The network for 'outflow tract morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

outflow tract morphogenesis

The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pitx2 paired-like homeodomain transcription factor 2 0.999
Fgf8 fibroblast growth factor 8 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.998
Pax2 paired box gene 2 0.998
Eya1 eyes absent 1 homolog (Drosophila) 0.998
Tbx3 T-box 3 0.998
Gli3 GLI-Kruppel family member GLI3 0.998
Fgfr2 fibroblast growth factor receptor 2 0.997
Foxc1 forkhead box C1 0.996
Sox2 SRY-box containing gene 2 0.994
Gata4 GATA binding protein 4 0.994
Smad6 MAD homolog 6 (Drosophila) 0.992
Fgfr1 fibroblast growth factor receptor 1 0.990
Meox2 mesenchyme homeobox 2 0.989
Hes1 hairy and enhancer of split 1 (Drosophila) 0.986
Ctnnb1 catenin (cadherin associated protein), beta 1 0.984
Nog noggin 0.983
Tcfap2a transcription factor AP-2, alpha 0.981
Pax3 paired box gene 3 0.981
Vangl2 vang-like 2 (van gogh, Drosophila) 0.978
Pitx1 paired-like homeodomain transcription factor 1 0.978
Foxc2 forkhead box C2 0.968
Hes5 hairy and enhancer of split 5 (Drosophila) 0.964
Foxg1 forkhead box G1 0.964
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.956
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.947
Fgf10 fibroblast growth factor 10 0.941
Gli2 GLI-Kruppel family member GLI2 0.938
Sox11 SRY-box containing gene 11 0.934
Sox9 SRY-box containing gene 9 0.928
Tbx1 T-box 1 0.922
Chd7 chromodomain helicase DNA binding protein 7 0.919
Notch1 Notch gene homolog 1 (Drosophila) 0.913
Rarg retinoic acid receptor, gamma 0.908
Emx1 empty spiracles homolog 1 (Drosophila) 0.907
Dlx5 distal-less homeobox 5 0.894
Hoxa13 homeobox A13 0.893
Hoxa1 homeobox A1 0.883
Pax8 paired box gene 8 0.877
Isl1 ISL1 transcription factor, LIM/homeodomain 0.868
Robo1 roundabout homolog 1 (Drosophila) 0.866
Pten phosphatase and tensin homolog 0.865
Vegfa vascular endothelial growth factor A 0.850
Emx2 empty spiracles homolog 2 (Drosophila) 0.846
Lhx1 LIM homeobox protein 1 0.819
Jag1 jagged 1 0.808
Hoxa2 homeobox A2 0.807
En1 engrailed 1 0.799
Hand2 heart and neural crest derivatives expressed transcript 2 0.780
Nodal nodal 0.773
Tbx2 T-box 2 0.769
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.768
Pax6 paired box gene 6 0.763
Efnb2 ephrin B2 0.744
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.739
Hand1 heart and neural crest derivatives expressed transcript 1 0.736
Gata6 GATA binding protein 6 0.722
Nos3 nitric oxide synthase 3, endothelial cell 0.720
Gdnf glial cell line derived neurotrophic factor 0.710
Lmx1a LIM homeobox transcription factor 1 alpha 0.706
Bmp4 bone morphogenetic protein 4 0.665
Lhx3 LIM homeobox protein 3 0.664
Hoxa10 homeobox A10 0.660
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.656
Tlx3 T-cell leukemia, homeobox 3 0.652
Sox7 SRY-box containing gene 7 0.641
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.635
Ptk7 PTK7 protein tyrosine kinase 7 0.635
Smad3 MAD homolog 3 (Drosophila) 0.632
Dll1 delta-like 1 (Drosophila) 0.632
Wnt4 wingless-related MMTV integration site 4 0.632
Lmx1b LIM homeobox transcription factor 1 beta 0.614
Prrx2 paired related homeobox 2 0.600
Notch2 Notch gene homolog 2 (Drosophila) 0.594
Vax1 ventral anterior homeobox containing gene 1 0.574
Fos FBJ osteosarcoma oncogene 0.567
Mesp1 mesoderm posterior 1 0.562
Rxra retinoid X receptor alpha 0.560
Rb1 retinoblastoma 1 0.560
Tgfb2 transforming growth factor, beta 2 0.557
Dlx1 distal-less homeobox 1 0.549
Bmpr1a bone morphogenetic protein receptor, type 1A 0.546
Nhlh1 nescient helix loop helix 1 0.543
Hoxd3 homeobox D3 0.542
Pax1 paired box gene 1 0.541
Grb10 growth factor receptor bound protein 10 0.531
Neurod1 neurogenic differentiation 1 0.524
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.520
Sox3 SRY-box containing gene 3 0.518
Insm1 insulinoma-associated 1 0.507
Rara retinoic acid receptor, alpha 0.501
Hoxd13 homeobox D13 0.489
Ilk integrin linked kinase 0.485
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.482
Snai1 snail homolog 1 (Drosophila) 0.476
Wnt3a wingless-related MMTV integration site 3A 0.466
Pou3f3 POU domain, class 3, transcription factor 3 0.432
Neurog2 neurogenin 2 0.430
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 1.000
cdh2 cadherin 2, neuronal 0.980
mmp2 matrix metalloproteinase 2 0.850
spry4 sprouty (Drosophila) homolog 4 0.834
tbx5a T-box 5a 0.814
pax2a paired box gene 2a 0.801
nkx2.5 NK2 transcription factor related 5 0.794
shha sonic hedgehog a 0.779
mef2cb myocyte enhancer factor 2cb 0.762
alcama activated leukocyte cell adhesion molecule a 0.754
tpm4 tropomyosin 4 0.743
bmp2b bone morphogenetic protein 2b 0.737
jag1b jagged 1b 0.727
eya1 eyes absent homolog 1 0.726
wnt11r wingless-type MMTV integration site family, member 11, related 0.724
ctgf connective tissue growth factor 0.654
smyd1b SET and MYND domain containing 1b 0.649
ndr2 nodal-related 2 0.626
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.623
fn1 fibronectin 1 0.606
myl7 myosin, light polypeptide 7, regulatory 0.603
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.600
slit1a slit homolog 1a (Drosophila) 0.592
fibin fin bud initiation factor 0.587
col5a2l collagen, type V, alpha 2-like 0.587
loxl2b lysyl oxidase-like 2b 0.567
fzd7a frizzled homolog 7a 0.552
spaw southpaw 0.549
prdm1a PR domain containing 1a, with ZNF domain 0.548
wu:fv91b12 wu:fv91b12 0.530
wnt5b wingless-type MMTV integration site family, member 5b 0.520
etv2 ets variant gene 2 0.514
neo1 neogenin 1 0.508
gata2a GATA-binding protein 2a 0.505
prrx1a paired related homeobox 1a 0.493
robo1 roundabout homolog 1 0.490
hhex hematopoietically expressed homeobox 0.489
axin1 axin 1 0.487
wnt11 wingless-type MMTV integration site family, member 11 0.486
tmem2 transmembrane protein 2 0.447
lmo4a LIM domain only 4a 0.425
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.405
ryr3 ryanodine receptor 3 0.398
lamc1 laminin, gamma 1 0.398
bmp4 bone morphogenetic protein 4 0.384
mef2ca myocyte enhancer factor 2ca 0.362
znf148 zinc finger protein 148 0.358
foxa1 forkhead box A1 0.338
ptgs1 prostaglandin-endoperoxide synthase 1 0.337
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.336
hand2 heart and neural crest derivatives expressed transcript 2 0.335
foxi1 forkhead box I1 0.325
edn1 endothelin 1 0.320
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.301
ttna titin a 0.291
isl2a islet2a 0.285
has2 hyaluronan synthase 2 0.284
isl1 islet1 0.284
twist3 twist3 0.282
six3b sine oculis homeobox homolog 3b 0.281
notch3 notch homolog 3 0.278
efnb3b ephrin B3b 0.266
ntn1a netrin 1a 0.265
jam3b junctional adhesion molecule 3b 0.260
foxp2 forkhead box P2 0.255
six2a sine oculis-related homeobox 2a 0.254
traf4a tnf receptor-associated factor 4a 0.251
fgf8a fibroblast growth factor 8 a 0.250
pcdh8 protocadherin 8 0.246
myod1 myogenic differentiation 1 0.245
il17rd interleukin 17 receptor D 0.242
hnf1ba HNF1 homeobox Ba 0.241
six4b sine oculis homeobox homolog 4b 0.241
eng1a engrailed 1a 0.233
chd chordin 0.232
fgfrl1b fibroblast growth factor receptor-like 1b 0.232
col1a1a collagen, type I, alpha 1a 0.231
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.228
hhip hedgehog interacting protein 0.225
igfbp3 insulin-like growth factor binding protein 3 0.223
col9a3 collagen, type IX, alpha 3 0.222
slit1b slit homolog 1b (Drosophila) 0.219
sox32 SRY-box containing gene 32 0.216
itga3b integrin, alpha 3b 0.211
wnt3 wingless-type MMTV integration site family, member 3 0.210
tbx16 T-box gene 16 0.207
pkd2 polycystic kidney disease 2 0.203
tmem88a transmembrane protein 88 a 0.201
tbx2a T-box gene 2a 0.195
skia nuclear oncoprotein skia 0.195
nrp1a neuropilin 1a 0.192
tcf12 transcription factor 12 0.192
ahr2 aryl hydrocarbon receptor 2 0.186
matn4 matrilin 4 0.184
dag1 dystroglycan 1 0.179
vcanb versican b 0.171
tbx5b T-box 5b 0.170
slit2 slit (Drosophila) homolog 2 0.170
aplnrb apelin receptor b 0.165
lft1 lefty1 0.165
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Drosophila melanogaster
Name Description Probability Func Analog Organism
aop anterior open 0.900
robo roundabout 0.819
slou slouch 0.743
LanB2 Laminin B2 0.621
sim single-minded 0.552
tin tinman 0.459
ci cubitus interruptus 0.433
lea leak 0.432
sli slit 0.418
bnl branchless 0.326
comm commissureless 0.309
ush u-shaped 0.284
sr stripe 0.262
mid midline 0.220
kn knot 0.217
foi fear-of-intimacy 0.217
stumps CG31317 gene product from transcript CG31317-RC 0.214
Egfr Epidermal growth factor receptor 0.211
pnr pannier 0.202
Rel Relish 0.186
LamC Lamin C 0.185
tsh teashirt 0.177
Cdc42 CG12530 gene product from transcript CG12530-RA 0.161
Mrtf Myocardin-related transcription factor 0.155
ey eyeless 0.144
Su(H) Suppressor of Hairless 0.136
bowl brother of odd with entrails limited 0.131
fz2 frizzled 2 0.125
gcm glial cells missing 0.124
slp1 sloppy paired 1 0.122
Hand CG18144 gene product from transcript CG18144-RA 0.120
twi twist 0.116
wts warts 0.114
wb wing blister 0.113
CadN Cadherin-N 0.111
ap apterous 0.097
nub nubbin 0.096
mirr mirror 0.089
hth homothorax 0.086
repo reversed polarity 0.085
pon partner of numb 0.084
Dcr-1 Dicer-1 0.078
fas faint sausage 0.075
en engrailed 0.075
Wnt5 Wnt oncogene analog 5 0.075
Wnt2 Wnt oncogene analog 2 0.074
dsh dishevelled 0.073
robo3 CG5423 gene product from transcript CG5423-RA 0.073
nau nautilus 0.072
ems empty spiracles 0.069
bab2 CG9102 gene product from transcript CG9102-RA 0.066
baz bazooka 0.064
rib ribbon 0.063
LanB1 CG7123 gene product from transcript CG7123-RA 0.063
tw Protein O-mannosyltransferase 2 0.063
Pvr PDGF- and VEGF-receptor related 0.062
disco disconnected 0.062
abs abstrakt 0.060
drpr draper 0.059
tutl turtle 0.058
e(y)3 enhancer of yellow 3 0.057
Dll Distal-less 0.056
t tan 0.056
srp serpent 0.054
eve even skipped 0.054
Grip Glutamate receptor binding protein 0.054
ed echinoid 0.054
noc no ocelli 0.054
zfh2 Zn finger homeodomain 2 0.054
insc inscuteable 0.054
dac dachshund 0.052
rap retina aberrant in pattern 0.051
rt rotated abdomen 0.051
sw short wing 0.050
Six4 CG3871 gene product from transcript CG3871-RA 0.050
rok Rho-kinase 0.049
cnc cap-n-collar 0.047
sls sallimus 0.046
Poxn Pox neuro 0.046
Hr38 Hormone receptor-like in 38 0.045
Shal Shaker cognate l 0.045
sna snail 0.045
trx trithorax 0.045
CG6981 CG6981 gene product from transcript CG6981-RB 0.045
slbo slow border cells 0.045
eya eyes absent 0.044
grn grain 0.044
tll tailless 0.044
ara araucan 0.043
ds dachsous 0.042
mmy mummy 0.041
slow slowdown 0.041
wg wingless 0.041
sec5 CG8843 gene product from transcript CG8843-RA 0.040
Optix CG18455 gene product from transcript CG18455-RA 0.040
CG32702 CG32702 gene product from transcript CG32702-RB 0.040
ena enabled 0.040
capt capulet 0.040
ct cut 0.039
Hr51 Hormone receptor 51 0.038
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Homo sapiens
Name Description Probability Func Analog Organism
SIRT1 sirtuin 1 0.679
TAL1 T-cell acute lymphocytic leukemia 1 0.648
NOTCH1 notch 1 0.509
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.456
TBX5 T-box 5 0.370
FGF1 fibroblast growth factor 1 (acidic) 0.219
GATA4 GATA binding protein 4 0.145
NCOR1 nuclear receptor corepressor 1 0.142
EP300 E1A binding protein p300 0.142
RXRA retinoid X receptor, alpha 0.125
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.112
NRP1 neuropilin 1 0.093
CSNK1E casein kinase 1, epsilon 0.079
NOTCH3 notch 3 0.064
FGF10 fibroblast growth factor 10 0.064
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.059
SMAD9 SMAD family member 9 0.056
AXIN1 axin 1 0.053
MED25 mediator complex subunit 25 0.052
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.049
RUNX1 runt-related transcription factor 1 0.044
NCOA1 nuclear receptor coactivator 1 0.043
FGFR1 fibroblast growth factor receptor 1 0.043
GSK3B glycogen synthase kinase 3 beta 0.041
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.036
KAT2B K(lysine) acetyltransferase 2B 0.036
APC adenomatous polyposis coli 0.035
SETD8 SET domain containing (lysine methyltransferase) 8 0.030
GATA2 GATA binding protein 2 0.027
SEC23A Sec23 homolog A (S. cerevisiae) 0.027
LRRK2 leucine-rich repeat kinase 2 0.026
TCF4 transcription factor 4 0.025
JAG1 jagged 1 0.025
NBN nibrin 0.024
ATF2 activating transcription factor 2 0.024
WNT3A wingless-type MMTV integration site family, member 3A 0.022
PGF placental growth factor 0.021
ARID1A AT rich interactive domain 1A (SWI-like) 0.021
SMAD3 SMAD family member 3 0.021
MAML1 mastermind-like 1 (Drosophila) 0.021
MSX1 msh homeobox 1 0.021
TP53 tumor protein p53 0.020
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.020
ILK integrin-linked kinase 0.019
HIC1 hypermethylated in cancer 1 0.018
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.018
NCOA3 nuclear receptor coactivator 3 0.018
DUSP1 dual specificity phosphatase 1 0.018
SMAD4 SMAD family member 4 0.018
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.017
NCOA6 nuclear receptor coactivator 6 0.017
CPE carboxypeptidase E 0.017
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.017
EPAS1 endothelial PAS domain protein 1 0.015
ZNF512B zinc finger protein 512B 0.015
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.015
ARID1B AT rich interactive domain 1B (SWI1-like) 0.015
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.014
MYOD1 myogenic differentiation 1 0.014
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.014
COL5A1 collagen, type V, alpha 1 0.014
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.014
PICK1 protein interacting with PRKCA 1 0.014
FGF7 fibroblast growth factor 7 0.013
CREB1 cAMP responsive element binding protein 1 0.013
FZD1 frizzled homolog 1 (Drosophila) 0.013
COL4A1 collagen, type IV, alpha 1 0.013
GRIP1 glutamate receptor interacting protein 1 0.013
FBXW11 F-box and WD repeat domain containing 11 0.013
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.013
NOTCH2 notch 2 0.013
WNT5A wingless-type MMTV integration site family, member 5A 0.013
PAX8 paired box 8 0.013
MAPK14 mitogen-activated protein kinase 14 0.013
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.013
SP1 Sp1 transcription factor 0.013
TBX2 T-box 2 0.012
WT1 Wilms tumor 1 0.012
SMAD6 SMAD family member 6 0.012
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.012
HDAC4 histone deacetylase 4 0.012
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.012
HOXD12 homeobox D12 0.011
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.011
FGF3 fibroblast growth factor 3 0.011
FOXF2 forkhead box F2 0.010
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.010
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.010
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.010
QKI quaking homolog, KH domain RNA binding (mouse) 0.010
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism