The network for 'lung alveolus development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lung alveolus development

The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.

Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
FGF1 fibroblast growth factor 1 (acidic) 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.000
NRP1 neuropilin 1 1.000
BMPR1A bone morphogenetic protein receptor, type IA 0.999
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.997
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.994
GH1 growth hormone 1 0.993
VEGFA vascular endothelial growth factor A 0.991
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.964
FGF10 fibroblast growth factor 10 0.948
FGFR1 fibroblast growth factor receptor 1 0.944
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.929
PDZD11 PDZ domain containing 11 0.928
GH2 growth hormone 2 0.913
CSH2 chorionic somatomammotropin hormone 2 0.910
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.900
CSHL1 chorionic somatomammotropin hormone-like 1 0.841
PLCG1 phospholipase C, gamma 1 0.840
FSTL1 follistatin-like 1 0.747
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.723
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.696
FGF7 fibroblast growth factor 7 0.680
CDH5 cadherin 5, type 2 (vascular endothelium) 0.679
PRKG1 protein kinase, cGMP-dependent, type I 0.573
ARL4D ADP-ribosylation factor-like 4D 0.515
PAX8 paired box 8 0.468
ACVR1 activin A receptor, type I 0.407
PGF placental growth factor 0.388
PDGFC platelet derived growth factor C 0.380
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.372
FZD1 frizzled homolog 1 (Drosophila) 0.370
FLNB filamin B, beta 0.327
WNT5A wingless-type MMTV integration site family, member 5A 0.324
DMBT1 deleted in malignant brain tumors 1 0.277
CIB1 calcium and integrin binding 1 (calmyrin) 0.252
FGF8 fibroblast growth factor 8 (androgen-induced) 0.249
PSEN1 presenilin 1 0.228
RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) 0.226
HOXA7 homeobox A7 0.207
FGF4 fibroblast growth factor 4 0.204
KRT8 keratin 8 0.199
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.197
MAPK8 mitogen-activated protein kinase 8 0.184
BMP2 bone morphogenetic protein 2 0.177
FHL2 four and a half LIM domains 2 0.159
LMO4 LIM domain only 4 0.152
CTGF connective tissue growth factor 0.148
PTPRB protein tyrosine phosphatase, receptor type, B 0.144
BHLHE40 basic helix-loop-helix family, member e40 0.143
BMP4 bone morphogenetic protein 4 0.135
FLT4 fms-related tyrosine kinase 4 0.123
MAP2K7 mitogen-activated protein kinase kinase 7 0.122
HIPK3 homeodomain interacting protein kinase 3 0.119
TGFB2 transforming growth factor, beta 2 0.119
WNT3A wingless-type MMTV integration site family, member 3A 0.114
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.114
NOG noggin 0.113
PTGIS prostaglandin I2 (prostacyclin) synthase 0.110
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.109
CXCL12 chemokine (C-X-C motif) ligand 12 0.108
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.105
HOXA10 homeobox A10 0.101
FGFR3 fibroblast growth factor receptor 3 0.096
SHB Src homology 2 domain containing adaptor protein B 0.096
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.095
TBX2 T-box 2 0.095
TWIST1 twist homolog 1 (Drosophila) 0.094
SALL2 sal-like 2 (Drosophila) 0.091
CCDC6 coiled-coil domain containing 6 0.088
FGF19 fibroblast growth factor 19 0.087
EXOC5 exocyst complex component 5 0.080
IGFBP5 insulin-like growth factor binding protein 5 0.079
SRI sorcin 0.077
KIAA2026 KIAA2026 0.077
TGFBR3 transforming growth factor, beta receptor III 0.076
SDC4 syndecan 4 0.075
SFTPC surfactant protein C 0.075
STC1 stanniocalcin 1 0.074
WNT1 wingless-type MMTV integration site family, member 1 0.074
EEA1 early endosome antigen 1 0.073
ANGPT1 angiopoietin 1 0.070
LIFR leukemia inhibitory factor receptor alpha 0.068
FGF18 fibroblast growth factor 18 0.068
COL6A1 collagen, type VI, alpha 1 0.067
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.067
FZD7 frizzled homolog 7 (Drosophila) 0.066
PICK1 protein interacting with PRKCA 1 0.066
CCDC48 coiled-coil domain containing 48 0.065
TRIM32 tripartite motif containing 32 0.064
FOXF2 forkhead box F2 0.063
TEK TEK tyrosine kinase, endothelial 0.061
HBZ hemoglobin, zeta 0.061
KLF15 Kruppel-like factor 15 0.060
SFTPD surfactant protein D 0.060
BMPR1B bone morphogenetic protein receptor, type IB 0.060
LDLR low density lipoprotein receptor 0.059
SHROOM3 shroom family member 3 0.058
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.058
SDC2 syndecan 2 0.057
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Gli2 GLI-Kruppel family member GLI2 0.960
Vegfa vascular endothelial growth factor A 0.953
Tcf21 transcription factor 21 0.942
Hoxa5 homeobox A5 0.922
Gata6 GATA binding protein 6 0.921
Shh sonic hedgehog 0.907
Tgfbr2 transforming growth factor, beta receptor II 0.878
Pten phosphatase and tensin homolog 0.878
Fgfr2 fibroblast growth factor receptor 2 0.850
Fbn1 fibrillin 1 0.796
Fgf10 fibroblast growth factor 10 0.754
Meox2 mesenchyme homeobox 2 0.738
Flt4 FMS-like tyrosine kinase 4 0.720
Sox9 SRY-box containing gene 9 0.715
Col1a1 collagen, type I, alpha 1 0.705
Nos3 nitric oxide synthase 3, endothelial cell 0.665
Twist2 twist homolog 2 (Drosophila) 0.650
She src homology 2 domain-containing transforming protein E 0.642
Tgfbr1 transforming growth factor, beta receptor I 0.634
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.633
Kdr kinase insert domain protein receptor 0.620
Nkx2-1 NK2 homeobox 1 0.617
Sox7 SRY-box containing gene 7 0.611
Fgf8 fibroblast growth factor 8 0.601
Hoxc5 homeobox C5 0.587
Acvr1 activin A receptor, type 1 0.585
Hoxa1 homeobox A1 0.580
Foxc2 forkhead box C2 0.559
Pthlh parathyroid hormone-like peptide 0.540
Tgfb2 transforming growth factor, beta 2 0.516
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.511
Fgf9 fibroblast growth factor 9 0.498
Grb10 growth factor receptor bound protein 10 0.495
Gli3 GLI-Kruppel family member GLI3 0.474
Hoxd3 homeobox D3 0.471
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.449
Pax3 paired box gene 3 0.431
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.428
Tbx3 T-box 3 0.423
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.383
Hoxc9 homeobox C9 0.371
Foxf1a forkhead box F1a 0.361
Hoxc6 homeobox C6 0.357
Hoxb5 homeobox B5 0.347
Pax2 paired box gene 2 0.341
Bmp4 bone morphogenetic protein 4 0.341
Ddr2 discoidin domain receptor family, member 2 0.340
Klc1 kinesin light chain 1 0.335
Notch3 Notch gene homolog 3 (Drosophila) 0.330
Fgf18 fibroblast growth factor 18 0.327
Tgfbr3 transforming growth factor, beta receptor III 0.320
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.319
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.319
Notch1 Notch gene homolog 1 (Drosophila) 0.317
Npr3 natriuretic peptide receptor 3 0.305
Hoxb4 homeobox B4 0.272
Fgfr3 fibroblast growth factor receptor 3 0.269
Mapk8 mitogen-activated protein kinase 8 0.265
Hoxb6 homeobox B6 0.256
Dhh desert hedgehog 0.252
Gata3 GATA binding protein 3 0.240
Ptprb protein tyrosine phosphatase, receptor type, B 0.236
Meox1 mesenchyme homeobox 1 0.232
Sox18 SRY-box containing gene 18 0.231
Sorbs3 sorbin and SH3 domain containing 3 0.226
Hoxa11 homeobox A11 0.226
Bnc1 basonuclin 1 0.223
Jag1 jagged 1 0.216
Smad6 MAD homolog 6 (Drosophila) 0.216
Foxa2 forkhead box A2 0.208
Ednra endothelin receptor type A 0.207
Eng endoglin 0.204
Fzd4 frizzled homolog 4 (Drosophila) 0.204
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.202
Fgf4 fibroblast growth factor 4 0.200
Tead4 TEA domain family member 4 0.196
Fst follistatin 0.194
Epas1 endothelial PAS domain protein 1 0.193
Ldlr low density lipoprotein receptor 0.192
Tcfap2a transcription factor AP-2, alpha 0.186
Tcf15 transcription factor 15 0.186
Flt1 FMS-like tyrosine kinase 1 0.185
Atf4 activating transcription factor 4 0.185
Hoxa3 homeobox A3 0.184
Inhba inhibin beta-A 0.183
Hhex hematopoietically expressed homeobox 0.180
Hoxa9 homeobox A9 0.176
Chd7 chromodomain helicase DNA binding protein 7 0.175
Nes nestin 0.170
Hand1 heart and neural crest derivatives expressed transcript 1 0.169
Wt1 Wilms tumor 1 homolog 0.168
Hoxc4 homeobox C4 0.167
Bdkrb2 bradykinin receptor, beta 2 0.165
Gata2 GATA binding protein 2 0.155
Foxd2 forkhead box D2 0.152
Cdh5 cadherin 5 0.151
Pitx2 paired-like homeodomain transcription factor 2 0.149
Ikzf1 IKAROS family zinc finger 1 0.149
Smad4 MAD homolog 4 (Drosophila) 0.147
Efnb2 ephrin B2 0.146
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Rattus norvegicus
Name Description Probability Func Analog Organism
Vcsa2 variable coding sequence A2 0.027
Loxl1 lysyl oxidase-like 1 0.023
Pou1f1 POU class 1 homeobox 1 0.020
Lepr leptin receptor 0.018
Psgb1 pregnancy-specific beta 1-glycoprotein 0.017
Dchs1 dachsous 1 (Drosophila) 0.015
Prl3c1 Prolactin family 3, subfamily c, member 1 0.015
Ednra endothelin receptor type A 0.014
Agtr1b angiotensin II receptor, type 1b 0.012
Vom2r53 vomeronasal 2 receptor, 53 0.012
Myf6 myogenic factor 6 0.011
ND4 NADH dehydrogenase subunit 4 0.011
Shox2 short stature homeobox 2 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism