The network for 'intestinal epithelial structure maintenance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intestinal epithelial structure maintenance

A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.

Mus musculus
Name Description Probability Func Analog Organism
Isl1 ISL1 transcription factor, LIM/homeodomain 0.966
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.951
Pax3 paired box gene 3 0.882
Otx2 orthodenticle homolog 2 (Drosophila) 0.807
Shh sonic hedgehog 0.760
Pax6 paired box gene 6 0.756
Col1a1 collagen, type I, alpha 1 0.688
Meox2 mesenchyme homeobox 2 0.671
Gli3 GLI-Kruppel family member GLI3 0.629
Tlr4 toll-like receptor 4 0.626
Hes1 hairy and enhancer of split 1 (Drosophila) 0.622
Trp53 transformation related protein 53 0.604
Raver2 ribonucleoprotein, PTB-binding 2 0.601
Gnrh1 gonadotropin releasing hormone 1 0.576
Gli2 GLI-Kruppel family member GLI2 0.574
Prrx1 paired related homeobox 1 0.556
Sox11 SRY-box containing gene 11 0.502
Hesx1 homeobox gene expressed in ES cells 0.501
Ptf1a pancreas specific transcription factor, 1a 0.477
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.435
Mecom MDS1 and EVI1 complex locus 0.401
Onecut1 one cut domain, family member 1 0.386
Gata4 GATA binding protein 4 0.363
Hic1 hypermethylated in cancer 1 0.324
Neurod1 neurogenic differentiation 1 0.321
Prrx2 paired related homeobox 2 0.305
Ebf3 early B-cell factor 3 0.304
Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.295
Aplnr apelin receptor 0.273
Sox4 SRY-box containing gene 4 0.267
Efna2 ephrin A2 0.264
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.255
Ntf3 neurotrophin 3 0.252
Nf1 neurofibromatosis 1 0.250
Hoxd13 homeobox D13 0.247
Cdh5 cadherin 5 0.236
Zeb1 zinc finger E-box binding homeobox 1 0.235
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.234
Hbb-bh1 hemoglobin Z, beta-like embryonic chain 0.233
Runx2 runt related transcription factor 2 0.221
Ccr2 chemokine (C-C motif) receptor 2 0.213
Gata1 GATA binding protein 1 0.212
Nkx3-2 NK3 homeobox 2 0.210
Cdx2 caudal type homeobox 2 0.209
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.207
Hoxa2 homeobox A2 0.205
Pten phosphatase and tensin homolog 0.191
Alx3 aristaless-like homeobox 3 0.191
Fgf4 fibroblast growth factor 4 0.184
Fhl3 four and a half LIM domains 3 0.173
Emx1 empty spiracles homolog 1 (Drosophila) 0.169
Galr1 galanin receptor 1 0.167
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.161
Pitx2 paired-like homeodomain transcription factor 2 0.159
Tcf21 transcription factor 21 0.158
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.157
Msx1 homeobox, msh-like 1 0.157
En1 engrailed 1 0.155
Bcl6b B-cell CLL/lymphoma 6, member B 0.155
Hand1 heart and neural crest derivatives expressed transcript 1 0.153
Alx4 aristaless-like homeobox 4 0.151
Gdf11 growth differentiation factor 11 0.148
Myd88 myeloid differentiation primary response gene 88 0.145
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.143
Tcf3 transcription factor 3 0.141
Tcfap2a transcription factor AP-2, alpha 0.138
Lep leptin 0.132
Pou3f1 POU domain, class 3, transcription factor 1 0.131
Sfrp2 secreted frizzled-related protein 2 0.130
Gpr50 G-protein-coupled receptor 50 0.129
Hhex hematopoietically expressed homeobox 0.128
Eda ectodysplasin-A 0.126
Kiss1 KiSS-1 metastasis-suppressor 0.119
Tgfb2 transforming growth factor, beta 2 0.118
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.113
Aim2 absent in melanoma 2 0.112
Raver1 ribonucleoprotein, PTB-binding 1 0.112
Prph2 peripherin 2 0.111
Sall3 sal-like 3 (Drosophila) 0.111
Cldn5 claudin 5 0.110
Has2 hyaluronan synthase 2 0.110
Foxd2 forkhead box D2 0.107
Meox1 mesenchyme homeobox 1 0.104
Arx aristaless related homeobox 0.103
Ticam1 toll-like receptor adaptor molecule 1 0.103
Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex 0.102
Alx1 ALX homeobox 1 0.102
Nhlh1 nescient helix loop helix 1 0.100
Efs embryonal Fyn-associated substrate 0.099
Lhx3 LIM homeobox protein 3 0.099
Gja4 gap junction protein, alpha 4 0.097
Kcne1l potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene 0.097
Gata6 GATA binding protein 6 0.097
Lhx9 LIM homeobox protein 9 0.092
Tead4 TEA domain family member 4 0.092
Neurog3 neurogenin 3 0.089
Bmp2 bone morphogenetic protein 2 0.089
Sox3 SRY-box containing gene 3 0.086
Fgf17 fibroblast growth factor 17 0.086
Pdx1 pancreatic and duodenal homeobox 1 0.084
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ptch2 patched 2 0.674
sox9b SRY-box containing gene 9b 0.520
sox10 SRY-box containing gene 10 0.059
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.055
gdf6a growth differentiation factor 6a 0.052
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.051
rag1 recombination activating gene 1 0.048
erf Ets2 repressor factor 0.043
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.043
hhip hedgehog interacting protein 0.041
notch3 notch homolog 3 0.039
foxi1 forkhead box I1 0.038
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.034
ptch1 patched 1 0.031
nr2f6a nuclear receptor subfamily 2, group F, member 6a 0.030
apc adenomatosis polyposis coli 0.028
runx1 runt-related transcription factor 1 0.026
tbr1b T-box, brain, 1b 0.025
tcf7l1b transcription factor 7-like 1b (T-cell specific, HMG-box) 0.024
ocrl oculocerebrorenal syndrome of Lowe 0.021
neurog1 neurogenin 1 0.020
clint1 clathrin interactor 1 0.020
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.020
pak2a p21 (CDKN1A)-activated kinase 2a 0.019
zgc:64114 zgc:64114 0.019
zgc:64040 zgc:64040 0.018
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.017
tp53 tumor protein p53 0.017
sufu suppressor of fused homolog (Drosophila) 0.016
axin1 axin 1 0.015
sox21a SRY-box containing gene 21a 0.015
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.014
furina furin (paired basic amino acid cleaving enzyme) a 0.014
ahctf1 AT hook containing transcription factor 1 0.014
ptf1a pancreas specific transcription factor, 1a 0.013
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.013
chn1 chimerin (chimaerin) 1 0.013
rp2 retinitis pigmentosa 2 (X-linked recessive) 0.012
or103-1 odorant receptor, family C, subfamily 103, member 1 0.011
insrb insulin receptor b 0.011
zgc:109736 zgc:109736 0.011
slc43a1a solute carrier family 43, member 1a 0.011
psen1 presenilin 1 0.011
stil TAL1 (SCL) interrupting locus 0.011
si:ch73-60i13.2 si:ch73-60i13.2 0.011
si:ch211-198a12.6 si:ch211-198a12.6 0.010
tsc2 tuberous sclerosis 2 0.010
vangl2 vang-like 2 (van gogh, Drosophila) 0.010
srsf4 serine/arginine-rich splicing factor 4 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ena enabled 0.146
Smr Smrter 0.085
Pcl Polycomblike 0.029
Akt1 CG4006 gene product from transcript CG4006-RA 0.028
hipk homeodomain interacting protein kinase 0.016
nej nejire 0.015
Gef26 CG9491 gene product from transcript CG9491-RB 0.014
simj simjang 0.013
sfl sulfateless 0.012
kibra kibra ortholog 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
LY96 lymphocyte antigen 96 0.069
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.037
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.032
TICAM2 toll-like receptor adaptor molecule 2 0.027
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.023
MYD88 myeloid differentiation primary response gene (88) 0.023
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.018
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.014
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.014
JUP junction plakoglobin 0.014
PCBP1 poly(rC) binding protein 1 0.013
TNIK TRAF2 and NCK interacting kinase 0.012
PSEN1 presenilin 1 0.012
PTBP2 polypyrimidine tract binding protein 2 0.012
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.011
IRAK2 interleukin-1 receptor-associated kinase 2 0.011
HIC1 hypermethylated in cancer 1 0.011
TCF4 transcription factor 4 0.011
GLIS2 GLIS family zinc finger 2 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100360491 60S ribosomal protein L13-like 0.024
Tceb2 transcription elongation factor B (SIII), polypeptide 2 0.023
Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.021
Rpsa ribosomal protein SA 0.020
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.017
Rpl19 ribosomal protein L19 0.014
Rps19 ribosomal protein S19 0.014
Rps6 ribosomal protein S6 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism