The network for 'protein monoubiquitination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein monoubiquitination

Addition of a single ubiquitin group to a protein.

Homo sapiens
Name Description Probability Func Analog Organism
RNF11 ring finger protein 11 1.000
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 1.000
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 1.000
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1.000
RNF2 ring finger protein 2 1.000
RNF5 ring finger protein 5 0.999
RING1 ring finger protein 1 0.998
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.996
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.994
UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) 0.988
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.980
RNF20 ring finger protein 20 0.979
ZNRF1 zinc and ring finger 1 0.970
BCOR BCL6 corepressor 0.951
TRIM39 tripartite motif containing 39 0.947
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.943
CUL1 cullin 1 0.933
CBX8 chromobox homolog 8 0.910
XIAP X-linked inhibitor of apoptosis 0.903
RNF126 ring finger protein 126 0.898
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.897
CUL4A cullin 4A 0.884
ARIH2 ariadne homolog 2 (Drosophila) 0.873
UBXN7 UBX domain protein 7 0.845
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.839
DZIP3 DAZ interacting protein 3, zinc finger 0.832
SKP1 S-phase kinase-associated protein 1 0.820
RNF111 ring finger protein 111 0.773
UBA1 ubiquitin-like modifier activating enzyme 1 0.769
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.760
CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.716
BMI1 BMI1 polycomb ring finger oncogene 0.714
CUL3 cullin 3 0.712
SIAH1 seven in absentia homolog 1 (Drosophila) 0.692
RAD18 RAD18 homolog (S. cerevisiae) 0.678
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.677
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.653
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.631
KLHL12 kelch-like 12 (Drosophila) 0.627
RYBP RING1 and YY1 binding protein 0.622
PCGF1 polycomb group ring finger 1 0.616
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.590
DDB1 damage-specific DNA binding protein 1, 127kDa 0.569
MIB1 mindbomb homolog 1 (Drosophila) 0.552
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.530
CBX7 chromobox homolog 7 0.523
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.516
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.483
YY1 YY1 transcription factor 0.432
RNF114 ring finger protein 114 0.431
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.430
TCEA1 transcription elongation factor A (SII), 1 0.379
MARCH7 membrane-associated ring finger (C3HC4) 7 0.376
EED embryonic ectoderm development 0.373
PEX5 peroxisomal biogenesis factor 5 0.345
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.322
RNF14 ring finger protein 14 0.313
CBX6 chromobox homolog 6 0.293
PCGF3 polycomb group ring finger 3 0.261
TRIM43 tripartite motif containing 43 0.258
MARCH5 membrane-associated ring finger (C3HC4) 5 0.245
BTRC beta-transducin repeat containing 0.243
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.240
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.239
RFWD2 ring finger and WD repeat domain 2 0.230
TRAF6 TNF receptor-associated factor 6 0.229
UBE2E2 ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) 0.216
FBXW11 F-box and WD repeat domain containing 11 0.214
USP11 ubiquitin specific peptidase 11 0.212
TRAF3 TNF receptor-associated factor 3 0.208
RNF4 ring finger protein 4 0.208
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.204
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.197
RNF10 ring finger protein 10 0.194
WDR61 WD repeat domain 61 0.192
UBE2E3 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) 0.189
TRIM5 tripartite motif containing 5 0.188
ZNF263 zinc finger protein 263 0.187
KDM2B lysine (K)-specific demethylase 2B 0.182
MKRN1 makorin ring finger protein 1 0.182
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.177
TRIM27 tripartite motif containing 27 0.171
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.170
PCNA proliferating cell nuclear antigen 0.164
RNF38 ring finger protein 38 0.153
CNOT4 CCR4-NOT transcription complex, subunit 4 0.152
WNK4 WNK lysine deficient protein kinase 4 0.152
CUL4B cullin 4B 0.150
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.148
TRIM32 tripartite motif containing 32 0.145
FANCM Fanconi anemia, complementation group M 0.143
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.137
CHFR checkpoint with forkhead and ring finger domains 0.132
PCGF2 polycomb group ring finger 2 0.128
INO80 INO80 homolog (S. cerevisiae) 0.126
UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.124
XPC xeroderma pigmentosum, complementation group C 0.122
RNF130 ring finger protein 130 0.113
CBX4 chromobox homolog 4 0.110
ANKRD13A ankyrin repeat domain 13A 0.108
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Rnf2 ring finger protein 2 0.998
Rybp RING1 and YY1 binding protein 0.571
Bmi1 Bmi1 polycomb ring finger oncogene 0.248
Pcgf2 polycomb group ring finger 2 0.052
Skp1a S-phase kinase-associated protein 1A 0.045
Fbxl20 F-box and leucine-rich repeat protein 20 0.031
Rnf11 ring finger protein 11 0.030
Ctbp1 C-terminal binding protein 1 0.027
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.027
Cpeb3 cytoplasmic polyadenylation element binding protein 3 0.027
Pcgf1 polycomb group ring finger 1 0.025
Csnk2a1 casein kinase 2, alpha 1 polypeptide 0.024
Kdm2b lysine (K)-specific demethylase 2B 0.021
Cbx3 chromobox homolog 3 (Drosophila HP1 gamma) 0.020
Cbx8 chromobox homolog 8 (Drosophila Pc class) 0.020
Kdm1a lysine (K)-specific demethylase 1A 0.020
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.017
Pcgf6 polycomb group ring finger 6 0.014
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.013
Vapa vesicle-associated membrane protein, associated protein A 0.013
Rag2 recombination activating gene 2 0.013
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 0.013
Zfp830 zinc finger protein 830 0.012
Trp53bp1 transformation related protein 53 binding protein 1 0.011
Rac1 RAS-related C3 botulinum substrate 1 0.011
Cbx7 chromobox homolog 7 0.011
Stat1 signal transducer and activator of transcription 1 0.011
Tmem64 transmembrane protein 64 0.011
Vcp valosin containing protein 0.011
Eif4a2 eukaryotic translation initiation factor 4A2 0.010
Csnk1a1 casein kinase 1, alpha 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Zfand5 zinc finger, AN1-type domain 5 0.043
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.029
Rnf138 ring finger protein 138 0.022
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.019
March5 membrane-associated ring finger (C3HC4) 5 0.016
Rbm18 RNA binding motif protein 18 0.013
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RAD6 Rad6p 0.423
UBR2 Ubr2p 0.412
PEX2 Pex2p 0.097
MOT2 Mot2p 0.090
RTF1 Rtf1p 0.077
MUB1 Mub1p 0.074
PAF1 Paf1p 0.058
UBR1 Ubr1p 0.055
CDC53 Cdc53p 0.053
PEX15 Pex15p 0.042
BUL1 Bul1p 0.039
RAD9 Rad9p 0.035
CDC34 Cdc34p 0.034
TCO89 Tco89p 0.033
UFD4 Ufd4p 0.030
UBA1 Uba1p 0.029
CDC4 Cdc4p 0.027
PEX11 Pex11p 0.027
RAD52 Rad52p 0.026
VPS9 Vps9p 0.025
SSM4 Ssm4p 0.023
SET2 Set2p 0.021
SRD1 Srd1p 0.021
ADH2 Adh2p 0.021
ARP10 Arp10p 0.018
LEU2 Leu2p 0.018
CRP1 Crp1p 0.018
YLR162W hypothetical protein 0.018
YLR264C-A hypothetical protein 0.018
YOL038C-A hypothetical protein 0.018
MER1 Mer1p 0.017
IML1 Iml1p 0.017
SNA2 Sna2p 0.017
VAC7 Vac7p 0.017
YBR085C-A hypothetical protein 0.017
YDR034W-B hypothetical protein 0.017
UFO1 Ufo1p 0.016
POP2 Pop2p 0.016
ZPS1 Zps1p 0.016
YAR068W hypothetical protein 0.016
NCE103 Nce103p 0.016
CHA1 Cha1p 0.016
YIL151C hypothetical protein 0.016
PEX10 Pex10p 0.015
URA3 Ura3p 0.015
HDA2 Hda2p 0.015
MRS6 Mrs6p 0.015
FMP52 Fmp52p 0.015
ATP6 Atp6p 0.015
YBR013C hypothetical protein 0.014
UME1 Ume1p 0.014
UPC2 Upc2p 0.014
UBC13 Ubc13p 0.014
BRN1 Brn1p 0.014
ARG8 Arg8p 0.014
HPF1 Hpf1p 0.014
CUP1-1 Cup1-1p 0.014
YLR042C hypothetical protein 0.014
MYO1 Myo1p 0.014
AGE1 Age1p 0.014
PRS2 Prs2p 0.014
SPL2 Spl2p 0.014
PEX12 Pex12p 0.013
PEX22 Pex22p 0.013
SPT16 Spt16p 0.013
HXT3 Hxt3p 0.013
YNL155W hypothetical protein 0.013
YPR157W hypothetical protein 0.013
AUA1 Aua1p 0.013
MAK10 Mak10p 0.013
MMS1 Mms1p 0.013
KIC1 Kic1p 0.013
YIL001W hypothetical protein 0.012
YOL013W-A hypothetical protein 0.012
PBY1 Pby1p 0.012
PCT1 Pct1p 0.012
FMT1 Fmt1p 0.012
ICS2 Ics2p 0.012
CPD1 Cpd1p 0.012
YKR075C hypothetical protein 0.012
KNH1 Knh1p 0.012
RAD14 Rad14p 0.012
SCM4 Scm4p 0.012
HFA1 Hfa1p 0.012
ART5 Art5p 0.012
CUE4 Cue4p 0.012
PEX4 Pex4p 0.012
RUP1 Rup1p 0.012
LCL1 Lcl1p 0.012
TYE7 Tye7p 0.012
HO Hop 0.012
DST1 Dst1p 0.012
YIR035C hypothetical protein 0.012
UBC6 Ubc6p 0.012
FAA2 Faa2p 0.011
GYL1 Gyl1p 0.011
BLM10 Blm10p 0.011
SOV1 Sov1p 0.011
BNA4 Bna4p 0.011
MF(ALPHA)2 Mf(alpha)2p 0.011