The network for 'sprouting angiogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sprouting angiogenesis

The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.

Mus musculus
Name Description Probability Func Analog Organism
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.996
Ctnnb1 catenin (cadherin associated protein), beta 1 0.994
Efnb2 ephrin B2 0.985
Fgfr1 fibroblast growth factor receptor 1 0.982
Psen1 presenilin 1 0.947
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.941
Notch1 Notch gene homolog 1 (Drosophila) 0.912
Flt4 FMS-like tyrosine kinase 4 0.910
Ilk integrin linked kinase 0.873
Notch2 Notch gene homolog 2 (Drosophila) 0.811
Foxc1 forkhead box C1 0.766
Cdh5 cadherin 5 0.749
Fgfr2 fibroblast growth factor receptor 2 0.736
Hif1a hypoxia inducible factor 1, alpha subunit 0.733
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.689
Rb1 retinoblastoma 1 0.677
Kit kit oncogene 0.656
Tgfb2 transforming growth factor, beta 2 0.623
Lef1 lymphoid enhancer binding factor 1 0.614
Eng endoglin 0.580
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.548
Ptk2 PTK2 protein tyrosine kinase 2 0.534
Pax3 paired box gene 3 0.506
Gli3 GLI-Kruppel family member GLI3 0.501
Flt1 FMS-like tyrosine kinase 1 0.484
Slit3 slit homolog 3 (Drosophila) 0.450
Snai1 snail homolog 1 (Drosophila) 0.438
Pax6 paired box gene 6 0.419
Mef2d myocyte enhancer factor 2D 0.402
Inpp5d inositol polyphosphate-5-phosphatase D 0.400
Kdr kinase insert domain protein receptor 0.394
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.388
Vegfa vascular endothelial growth factor A 0.371
Nos3 nitric oxide synthase 3, endothelial cell 0.366
Lama5 laminin, alpha 5 0.360
Hic1 hypermethylated in cancer 1 0.348
Dll1 delta-like 1 (Drosophila) 0.328
Hes1 hairy and enhancer of split 1 (Drosophila) 0.326
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.324
Prl7d1 prolactin family 7, subfamily d, member 1 0.322
Jag1 jagged 1 0.306
Pcdh12 protocadherin 12 0.295
Dll4 delta-like 4 (Drosophila) 0.269
Pbx1 pre B-cell leukemia transcription factor 1 0.263
Shh sonic hedgehog 0.256
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.252
Meox2 mesenchyme homeobox 2 0.250
Fyn Fyn proto-oncogene 0.250
Pax8 paired box gene 8 0.249
Egfl7 EGF-like domain 7 0.241
Itga3 integrin alpha 3 0.237
Otx2 orthodenticle homolog 2 (Drosophila) 0.235
Foxa2 forkhead box A2 0.230
Ednra endothelin receptor type A 0.229
Prl8a2 prolactin family 8, subfamily a, member 2 0.215
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.208
Kitl kit ligand 0.207
Cxcl12 chemokine (C-X-C motif) ligand 12 0.202
Vhl von Hippel-Lindau tumor suppressor 0.201
Bcl2 B-cell leukemia/lymphoma 2 0.197
Fstl1 follistatin-like 1 0.197
Gata4 GATA binding protein 4 0.197
Prl7a1 prolactin family 7, subfamily a, member 1 0.196
Hand2 heart and neural crest derivatives expressed transcript 2 0.193
Gdnf glial cell line derived neurotrophic factor 0.184
Hand1 heart and neural crest derivatives expressed transcript 1 0.180
Ncor2 nuclear receptor co-repressor 2 0.177
Rag1 recombination activating gene 1 0.168
Emx1 empty spiracles homolog 1 (Drosophila) 0.167
Acvr1 activin A receptor, type 1 0.165
Cd151 CD151 antigen 0.163
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.163
Epha4 Eph receptor A4 0.158
Sox18 SRY-box containing gene 18 0.155
Bmp1 bone morphogenetic protein 1 0.152
Nrp1 neuropilin 1 0.146
Pecam1 platelet/endothelial cell adhesion molecule 1 0.145
Ntf3 neurotrophin 3 0.142
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.142
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.141
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.139
Egr1 early growth response 1 0.138
Ehd2 EH-domain containing 2 0.136
Ltbp1 latent transforming growth factor beta binding protein 1 0.133
Nos2 nitric oxide synthase 2, inducible 0.133
Sox7 SRY-box containing gene 7 0.131
Gas1 growth arrest specific 1 0.128
Ppap2b phosphatidic acid phosphatase type 2B 0.125
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.123
Src Rous sarcoma oncogene 0.119
Ceacam11 carcinoembryonic antigen-related cell adhesion molecule 11 0.114
Smad3 MAD homolog 3 (Drosophila) 0.109
Col4a2 collagen, type IV, alpha 2 0.107
Pten phosphatase and tensin homolog 0.102
Gpc3 glypican 3 0.099
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.096
Lox lysyl oxidase 0.096
Tcf21 transcription factor 21 0.096
Ephb2 Eph receptor B2 0.094
Foxf2 forkhead box F2 0.090
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 1.000
nrp1a neuropilin 1a 0.993
dll4 delta-like 4 (Drosophila) 0.989
notch3 notch homolog 3 0.987
vegfc vascular endothelial growth factor c 0.940
sulf1 sulfatase 1 0.934
tie2 endothelium-specific receptor tyrosine kinase 2 0.805
ptprb protein tyrosine phosphatase, receptor type, b 0.711
sema3fa semaphorin 3fa 0.664
pitx3 paired-like homeodomain transcription factor 3 0.644
col2a1a collagen type II, alpha-1a 0.629
itgb3b integrin beta 3b 0.607
efnb2a ephrin B2a 0.602
nrarpa notch-regulated ankyrin repeat protein a 0.600
flt4 fms-related tyrosine kinase 4 0.591
rtn4b reticulon 4b 0.568
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.564
gng2 guanine nucleotide binding protein (G protein), gamma 2 0.560
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.540
si:ch211-235f6.2 si:ch211-235f6.2 0.460
rxrgb retinoid X receptor, gamma b 0.448
wu:fv91b12 wu:fv91b12 0.444
cxcr4a chemokine (C-X-C motif) receptor 4a 0.440
mmp2 matrix metalloproteinase 2 0.438
fn1 fibronectin 1 0.418
tal1 T-cell acute lymphocytic leukemia 1 0.405
itgb1b.2 integrin, beta 1b.2 0.394
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.391
jag1b jagged 1b 0.387
ednra endothelin receptor type A 0.383
sema3aa semaphorin 3aa 0.374
dlx2a distal-less homeobox gene 2a 0.371
pdgfrb2 platelet derived growth factor receptor beta 2 0.368
alcama activated leukocyte cell adhesion molecule a 0.363
gro2 groucho 2 0.361
ptgs1 prostaglandin-endoperoxide synthase 1 0.354
antxr1 anthrax toxin receptor 1 0.352
sdc2 syndecan 2 0.348
rarga retinoic acid receptor gamma a 0.338
bmp2a bone morphogenetic protein 2a 0.330
dlc deltaC 0.321
aplnra apelin receptor a 0.296
ntn4 netrin 4 0.290
nrp2a neuropilin 2a 0.288
tbx1 T-box 1 0.287
plcg1 phospholipase C, gamma 1 0.287
fgfrl1b fibroblast growth factor receptor-like 1b 0.284
plxnd1 plexin D1 0.281
itgb1b integrin, beta 1b 0.281
igfbp7 insulin-like growth factor binding protein 7 0.275
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.274
nadl1.1 neural adhesion molecule L1.1 0.272
gngt2b guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b 0.272
foxi1 forkhead box I1 0.271
emx3 empty spiracles homeobox 3 0.270
edn1 endothelin 1 0.268
col4a2 collagen, type IV, alpha 2 0.263
nrp2b neuropilin 2b 0.262
etv2 ets variant gene 2 0.260
twist1a twist1a 0.258
jag2 jagged 2 0.258
kal1b Kallmann syndrome 1b sequence 0.258
notch2 notch homolog 2 0.254
met met proto-oncogene (hepatocyte growth factor receptor) 0.245
plekhg5a pleckstrin homology domain containing, family G (with RhoGef domain) member 5a 0.242
dld deltaD 0.242
wls wntless homolog (Drosophila) 0.241
si:ch211-212m21.5 si:ch211-212m21.5 0.239
ccbe1 collagen and calcium binding EGF domains 1 0.238
bmper BMP binding endothelial regulator 0.238
rad21 RAD21 homolog (S. pombe) 0.233
lpar1 lysophosphatidic acid receptor 1 0.229
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.229
bmp2b bone morphogenetic protein 2b 0.224
dlb deltaB 0.224
ccm2 cerebral cavernous malformation 2 0.218
fbn2b fibrillin 2b 0.217
grna granulin a 0.215
cdh5 cadherin 5 0.215
foxe1 forkhead box E1 (thyroid transcription factor 2) 0.212
lef1 lymphocyte enhancer binding factor 1 0.208
wu:fc25e04 wu:fc25e04 0.207
chrna6 cholinergic receptor, nicotinic, alpha 6 0.201
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.198
foxj1b forkhead box J1b 0.196
isl1 islet1 0.196
mrc1a mannose receptor, C type 1a 0.195
utrn utrophin 0.194
gngt2a guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a 0.194
arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.190
tfr1b transferrin receptor 1b 0.186
slc2a1a solute carrier family 2 (facilitated glucose transporter), member 1a 0.177
vegfaa vascular endothelial growth factor Aa 0.177
sox1a SRY-box containing gene 1a 0.174
ptrfb polymerase I and transcript release factor b 0.172
gb:bm036580 gb:bm036580 0.170
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.168
si:ch73-60e21.1 si:ch73-60e21.1 0.160
rargb retinoic acid receptor, gamma b 0.160
col4a4 collagen, type IV, alpha 4 0.159
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
VEGFA vascular endothelial growth factor A 1.000
TEK TEK tyrosine kinase, endothelial 1.000
JAG1 jagged 1 1.000
FGFR2 fibroblast growth factor receptor 2 1.000
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 1.000
NOTCH1 notch 1 0.999
FGF1 fibroblast growth factor 1 (acidic) 0.990
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.987
NOTCH3 notch 3 0.986
E2F7 E2F transcription factor 7 0.986
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.982
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.979
ILK integrin-linked kinase 0.977
NRP1 neuropilin 1 0.971
FGFR1 fibroblast growth factor receptor 1 0.965
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.960
E2F8 E2F transcription factor 8 0.942
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.931
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.922
GRB7 growth factor receptor-bound protein 7 0.892
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.887
CTGF connective tissue growth factor 0.857
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.839
ENG endoglin 0.838
TGFB1 transforming growth factor, beta 1 0.825
KLF4 Kruppel-like factor 4 (gut) 0.825
ZNF746 zinc finger protein 746 0.824
FN1 fibronectin 1 0.812
LCK lymphocyte-specific protein tyrosine kinase 0.809
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.789
CDH5 cadherin 5, type 2 (vascular endothelium) 0.789
COL5A1 collagen, type V, alpha 1 0.756
COL6A1 collagen, type VI, alpha 1 0.735
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.702
NCOR2 nuclear receptor corepressor 2 0.686
COL4A1 collagen, type IV, alpha 1 0.621
THBS1 thrombospondin 1 0.617
ANGPT2 angiopoietin 2 0.607
EGR2 early growth response 2 0.587
EGR1 early growth response 1 0.582
HSPG2 heparan sulfate proteoglycan 2 0.521
EFNA1 ephrin-A1 0.516
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.508
PTPRJ protein tyrosine phosphatase, receptor type, J 0.496
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.482
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.471
BMPR1A bone morphogenetic protein receptor, type IA 0.467
VEGFC vascular endothelial growth factor C 0.464
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.459
PGF placental growth factor 0.458
GDF9 growth differentiation factor 9 0.456
HMOX2 heme oxygenase (decycling) 2 0.445
MEF2C myocyte enhancer factor 2C 0.430
PLCG1 phospholipase C, gamma 1 0.420
FLNA filamin A, alpha 0.393
NCK2 NCK adaptor protein 2 0.392
FGA fibrinogen alpha chain 0.385
PTPRB protein tyrosine phosphatase, receptor type, B 0.372
DLL1 delta-like 1 (Drosophila) 0.346
COL4A2 collagen, type IV, alpha 2 0.310
EGR3 early growth response 3 0.308
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.296
CYR61 cysteine-rich, angiogenic inducer, 61 0.294
FSTL1 follistatin-like 1 0.289
CD63 CD63 molecule 0.280
BCL6 B-cell CLL/lymphoma 6 0.274
FYN FYN oncogene related to SRC, FGR, YES 0.271
EGFL7 EGF-like-domain, multiple 7 0.258
COL1A1 collagen, type I, alpha 1 0.258
PSEN2 presenilin 2 (Alzheimer disease 4) 0.242
HDAC3 histone deacetylase 3 0.227
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.225
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.225
TGFB2 transforming growth factor, beta 2 0.225
FBN1 fibrillin 1 0.219
BTRC beta-transducin repeat containing 0.219
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.207
DSG2 desmoglein 2 0.203
FBLN1 fibulin 1 0.202
JAG2 jagged 2 0.199
CD34 CD34 molecule 0.198
MYOCD myocardin 0.193
FBLN5 fibulin 5 0.190
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.185
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.184
MKL1 megakaryoblastic leukemia (translocation) 1 0.180
MAPK7 mitogen-activated protein kinase 7 0.175
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.169
PECAM1 platelet/endothelial cell adhesion molecule 0.158
IL8 interleukin 8 0.155
ANGPT1 angiopoietin 1 0.151
DSP desmoplakin 0.144
TIMP3 TIMP metallopeptidase inhibitor 3 0.142
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.138
TCF4 transcription factor 4 0.138
CPE carboxypeptidase E 0.137
STX5 syntaxin 5 0.134
LAMA4 laminin, alpha 4 0.130
EPHA3 EPH receptor A3 0.126
STC1 stanniocalcin 1 0.120
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism