The network for 'negative regulation of blood pressure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of blood pressure

Any process in which the force of blood traveling through the circulatory system is decreased.

Homo sapiens
Name Description Probability Func Analog Organism
C1QA complement component 1, q subcomponent, A chain 0.993
ADORA2A adenosine A2a receptor 0.923
HBB hemoglobin, beta 0.907
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.850
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.749
ENG endoglin 0.709
C1QC complement component 1, q subcomponent, C chain 0.680
BMP2 bone morphogenetic protein 2 0.604
HBG2 hemoglobin, gamma G 0.580
NCOR2 nuclear receptor corepressor 2 0.563
TGFB3 transforming growth factor, beta 3 0.537
PLCG1 phospholipase C, gamma 1 0.512
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.467
C1QB complement component 1, q subcomponent, B chain 0.395
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.331
GDF5 growth differentiation factor 5 0.324
VAC14 Vac14 homolog (S. cerevisiae) 0.300
EXOC7 exocyst complex component 7 0.241
PRKG1 protein kinase, cGMP-dependent, type I 0.236
BBS2 Bardet-Biedl syndrome 2 0.229
CRHR1 corticotropin releasing hormone receptor 1 0.203
TGFB1 transforming growth factor, beta 1 0.191
SMAD7 SMAD family member 7 0.172
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.158
FKBP1A FK506 binding protein 1A, 12kDa 0.156
BMPR1A bone morphogenetic protein receptor, type IA 0.153
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.146
ZMYND11 zinc finger, MYND-type containing 11 0.143
ARRDC3 arrestin domain containing 3 0.141
BBS1 Bardet-Biedl syndrome 1 0.118
ACVR1 activin A receptor, type I 0.104
PRNP prion protein 0.103
ARNT aryl hydrocarbon receptor nuclear translocator 0.101
BBS9 Bardet-Biedl syndrome 9 0.094
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.093
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.091
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.087
NRP1 neuropilin 1 0.087
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.081
ACVR1B activin A receptor, type IB 0.080
TIMP3 TIMP metallopeptidase inhibitor 3 0.080
DUSP6 dual specificity phosphatase 6 0.077
WNK1 WNK lysine deficient protein kinase 1 0.077
TTC8 tetratricopeptide repeat domain 8 0.065
RXRA retinoid X receptor, alpha 0.062
FSTL1 follistatin-like 1 0.062
BBS7 Bardet-Biedl syndrome 7 0.058
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.052
HBA2 hemoglobin, alpha 2 0.051
NCOA7 nuclear receptor coactivator 7 0.051
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.049
AVPR2 arginine vasopressin receptor 2 0.048
CUX1 cut-like homeobox 1 0.048
HBE1 hemoglobin, epsilon 1 0.047
NCOA6 nuclear receptor coactivator 6 0.046
MAPK8 mitogen-activated protein kinase 8 0.046
HBD hemoglobin, delta 0.044
GAB2 GRB2-associated binding protein 2 0.044
USP15 ubiquitin specific peptidase 15 0.043
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.043
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.042
VEGFA vascular endothelial growth factor A 0.042
RIPK2 receptor-interacting serine-threonine kinase 2 0.040
CHD9 chromodomain helicase DNA binding protein 9 0.039
SLC9A3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.038
RB1 retinoblastoma 1 0.037
TKT transketolase 0.036
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.036
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.036
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.034
MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 0.034
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.034
SKIL SKI-like oncogene 0.033
PURA purine-rich element binding protein A 0.032
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.032
DUSP5 dual specificity phosphatase 5 0.032
BMP4 bone morphogenetic protein 4 0.032
ARL6 ADP-ribosylation factor-like 6 0.031
BHLHE23 basic helix-loop-helix family, member e23 0.031
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.031
NDFIP2 Nedd4 family interacting protein 2 0.030
ALDOB aldolase B, fructose-bisphosphate 0.030
CXCL3 chemokine (C-X-C motif) ligand 3 0.029
HSCB HscB iron-sulfur cluster co-chaperone homolog (E. coli) 0.028
CXCL2 chemokine (C-X-C motif) ligand 2 0.027
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.027
ANTXR2 anthrax toxin receptor 2 0.027
GATAD2B GATA zinc finger domain containing 2B 0.027
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.026
PAX7 paired box 7 0.026
NCOR1 nuclear receptor corepressor 1 0.026
GLB1 galactosidase, beta 1 0.026
HIPK3 homeodomain interacting protein kinase 3 0.026
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.025
PYY peptide YY 0.025
PGR progesterone receptor 0.025
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.025
BMP8A bone morphogenetic protein 8a 0.025
SMAD2 SMAD family member 2 0.025
E2F2 E2F transcription factor 2 0.024
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.948
Ren1 renin 1 structural 0.802
Ghr growth hormone receptor 0.762
Drd2 dopamine receptor D2 0.705
Kl klotho 0.560
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.541
Crhr1 corticotropin releasing hormone receptor 1 0.499
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.480
Pnpla2 patatin-like phospholipase domain containing 2 0.441
Cckbr cholecystokinin B receptor 0.421
Slc12a1 solute carrier family 12, member 1 0.397
Nos1 nitric oxide synthase 1, neuronal 0.356
Agtr1a angiotensin II receptor, type 1a 0.347
Npy1r neuropeptide Y receptor Y1 0.257
Plau plasminogen activator, urokinase 0.248
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.242
Bbs2 Bardet-Biedl syndrome 2 (human) 0.241
Pparg peroxisome proliferator activated receptor gamma 0.236
Ar androgen receptor 0.228
Cav1 caveolin 1, caveolae protein 0.215
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.209
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.206
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.201
Insr insulin receptor 0.192
Npy2r neuropeptide Y receptor Y2 0.181
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.175
Mas1 MAS1 oncogene 0.172
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.154
Hrh1 histamine receptor H1 0.153
Esr1 estrogen receptor 1 (alpha) 0.141
Pgr progesterone receptor 0.141
Sstr4 somatostatin receptor 4 0.139
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.135
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.135
Sstr3 somatostatin receptor 3 0.131
Cnr1 cannabinoid receptor 1 (brain) 0.128
Nos2 nitric oxide synthase 2, inducible 0.128
Grid1 glutamate receptor, ionotropic, delta 1 0.124
Lep leptin 0.116
Sstr1 somatostatin receptor 1 0.112
Mog myelin oligodendrocyte glycoprotein 0.108
Tcf7l2 transcription factor 7-like 2, T-cell specific, HMG-box 0.105
Adra2b adrenergic receptor, alpha 2b 0.100
Gpr27 G protein-coupled receptor 27 0.098
Adrb1 adrenergic receptor, beta 1 0.097
Cyld cylindromatosis (turban tumor syndrome) 0.094
Rac1 RAS-related C3 botulinum substrate 1 0.093
Ddah1 dimethylarginine dimethylaminohydrolase 1 0.092
Aqp2 aquaporin 2 0.090
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.088
ND6 NADH dehydrogenase subunit 6 0.087
Ptgs2 prostaglandin-endoperoxide synthase 2 0.086
Htr4 5 hydroxytryptamine (serotonin) receptor 4 0.085
Pomc pro-opiomelanocortin-alpha 0.084
Bbs1 Bardet-Biedl syndrome 1 (human) 0.084
Tacr1 tachykinin receptor 1 0.083
Oprm1 opioid receptor, mu 1 0.080
Umod uromodulin 0.079
Krt86 keratin 86 0.079
Adora2a adenosine A2a receptor 0.076
Ikzf4 IKAROS family zinc finger 4 0.074
Neurod2 neurogenic differentiation 2 0.073
Smad7 MAD homolog 7 (Drosophila) 0.071
Bhlhe40 basic helix-loop-helix family, member e40 0.069
Adrb2 adrenergic receptor, beta 2 0.069
Fzd4 frizzled homolog 4 (Drosophila) 0.069
Oprd1 opioid receptor, delta 1 0.067
Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit 0.066
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.066
Bglap bone gamma carboxyglutamate protein 0.062
Lhx6 LIM homeobox protein 6 0.061
Acr acrosin prepropeptide 0.061
Agtr2 angiotensin II receptor, type 2 0.060
Kcns2 K+ voltage-gated channel, subfamily S, 2 0.060
Tmem64 transmembrane protein 64 0.060
Kcnk3 potassium channel, subfamily K, member 3 0.059
Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 0.059
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.058
Adra2c adrenergic receptor, alpha 2c 0.057
Adra1b adrenergic receptor, alpha 1b 0.057
Epha8 Eph receptor A8 0.057
Tgfb1 transforming growth factor, beta 1 0.057
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.055
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.055
Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 0.054
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.052
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.052
Adipoq adiponectin, C1Q and collagen domain containing 0.052
Ccl2 chemokine (C-C motif) ligand 2 0.052
Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 0.051
Wnt7a wingless-related MMTV integration site 7A 0.050
Alx3 aristaless-like homeobox 3 0.050
Snta1 syntrophin, acidic 1 0.050
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.049
Inhbc inhibin beta-C 0.049
Mc5r melanocortin 5 receptor 0.049
Foxd2 forkhead box D2 0.048
Col4a4 collagen, type IV, alpha 4 0.047
Clcnka chloride channel Ka 0.047
Olfr71 olfactory receptor 71 0.047
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Rattus norvegicus
Name Description Probability Func Analog Organism
Alas2 aminolevulinate, delta-, synthase 2 0.414
Hbb hemoglobin, beta 0.210
LOC689064 beta-globin 0.072
LOC100134871 beta globin minor gene 0.066
Pip prolactin induced protein 0.055
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.047
Rgs14 regulator of G-protein signaling 14 0.047
Olr1500 olfactory receptor 1500 0.042
Hbb-b1 hemoglobin, beta adult major chain 0.042
LOC60591 calcium-activated potassium channel beta subunit 0.042
Tpbpa trophoblast specific protein alpha 0.037
Cmklr1 chemokine-like receptor 1 0.036
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.036
Il1rn interleukin 1 receptor antagonist 0.032
Mmp9 matrix metallopeptidase 9 0.032
Foxi2 forkhead box I2 0.032
Glp1r glucagon-like peptide 1 receptor 0.029
Lif leukemia inhibitory factor 0.029
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.028
Ednra endothelin receptor type A 0.028
Gal galanin prepropeptide 0.026
Ppy pancreatic polypeptide 0.026
Cxcr5 chemokine (C-X-C motif) receptor 5 0.026
Dio3 deiodinase, iodothyronine, type III 0.025
Mag myelin-associated glycoprotein 0.025
Tbx2 T-box 2 0.025
Lim2 lens intrinsic membrane protein 2 0.024
Omp olfactory marker protein 0.023
Il13 interleukin 13 0.023
Aqp2 aquaporin 2 (collecting duct) 0.022
Ptafr platelet-activating factor receptor 0.022
Padi1 peptidyl arginine deiminase, type I 0.021
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.021
Sgp158 proline-rich glycoprotein (sgp158) 0.020
Prlh prolactin releasing hormone 0.019
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.019
Crybb1 crystallin, beta B1 0.019
Fgf17 fibroblast growth factor 17 0.019
Si sucrase-isomaltase (alpha-glucosidase) 0.019
Tacr2 tachykinin receptor 2 0.019
Prp15 proline-rich protein 15 0.018
Ush1c Usher syndrome 1C homolog (human) 0.018
Gast gastrin 0.018
Itgam integrin, alpha M 0.018
Acot12 acyl-CoA thioesterase 12 0.018
Cpb1 carboxypeptidase B1 (tissue) 0.018
Iapp islet amyloid polypeptide 0.018
Gfra1 GDNF family receptor alpha 1 0.018
Rgs9 regulator of G-protein signaling 9 0.018
Nlrp6 NLR family, pyrin domain containing 6 0.017
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.017
Selp selectin P 0.017
Avpr2 arginine vasopressin receptor 2 0.017
Irf2 interferon regulatory factor 2 0.017
Il1r1 interleukin 1 receptor, type I 0.017
Cga glycoprotein hormones, alpha polypeptide 0.017
Rorb RAR-related orphan receptor B 0.017
S1pr2 sphingosine-1-phosphate receptor 2 0.017
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.016
Fam70b family with sequence similarity 70, member B 0.016
Prg2 proteoglycan 2, bone marrow 0.016
Syt6 synaptotagmin VI 0.016
Grm6 glutamate receptor, metabotropic 6 0.016
Vom2r53 vomeronasal 2 receptor, 53 0.016
Ifna1 interferon-alpha 1 0.016
Prss3 protease, serine, 3 0.016
Flt1 FMS-related tyrosine kinase 1 0.015
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.015
Tac2 tachykinin 2 0.015
Il8ra interleukin 8 receptor, alpha 0.015
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.015
Drd2 dopamine receptor D2 0.015
Egfl7 EGF-like-domain, multiple 7 0.015
Hoxa2 homeo box A2 0.015
Tff1 trefoil factor 1 0.014
Lpl lipoprotein lipase 0.014
Gper G protein-coupled estrogen receptor 1 0.014
Olr1361 olfactory receptor 1361 0.014
Cd52 CD52 antigen 0.014
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.014
Drd1a dopamine receptor D1A 0.014
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.014
Cryba4 crystallin, beta A4 0.014
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.014
Ctrc chymotrypsin C (caldecrin) 0.014
Pitx3 paired-like homeodomain 3 0.014
Prl8a2 prolactin family 8, subfamily a, member 2 0.014
Chrna6 cholinergic receptor, nicotinic, alpha 6 0.014
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.014
Hk2 hexokinase 2 0.014
Nrg1 neuregulin 1 0.013
Smad3 SMAD family member 3 0.013
Ppara peroxisome proliferator activated receptor alpha 0.013
Trhr2 thyrotropin releasing hormone receptor 2 0.013
Rhd Rh blood group, D antigen 0.013
Sox17 SRY (sex determining region Y)-box 17 0.013
Aspg asparaginase homolog (S. cerevisiae) 0.013
Ngf nerve growth factor (beta polypeptide) 0.012
Gja4 gap junction protein, alpha 4 0.012
Syt8 synaptotagmin VIII 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism