The network for 'regulation of isotype switching' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of isotype switching

Any process that modulates the frequency, rate or extent of isotype switching.

Homo sapiens
Name Description Probability Func Analog Organism
IL4R interleukin 4 receptor 0.882
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.394
ENG endoglin 0.163
TRAF3 TNF receptor-associated factor 3 0.152
GRAP2 GRB2-related adaptor protein 2 0.129
TP53BP1 tumor protein p53 binding protein 1 0.092
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.089
THOC5 THO complex 5 0.088
THOC2 THO complex 2 0.069
FSTL1 follistatin-like 1 0.067
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.063
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.059
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.057
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.056
TMEM173 transmembrane protein 173 0.042
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.041
IL2RG interleukin 2 receptor, gamma 0.041
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.036
NCOR2 nuclear receptor corepressor 2 0.034
TGFBR1 transforming growth factor, beta receptor 1 0.034
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.031
PCDH9 protocadherin 9 0.031
TRAF1 TNF receptor-associated factor 1 0.031
MDC1 mediator of DNA-damage checkpoint 1 0.030
THOC4 THO complex 4 0.030
SMC1A structural maintenance of chromosomes 1A 0.027
TRAF2 TNF receptor-associated factor 2 0.026
TGFB3 transforming growth factor, beta 3 0.026
TRAF5 TNF receptor-associated factor 5 0.025
AR androgen receptor 0.024
THBS1 thrombospondin 1 0.024
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.022
CD22 CD22 molecule 0.022
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.022
CHTOP chromatin target of PRMT1 0.021
BIRC3 baculoviral IAP repeat containing 3 0.021
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.020
CD80 CD80 molecule 0.020
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.020
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.019
NCOA6 nuclear receptor coactivator 6 0.019
HDAC9 histone deacetylase 9 0.019
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.019
NCAPD3 non-SMC condensin II complex, subunit D3 0.019
RIPK2 receptor-interacting serine-threonine kinase 2 0.018
NRP1 neuropilin 1 0.017
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.016
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.014
CD2 CD2 molecule 0.014
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.013
IRS1 insulin receptor substrate 1 0.013
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.013
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.013
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.013
MYST2 MYST histone acetyltransferase 2 0.012
SYK spleen tyrosine kinase 0.012
C16orf53 chromosome 16 open reading frame 53 0.012
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 0.012
HDAC5 histone deacetylase 5 0.012
IL4 interleukin 4 0.012
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.011
NXF1 nuclear RNA export factor 1 0.011
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.011
PPAP2B phosphatidic acid phosphatase type 2B 0.011
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.011
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.011
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.011
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.010
KAT5 K(lysine) acetyltransferase 5 0.010
TRADD TNFRSF1A-associated via death domain 0.010
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Foxp3 forkhead box P3 0.988
Ifng interferon gamma 0.959
Il10 interleukin 10 0.922
Cd19 CD19 antigen 0.872
Tnf tumor necrosis factor 0.800
Prf1 perforin 1 (pore forming protein) 0.678
Il2 interleukin 2 0.576
Fyn Fyn proto-oncogene 0.557
Pitx1 paired-like homeodomain transcription factor 1 0.469
Il6 interleukin 6 0.410
Stat5b signal transducer and activator of transcription 5B 0.400
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.400
Tcra T-cell receptor alpha chain 0.396
Ikzf1 IKAROS family zinc finger 1 0.339
Fas Fas (TNF receptor superfamily member 6) 0.331
Rag1 recombination activating gene 1 0.324
Cd28 CD28 antigen 0.278
Lyz2 lysozyme 2 0.262
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.210
Stat5a signal transducer and activator of transcription 5A 0.205
Irf9 interferon regulatory factor 9 0.176
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.165
Rag2 recombination activating gene 2 0.153
Stat3 signal transducer and activator of transcription 3 0.152
Cd40 CD40 antigen 0.141
Pitx2 paired-like homeodomain transcription factor 2 0.138
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.136
Socs1 suppressor of cytokine signaling 1 0.133
Inpp5d inositol polyphosphate-5-phosphatase D 0.126
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.126
Il4 interleukin 4 0.120
Fasl Fas ligand (TNF superfamily, member 6) 0.109
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.108
Tbx3 T-box 3 0.104
Csf1 colony stimulating factor 1 (macrophage) 0.102
Lta lymphotoxin A 0.093
Il4ra interleukin 4 receptor, alpha 0.093
Ccl2 chemokine (C-C motif) ligand 2 0.087
Tlr4 toll-like receptor 4 0.087
Il6st interleukin 6 signal transducer 0.086
Ccr7 chemokine (C-C motif) receptor 7 0.081
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.075
Igh immunoglobulin heavy chain complex 0.072
Pdcd1 programmed cell death 1 0.069
Chd7 chromodomain helicase DNA binding protein 7 0.067
Stat1 signal transducer and activator of transcription 1 0.062
Smad3 MAD homolog 3 (Drosophila) 0.059
Il2rg interleukin 2 receptor, gamma chain 0.057
Rc3h1 RING CCCH (C3H) domains 1 0.055
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.052
Fgfr2 fibroblast growth factor receptor 2 0.051
Nos2 nitric oxide synthase 2, inducible 0.049
Tbx21 T-box 21 0.047
Stat6 signal transducer and activator of transcription 6 0.045
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.044
Il1r1 interleukin 1 receptor, type I 0.042
Pax2 paired box gene 2 0.042
Nlrp3 NLR family, pyrin domain containing 3 0.040
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.036
Cd40lg CD40 ligand 0.036
Icos inducible T-cell co-stimulator 0.036
Spp1 secreted phosphoprotein 1 0.034
Apoe apolipoprotein E 0.034
Mmp9 matrix metallopeptidase 9 0.033
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.033
Myd88 myeloid differentiation primary response gene 88 0.033
Pou5f1 POU domain, class 5, transcription factor 1 0.032
Card11 caspase recruitment domain family, member 11 0.032
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.031
Spna1 spectrin alpha 1 0.030
Traf2 TNF receptor-associated factor 2 0.029
Zap70 zeta-chain (TCR) associated protein kinase 0.029
Lif leukemia inhibitory factor 0.029
Itk IL2-inducible T-cell kinase 0.029
Fgf10 fibroblast growth factor 10 0.028
Meox1 mesenchyme homeobox 1 0.028
Prrx1 paired related homeobox 1 0.028
Ccr6 chemokine (C-C motif) receptor 6 0.028
Il21r interleukin 21 receptor 0.027
Lag3 lymphocyte-activation gene 3 0.025
Foxp2 forkhead box P2 0.025
Dll4 delta-like 4 (Drosophila) 0.024
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.023
Hoxa13 homeobox A13 0.023
Rxra retinoid X receptor alpha 0.023
Sh2d1a SH2 domain protein 1A 0.023
Gpr132 G protein-coupled receptor 132 0.022
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.022
Foxp1 forkhead box P1 0.022
Wt1 Wilms tumor 1 homolog 0.021
Bcl6 B-cell leukemia/lymphoma 6 0.021
Sox7 SRY-box containing gene 7 0.021
B2m beta-2 microglobulin 0.020
Prkcd protein kinase C, delta 0.020
Cd4 CD4 antigen 0.020
Foxn1 forkhead box N1 0.019
Traf6 TNF receptor-associated factor 6 0.019
Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.019
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.019
Lat linker for activation of T cells 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd37 CD37 molecule 0.132
Cd53 Cd53 molecule 0.068
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.063
Cxcr4 chemokine (C-X-C motif) receptor 4 0.053
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.047
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.045
Syk spleen tyrosine kinase 0.043
Bin2 bridging integrator 2 0.037
Apol3 apolipoprotein L, 3 0.034
Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 0.034
Hck hemopoietic cell kinase 0.033
Slfn2 schlafen 2 0.032
Arhgap4 Rho GTPase activating protein 4 0.030
Il2rg interleukin 2 receptor, gamma 0.030
Casp1 caspase 1 0.029
Myh9 myosin, heavy chain 9, non-muscle 0.029
Arl5c ADP-ribosylation factor-like 5C 0.028
Cd247 Cd247 molecule 0.027
Pcgf6 polycomb group ring finger 6 0.026
Ctse cathepsin E 0.025
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.025
Mca32 mast cell antigen 32 0.025
Il1b interleukin 1 beta 0.025
Cd2 Cd2 molecule 0.025
Lcp2 lymphocyte cytosolic protein 2 0.025
Arhgap25 Rho GTPase activating protein 25 0.024
RT1-Db1 RT1 class II, locus Db1 0.024
Vav1 vav 1 guanine nucleotide exchange factor 0.023
Vcam1 vascular cell adhesion molecule 1 0.023
Trim47 tripartite motif-containing 47 0.022
Anpep alanyl (membrane) aminopeptidase 0.022
Zc3h7a zinc finger CCCH type containing 7 A 0.021
Ptafr platelet-activating factor receptor 0.021
Il16 interleukin 16 0.020
Gpsm3 G-protein signaling modulator 3 (AGS3-like, C. elegans) 0.020
Prpf38a PRP38 pre-mRNA processing factor 38 (yeast) domain containing A 0.020
Rcsd1 RCSD domain containing 1 0.018
Bak1 BCL2-antagonist/killer 1 0.018
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.018
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.017
LOC100363783 rCG53773-like 0.017
Tlr7 toll-like receptor 7 0.017
Cd80 Cd80 molecule 0.017
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.017
Ptpro protein tyrosine phosphatase, receptor type, O 0.017
Mmp8 matrix metallopeptidase 8 0.017
Zyx zyxin 0.016
Cd5 Cd5 molecule 0.016
Igsf6 immunoglobulin superfamily, member 6 0.016
Slc15a3 solute carrier family 15, member 3 0.016
Mcpt3 mast cell peptidase 3 0.016
Sell selectin L 0.016
Cnr2 cannabinoid receptor 2 (macrophage) 0.016
Lst1 leukocyte specific transcript 1 0.016
Sipa1 signal-induced proliferation-associated 1 0.016
Reg1a regenerating islet-derived 1 alpha 0.015
Yme1l1 YME1-like 1 (S. cerevisiae) 0.015
Sycp1 synaptonemal complex protein 1 0.015
Il7r interleukin 7 receptor 0.015
Cd4 Cd4 molecule 0.015
Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.015
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.015
Fosl1 fos-like antigen 1 0.015
Myo1g myosin IG 0.015
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.015
Ccl3 chemokine (C-C motif) ligand 3 0.015
Alox5 arachidonate 5-lipoxygenase 0.015
ND4 NADH dehydrogenase subunit 4 0.015
Mmp12 matrix metallopeptidase 12 0.015
Sla src-like adaptor 0.015
Cybb cytochrome b-245, beta polypeptide 0.015
Ddx52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 0.014
Npffr2 neuropeptide FF receptor 2 0.014
Sirpa signal-regulatory protein alpha 0.014
Cd22 CD22 molecule 0.014
Ncr3 natural cytotoxicity triggering receptor 3 0.014
Csn1s1 casein alpha s1 0.014
Herc4 hect domain and RLD 4 0.014
Stat4 signal transducer and activator of transcription 4 0.014
Ccl4 chemokine (C-C motif) ligand 4 0.014
Laptm5 lysosomal protein transmembrane 5 0.014
Gpr114 G protein-coupled receptor 114 0.014
Il4ra interleukin 4 receptor, alpha 0.014
LOC688276 similar to epidermodysplasia verruciformis 2 0.014
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.014
Vcan versican 0.014
Fabp2 fatty acid binding protein 2, intestinal 0.013
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.013
Vom2r27 vomeronasal 2 receptor, 27 0.013
Calcb calcitonin-related polypeptide, beta 0.013
Cd28 Cd28 molecule 0.013
Cubn cubilin (intrinsic factor-cobalamin receptor) 0.013
Il2rb interleukin 2 receptor, beta 0.013
Accn5 amiloride-sensitive cation channel 5, intestinal 0.013
Fmnl1 formin-like 1 0.013
Tpp2 tripeptidyl peptidase II 0.013
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.013
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.013
Dusp4 dual specificity phosphatase 4 0.013
Expi extracellular proteinase inhibitor 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism