The network for 'establishment or maintenance of microtubule cytoskeleton polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment or maintenance of microtubule cytoskeleton polarity

Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.

Homo sapiens
Name Description Probability Func Analog Organism
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1.000
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
EIF4A3 eukaryotic translation initiation factor 4A3 1.000
APC adenomatous polyposis coli 0.998
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.998
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.991
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.979
OCRL oculocerebrorenal syndrome of Lowe 0.965
GSK3B glycogen synthase kinase 3 beta 0.963
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.961
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.960
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.952
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.944
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.913
PRKCZ protein kinase C, zeta 0.905
MAPRE3 microtubule-associated protein, RP/EB family, member 3 0.894
KEAP1 kelch-like ECH-associated protein 1 0.875
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.825
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.800
PRKCI protein kinase C, iota 0.699
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.645
PTBP1 polypyrimidine tract binding protein 1 0.593
KIF1B kinesin family member 1B 0.588
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.552
AKAP11 A kinase (PRKA) anchor protein 11 0.529
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.507
STRADA STE20-related kinase adaptor alpha 0.499
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.479
HDAC4 histone deacetylase 4 0.440
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.430
AKAP9 A kinase (PRKA) anchor protein (yotiao) 9 0.385
SFN stratifin 0.379
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.378
KIFAP3 kinesin-associated protein 3 0.368
H2AFX H2A histone family, member X 0.354
CDC25B cell division cycle 25 homolog B (S. pombe) 0.337
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.330
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.320
SORBS3 sorbin and SH3 domain containing 3 0.317
TACC3 transforming, acidic coiled-coil containing protein 3 0.309
LMO2 LIM domain only 2 (rhombotin-like 1) 0.292
RAB11FIP2 RAB11 family interacting protein 2 (class I) 0.261
KIF5B kinesin family member 5B 0.247
MAPT microtubule-associated protein tau 0.247
F11R F11 receptor 0.243
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.229
CLIP1 CAP-GLY domain containing linker protein 1 0.222
NIN ninein (GSK3B interacting protein) 0.211
TMOD3 tropomodulin 3 (ubiquitous) 0.210
AKIP1 A kinase (PRKA) interacting protein 1 0.196
RAB14 RAB14, member RAS oncogene family 0.193
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.182
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.174
RAB5A RAB5A, member RAS oncogene family 0.169
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.168
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.167
PKP3 plakophilin 3 0.165
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.164
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.164
YAP1 Yes-associated protein 1 0.148
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.147
MARK2 MAP/microtubule affinity-regulating kinase 2 0.144
SCYL2 SCY1-like 2 (S. cerevisiae) 0.142
CHN2 chimerin (chimaerin) 2 0.137
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.135
PCBP1 poly(rC) binding protein 1 0.134
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.132
CLASP2 cytoplasmic linker associated protein 2 0.130
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.126
TAGLN2 transgelin 2 0.119
STRADB STE20-related kinase adaptor beta 0.116
CDH5 cadherin 5, type 2 (vascular endothelium) 0.114
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.110
TNIP2 TNFAIP3 interacting protein 2 0.109
SIAH2 seven in absentia homolog 2 (Drosophila) 0.108
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.108
LAD1 ladinin 1 0.107
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.106
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.105
MAFK v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) 0.103
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.099
MAP4 microtubule-associated protein 4 0.099
ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.098
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.097
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.096
HMGA1 high mobility group AT-hook 1 0.094
TSC2 tuberous sclerosis 2 0.094
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.092
NEK1 NIMA (never in mitosis gene a)-related kinase 1 0.092
ING1 inhibitor of growth family, member 1 0.091
NCKAP1 NCK-associated protein 1 0.091
SH3RF3 SH3 domain containing ring finger 3 0.091
SEPT2 septin 2 0.091
LLGL1 lethal giant larvae homolog 1 (Drosophila) 0.089
KIAA1191 KIAA1191 0.088
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.087
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.087
PMM1 phosphomannomutase 1 0.086
LMO4 LIM domain only 4 0.085
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
baz bazooka 0.997
Dhc64C Dynein heavy chain 64C 0.906
Lis-1 Lissencephaly-1 0.879
sqd squid 0.812
BicD Bicaudal D 0.800
gish gilgamesh 0.770
par-6 CG5884 gene product from transcript CG5884-RA 0.695
rok Rho-kinase 0.684
shg shotgun 0.523
Atx2 Ataxin-2 0.485
rin rasputin 0.378
sqh spaghetti squash 0.366
Klp64D Kinesin-like protein at 64D 0.356
Kap3 Kinesin associated protein 3 0.329
Khc Kinesin heavy chain 0.300
sec5 CG8843 gene product from transcript CG8843-RA 0.299
SRPK CG8174 gene product from transcript CG8174-RA 0.288
slmb supernumerary limbs 0.285
stai stathmin 0.281
orb oo18 RNA-binding protein 0.278
cpa capping protein alpha 0.276
par-1 CG8201 gene product from transcript CG8201-RA 0.267
Pak3 CG14895 gene product from transcript CG14895-RA 0.247
grk gurken 0.224
Src64B Src oncogene at 64B 0.213
Ras64B Ras oncogene at 64B 0.192
Rab5 Rab-protein 5 0.180
Rop Ras opposite 0.179
trc tricornered 0.179
Fs(2)Ket Female sterile (2) Ketel 0.177
glo glorund 0.172
tacc transforming acidic coiled-coil protein 0.165
klar klarsicht 0.157
Lam Lamin 0.155
Rho1 CG8416 gene product from transcript CG8416-RB 0.155
aPKC atypical protein kinase C 0.152
ovo CG6824 gene product from transcript CG6824-RE 0.152
spn-F CG12114 gene product from transcript CG12114-RA 0.150
Arp66B Actin-related protein 66B 0.146
capu cappuccino 0.146
Chc Clathrin heavy chain 0.144
bel belle 0.142
Catsup Catecholamines up 0.134
egh egghead 0.122
Gef26 CG9491 gene product from transcript CG9491-RB 0.122
dsh dishevelled 0.120
vas vasa 0.120
del deadlock 0.118
CG4680 CG4680 gene product from transcript CG4680-RA 0.112
pum pumilio 0.111
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.110
wls wntless 0.109
Sop2 Suppressor of profilin 2 0.107
elav embryonic lethal abnormal vision 0.105
Tm1 Tropomyosin 1 0.102
lkb1 CG9374 gene product from transcript CG9374-RJ 0.101
Dlic Dynein light intermediate chain 0.101
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.095
spen split ends 0.091
Cam Calmodulin 0.090
Eph Eph receptor tyrosine kinase 0.090
frc fringe connection 0.089
dp dumpy 0.088
Cdc42 CG12530 gene product from transcript CG12530-RA 0.084
Vang Van Gogh 0.082
msn misshapen 0.078
Rala Ras-related protein 0.077
trio CG18214 gene product from transcript CG18214-RA 0.077
sn singed 0.075
puc puckered 0.074
sm smooth 0.074
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.073
toc toucan 0.073
Klp10A CG1453 gene product from transcript CG1453-RA 0.072
tho2 CG31671 gene product from transcript CG31671-RA 0.072
neb nebbish 0.070
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.070
squ squash 0.069
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.069
aret arrest 0.069
CG4771 CG4771 gene product from transcript CG4771-RA 0.068
enc encore 0.068
katanin-60 katanin 60 0.067
loqs loquacious 0.067
jar jaguar 0.067
Mio Mlx interactor 0.066
Abl Abl tyrosine kinase 0.065
fs(1)h female sterile (1) homeotic 0.065
qua quail 0.065
nudE CG8104 gene product from transcript CG8104-RB 0.065
sra sarah 0.063
krz kurtz 0.062
osk oskar 0.061
Ctr1A Copper transporter 1A 0.061
Ephrin CG1862 gene product from transcript CG1862-RA 0.060
S6kII RPS6-protein kinase-II 0.059
flr flare 0.058
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.058
D19A CG10269 gene product from transcript CG10269-RA 0.057
HDAC4 CG1770 gene product from transcript CG1770-RE 0.055
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Mus musculus
Name Description Probability Func Analog Organism
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1.000
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.998
Kif3a kinesin family member 3A 0.990
Lmnb1 lamin B1 0.960
Rpgrip1l Rpgrip1-like 0.933
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.923
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.888
Gsk3b glycogen synthase kinase 3 beta 0.834
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.808
Lrrk2 leucine-rich repeat kinase 2 0.802
Vhl von Hippel-Lindau tumor suppressor 0.798
Prkcz protein kinase C, zeta 0.779
Raver2 ribonucleoprotein, PTB-binding 2 0.777
Fus fusion, derived from t(12;16) malignant liposarcoma (human) 0.688
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.688
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.672
Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 0.631
Bicd2 bicaudal D homolog 2 (Drosophila) 0.578
Stx12 syntaxin 12 0.550
Ccdc64 coiled-coil domain containing 64 0.547
Mtpn myotrophin 0.509
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.494
Nptn neuroplastin 0.493
Smad1 MAD homolog 1 (Drosophila) 0.447
Hnrpdl heterogeneous nuclear ribonucleoprotein D-like 0.439
Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like 0.434
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.422
Ap2b1 adaptor-related protein complex 2, beta 1 subunit 0.420
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.410
Ncoa2 nuclear receptor coactivator 2 0.409
Smad4 MAD homolog 4 (Drosophila) 0.381
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.373
Hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.370
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.365
Srsf2 serine/arginine-rich splicing factor 2 0.340
Ap2a1 adaptor protein complex AP-2, alpha 1 subunit 0.327
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.326
Thoc4 THO complex 4 0.310
Kifap3 kinesin-associated protein 3 0.303
Ctnnb1 catenin (cadherin associated protein), beta 1 0.296
Dctn1 dynactin 1 0.282
Raver1 ribonucleoprotein, PTB-binding 1 0.278
Ddx3x DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked 0.268
Orc1 origin recognition complex, subunit 1 0.264
Spnb2 spectrin beta 2 0.255
Kif3b kinesin family member 3B 0.254
Tcerg1 transcription elongation regulator 1 (CA150) 0.251
Purb purine rich element binding protein B 0.247
Exo1 exonuclease 1 0.246
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.240
Vapa vesicle-associated membrane protein, associated protein A 0.236
Ctnnd1 catenin (cadherin associated protein), delta 1 0.236
Eif4a1 eukaryotic translation initiation factor 4A1 0.228
Anp32e acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.222
Dync1i2 dynein cytoplasmic 1 intermediate chain 2 0.217
Itga3 integrin alpha 3 0.213
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.210
Klc1 kinesin light chain 1 0.210
Apc adenomatosis polyposis coli 0.209
Gna13 guanine nucleotide binding protein, alpha 13 0.207
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.204
Smad3 MAD homolog 3 (Drosophila) 0.199
Fam83g family with sequence similarity 83, member G 0.198
Impad1 inositol monophosphatase domain containing 1 0.198
Cltc clathrin, heavy polypeptide (Hc) 0.196
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.196
Plxna1 plexin A1 0.195
Sfn stratifin 0.184
Srsf6 serine/arginine-rich splicing factor 6 0.179
Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 0.175
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.170
Med21 mediator complex subunit 21 0.169
Chaf1b chromatin assembly factor 1, subunit B (p60) 0.167
Tbc1d4 TBC1 domain family, member 4 0.166
Macf1 microtubule-actin crosslinking factor 1 0.164
Csnk1a1 casein kinase 1, alpha 1 0.163
Snx6 sorting nexin 6 0.162
Gtf2ird1 general transcription factor II I repeat domain-containing 1 0.162
Ifrd1 interferon-related developmental regulator 1 0.153
Ewsr1 Ewing sarcoma breakpoint region 1 0.153
Fam64a family with sequence similarity 64, member A 0.153
Nova1 neuro-oncological ventral antigen 1 0.153
Lmnb2 lamin B2 0.151
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.151
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.146
Stxbp1 syntaxin binding protein 1 0.141
Arf3 ADP-ribosylation factor 3 0.139
Siah1a seven in absentia 1A 0.138
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.137
Qk quaking 0.134
Sykb spleen tyrosine kinase 0.132
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 0.131
Brca1 breast cancer 1 0.130
Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.130
Pa2g4 proliferation-associated 2G4 0.130
Set SET nuclear oncogene 0.128
Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) 0.128
Ank2 ankyrin 2, brain 0.127
Ncoa3 nuclear receptor coactivator 3 0.127
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism