IMP

Process View

Danio rerio

4 genes annotated in zebrafish

response to cold

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to cold"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to cold" (in gray)

Name	Description	Probability	Func Analog Organism
ef1a	elongation factor 1-alpha	0.356
adrb2a	adrenergic receptor, beta 2a	0.266
hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.210
hmgb1b	high-mobility group box 1b	0.201
acadl	acyl-Coenzyme A dehydrogenase, long chain	0.095
pparg	peroxisome proliferator activated receptor gamma	0.081	Rat
prmt1	protein arginine methyltransferase 1	0.079
entpd3	ectonucleoside triphosphate diphosphohydrolase 3	0.078
tgfb3	transforming growth factor, beta 3	0.067
p2rx8	purinergic receptor P2X, ligand-gated ion channel, 8	0.066
khdrbs1a	KH domain containing, RNA binding, signal transduction associated 1a	0.059
chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1	0.058
cdh4	cadherin 4, retinal	0.058
hmgb3a	high-mobility group box 3a	0.056
fabp11a	fatty acid binding protein 11a	0.054
p2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.054
hmgn2	high-mobility group nucleosomal binding domain 2	0.054
plxna4	plexin A4	0.049
ubtf	upstream binding transcription factor, RNA polymerase I	0.049
lhx6	LIM homeobox 6	0.048
trpa1b	transient receptor potential cation channel, subfamily A, member 1b	0.048	Mouse
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.044
eif4a1a	eukaryotic translation initiation factor 4A, isoform 1A	0.042
eif3s10	eukaryotic translation initiation factor 3, subunit 10 (theta)	0.038
anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.038
duox	dual oxidase	0.034
qk	quaking	0.034
stac3	SH3 and cysteine rich domain 3	0.034
smarce1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.033
adrb1	adrenergic receptor, beta 1	0.033	Mouse
hspa5	heat shock protein 5	0.031
LOC557722	similar to transient receptor potential cation channel, subfamily M, member 5	0.031
m17	IL-6 subfamily cytokine M17	0.029
hadha	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit	0.029
acvr2a	activin receptor IIa	0.029
cacnb3b	calcium channel, voltage-dependent, beta 3b	0.029
hmgb2a	high-mobility group box 2a	0.028
abcd3a	ATP-binding cassette, sub-family D (ALD), member 3a	0.028
caspa	caspase a	0.027
lancl1	LanC antibiotic synthetase component C-like 1 (bacterial)	0.027
acaa2	acetyl-CoA acyltransferase 2	0.026
mst1	macrophage stimulating 1 (hepatocyte growth factor-like)	0.026
hnrnpa0l	heterogeneous nuclear ribonucleoprotein A0, like	0.025
scn8ab	sodium channel, voltage-gated, type VIII, alpha b	0.025
hsp70l	heat shock cognate 70-kd protein, like	0.024
trpv1	transient receptor potential cation channel subfamily V member 1	0.024
srsf4	serine/arginine-rich splicing factor 4	0.024
sod1	superoxide dismutase 1, soluble	0.024
cpt2	carnitine palmitoyltransferase II	0.023
tph2	tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)	0.023
adipoql	adiponectin, C1Q and collagen domain containing, like	0.023
ech1	enoyl CoA hydratase 1, peroxisomal	0.023
cirbp	cold inducible RNA binding protein	0.023
wu:fc24e06	wu:fc24e06	0.023
ewsr1b	Ewing sarcoma breakpoint region 1b	0.022
etfb	electron-transfer-flavoprotein, beta polypeptide	0.022
tubb2c	tubulin, beta 2c	0.022
cisd1	CDGSH iron sulfur domain 1	0.022
serhl	serine hydrolase-like	0.022
thrab	thyroid hormone receptor alpha b	0.022	Mouse
ryr1b	ryanodine receptor 1b (skeletal)	0.022
cish	cytokine inducible SH2-containing protein	0.022
drgx	dorsal root ganglia homeobox	0.021
il6st	interleukin 6 signal transducer	0.021
ifng1-1	interferon, gamma 1-1	0.021
bcl2l1	bcl2-like 1	0.021
arl6	ADP-ribosylation factor-like 6	0.021
zgc:171553	zgc:171553	0.021
mef2ca	myocyte enhancer factor 2ca	0.020
LOC100331484	hypothetical protein LOC100331484	0.020
cat	catalase	0.020
stmn2b	stathmin-like 2b	0.020
dpf2l	D4, zinc and double PHD fingers family 2, like	0.020
homez	homeodomain leucine zipper gene	0.020
tardbp	TAR DNA binding protein	0.020
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.020
mtch2	mitochondrial carrier homolog 2	0.019
LOC100004946	transient receptor potential cation channel subfamily M member 4-like	0.019
vtg1	vitellogenin 1	0.018
slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.018
adipor1b	adiponectin receptor 1b	0.018
ldhbb	lactate dehydrogenase Bb	0.018
hadh	hydroxyacyl-Coenzyme A dehydrogenase	0.018
cacna1ab	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b	0.018
si:dkey-49m19.7	si:dkey-49m19.7	0.018
tbx22	T-box 22	0.018
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.018
srsf5b	serine/arginine-rich splicing factor 5b	0.018
zgc:175096	zgc:175096	0.017
ngfrl	nerve growth factor receptor (TNFR superfamily, member 16) like	0.017
ela2	elastase 2	0.017
zgc:77556	zgc:77556	0.017
hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.017
cry1b	cryptochrome 1b	0.017
nucks1a	nuclear casein kinase and cyclin-dependent kinase substrate 1a	0.017
aplp2	amyloid beta (A4) precursor-like protein 2	0.017
zgc:158138	zgc:158138	0.017
coq3	coenzyme Q3 homolog, methyltransferase (yeast)	0.017
thraa	thyroid hormone receptor alpha a	0.017	Mouse
hnrnpl2	heterogeneous nuclear ribonucleoprotein L2	0.016
zeb2b	zinc finger E-box binding homeobox 2b	0.016
hnrpr	heterogeneous nuclear ribonucleoprotein R	0.016
plg	plasminogen	0.016
ptprfb	protein tyrosine phosphatase, receptor type, f, b	0.016
h3f3d	H3 histone, family 3D	0.016
rbpms2	RNA binding protein with multiple splicing 2	0.016
ociad1	OCIA domain containing 1	0.016
acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.016
scn1ba	sodium channel, voltage-gated, type I, beta a	0.015
wu:fd15f08	wu:fd15f08	0.015
zgc:153921	zgc:153921	0.015
zgc:171629	zgc:171629	0.015
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.015
dnajb6b	DnaJ (Hsp40) homolog, subfamily B, member 6b	0.015
tfe3b	transcription factor binding to IGHM enhancer 3b	0.015
ak3	adenylate kinase 3	0.015
dpysl2b	dihydropyrimidinase-like 2b	0.015
gnrhr4	gonadotropin releasing hormone receptor 4	0.015
ephx1	epoxide hydrolase 1, microsomal (xenobiotic)	0.015
gsna	gelsolin a	0.015
sec14l1	SEC14-like 1 (S. cerevisiae)	0.015
igfbp1b	insulin-like growth factor binding protein 1b	0.015
zgc:123178	zgc:123178	0.015
LOC562316	klotho-like	0.015
hdc	histidine decarboxylase	0.015
ptgs2b	prostaglandin-endoperoxide synthase 2b	0.015
srsf5a	serine/arginine-rich splicing factor 5a	0.015
zgc:92851	zgc:92851	0.014
cyp2ad2	cytochrome P450, family 2, subfamily AD, polypeptide 2	0.014
nr4a1	nuclear receptor subfamily 4, group A, member 1	0.014
adh8a	alcohol dehydrogenase 8a	0.014
LOC569770	cytochrome c oxidase subunit 8B, mitochondrial-like	0.014
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.014
zgc:77051	zgc:77051	0.014
zgc:92030	zgc:92030	0.014
pdia4	protein disulfide isomerase associated 4	0.014
stk10	serine/threonine kinase 10	0.014
fth1a	ferritin, heavy polypeptide 1a	0.014
got2a	glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)	0.014
si:ch1073-126c3.2	si:ch1073-126c3.2	0.014
slc9a1	solute carrier family 9 (sodium/hydrogen exchanger), member 1	0.014
bbc3	BCL2 binding component 3	0.014
tlr18	toll-like receptor 18	0.014
tas2r200.1	taste receptor, type 2, member 200.1	0.014
bzw1a	basic leucine zipper and W2 domains 1a	0.014
cntn2	contactin 2	0.014
flot1	flotillin 1	0.014
rnf2	ring finger protein 2	0.013
idh2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.013
rpl3	ribosomal protein L3	0.013
ipo7	importin 7	0.013
gtpbp4	GTP binding protein 4	0.013
tmbim1	transmembrane BAX inhibitor motif containing 1	0.013
col4a3	collagen, type IV, alpha 3	0.013
wu:fb39a06	wu:fb39a06	0.013
pdip5	protein disulfide isomerase-related protein (provisional)	0.013
olfm1b	olfactomedin 1b	0.013
serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.013
nsdhl	NAD(P) dependent steroid dehydrogenase-like	0.013
nrg1	neuregulin 1	0.013
gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.013
acsf2	acyl-CoA synthetase family member 2	0.013
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.013
cpt1b	carnitine palmitoyltransferase 1B (muscle)	0.013
serpinb1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.013
junb	jun B proto-oncogene	0.013
zgc:136346	zgc:136346	0.013
lifrb	leukemia inhibitory factor receptor alpha b	0.013
tas2r200.2	taste receptor, type 2, member 200.2	0.013
tmem177	transmembrane protein 177	0.013
kdsr	3-ketodihydrosphingosine reductase	0.013
si:rp71-39b20.7	si:rp71-39b20.7	0.013
LOC100331455	arf-GAP with dual PH domain-containing protein 2-like	0.013
illr1	immune-related, lectin-like receptor 1	0.013
dusp22a	dual specificity phosphatase 22a	0.012
hmbsb	hydroxymethylbilane synthase, b	0.012
zgc:103668	zgc:103668	0.012
atp2b1b	ATPase, Ca++ transporting, plasma membrane 1b	0.012	Rat
dpf3	D4, zinc and double PHD fingers, family 3	0.012
atxn7l3	ataxin 7-like 3	0.012
LOC100536988	Gig2-like protein DreQ	0.012
cry2a	cryptochrome 2a	0.012
cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.012
pacsin2	protein kinase C and casein kinase substrate in neurons 2	0.012
sod2	superoxide dismutase 2, mitochondrial	0.012
rhd	Rh blood group, D antigen	0.012
bactin2	bactin2	0.012
slc25a10	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0.012
zgc:55307	zgc:55307	0.012
zgc:91860	zgc:91860	0.012
s100a10a	S100 calcium binding protein A10a	0.012
kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.012
ambra1	autophagy/beclin-1 regulator 1	0.012
srsf2	serine/arginine-rich splicing factor 2	0.012
pdpk1a	3-phosphoinositide dependent protein kinase-1a	0.012
nsmaf	neutral sphingomyelinase (N-SMase) activation associated factor	0.012
taf8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.012
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.012
fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.012
LOC794630	retinol-binding protein 3-like	0.012
mical2a	microtubule associated monoxygenase, calponin and LIM domain containing 2a	0.012
tlr9	toll-like receptor 9	0.012
ubc	ubiquitin C	0.012
zswim5	zinc finger, SWIM-type containing 5	0.012
cd247l	CD247 antigen like	0.012
foxo3a	forkhead box O3A	0.012
chrna5	cholinergic receptor, nicotinic, alpha 5	0.012
gpia	glucose phosphate isomerase a	0.011
tlr4ba	toll-like receptor 4b, duplicate a	0.011
acads	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	0.011
zgc:110256	zgc:110256	0.011
LOC100537909	histone-lysine N-methyltransferase MLL4-like	0.011
sulf1	sulfatase 1	0.011
ss18	synovial sarcoma translocation, chromosome 18 (H. sapiens)	0.011
pafah1b1b	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b	0.011
opa3	optic atrophy 3	0.011
zgc:195195	zgc:195195	0.011
zgc:165626	zgc:165626	0.011
adrb3a	adrenergic receptor, beta 3a	0.011	Mouse Rat
zgc:162126	zgc:162126	0.011
slc25a25a	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a	0.011
cnot6	CCR4-NOT transcription complex, subunit 6	0.011
slc10a4	solute carrier family 10 (sodium/bile acid cotransporter family), member 4	0.011
kiss1	KiSS-1 metastasis-suppressor	0.011
tardbpl	TAR DNA binding protein, like	0.011
zgc:112054	zgc:112054	0.011
hrh1	histamine receptor H1	0.011
wu:fc18c07	wu:fc18c07	0.011
fgf20a	fibroblast growth factor 20a	0.011
ngfra	nerve growth factor receptor a (TNFR superfamily, member 16)	0.011
sqrdl	sulfide quinone reductase-like (yeast)	0.011
mmadhc	methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria	0.011
rrm2b	ribonucleotide reductase M2 b	0.011
grn1	granulin 1	0.011
LOC556160	guanine nucleotide-binding protein subunit alpha-14-like	0.011
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.011
serpind1	serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1	0.011
ppcs	phosphopantothenoylcysteine synthetase	0.011
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.011
hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.011
sb:cb101	sb:cb101	0.011
LOC100330645	heterogeneous nuclear ribonucleoprotein U-like protein 1-like	0.011
LOC565513	sorting nexin-29-like	0.011
uevld	UEV and lactate/malate dehyrogenase domains	0.011
si:dkey-180p18.9	si:dkey-180p18.9	0.011
echs1	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	0.011
aldh3a2	aldehyde dehydrogenase 3 family, member A2	0.011
trim13	tripartite motif-containing 13	0.011
sult1st7	sulfotransferase family 1, cytosolic sulfotransferase 7	0.011
cpa5	carboxypeptidase A5	0.011
bik	BCL2-interacting killer (apoptosis-inducing)	0.011
nme3	non-metastatic cells 3, protein expressed in	0.011
cpeb4	cytoplasmic polyadenylation element binding protein 4	0.011
mid2	midline 2	0.011
unc45b	unc-45 homolog B (C. elegans)	0.011
slc9a8	solute carrier family 9 (sodium/hydrogen exchanger), member 8	0.010
eif5a	eukaryotic translation initiation factor 5A	0.010
fam60al	family with sequence similarity 60, member A, like	0.010
hrh3	histamine receptor H3	0.010
zgc:193699	zgc:193699	0.010
arl4aa	ADP-ribosylation factor-like 4aa	0.010
cry2b	cryptochrome 2b	0.010
trnt1	tRNA nucleotidyl transferase, CCA-adding, 1	0.010
hmgb3b	high-mobility group box 3b	0.010
srebf2	sterol regulatory element binding transcription factor 2	0.010
zgc:92763	zgc:92763	0.010
elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	0.010
cyp2k18	cytochrome P450, family 2, subfamily K, polypeptide 18	0.010
zgc:91976	zgc:91976	0.010
yy1a	YY1 transcription factor a	0.010
tas1r1	taste receptor, type 1, member 1	0.010
zgc:112056	zgc:112056	0.010
rxrba	retinoid x receptor, beta a	0.010
atf3	activating transcription factor 3	0.010
igfbp1a	insulin-like growth factor binding protein 1a	0.010
slc25a11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	0.010
acad8	acyl-Coenzyme A dehydrogenase family, member 8	0.010
phf23a	PHD finger protein 23a	0.010
zgc:112254	zgc:112254	0.010
esr2b	estrogen receptor 2b	0.010
pitpna	phosphatidylinositol transfer protein, alpha	0.010
acvr2b	activin receptor IIb	0.010