The network for 'regulation of myotube differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of myotube differentiation

Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

Homo sapiens
Name Description Probability Func Analog Organism
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.996
NOTCH1 notch 1 0.982
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.974
HDAC4 histone deacetylase 4 0.957
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.951
JAG1 jagged 1 0.942
TTN titin 0.896
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.780
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.759
PSG9 pregnancy specific beta-1-glycoprotein 9 0.695
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.511
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.504
TBX5 T-box 5 0.447
PSG6 pregnancy specific beta-1-glycoprotein 6 0.296
IL4R interleukin 4 receptor 0.286
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.270
ATF3 activating transcription factor 3 0.256
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.253
FSTL1 follistatin-like 1 0.240
NOTCH3 notch 3 0.222
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.183
PARVA parvin, alpha 0.175
BMPR1A bone morphogenetic protein receptor, type IA 0.175
NCOR2 nuclear receptor corepressor 2 0.161
MEF2C myocyte enhancer factor 2C 0.160
ENG endoglin 0.157
BCL2L1 BCL2-like 1 0.154
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.152
BCL6 B-cell CLL/lymphoma 6 0.150
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.138
DPP4 dipeptidyl-peptidase 4 0.132
MEF2A myocyte enhancer factor 2A 0.118
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.116
PSG4 pregnancy specific beta-1-glycoprotein 4 0.112
PTK2 PTK2 protein tyrosine kinase 2 0.107
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.089
ATXN1 ataxin 1 0.084
PTRF polymerase I and transcript release factor 0.077
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.074
CNOT8 CCR4-NOT transcription complex, subunit 8 0.074
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.065
LIMS1 LIM and senescent cell antigen-like domains 1 0.064
TP53 tumor protein p53 0.060
FBLN1 fibulin 1 0.055
FN1 fibronectin 1 0.055
PRKD2 protein kinase D2 0.054
PSG5 pregnancy specific beta-1-glycoprotein 5 0.051
IL2RG interleukin 2 receptor, gamma 0.050
CXCL11 chemokine (C-X-C motif) ligand 11 0.049
NCOR1 nuclear receptor corepressor 1 0.049
COL1A2 collagen, type I, alpha 2 0.048
DLL1 delta-like 1 (Drosophila) 0.047
MAP2K3 mitogen-activated protein kinase kinase 3 0.046
IL4 interleukin 4 0.045
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.043
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.040
PAX8 paired box 8 0.039
RARA retinoic acid receptor, alpha 0.036
NOTCH2NL notch 2 N-terminal like 0.034
PXN paxillin 0.034
PSG3 pregnancy specific beta-1-glycoprotein 3 0.033
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.032
IRS1 insulin receptor substrate 1 0.031
JUN jun proto-oncogene 0.031
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.031
INO80B INO80 complex subunit B 0.030
PLCG1 phospholipase C, gamma 1 0.030
PSG1 pregnancy specific beta-1-glycoprotein 1 0.030
PNRC1 proline-rich nuclear receptor coactivator 1 0.028
IGF2 insulin-like growth factor 2 (somatomedin A) 0.026
PML promyelocytic leukemia 0.026
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.026
GATA4 GATA binding protein 4 0.026
DBP D site of albumin promoter (albumin D-box) binding protein 0.026
VIM vimentin 0.024
JAG2 jagged 2 0.024
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.024
H3F3C H3 histone, family 3C 0.024
MAML1 mastermind-like 1 (Drosophila) 0.024
AR androgen receptor 0.024
TGFB3 transforming growth factor, beta 3 0.023
ANKFY1 ankyrin repeat and FYVE domain containing 1 0.023
SPEN spen homolog, transcriptional regulator (Drosophila) 0.023
HSPG2 heparan sulfate proteoglycan 2 0.022
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.022
EP300 E1A binding protein p300 0.022
IQGAP1 IQ motif containing GTPase activating protein 1 0.021
MYL9 myosin, light chain 9, regulatory 0.021
BCAR1 breast cancer anti-estrogen resistance 1 0.021
HDAC9 histone deacetylase 9 0.020
IGFBP4 insulin-like growth factor binding protein 4 0.020
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.019
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.019
ADAM12 ADAM metallopeptidase domain 12 0.019
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 0.018
TRIM43 tripartite motif containing 43 0.018
COL1A1 collagen, type I, alpha 1 0.018
EPAS1 endothelial PAS domain protein 1 0.017
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.017
TNS1 tensin 1 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
myod1 myogenic differentiation 1 0.485
mef2ca myocyte enhancer factor 2ca 0.380
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.354
myog myogenin 0.351
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.345
hspb1 heat shock protein, alpha-crystallin-related, 1 0.335
tgfb3 transforming growth factor, beta 3 0.331
dlx5a distal-less homeobox gene 5a 0.283
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.265
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.246
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.245
efnb2a ephrin B2a 0.207
hand2 heart and neural crest derivatives expressed transcript 2 0.205
xirp1 xin actin-binding repeat containing 1 0.204
mef2d myocyte enhancer factor 2d 0.187
desma desmin a 0.182
LOC100332039 ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like 0.156
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.144
sox9a SRY-box containing gene 9a 0.144
vasp vasodilator-stimulated phosphoprotein 0.144
prkci protein kinase C, iota 0.142
tbx2b T-box 2b 0.136
jam2b junctional adhesion molecule 2b 0.131
myf5 myogenic factor 5 0.130
unc45b unc-45 homolog B (C. elegans) 0.128
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.124
ptch2 patched 2 0.117
mef2a myocyte enhancer factor 2a 0.115
tnnt1 troponin T1, skeletal, slow 0.114
jam3b junctional adhesion molecule 3b 0.112
zgc:64114 zgc:64114 0.112
pak2a p21 (CDKN1A)-activated kinase 2a 0.111
actc1a actin, alpha, cardiac muscle 1a 0.110
pitx3 paired-like homeodomain transcription factor 3 0.109
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.108
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.106
tbx2a T-box gene 2a 0.105
yrk Yes-related kinase 0.104
ripk2 receptor-interacting serine-threonine kinase 2 0.102
mafl v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L 0.100
hsp90a.1 heat shock protein 90-alpha 1 0.098
smyd1b SET and MYND domain containing 1b 0.098
tpm4 tropomyosin 4 0.098
tbx5a T-box 5a 0.096
lmna lamin A 0.095
lgi1b leucine-rich, glioma inactivated 1b 0.092
cdh2 cadherin 2, neuronal 0.087
acta1a actin, alpha 1a, skeletal muscle 0.087
flncb filamin C, gamma b (actin binding protein 280) 0.085
wnt11r wingless-type MMTV integration site family, member 11, related 0.083
fsta follistatin a 0.083
zgc:86757 zgc:86757 0.083
zgc:111821 zgc:111821 0.082
edn1 endothelin 1 0.081
tnnt2a troponin T2a, cardiac 0.079
kbtbd10b kelch repeat and BTB (POZ) domain containing 10b 0.079
neb nebulin 0.079
ttna titin a 0.078
igfbp1a insulin-like growth factor binding protein 1a 0.075
grifin galectin related inter-fiber protein 0.075
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.075
cxc46 CXC chemokine 46 0.073
pob partial optokinetic response b 0.072
zgc:172136 zgc:172136 0.071
cxcr4a chemokine (C-X-C motif) receptor 4a 0.070
myhc4 myosin heavy chain 4 0.068
cdh5 cadherin 5 0.068
tcf12 transcription factor 12 0.068
nexn nexilin (F actin binding protein) 0.068
nkx2.5 NK2 transcription factor related 5 0.068
tomm40l translocase of outer mitochondrial membrane 40 homolog, like 0.066
fgf10a fibroblast growth factor 10a 0.066
dmd dystrophin 0.065
bmper BMP binding endothelial regulator 0.065
hoxc6a homeo box C6a 0.065
prkcq protein kinase C, theta 0.064
csrp1a cysteine and glycine-rich protein 1a 0.064
chrna4 cholinergic receptor, nicotinic, alpha 4 0.064
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.064
mbnl2 muscleblind-like 2 (Drosophila) 0.064
eef1g eukaryotic translation elongation factor 1 gamma 0.062
myf6 myogenic factor 6 0.062
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.061
efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.060
atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.059
jam2a junctional adhesion molecule 2a 0.059
fstl1b follistatin-like 1b 0.058
mybpc2b myosin binding protein C, fast type b 0.056
cxc64 CXC chemokine 64 0.055
hoxb1a homeo box B1a 0.055
fam20b family with sequence similarity 20, member B (H. sapiens) 0.055
chst11 carbohydrate (chondroitin 4) sulfotransferase 11 0.055
il1b interleukin 1, beta and interleukin 1, beta 0.055
vegfaa vascular endothelial growth factor Aa 0.054
sulf2l sulfatase 2, like 0.054
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.053
lamb2 laminin, beta 2 (laminin S) 0.053
zgc:112257 zgc:112257 0.053
wnt9a wingless-type MMTV integration site family, member 9A 0.053
sesn1 sestrin 1 0.053
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Drosophila melanogaster
Name Description Probability Func Analog Organism
lbe ladybird early 0.994
kirre kin of irre 0.993
sns sticks and stones 0.829
slou slouch 0.770
eve even skipped 0.659
hbs hibris 0.424
blow blown fuse 0.210
rst roughest 0.173
nau nautilus 0.159
LamC Lamin C 0.153
zfh1 Zn finger homeodomain 1 0.152
rols rolling pebbles 0.149
foxo forkhead box, sub-group O 0.125
klg klingon 0.123
Mp20 Muscle protein 20 0.117
Pax Paxillin 0.105
Vrp1 Verprolin 1 0.092
Ubx Ultrabithorax 0.090
sna snail 0.071
run runt 0.069
Dlic Dynein light intermediate chain 0.068
al aristaless 0.067
kon kon-tiki 0.066
sing singles bar 0.063
phyl phyllopod 0.053
Pglym78 Phosphoglyceromutase 0.053
slp1 sloppy paired 1 0.051
InR Insulin-like receptor 0.042
Gyc76C Guanylyl cyclase at 76C 0.038
tin tinman 0.036
mfrn mitoferrin 0.032
Wnt4 Wnt oncogene analog 4 0.030
byn brachyenteron 0.029
G-oalpha47A G protein oalpha 47A 0.029
tld tolloid 0.029
amos absent MD neurons and olfactory sensilla 0.027
Tpi Triose phosphate isomerase 0.026
org-1 optomotor-blind-related-gene-1 0.026
Myd88 CG2078 gene product from transcript CG2078-RA 0.024
Antp Antennapedia 0.022
pb proboscipedia 0.022
kn knot 0.020
Gapdh1 Glyceraldehyde 3 phosphate dehydrogenase 1 0.019
mew multiple edematous wings 0.018
Thor CG8846 gene product from transcript CG8846-RA 0.017
Atg18 Autophagy-specific gene 18 0.017
elB elbow B 0.016
ap apterous 0.016
dp dumpy 0.015
inv invected 0.015
lbl ladybird late 0.014
in inturned 0.013
cdi center divider 0.013
otk off-track 0.013
Doc2 Dorsocross2 0.013
ImpL3 Ecdysone-inducible gene L3 0.013
Mlp84B Muscle LIM protein at 84B 0.012
CG42863 CG42863 gene product from transcript CG42863-RB 0.011
ct cut 0.011
ptc patched 0.011
Poxm Pox meso 0.011
unc-104 CG8566 gene product from transcript CG8566-RB 0.010
HLH54F CG5005 gene product from transcript CG5005-RA 0.010
Actbeta Activin-beta 0.010
Pde8 Phosphodiesterase 8 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Pitx2 paired-like homeodomain transcription factor 2 0.994
Shh sonic hedgehog 0.972
Rarg retinoic acid receptor, gamma 0.965
Pax3 paired box gene 3 0.932
Hand1 heart and neural crest derivatives expressed transcript 1 0.927
Tcfap2a transcription factor AP-2, alpha 0.893
Hand2 heart and neural crest derivatives expressed transcript 2 0.893
Bcl2 B-cell leukemia/lymphoma 2 0.883
Pitx1 paired-like homeodomain transcription factor 1 0.869
Prrx1 paired related homeobox 1 0.864
Vegfa vascular endothelial growth factor A 0.858
Mapk14 mitogen-activated protein kinase 14 0.853
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.841
Fgfr2 fibroblast growth factor receptor 2 0.830
Ifng interferon gamma 0.802
Tbx1 T-box 1 0.781
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.758
Foxg1 forkhead box G1 0.744
Ccl2 chemokine (C-C motif) ligand 2 0.738
Mef2d myocyte enhancer factor 2D 0.726
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.709
Csf1 colony stimulating factor 1 (macrophage) 0.705
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.704
Runx2 runt related transcription factor 2 0.694
Foxc1 forkhead box C1 0.685
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.670
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.622
Fas Fas (TNF receptor superfamily member 6) 0.617
Ccl7 chemokine (C-C motif) ligand 7 0.602
Id3 inhibitor of DNA binding 3 0.587
Rxra retinoid X receptor alpha 0.573
Otx2 orthodenticle homolog 2 (Drosophila) 0.560
Inpp5d inositol polyphosphate-5-phosphatase D 0.552
Bmp7 bone morphogenetic protein 7 0.551
Cxcl13 chemokine (C-X-C motif) ligand 13 0.547
Il1b interleukin 1 beta 0.535
Prrx2 paired related homeobox 2 0.511
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.511
Fgfr1 fibroblast growth factor receptor 1 0.502
Myod1 myogenic differentiation 1 0.501
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.488
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.480
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.452
Sox4 SRY-box containing gene 4 0.452
Tcf3 transcription factor 3 0.442
Tbx4 T-box 4 0.440
Id1 inhibitor of DNA binding 1 0.439
Dll4 delta-like 4 (Drosophila) 0.422
Msx1 homeobox, msh-like 1 0.412
Bmp4 bone morphogenetic protein 4 0.404
Pten phosphatase and tensin homolog 0.401
Gata4 GATA binding protein 4 0.395
Meox2 mesenchyme homeobox 2 0.385
Pbx1 pre B-cell leukemia transcription factor 1 0.376
Socs1 suppressor of cytokine signaling 1 0.361
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.354
Foxc2 forkhead box C2 0.350
Ptrf polymerase I and transcript release factor 0.339
Ccl12 chemokine (C-C motif) ligand 12 0.335
Cd40 CD40 antigen 0.332
Nodal nodal 0.330
Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 0.327
Cxcl1 chemokine (C-X-C motif) ligand 1 0.315
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.315
Nf1 neurofibromatosis 1 0.314
Ednra endothelin receptor type A 0.304
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.292
Il10 interleukin 10 0.282
Stat6 signal transducer and activator of transcription 6 0.280
Bax BCL2-associated X protein 0.280
Ikzf1 IKAROS family zinc finger 1 0.273
Wt1 Wilms tumor 1 homolog 0.271
Smo smoothened homolog (Drosophila) 0.265
Lif leukemia inhibitory factor 0.263
Gdnf glial cell line derived neurotrophic factor 0.259
Snai1 snail homolog 1 (Drosophila) 0.252
Zic3 zinc finger protein of the cerebellum 3 0.247
Tcfap2c transcription factor AP-2, gamma 0.245
Cxcl2 chemokine (C-X-C motif) ligand 2 0.243
Smad6 MAD homolog 6 (Drosophila) 0.242
Isl1 ISL1 transcription factor, LIM/homeodomain 0.238
Acvr1 activin A receptor, type 1 0.236
Tgfb2 transforming growth factor, beta 2 0.235
Gli3 GLI-Kruppel family member GLI3 0.235
Gsc goosecoid homeobox 0.234
Hes1 hairy and enhancer of split 1 (Drosophila) 0.222
Myf5 myogenic factor 5 0.222
Rara retinoic acid receptor, alpha 0.222
Sox9 SRY-box containing gene 9 0.221
Igh immunoglobulin heavy chain complex 0.212
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.208
Mknk2 MAP kinase-interacting serine/threonine kinase 2 0.201
Chrd chordin 0.194
Il6 interleukin 6 0.192
Irx1 Iroquois related homeobox 1 (Drosophila) 0.192
Pax1 paired box gene 1 0.190
Shox2 short stature homeobox 2 0.189
Ccr1 chemokine (C-C motif) receptor 1 0.183
Fuz fuzzy homolog (Drosophila) 0.182
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.180
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism