IMP
Process View
The network for 'interleukin 2 mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
interleukin 2 mediated signaling pathway
A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 1.000 | |
| GHR | growth hormone receptor | 0.998 | |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.993 | |
| STAT5A | signal transducer and activator of transcription 5A | 0.967 | |
| JAK2 | Janus kinase 2 | 0.789 | |
| SOCS3 | suppressor of cytokine signaling 3 | 0.789 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.766 | |
| EGFR | epidermal growth factor receptor | 0.702 | |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.639 | |
| STAT5B | signal transducer and activator of transcription 5B | 0.542 | |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.438 | |
| IFNGR1 | interferon gamma receptor 1 | 0.411 | |
| EPOR | erythropoietin receptor | 0.393 | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.374 | |
| ESR1 | estrogen receptor 1 | 0.285 | |
| LAT | linker for activation of T cells | 0.263 | |
| IL6ST | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 0.246 | |
| STAM2 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 0.235 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.220 | |
| SOCS1 | suppressor of cytokine signaling 1 | 0.204 | |
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.193 | |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.144 | |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.140 | |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.134 | |
| CAPN1 | calpain 1, (mu/I) large subunit | 0.115 | |
| INSR | insulin receptor | 0.113 | |
| SH2B1 | SH2B adaptor protein 1 | 0.088 | |
| DNM2 | dynamin 2 | 0.084 | |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.083 | |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 0.044 | |
| JAK1 | Janus kinase 1 | 0.041 | |
| IRS1 | insulin receptor substrate 1 | 0.038 | |
| SOCS2 | suppressor of cytokine signaling 2 | 0.034 | |
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.034 | |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.026 | |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.026 | |
| PTPN2 | protein tyrosine phosphatase, non-receptor type 2 | 0.024 | |
| BCR | breakpoint cluster region | 0.024 | |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.023 | |
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.022 | |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.020 | |
| SLC4A1 | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) | 0.019 | |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.018 | |
| CTTN | cortactin | 0.016 | |
| NMI | N-myc (and STAT) interactor | 0.016 | |
| TRPV6 | transient receptor potential cation channel, subfamily V, member 6 | 0.016 | |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.012 | |
| IL6R | interleukin 6 receptor | 0.012 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.012 | |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.012 | |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.011 | |
| LTK | leukocyte receptor tyrosine kinase | 0.011 | |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.011 | |
| IL12RB2 | interleukin 12 receptor, beta 2 | 0.011 | |
| PTPN9 | protein tyrosine phosphatase, non-receptor type 9 | 0.010 | |
| IGF1R | insulin-like growth factor 1 receptor | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Il2rg | interleukin 2 receptor, gamma chain | 0.822 | |
| Lck | lymphocyte protein tyrosine kinase | 0.626 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.592 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.423 | |
| Itk | IL2-inducible T-cell kinase | 0.283 | |
| Lat | linker for activation of T cells | 0.173 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.171 | |
| Jak2 | Janus kinase 2 | 0.170 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.158 | |
| Il6st | interleukin 6 signal transducer | 0.147 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.091 | |
| Icos | inducible T-cell co-stimulator | 0.084 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.076 | |
| Cd28 | CD28 antigen | 0.073 | |
| Socs3 | suppressor of cytokine signaling 3 | 0.070 | |
| Sh2d2a | SH2 domain protein 2A | 0.069 | |
| Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.067 | |
| Cd247 | CD247 antigen | 0.066 | |
| Fyn | Fyn proto-oncogene | 0.050 | |
| Il4ra | interleukin 4 receptor, alpha | 0.048 | |
| Batf | basic leucine zipper transcription factor, ATF-like | 0.044 | |
| Cd47 | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) | 0.042 | |
| Flii | flightless I homolog (Drosophila) | 0.040 | |
| Nsf | N-ethylmaleimide sensitive fusion protein | 0.039 | |
| Il10 | interleukin 10 | 0.038 | |
| Il2 | interleukin 2 | 0.037 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.037 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.036 | |
| Jak1 | Janus kinase 1 | 0.036 | |
| Gzmb | granzyme B | 0.035 | |
| Cd5 | CD5 antigen | 0.031 | |
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.030 | |
| Gna13 | guanine nucleotide binding protein, alpha 13 | 0.028 | |
| Cd4 | CD4 antigen | 0.027 | |
| Ifnar1 | interferon (alpha and beta) receptor 1 | 0.027 | |
| Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.027 | |
| Kctd10 | potassium channel tetramerisation domain containing 10 | 0.027 | |
| Cd3e | CD3 antigen, epsilon polypeptide | 0.026 | |
| Map4k4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.026 | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.024 | |
| Ugcg | UDP-glucose ceramide glucosyltransferase | 0.024 | |
| Ifng | interferon gamma | 0.024 | |
| Pxk | PX domain containing serine/threonine kinase | 0.022 | |
| 4933426M11Rik | RIKEN cDNA 4933426M11 gene | 0.022 | |
| Cst7 | cystatin F (leukocystatin) | 0.021 | |
| Rac1 | RAS-related C3 botulinum substrate 1 | 0.021 | |
| Gnai2 | guanine nucleotide binding protein (G protein), alpha inhibiting 2 | 0.021 | |
| Arpc2 | actin related protein 2/3 complex, subunit 2 | 0.019 | |
| Tnf | tumor necrosis factor | 0.019 | |
| Sh2d1a | SH2 domain protein 1A | 0.018 | |
| Cd96 | CD96 antigen | 0.018 | |
| Ccr9 | chemokine (C-C motif) receptor 9 | 0.018 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.018 | |
| Pdcd1 | programmed cell death 1 | 0.018 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.017 | |
| Crtap | cartilage associated protein | 0.017 | |
| Ptprcap | protein tyrosine phosphatase, receptor type, C polypeptide-associated protein | 0.017 | |
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.017 | |
| Tpm4 | tropomyosin 4 | 0.016 | |
| Med10 | mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae) | 0.016 | |
| Cd8a | CD8 antigen, alpha chain | 0.016 | |
| Phc2 | polyhomeotic-like 2 (Drosophila) | 0.016 | |
| Foxp3 | forkhead box P3 | 0.015 | |
| Traf1 | TNF receptor-associated factor 1 | 0.015 | |
| Rnf19b | ring finger protein 19B | 0.015 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.014 | |
| Sptlc2 | serine palmitoyltransferase, long chain base subunit 2 | 0.014 | |
| Tiparp | TCDD-inducible poly(ADP-ribose) polymerase | 0.014 | |
| Tbk1 | TANK-binding kinase 1 | 0.014 | |
| Stat5a | signal transducer and activator of transcription 5A | 0.014 | |
| Pparg | peroxisome proliferator activated receptor gamma | 0.014 | |
| Rbms1 | RNA binding motif, single stranded interacting protein 1 | 0.014 | |
| Bcl10 | B-cell leukemia/lymphoma 10 | 0.014 | |
| Soat2 | sterol O-acyltransferase 2 | 0.013 | |
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.013 | |
| Cd44 | CD44 antigen | 0.012 | |
| Txk | TXK tyrosine kinase | 0.012 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.012 | |
| Phf23 | PHD finger protein 23 | 0.012 | |
| Junb | Jun-B oncogene | 0.012 | |
| Cd7 | CD7 antigen | 0.012 | |
| Stat4 | signal transducer and activator of transcription 4 | 0.012 | |
| Klf7 | Kruppel-like factor 7 (ubiquitous) | 0.012 | |
| Gcet2 | germinal center expressed transcript 2 | 0.012 | |
| Grap2 | GRB2-related adaptor protein 2 | 0.012 | |
| Nfatc2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.012 | |
| Irf4 | interferon regulatory factor 4 | 0.011 | |
| Sell | selectin, lymphocyte | 0.011 | |
| Xpo6 | exportin 6 | 0.011 | |
| Cdc42se1 | CDC42 small effector 1 | 0.010 | |
| Cd6 | CD6 antigen | 0.010 | |
| Il15 | interleukin 15 | 0.010 | |
| Rel | reticuloendotheliosis oncogene | 0.010 |