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Danio rerio

16 genes annotated in zebrafish

negative regulation of protein metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
pcna	proliferating cell nuclear antigen	0.270
notch1a	notch homolog 1a	0.142
sema3aa	semaphorin 3aa	0.113
frem3	Fras1 related extracellular matrix 3	0.091
egr1	early growth response 1	0.068	Worm
bcl2l1	bcl2-like 1	0.060
ccnd1	cyclin D1	0.059
ywhabb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b	0.056
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.055	Mouse
brca2	breast cancer 2, early onset	0.050
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.050
cx43.4	connexin 43.4	0.046
bmp2b	bone morphogenetic protein 2b	0.044
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.044
smoc1	SPARC related modular calcium binding 1	0.043
alcama	activated leukocyte cell adhesion molecule a	0.041
usp5	ubiquitin specific protease 5	0.038
ccnb1	cyclin B1	0.037	Rat
ncl	nucleolin	0.037
rarab	retinoic acid receptor, alpha b	0.037	Mouse
fgfr1a	fibroblast growth factor receptor 1a	0.037
pax8	paired box gene 8	0.037
pou3f1	POU class 3 homeobox 1	0.036
gli1	GLI-Kruppel family member 1	0.034
spry4	sprouty (Drosophila) homolog 4	0.034	Mouse
caprin1a	cell cycle associated protein 1a	0.032
igf1ra	insulin-like growth factor 1a receptor	0.032
sall1a	sal-like 1a (Drosophila)	0.032
dab1a	disabled homolog 1a (Drosophila)	0.030
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.029
pxn	paxillin	0.029
ntn2	netrin 2	0.029
ptch2	patched 2	0.029
stc1l	stanniocalcin 1, like	0.029
meis1	myeloid ecotropic viral integration 1	0.029
zgc:195154	zgc:195154	0.028
hsp90a.2	heat shock protein 90-alpha 2	0.028
sox11a	SRY-box containing gene 11a	0.028
dld	deltaD	0.027
nf1a	neurofibromin 1a	0.027	Mouse
hs6st1a	heparan sulfate 6-O-sulfotransferase 1a	0.027
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.025
furina	furin (paired basic amino acid cleaving enzyme) a	0.025	Human
zgc:56304	zgc:56304	0.025
sulf2l	sulfatase 2, like	0.025
hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.024
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.024
ryk	receptor-like tyrosine kinase	0.024
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.024
bactin2	bactin2	0.024
nrg2a	neuregulin 2a	0.023
sox11b	SRY-box containing gene 11b	0.023
u2af2b	U2 small nuclear RNA auxiliary factor 2b	0.023
ptn	pleiotrophin	0.023
dusp6	dual specificity phosphatase 6	0.023	Human Mouse
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.022
mcl1a	myeloid cell leukemia sequence 1a	0.022
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.022
mbtps1	membrane-bound transcription factor protease, site 1	0.022
crip2	cysteine-rich protein 2	0.022
shha	sonic hedgehog a	0.022	Mouse Fly
ywhabl	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like	0.022
rab11fip4a	RAB11 family interacting protein 4 (class II) a	0.021
naa50	N(alpha)-acetyltransferase 50, NatE catalytic subunit	0.021
ptpro	protein tyrosine phosphatase, receptor type, O	0.021
sox2	SRY-box containing gene 2	0.021
clint1	clathrin interactor 1	0.021
fgg	fibrinogen, gamma polypeptide	0.021
tgfb1a	transforming growth factor, beta 1a	0.020	Human
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.020
ncapg	non-SMC condensin I complex, subunit G	0.020
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.020
srsf1a	serine/arginine-rich splicing factor 1a	0.020	Yeast
nog2	noggin 2	0.020
nap1l1	nucleosome assembly protein 1, like 1	0.020
cct8	chaperonin containing TCP1, subunit 8 (theta)	0.020
rhogb	ras homolog gene family, member Gb	0.020
mbnl2	muscleblind-like 2 (Drosophila)	0.020
zgc:112211	zgc:112211	0.020
gmnn	geminin, DNA replication inhibitor	0.019
eif3s10	eukaryotic translation initiation factor 3, subunit 10 (theta)	0.019
sepw1	selenoprotein W, 1	0.019
col7a1l	collagen type VII alpha 1-like	0.019
otpb	orthopedia homolog b	0.019
lhx2b	LIM homeobox 2b	0.019
cdk8	cyclin-dependent kinase 8	0.018
fabp10a	fatty acid binding protein 10a, liver basic	0.018
evx1	even-skipped homeobox 1	0.018
mapk1	mitogen-activated protein kinase 1	0.018
gpr126	G protein-coupled receptor 126	0.018
pak2a	p21 (CDKN1A)-activated kinase 2a	0.018	Human
wnt1	wingless-type MMTV integration site family, member 1	0.018	Mouse
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.018
acvr1l	activin A receptor, type I like	0.018
zgc:86759	zgc:86759	0.018
stac3	SH3 and cysteine rich domain 3	0.018
baxa	bcl2-associated X protein, a	0.018	Zebrafish Mouse
rfng	radical fringe homolog (Drosophila)	0.017
etv5b	ets variant 5b	0.017
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.017
gro1	groucho 1	0.017
pea3	ETS-domain transcription factor pea3	0.017
ccna2	cyclin A2	0.017
cdc20	cell division cycle 20 homolog	0.017	Yeast
hp1bp3	heterochromatin protein 1, binding protein 3	0.017
mapk3	mitogen-activated protein kinase 3	0.017
pdlim4	PDZ and LIM domain 4	0.017
mmp2	matrix metalloproteinase 2	0.017
tlr3	toll-like receptor 3	0.016
ywhaqa	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a	0.016
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.016
ube2i2	ubiquitin-conjugating enzyme E2I2	0.016
gli2b	GLI-Kruppel family member GLI2b	0.016
fkbp1b	FK506 binding protein 1b	0.016
chd7	chromodomain helicase DNA binding protein 7	0.016
per2	period homolog 2 (Drosophila)	0.016	Mouse
nfe2l2	nuclear factor (erythroid-derived 2)-like 2	0.016
flot2a	flotillin 2a	0.016	Human
prdm5	PR domain containing 5	0.016
fkbp4	FK506 binding protein 4	0.016
mapk12	mitogen-activated protein kinase 12	0.016
smyhc1	slow myosin heavy chain 1	0.016
vcana	versican a	0.016
sh3gl1b	SH3-domain GRB2-like 1b	0.016
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.016
cxcr3.2	chemokine (C-X-C motif) receptor 3.2	0.015
neurod4	neurogenic differentiation 4	0.015
usp10	ubiquitin specific peptidase 10	0.015
ptch1	patched 1	0.015
rxrba	retinoid x receptor, beta a	0.015
grem1a	gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)	0.015	Human
zfyve26	zinc finger, FYVE domain containing 26	0.015
ywhae1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	0.015	Human Mouse
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.015
ywhaqb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b	0.015	Yeast
trim71	tripartite motif-containing 71	0.015
pdx1	pancreatic and duodenal homeobox 1	0.015
neu4	sialidase 4	0.015
irx4b	iroquois homeobox protein 4b	0.015
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.015
ef1a	elongation factor 1-alpha	0.015
mapk14a	mitogen-activated protein kinase 14a	0.015
mmp13a	matrix metalloproteinase 13a	0.015
rbp1a	retinol binding protein 1a, cellular	0.015
jag1a	jagged 1a	0.015
rx2	retinal homeobox gene 2	0.015
mfn2	mitofusin 2	0.014
rhoub	ras homolog gene family, member Ub	0.014
naa15a	N(alpha)-acetyltransferase 15, NatA auxiliary subunit a	0.014
sass6	spindle assembly 6 homolog (C. elegans)	0.014
mcl1b	myeloid cell leukemia sequence 1b	0.014
gap43	growth associated protein 43	0.014
nucks1a	nuclear casein kinase and cyclin-dependent kinase substrate 1a	0.014
tbx2b	T-box 2b	0.014
snai3	snail homolog 3	0.014
zgc:77714	zgc:77714	0.014
si:ch211-59d15.5	si:ch211-59d15.5	0.014
wtip	Wilms tumor 1 interacting protein	0.014
tbpl2	TATA box binding protein like 2	0.014
spred1	sprouty-related, EVH1 domain containing 1	0.014	Human Mouse
wnt4a	wingless-type MMTV integration site family, member 4a	0.014
robo3	roundabout homolog 3	0.014
cnot6	CCR4-NOT transcription complex, subunit 6	0.014
bad	BCL2-antagonist of cell death	0.014
egr2a	early growth response 2a	0.013	Worm
sema3fb	semaphorin 3fb	0.013
LOC570775	protein argonaute-1-like	0.013
fes	feline sarcoma oncogene	0.013
gadd45bb	growth arrest and DNA-damage-inducible, beta b	0.013	Mouse
srsf2	serine/arginine-rich splicing factor 2	0.013
crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.013
ptena	phosphatase and tensin homolog A	0.013	Human
fzd7a	frizzled homolog 7a	0.013
wu:fj39b01	wu:fj39b01	0.013
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.013
ifnphi1	interferon phi 1	0.013
cul1a	cullin 1a	0.013
fbln4	fibulin 4	0.013
nadl1.1	neural adhesion molecule L1.1	0.013
ncaph	non-SMC condensin I complex, subunit H	0.013
wnt3a	wingless-type MMTV integration site family, member 3A	0.013
crabp1b	cellular retinoic acid binding protein 1b	0.013
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.013
ca2	carbonic anhydrase II	0.013
srsf6b	serine/arginine-rich splicing factor 6b	0.013
ybx1	Y box binding protein 1	0.013
smad1	MAD homolog 1 (Drosophila)	0.013
rab11al	RAB11a, member RAS oncogene family, like	0.013
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.013
clptm1	cleft lip and palate associated transmembrane protein 1	0.013
wars	tryptophanyl-tRNA synthetase	0.012
wu:fc61g08	wu:fc61g08	0.012
cryaba	crystallin, alpha B, a	0.012
keap1b	kelch-like ECH-associated protein 1b	0.012
hnrpl	heterogeneous nuclear ribonucleoprotein L	0.012
nrg1	neuregulin 1	0.012	Mouse
skp1	S-phase kinase-associated protein 1	0.012
dag1	dystroglycan 1	0.012
birc5b	baculoviral IAP repeat-containing 5B	0.012
hoxd3a	homeo box D3a	0.012
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.012
vdrb	vitamin D receptor b	0.012
btg2	B-cell translocation gene 2	0.012
brd2a	bromodomain-containing 2a	0.012
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.012
tfa	transferrin-a	0.012
thrb	thyroid hormone receptor beta	0.012
boc	brother of CDO	0.012
mapk7	mitogen-activated protein kinase 7	0.012
cand1	cullin-associated and neddylation-dissociated 1	0.012
hs6st1b	heparan sulfate 6-O-sulfotransferase 1b	0.012
cdh1	cadherin 1, epithelial	0.012
LOC795916	mucolipin-1-like	0.012
spna2	spectrin alpha 2	0.012
rbb4l	retinoblastoma binding protein 4, like	0.012
hspa4b	heat shock protein 4b	0.012	Rat
wu:fi25h02	wu:fi25h02	0.012
hs3st1l1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like1	0.012
LOC555504	novel protocadherin protein	0.012
hhip	hedgehog interacting protein	0.012
wu:fc48e01	wu:fc48e01	0.012
ldb1a	LIM-domain binding factor 1a	0.012
elk4	ELK4, ETS-domain protein	0.012
zgc:77155	zgc:77155	0.012
npepps	aminopeptidase puromycin sensitive	0.012
id1	inhibitor of DNA binding 1	0.011
prpf8	pre-mRNA processing factor 8	0.011
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.011
ext1a	exostoses (multiple) 1a	0.011
chac1	ChaC, cation transport regulator-like 1	0.011
otud7b	OTU domain containing 7B	0.011
ahsa1l	AHA1, activator of heat shock protein ATPase homolog 1, like	0.011
smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.011
csnk1da	casein kinase 1, delta a	0.011
apom	apolipoprotein M	0.011
osr1	odd-skipped related 1 (Drosophila)	0.011
lsm12	LSM12 homolog (S. cerevisiae)	0.011
tpm3	tropomyosin 3	0.011
hmx1	H6 homeo box 1	0.011
fcho2	FCH domain only 2	0.011
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.011
prox2	prospero homeobox 2	0.011
fgfr2	fibroblast growth factor receptor 2	0.011
hmx4	H6 family homeobox 4	0.011
tgif1	TGFB-induced factor homeobox 1	0.011
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.011
cdc25	cell division cycle 25 homolog	0.011
lims1	LIM and senescent cell antigen-like domains 1	0.011
safb	scaffold attachment factor B	0.011
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.011
tnpo3	transportin 3	0.011
mapk6	mitogen-activated protein kinase 6	0.011
nrg2b	neuregulin 2b	0.011
zgc:123326	zgc:123326	0.011
s1pr1	sphingosine-1-phosphate receptor 1	0.011
kbp	kif1-binding protein	0.011
sox9b	SRY-box containing gene 9b	0.011
bmp6	bone morphogenetic protein 6	0.011
dzip1	DAZ interacting protein 1	0.011
bc2	putative breast adenocarcinoma marker	0.011
pparg	peroxisome proliferator activated receptor gamma	0.011
wu:fj34h01	wu:fj34h01	0.010
zgc:66385	zgc:66385	0.010
si:dkey-222f8.3	si:dkey-222f8.3	0.010
nanos3	nanos homolog 3	0.010
acvr1b	activin A receptor, type IB	0.010
a1cf	apobec1 complementation factor	0.010
igf1rb	insulin-like growth factor 1b receptor	0.010
st8sia6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	0.010
sfxn1	sideroflexin 1	0.010
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.010
hspa12b	heat shock protein 12B	0.010
si:ch211-57k11.10	si:ch211-57k11.10	0.010
polr2b	polymerase (RNA) II (DNA directed) polypeptide B	0.010
dkk1b	dickkopf 1b	0.010
glmna	glomulin, FKBP associated protein a	0.010
smad5	MAD homolog 5 (Drosophila)	0.010
tardbp	TAR DNA binding protein	0.010
apoeb	apolipoprotein Eb	0.010	Human
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.010
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.010
trim8	tripartite motif-containing 8	0.010