forkhead box G1a	0.012
raraa	retinoic acid receptor, alpha a	0.012
gdf6b	growth differentiation factor 6b	0.012	Zebrafish
vsx1	visual system homeobox 1 homolog, chx10-like	0.012
ctgf	connective tissue growth factor	0.012
tfe3b	transcription factor binding to IGHM enhancer 3b	0.012
col4a6	collagen, type IV, alpha 6	0.011
zfand5a	zinc finger, AN1-type domain 5a	0.011
tbx16	T-box gene 16	0.011
insb	preproinsulin b	0.011
pitx2	paired-like homeodomain transcription factor 2	0.011
runx2b	runt-related transcription factor 2b	0.011
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.011
frzb	frizzled-related protein	0.011
col7a1l	collagen type VII alpha 1-like	0.011
cdx4	caudal type homeo box transcription factor 4	0.011
dkk3	dickkopf homolog 3 (Xenopus laevis)	0.011
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
barhl1.2	BarH-like 1.2	0.011
tbx2a	T-box gene 2a	0.011
foxj1a	forkhead box J1a	0.011
hdr	hematopoietic death receptor	0.011
wnt7bb	wingless-type MMTV integration site family, member 7Bb	0.011
snai1b	snail homolog 1b (Drosophila)	0.010
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.010
cbx2	chromobox homolog 2 (Drosophila Pc class)	0.010
cstf3	cleavage stimulation factor, 3' pre-RNA, subunit 3	0.010
bmp7a	bone morphogenetic protein 7a	0.010
gucy2f	guanylate cyclase 2F, retinal	0.010