The network for 'regulation of epithelial to mesenchymal transition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of epithelial to mesenchymal transition

Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 0.999
Efnb2 ephrin B2 0.998
Fgfr2 fibroblast growth factor receptor 2 0.996
Tgfb2 transforming growth factor, beta 2 0.996
Foxc1 forkhead box C1 0.974
Ephb2 Eph receptor B2 0.962
Gli2 GLI-Kruppel family member GLI2 0.958
Ctnnb1 catenin (cadherin associated protein), beta 1 0.956
Pax3 paired box gene 3 0.947
Bmp4 bone morphogenetic protein 4 0.946
Jag1 jagged 1 0.933
Pitx2 paired-like homeodomain transcription factor 2 0.924
Hand1 heart and neural crest derivatives expressed transcript 1 0.904
Msx1 homeobox, msh-like 1 0.901
Pbx1 pre B-cell leukemia transcription factor 1 0.883
Efnb1 ephrin B1 0.881
Tcfap2a transcription factor AP-2, alpha 0.880
Pax6 paired box gene 6 0.877
Hand2 heart and neural crest derivatives expressed transcript 2 0.875
Sfrp2 secreted frizzled-related protein 2 0.862
Snai1 snail homolog 1 (Drosophila) 0.862
Nodal nodal 0.832
Prrx1 paired related homeobox 1 0.829
Gdnf glial cell line derived neurotrophic factor 0.812
Notch1 Notch gene homolog 1 (Drosophila) 0.802
Smad3 MAD homolog 3 (Drosophila) 0.798
Prrx2 paired related homeobox 2 0.790
Foxc2 forkhead box C2 0.788
Tbx3 T-box 3 0.788
Rarg retinoic acid receptor, gamma 0.785
Smad4 MAD homolog 4 (Drosophila) 0.783
Gata4 GATA binding protein 4 0.779
Runx2 runt related transcription factor 2 0.769
Foxa2 forkhead box A2 0.747
Neurod1 neurogenic differentiation 1 0.739
Fgf8 fibroblast growth factor 8 0.730
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.721
Tgfbr2 transforming growth factor, beta receptor II 0.718
Msx2 homeobox, msh-like 2 0.712
Hoxa1 homeobox A1 0.705
Hoxd13 homeobox D13 0.702
Tcf21 transcription factor 21 0.697
Ptf1a pancreas specific transcription factor, 1a 0.676
Sox11 SRY-box containing gene 11 0.670
Gas1 growth arrest specific 1 0.663
Vangl2 vang-like 2 (van gogh, Drosophila) 0.649
Foxg1 forkhead box G1 0.647
Bmp7 bone morphogenetic protein 7 0.644
Smad6 MAD homolog 6 (Drosophila) 0.644
Hic1 hypermethylated in cancer 1 0.643
Crb2 crumbs homolog 2 (Drosophila) 0.633
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.625
Twist2 twist homolog 2 (Drosophila) 0.618
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.612
Tbx1 T-box 1 0.605
Otx2 orthodenticle homolog 2 (Drosophila) 0.596
Foxh1 forkhead box H1 0.594
Ephb3 Eph receptor B3 0.592
Fgfr1 fibroblast growth factor receptor 1 0.574
Wnt5a wingless-related MMTV integration site 5A 0.527
Eya1 eyes absent 1 homolog (Drosophila) 0.524
Dlx5 distal-less homeobox 5 0.501
Lef1 lymphoid enhancer binding factor 1 0.500
Hoxd11 homeobox D11 0.500
Dab1 disabled homolog 1 (Drosophila) 0.492
Neurog2 neurogenin 2 0.478
Gata6 GATA binding protein 6 0.461
Smad1 MAD homolog 1 (Drosophila) 0.450
Psen1 presenilin 1 0.439
Pax9 paired box gene 9 0.432
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.425
Yap1 yes-associated protein 1 0.419
Axin1 axin 1 0.414
Ptk7 PTK7 protein tyrosine kinase 7 0.409
Pax2 paired box gene 2 0.406
Ntf3 neurotrophin 3 0.402
Smo smoothened homolog (Drosophila) 0.402
Chrd chordin 0.382
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.382
Col2a1 collagen, type II, alpha 1 0.381
Atoh7 atonal homolog 7 (Drosophila) 0.373
Tlx3 T-cell leukemia, homeobox 3 0.373
Meox2 mesenchyme homeobox 2 0.366
Gpc3 glypican 3 0.359
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.354
Emx1 empty spiracles homolog 1 (Drosophila) 0.350
Bnc1 basonuclin 1 0.350
Epha4 Eph receptor A4 0.345
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.338
Vegfa vascular endothelial growth factor A 0.336
Hoxa13 homeobox A13 0.332
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.322
Sox2 SRY-box containing gene 2 0.315
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.314
Hes1 hairy and enhancer of split 1 (Drosophila) 0.310
Zic3 zinc finger protein of the cerebellum 3 0.303
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.300
Fzd2 frizzled homolog 2 (Drosophila) 0.298
Acvr1 activin A receptor, type 1 0.295
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.891
col1a2 collagen, type I, alpha 2 0.834
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.765
bmp2a bone morphogenetic protein 2a 0.677
bmp4 bone morphogenetic protein 4 0.646
lhx2b LIM homeobox 2b 0.399
gdf6a growth differentiation factor 6a 0.320
col5a1 procollagen, type V, alpha 1 0.242
hapln1a hyaluronan and proteoglycan link protein 1a 0.211
shha sonic hedgehog a 0.201
osr1 odd-skipped related 1 (Drosophila) 0.191
lef1 lymphocyte enhancer binding factor 1 0.188
msxc muscle segment homeobox C 0.182
fgf3 fibroblast growth factor 3 0.181
foxn4 forkhead box N4 0.176
nrarpa notch-regulated ankyrin repeat protein a 0.174
nkx2.3 NK2 transcription factor related 3 0.171
sfrp1a secreted frizzled-related protein 1a 0.168
mab21l2 mab-21-like 2 0.166
axin2 axin 2 (conductin, axil) 0.165
wnt11r wingless-type MMTV integration site family, member 11, related 0.161
lmo4a LIM domain only 4a 0.155
foxa3 forkhead box A3 0.145
sox11b SRY-box containing gene 11b 0.144
notch3 notch homolog 3 0.141
gata6 GATA-binding protein 6 0.140
tbx20 T-box 20 0.137
sparc secreted acidic cysteine rich glycoprotein 0.132
cdh2 cadherin 2, neuronal 0.132
frem3 Fras1 related extracellular matrix 3 0.124
dlx3b distal-less homeobox gene 3b 0.115
has2 hyaluronan synthase 2 0.105
eya1 eyes absent homolog 1 0.105
wnt3 wingless-type MMTV integration site family, member 3 0.100
nkx2.1a NK2 homeobox 1a 0.100
plcg1 phospholipase C, gamma 1 0.098
fgf17 fibroblast growth factor 17 0.097
epha4b eph receptor A4b 0.097
wnt4a wingless-type MMTV integration site family, member 4a 0.097
aplnra apelin receptor a 0.096
ptch1 patched 1 0.095
fn1 fibronectin 1 0.094
twist3 twist3 0.092
rarga retinoic acid receptor gamma a 0.089
igf1rb insulin-like growth factor 1b receptor 0.088
lhx1b LIM homeobox 1b 0.086
wnt5b wingless-type MMTV integration site family, member 5b 0.086
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.085
itga3b integrin, alpha 3b 0.082
hmx4 H6 family homeobox 4 0.080
hoxc4a homeo box C4a 0.080
crb2a crumbs homolog 2a 0.078
hhip hedgehog interacting protein 0.077
bmp1a bone morphogenetic protein 1a 0.077
hoxc8a homeo box C8a 0.077
tgfbi transforming growth factor, beta-induced 0.077
runx2a runt-related transcription factor 2a 0.075
jag1b jagged 1b 0.075
vcanb versican b 0.074
rasl11b RAS-like, family 11, member B 0.074
nkx3.2 NK3 homeobox 2 0.073
sox2 SRY-box containing gene 2 0.072
dcn decorin 0.072
rtcd1 RNA terminal phosphate cyclase domain 1 0.072
wif1 wnt inhibitory factor 1 0.071
gyltl1b glycosyltransferase-like 1b 0.071
tgfb1a transforming growth factor, beta 1a 0.071
grem2 gremlin 2, cysteine knot superfamily 0.070
LOC100000500 sclerostin-like 0.069
p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 0.069
met met proto-oncogene (hepatocyte growth factor receptor) 0.067
dla deltaA 0.067
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.066
wnt3a wingless-type MMTV integration site family, member 3A 0.066
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.066
notch1a notch homolog 1a 0.066
pax9 paired box gene 9 0.064
tfec transcription factor EC 0.064
dlx2a distal-less homeobox gene 2a 0.064
dlc deltaC 0.063
znf703 zinc finger protein 703 0.062
prkci protein kinase C, iota 0.062
si:dkey-11e23.5 si:dkey-11e23.5 0.061
sfrp5 secreted frizzled-related protein 5 0.061
zgc:154063 zgc:154063 0.061
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.060
sox1a SRY-box containing gene 1a 0.060
vgll4l vestigial like 4 like 0.060
spry4 sprouty (Drosophila) homolog 4 0.059
tp63 tumor protein p63 0.058
fgf10a fibroblast growth factor 10a 0.058
ephb4b eph receptor B4b 0.056
msxe muscle segment homeobox E 0.056
tbx2a T-box gene 2a 0.056
ripply1 ripply1 0.055
twist1a twist1a 0.054
hoxa2b homeo box A2b 0.054
evx1 even-skipped homeobox 1 0.053
neurod4 neurogenic differentiation 4 0.053
cx43.4 connexin 43.4 0.053
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.000
SMAD1 SMAD family member 1 0.986
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.983
SMAD3 SMAD family member 3 0.981
NOTCH1 notch 1 0.967
SMAD2 SMAD family member 2 0.967
SMAD7 SMAD family member 7 0.961
JAG1 jagged 1 0.961
COL1A1 collagen, type I, alpha 1 0.955
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.945
COL3A1 collagen, type III, alpha 1 0.815
COL4A1 collagen, type IV, alpha 1 0.802
FSTL1 follistatin-like 1 0.751
AR androgen receptor 0.738
SMAD4 SMAD family member 4 0.677
COL1A2 collagen, type I, alpha 2 0.668
POU5F1 POU class 5 homeobox 1 0.638
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.561
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.546
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.518
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.494
BMPR1A bone morphogenetic protein receptor, type IA 0.493
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.491
SMAD5 SMAD family member 5 0.486
TBX5 T-box 5 0.462
FHL2 four and a half LIM domains 2 0.390
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.351
GATA4 GATA binding protein 4 0.319
NOTCH3 notch 3 0.310
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.304
SETD8 SET domain containing (lysine methyltransferase) 8 0.303
TGFBR1 transforming growth factor, beta receptor 1 0.299
TGFB3 transforming growth factor, beta 3 0.298
PARVA parvin, alpha 0.291
STRN3 striatin, calmodulin binding protein 3 0.279
COL5A1 collagen, type V, alpha 1 0.271
COL6A1 collagen, type VI, alpha 1 0.263
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.256
DDR2 discoidin domain receptor tyrosine kinase 2 0.255
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.247
YAP1 Yes-associated protein 1 0.241
SKIL SKI-like oncogene 0.236
SMAD6 SMAD family member 6 0.228
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.193
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.193
CTNNBIP1 catenin, beta interacting protein 1 0.190
APC adenomatous polyposis coli 0.189
FBLN1 fibulin 1 0.185
TCF4 transcription factor 4 0.183
PTK2 PTK2 protein tyrosine kinase 2 0.178
ZFYVE9 zinc finger, FYVE domain containing 9 0.173
COL5A2 collagen, type V, alpha 2 0.169
LPXN leupaxin 0.161
GLIS2 GLIS family zinc finger 2 0.159
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.153
TGFB1 transforming growth factor, beta 1 0.148
RUNX1 runt-related transcription factor 1 0.147
GATA2 GATA binding protein 2 0.143
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.136
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.136
NRP1 neuropilin 1 0.135
NCK2 NCK adaptor protein 2 0.130
PDX1 pancreatic and duodenal homeobox 1 0.123
FN1 fibronectin 1 0.119
CXXC5 CXXC finger protein 5 0.114
FOXF2 forkhead box F2 0.113
BGN biglycan 0.110
AXIN1 axin 1 0.105
POSTN periostin, osteoblast specific factor 0.103
BTRC beta-transducin repeat containing 0.103
HIC1 hypermethylated in cancer 1 0.095
MYOD1 myogenic differentiation 1 0.094
WDYHV1 WDYHV motif containing 1 0.087
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.084
LIMS1 LIM and senescent cell antigen-like domains 1 0.081
FGF3 fibroblast growth factor 3 0.081
PAX8 paired box 8 0.080
ADAM12 ADAM metallopeptidase domain 12 0.079
COL11A1 collagen, type XI, alpha 1 0.075
SKI v-ski sarcoma viral oncogene homolog (avian) 0.073
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.073
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.071
TJP2 tight junction protein 2 (zona occludens 2) 0.069
EP300 E1A binding protein p300 0.069
MXRA5 matrix-remodelling associated 5 0.066
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.065
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.064
COL2A1 collagen, type II, alpha 1 0.064
DLL1 delta-like 1 (Drosophila) 0.063
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.062
CREBBP CREB binding protein 0.055
PHF21A PHD finger protein 21A 0.055
LOX lysyl oxidase 0.055
FOXD3 forkhead box D3 0.054
GSK3B glycogen synthase kinase 3 beta 0.054
SOX1 SRY (sex determining region Y)-box 1 0.053
HOXA1 homeobox A1 0.053
LRRN2 leucine rich repeat neuronal 2 0.053
S100B S100 calcium binding protein B 0.052
JUB jub, ajuba homolog (Xenopus laevis) 0.052
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col3a1 collagen, type III, alpha 1 0.531
Col5a1 collagen, type V, alpha 1 0.222
Bgn biglycan 0.131
Col1a2 collagen, type I, alpha 2 0.066
Col4a1 collagen, type IV, alpha 1 0.058
Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.047
Eln elastin 0.046
Rraga Ras-related GTP binding A 0.041
Lox lysyl oxidase 0.039
Col12a1 collagen, type XII, alpha 1 0.038
Lamc1 laminin, gamma 1 0.037
Col5a2 collagen, type V, alpha 2 0.036
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.033
Fbln2 fibulin 2 0.033
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.032
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.030
Slit3 slit homolog 3 (Drosophila) 0.027
Pmepa1 prostate transmembrane protein, androgen induced 1 0.026
Loxl1 lysyl oxidase-like 1 0.026
Bmp1 bone morphogenetic protein 1 0.025
C1d C1D nuclear receptor co-repressor 0.025
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.024
Fstl1 follistatin-like 1 0.022
Efnb1 ephrin B1 0.022
Tcf3 transcription factor 3 0.022
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.021
Ltbp4 latent transforming growth factor beta binding protein 4 0.021
Col18a1 collagen, type XVIII, alpha 1 0.020
Col14a1 collagen, type XIV, alpha 1 0.020
Timp2 TIMP metallopeptidase inhibitor 2 0.020
Flt1 FMS-related tyrosine kinase 1 0.020
Sox13 SRY (sex determining region Y)-box 13 0.020
Dchs1 dachsous 1 (Drosophila) 0.020
Fgfr1 Fibroblast growth factor receptor 1 0.018
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.017
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.017
Acta2 smooth muscle alpha-actin 0.017
Rest RE1-silencing transcription factor 0.017
Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 0.017
Fbn1 fibrillin 1 0.016
Tln1 talin 1 0.016
Met met proto-oncogene 0.016
Mmp23 matrix metallopeptidase 23 0.016
Col6a2 collagen, type VI, alpha 2 0.016
Elk3 ELK3, ETS-domain protein 0.016
Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.015
Col4a2 collagen, type IV, alpha 2 0.015
Pim1 pim-1 oncogene 0.015
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.014
Olfml2b olfactomedin-like 2B 0.014
Pcolce procollagen C-endopeptidase enhancer 0.014
Zyx zyxin 0.014
Nes nestin 0.014
Ece1 endothelin converting enzyme 1 0.014
Vapa VAMP (vesicle-associated membrane protein)-associated protein A 0.014
Col1a1 collagen, type I, alpha 1 0.014
Igfbp5 insulin-like growth factor binding protein 5 0.014
Fam38a family with sequence similarity 38, member A 0.014
Scgb1a1 secretoglobin, family 1A, member 1 (uteroglobin) 0.014
RGD1309188 similar to hypothetical protein BC011833 0.014
Has2 hyaluronan synthase 2 0.013
S1pr2 sphingosine-1-phosphate receptor 2 0.013
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.013
Figf c-fos induced growth factor 0.013
Uox urate oxidase 0.013
Tcfe2a transcription factor E2a 0.013
Mrfap1 Mof4 family associated protein 1 0.013
Crtap cartilage associated protein 0.013
Postn periostin, osteoblast specific factor 0.013
Stat6 signal transducer and activator of transcription 6 0.013
Onecut1 one cut homeobox 1 0.013
Mfap4 microfibrillar-associated protein 4 0.013
Ncor2 nuclear receptor co-repressor 2 0.013
Ier5l immediate early response 5-like 0.013
Wdr77 WD repeat domain 77 0.013
Fn1 fibronectin 1 0.013
Unc13d unc-13 homolog D (C. elegans) 0.013
Tcf4 transcription factor 4 0.012
Ecm1 extracellular matrix protein 1 0.012
Smad7 SMAD family member 7 0.012
Aebp1 AE binding protein 1 0.012
Tgfbr2 transforming growth factor, beta receptor II 0.012
Wisp2 WNT1 inducible signaling pathway protein 2 0.012
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.012
Lmcd1 LIM and cysteine-rich domains 1 0.012
Scarf2 scavenger receptor class F, member 2 0.012
Vash2 vasohibin 2 0.012
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.012
Sbk1 SH3-binding domain kinase 1 0.012
Fap fibroblast activation protein, alpha 0.012
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform 0.012
Pear1 platelet endothelial aggregation receptor 1 0.011
Fbxo22 F-box protein 22 0.011
Epas1 endothelial PAS domain protein 1 0.011
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.011
Gpc3 glypican 3 0.011
Col15a1 collagen, type XV, alpha 1 0.011
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.011
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.011
Col9a1 collagen, type IX, alpha 1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism