IMP
Process View
The network for 'closure of optic fissure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
closure of optic fissure
The closure of the temporary ventral gap in the optic cup that contributes to its shaping.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 1.000 | |
| Gli3 | GLI-Kruppel family member GLI3 | 1.000 | |
| Fgf8 | fibroblast growth factor 8 | 1.000 | |
| Pax3 | paired box gene 3 | 1.000 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 1.000 | |
| Bmp4 | bone morphogenetic protein 4 | 1.000 | |
| Foxc1 | forkhead box C1 | 1.000 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 1.000 | |
| Tcfap2a | transcription factor AP-2, alpha | 1.000 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 1.000 | |
| Pax2 | paired box gene 2 | 0.999 | |
| Tbx1 | T-box 1 | 0.999 | |
| Foxc2 | forkhead box C2 | 0.999 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.999 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.999 | |
| Pax6 | paired box gene 6 | 0.999 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.995 | |
| Msx1 | homeobox, msh-like 1 | 0.994 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.994 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.994 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.994 | |
| Prrx1 | paired related homeobox 1 | 0.993 | |
| Meox2 | mesenchyme homeobox 2 | 0.993 | |
| Smo | smoothened homolog (Drosophila) | 0.991 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.990 | |
| Jag1 | jagged 1 | 0.988 | |
| Rarg | retinoic acid receptor, gamma | 0.987 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.983 | |
| Fgf10 | fibroblast growth factor 10 | 0.980 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.980 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.975 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.972 | |
| Bmp7 | bone morphogenetic protein 7 | 0.970 | |
| Gata4 | GATA binding protein 4 | 0.966 | |
| Rarb | retinoic acid receptor, beta | 0.959 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.958 | |
| Ednra | endothelin receptor type A | 0.953 | |
| Efnb2 | ephrin B2 | 0.940 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.913 | |
| Foxg1 | forkhead box G1 | 0.910 | |
| Alx4 | aristaless-like homeobox 4 | 0.891 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.889 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.878 | |
| Vegfa | vascular endothelial growth factor A | 0.855 | |
| Fgf3 | fibroblast growth factor 3 | 0.843 | |
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.835 | |
| Rxra | retinoid X receptor alpha | 0.835 | |
| Hoxa1 | homeobox A1 | 0.825 | |
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.825 | |
| Sox9 | SRY-box containing gene 9 | 0.812 | |
| Dlx5 | distal-less homeobox 5 | 0.791 | |
| Nog | noggin | 0.756 | |
| Prrx2 | paired related homeobox 2 | 0.713 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.687 | |
| Msx2 | homeobox, msh-like 2 | 0.686 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.663 | |
| Tbx3 | T-box 3 | 0.648 | |
| Gsc | goosecoid homeobox | 0.646 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.627 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.603 | |
| Rara | retinoic acid receptor, alpha | 0.523 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.510 | |
| Hoxa3 | homeobox A3 | 0.510 | |
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.504 | |
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.469 | |
| Sox4 | SRY-box containing gene 4 | 0.444 | |
| Mesp1 | mesoderm posterior 1 | 0.443 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.396 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.390 | |
| Chrd | chordin | 0.364 | |
| Hoxa2 | homeobox A2 | 0.361 | |
| Nf1 | neurofibromatosis 1 | 0.360 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.339 | |
| Ntf3 | neurotrophin 3 | 0.337 | |
| Sox11 | SRY-box containing gene 11 | 0.337 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.316 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.300 | |
| Foxe3 | forkhead box E3 | 0.289 | |
| En1 | engrailed 1 | 0.284 | |
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.282 | |
| Gata3 | GATA binding protein 3 | 0.282 | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.276 | |
| Atoh7 | atonal homolog 7 (Drosophila) | 0.271 | |
| Sall3 | sal-like 3 (Drosophila) | 0.266 | |
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.261 | |
| Sox2 | SRY-box containing gene 2 | 0.252 | |
| Gata6 | GATA binding protein 6 | 0.230 | |
| Tbx2 | T-box 2 | 0.229 | |
| Six3 | sine oculis-related homeobox 3 homolog (Drosophila) | 0.213 | |
| Sall4 | sal-like 4 (Drosophila) | 0.210 | |
| Sox3 | SRY-box containing gene 3 | 0.201 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.200 | |
| Sox17 | SRY-box containing gene 17 | 0.195 | |
| Tcfap2c | transcription factor AP-2, gamma | 0.188 | |
| Ece1 | endothelin converting enzyme 1 | 0.169 | |
| Hspg2 | perlecan (heparan sulfate proteoglycan 2) | 0.164 | |
| Fgf4 | fibroblast growth factor 4 | 0.163 | |
| Acvr1 | activin A receptor, type 1 | 0.154 | |
| Alx3 | aristaless-like homeobox 3 | 0.154 | |
| Alx1 | ALX homeobox 1 | 0.153 |
Loading network...
Danio rerio
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| lmx1b.1 | LIM homeobox transcription factor 1, beta 1 | 0.763 | |
| lmx1b.2 | LIM homeobox transcription factor 1, beta 2 | 0.658 | |
| dlx2a | distal-less homeobox gene 2a | 0.408 | |
| olig2 | oligodendrocyte lineage transcription factor 2 | 0.319 | |
| osr1 | odd-skipped related 1 (Drosophila) | 0.290 | |
| lhx2b | LIM homeobox 2b | 0.257 | |
| otpa | orthopedia homolog a | 0.210 | |
| fgfr4 | fibroblast growth factor receptor 4 | 0.168 | |
| sp7 | Sp7 transcription factor | 0.158 | |
| sim1a | single-minded homolog 1a (Drosophila) | 0.146 | |
| nkx2.1a | NK2 homeobox 1a | 0.140 | |
| chrna2a | cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal) | 0.132 | |
| dmbx1a | diencephalon/mesencephalon homeobox 1a | 0.094 | |
| barhl2 | BarH-like 2 | 0.090 | |
| mecom | MDS1 and EVI1 complex locus | 0.087 | |
| osr2 | odd-skipped related 2 (Drosophila) | 0.084 | |
| pitx2 | paired-like homeodomain transcription factor 2 | 0.084 | |
| ascl1a | achaete-scute complex-like 1a (Drosophila) | 0.081 | |
| gata3 | GATA-binding protein 3 | 0.080 | |
| vax2 | ventral anterior homeobox 2 | 0.074 | |
| dla | deltaA | 0.070 | |
| meis2.1 | myeloid ecotropic viral integration site 2.1 | 0.068 | |
| etv2 | ets variant gene 2 | 0.063 | |
| otx2 | orthodenticle homolog 2 | 0.062 | |
| tbx5a | T-box 5a | 0.059 | |
| rx3 | retinal homeobox gene 3 | 0.058 | |
| olig4 | oligodendrocyte transcription factor 4 | 0.057 | |
| gata2a | GATA-binding protein 2a | 0.048 | |
| lhx6 | LIM homeobox 6 | 0.046 | |
| dlx2b | distal-less homeobox gene 2b | 0.046 | |
| arx | aristaless related homeobox | 0.043 | |
| pax6b | paired box gene 6b | 0.043 | |
| prl | prolactin | 0.037 | |
| six3b | sine oculis homeobox homolog 3b | 0.034 | |
| eya1 | eyes absent homolog 1 | 0.034 | |
| fsta | follistatin a | 0.034 | |
| six3a | sine oculis homeobox homolog 3a | 0.033 | |
| gbx2 | gastrulation brain homeo box 2 | 0.031 | |
| shhb | sonic hedgehog b | 0.031 | |
| vax1 | ventral anterior homeobox 1 | 0.030 | |
| neurog1 | neurogenin 1 | 0.030 | |
| notch1a | notch homolog 1a | 0.030 | |
| foxc1b | forkhead box C1b | 0.029 | |
| six4b | sine oculis homeobox homolog 4b | 0.027 | |
| oprk1 | opioid receptor, kappa 1 | 0.026 | |
| prdm1a | PR domain containing 1a, with ZNF domain | 0.026 | |
| otpb | orthopedia homolog b | 0.026 | |
| tfap2c | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.025 | |
| atoh7 | atonal homolog 7 | 0.024 | |
| dld | deltaD | 0.024 | |
| oprd1b | opioid receptor, delta 1b | 0.022 | |
| dlx1a | distal-less homeobox gene 1a | 0.022 | |
| dlx4a | distal-less homeobox gene 4a | 0.020 | |
| mab21l2 | mab-21-like 2 | 0.020 | |
| hhip | hedgehog interacting protein | 0.020 | |
| fgf10a | fibroblast growth factor 10a | 0.019 | |
| tac1 | tachykinin 1 | 0.019 | |
| lhx5 | LIM homeobox 5 | 0.019 | |
| pax8 | paired box gene 8 | 0.019 | |
| hoxb5a | homeo box B5a | 0.018 | |
| dlx6a | distal-less homeobox gene 6a | 0.017 | |
| slc6a6 | solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | 0.017 | |
| six2a | sine oculis-related homeobox 2a | 0.017 | |
| foxg1a | forkhead box G1a | 0.017 | |
| lhx3 | LIM homeobox 3 | 0.017 | |
| itgav | integrin, alpha V | 0.016 | |
| dbx1a | developing brain homeobox 1a | 0.016 | |
| foxn4 | forkhead box N4 | 0.015 | |
| lhx8a | LIM homeobox 8a | 0.015 | |
| hand2 | heart and neural crest derivatives expressed transcript 2 | 0.015 | |
| her15.1 | hairy and enhancer of split-related 15.1 | 0.014 | |
| fezf2 | FEZ family zinc finger 2 | 0.014 | |
| foxe3 | forkhead box E3 | 0.014 | |
| tagln2 | transgelin 2 | 0.014 | |
| adcyap1r1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | 0.013 | |
| irx1b | iroquois homeobox protein 1, b | 0.013 | |
| chrna6 | cholinergic receptor, nicotinic, alpha 6 | 0.013 | |
| insm1b | insulinoma-associated 1b | 0.013 | |
| znf503 | zinc finger protein 503 | 0.013 | |
| neurod4 | neurogenic differentiation 4 | 0.013 | |
| tph2 | tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) | 0.013 | |
| tbx2b | T-box 2b | 0.012 | |
| tfap2a | transcription factor AP-2 alpha | 0.012 | |
| mnx1 | motor neuron and pancreas homeobox 1 | 0.012 | |
| meis3 | myeloid ecotropic viral integration site 3 | 0.012 | |
| meis2.2 | myeloid ecotropic viral integration site 2.2 | 0.011 | |
| pcdh10b | protocadherin 10b | 0.011 | |
| six1b | sine oculis homeobox homolog 1b | 0.011 | |
| emx3 | empty spiracles homeobox 3 | 0.011 | |
| elavl3 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) | 0.011 | |
| nkx1.2la | NK1 transcription factor related 2-like,a | 0.011 | |
| cdh6 | cadherin 6 | 0.010 | |
| otx1a | orthodenticle homolog 1a | 0.010 | |
| sox21b | SRY-box containing gene 21 b | 0.010 |