The network for 'negative regulation of muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of muscle cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.929
Pitx2 paired-like homeodomain transcription factor 2 0.925
Fgfr2 fibroblast growth factor receptor 2 0.899
Gli3 GLI-Kruppel family member GLI3 0.870
Mef2d myocyte enhancer factor 2D 0.834
Pax3 paired box gene 3 0.817
Runx2 runt related transcription factor 2 0.808
Tcfap2a transcription factor AP-2, alpha 0.737
Hand1 heart and neural crest derivatives expressed transcript 1 0.682
Foxc1 forkhead box C1 0.662
Bmp4 bone morphogenetic protein 4 0.631
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.573
Jarid2 jumonji, AT rich interactive domain 2 0.525
Ccl12 chemokine (C-C motif) ligand 12 0.522
Hand2 heart and neural crest derivatives expressed transcript 2 0.507
Smo smoothened homolog (Drosophila) 0.501
Fgfr1 fibroblast growth factor receptor 1 0.428
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.413
Otx2 orthodenticle homolog 2 (Drosophila) 0.411
Nodal nodal 0.392
Ccl7 chemokine (C-C motif) ligand 7 0.371
Fgf8 fibroblast growth factor 8 0.370
Notch1 Notch gene homolog 1 (Drosophila) 0.339
Cxcl13 chemokine (C-X-C motif) ligand 13 0.332
Ctnnb1 catenin (cadherin associated protein), beta 1 0.317
Meox2 mesenchyme homeobox 2 0.307
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.283
Tcfap2c transcription factor AP-2, gamma 0.277
Sox9 SRY-box containing gene 9 0.277
Hes1 hairy and enhancer of split 1 (Drosophila) 0.273
Hoxd13 homeobox D13 0.270
Tgfb2 transforming growth factor, beta 2 0.269
Cd40 CD40 antigen 0.257
Isl1 ISL1 transcription factor, LIM/homeodomain 0.241
Ltb lymphotoxin B 0.229
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.216
Cxcl2 chemokine (C-X-C motif) ligand 2 0.197
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.197
Il1b interleukin 1 beta 0.196
Il7 interleukin 7 0.194
Ccl2 chemokine (C-C motif) ligand 2 0.192
Ifng interferon gamma 0.188
Prl7d1 prolactin family 7, subfamily d, member 1 0.188
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.185
Prrx2 paired related homeobox 2 0.174
Csf3 colony stimulating factor 3 (granulocyte) 0.173
Ccl8 chemokine (C-C motif) ligand 8 0.170
Tbx1 T-box 1 0.165
Raver2 ribonucleoprotein, PTB-binding 2 0.165
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.163
Tbx3 T-box 3 0.157
Hbb-bh1 hemoglobin Z, beta-like embryonic chain 0.155
Lta lymphotoxin A 0.149
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.142
Tcf3 transcription factor 3 0.140
Tbx4 T-box 4 0.139
Cxcl1 chemokine (C-X-C motif) ligand 1 0.139
Sox4 SRY-box containing gene 4 0.138
Irx1 Iroquois related homeobox 1 (Drosophila) 0.137
Pitx1 paired-like homeodomain transcription factor 1 0.137
Mx2 myxovirus (influenza virus) resistance 2 0.131
Ccl4 chemokine (C-C motif) ligand 4 0.129
Ccl3 chemokine (C-C motif) ligand 3 0.128
Bmp7 bone morphogenetic protein 7 0.127
Il1rn interleukin 1 receptor antagonist 0.125
Prl7a1 prolactin family 7, subfamily a, member 1 0.124
Socs1 suppressor of cytokine signaling 1 0.123
Vegfa vascular endothelial growth factor A 0.121
Gja1 gap junction protein, alpha 1 0.120
Prrx1 paired related homeobox 1 0.112
Chd7 chromodomain helicase DNA binding protein 7 0.111
Zic3 zinc finger protein of the cerebellum 3 0.106
Saa3 serum amyloid A 3 0.103
Dll1 delta-like 1 (Drosophila) 0.102
Irg1 immunoresponsive gene 1 0.101
Nf1 neurofibromatosis 1 0.101
Pkd1 polycystic kidney disease 1 homolog 0.099
Psg19 pregnancy specific glycoprotein 19 0.098
Sox2 SRY-box containing gene 2 0.096
Lef1 lymphoid enhancer binding factor 1 0.090
Csf1 colony stimulating factor 1 (macrophage) 0.088
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.088
Irx2 Iroquois related homeobox 2 (Drosophila) 0.088
Psen1 presenilin 1 0.088
Psg17 pregnancy specific glycoprotein 17 0.087
Ccl22 chemokine (C-C motif) ligand 22 0.084
Sox17 SRY-box containing gene 17 0.083
Jag1 jagged 1 0.082
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.081
Sox11 SRY-box containing gene 11 0.080
Tnf tumor necrosis factor 0.080
Tpbpa trophoblast specific protein alpha 0.078
Clec4d C-type lectin domain family 4, member d 0.075
Tbx5 T-box 5 0.075
Mmp3 matrix metallopeptidase 3 0.073
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.072
Cd14 CD14 antigen 0.072
Ceacam11 carcinoembryonic antigen-related cell adhesion molecule 11 0.071
Mmp12 matrix metallopeptidase 12 0.071
Selp selectin, platelet 0.070
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.988
bmp4 bone morphogenetic protein 4 0.896
col2a1a collagen type II, alpha-1a 0.315
sox9b SRY-box containing gene 9b 0.238
has2 hyaluronan synthase 2 0.233
dlx3b distal-less homeobox gene 3b 0.190
tbx5a T-box 5a 0.164
tgfb3 transforming growth factor, beta 3 0.133
tbx20 T-box 20 0.101
bmp2a bone morphogenetic protein 2a 0.090
tbx2b T-box 2b 0.088
sox9a SRY-box containing gene 9a 0.085
prdm1a PR domain containing 1a, with ZNF domain 0.078
zgc:111821 zgc:111821 0.076
zgc:64040 zgc:64040 0.076
chd chordin 0.073
slc43a1a solute carrier family 43, member 1a 0.066
rasl11b RAS-like, family 11, member B 0.066
cdh5 cadherin 5 0.065
rtcd1 RNA terminal phosphate cyclase domain 1 0.065
cxcr4a chemokine (C-X-C motif) receptor 4a 0.060
dlx5a distal-less homeobox gene 5a 0.059
gdf6a growth differentiation factor 6a 0.056
kbtbd10b kelch repeat and BTB (POZ) domain containing 10b 0.055
jup junction plakoglobin 0.052
nkx3.2 NK3 homeobox 2 0.050
sp7 Sp7 transcription factor 0.047
rarga retinoic acid receptor gamma a 0.045
ctsl1b cathepsin L, 1 b 0.044
tfec transcription factor EC 0.041
runx2a runt-related transcription factor 2a 0.041
zgc:158604 zgc:158604 0.040
celsr1a cadherin EGF LAG seven-pass G-type receptor 1a 0.039
msxe muscle segment homeobox E 0.039
si:ch211-173b8.2 si:ch211-173b8.2 0.039
fgf8a fibroblast growth factor 8 a 0.039
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.038
foxa2 forkhead box A2 0.038
dlx2a distal-less homeobox gene 2a 0.037
ptbp1a polypyrimidine tract binding protein 1a 0.037
foxa3 forkhead box A3 0.037
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.036
nr2f6a nuclear receptor subfamily 2, group F, member 6a 0.036
skia nuclear oncoprotein skia 0.035
cx43.4 connexin 43.4 0.034
spry4 sprouty (Drosophila) homolog 4 0.034
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.034
notch1b notch homolog 1b 0.034
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.033
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.033
fzd8a frizzled homolog 8a 0.033
itga3b integrin, alpha 3b 0.033
msxb muscle segment homeobox B 0.033
shisa2 shisa homolog 2 (Xenopus laevis) 0.031
fgf10a fibroblast growth factor 10a 0.031
mbtps1 membrane-bound transcription factor protease, site 1 0.031
mef2a myocyte enhancer factor 2a 0.030
osr1 odd-skipped related 1 (Drosophila) 0.030
apln apelin 0.030
hoxc6a homeo box C6a 0.029
tp63 tumor protein p63 0.029
zgc:172136 zgc:172136 0.028
cxc64 CXC chemokine 64 0.027
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.027
map1lc3b microtubule-associated protein 1 light chain 3 beta 0.026
zgc:77744 zgc:77744 0.026
fgf3 fibroblast growth factor 3 0.025
runx2b runt-related transcription factor 2b 0.025
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.025
wu:fi04f09 wu:fi04f09 0.025
msxc muscle segment homeobox C 0.024
snai2 snail homolog 2 (Drosophila) 0.024
si:dkey-222f8.3 si:dkey-222f8.3 0.024
zgc:64114 zgc:64114 0.024
dlx4a distal-less homeobox gene 4a 0.024
gpr126 G protein-coupled receptor 126 0.024
klf2a Kruppel-like factor 2a 0.023
cxc46 CXC chemokine 46 0.023
pak2a p21 (CDKN1A)-activated kinase 2a 0.023
tbx5b T-box 5b 0.022
wt1a wilms tumor 1a 0.022
otx1a orthodenticle homolog 1a 0.022
setd5 SET domain containing 5 0.021
pcdh8 protocadherin 8 0.021
epha2 eph receptor A2 0.020
micall2a mical-like 2a 0.020
lmna lamin A 0.020
nkx2.3 NK2 transcription factor related 3 0.020
id:ibd2573 id:ibd2573 0.020
antxr1 anthrax toxin receptor 1 0.019
cdh1 cadherin 1, epithelial 0.019
vasp vasodilator-stimulated phosphoprotein 0.019
btg1 B-cell translocation gene 1 0.019
pitx2 paired-like homeodomain transcription factor 2 0.019
prkcz protein kinase C, zeta 0.019
mapkapk2a mitogen-activated protein kinase-activated protein kinase 2a 0.019
atp2a2b ATPase, Ca++ transporting, cardiac muscle, slow twitch 2b 0.019
fam76b family with sequence similarity 76, member B 0.019
dnmt8 DNA (cytosine-5-)-methyltransferase 8 0.019
mmp9 matrix metalloproteinase 9 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 1.000
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.999
JAG1 jagged 1 0.997
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.937
BMPR1A bone morphogenetic protein receptor, type IA 0.696
PSG6 pregnancy specific beta-1-glycoprotein 6 0.621
MEF2C myocyte enhancer factor 2C 0.619
FSTL1 follistatin-like 1 0.585
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.558
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.547
NOTCH1 notch 1 0.536
NOTCH3 notch 3 0.529
CREBBP CREB binding protein 0.502
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.451
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.382
AR androgen receptor 0.342
NCOR1 nuclear receptor corepressor 1 0.317
FAS Fas (TNF receptor superfamily, member 6) 0.272
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.257
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.225
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.215
MAML1 mastermind-like 1 (Drosophila) 0.208
PSG3 pregnancy specific beta-1-glycoprotein 3 0.207
PSG9 pregnancy specific beta-1-glycoprotein 9 0.194
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.169
BCL6 B-cell CLL/lymphoma 6 0.144
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.111
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.092
DLL1 delta-like 1 (Drosophila) 0.091
NCOR2 nuclear receptor corepressor 2 0.089
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.083
HDAC4 histone deacetylase 4 0.076
EED embryonic ectoderm development 0.074
MYOD1 myogenic differentiation 1 0.073
LRP6 low density lipoprotein receptor-related protein 6 0.073
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.070
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.069
DBP D site of albumin promoter (albumin D-box) binding protein 0.064
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.058
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.053
PAX8 paired box 8 0.051
FHL2 four and a half LIM domains 2 0.048
TRIM63 tripartite motif containing 63 0.048
FOXP3 forkhead box P3 0.048
ENG endoglin 0.048
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.045
PRKD2 protein kinase D2 0.045
ATF3 activating transcription factor 3 0.043
FADD Fas (TNFRSF6)-associated via death domain 0.041
JAG2 jagged 2 0.040
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.039
SMAD1 SMAD family member 1 0.039
GATA4 GATA binding protein 4 0.039
TTN titin 0.037
BMP2 bone morphogenetic protein 2 0.036
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.036
ZFYVE9 zinc finger, FYVE domain containing 9 0.035
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.034
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.030
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.029
PSG4 pregnancy specific beta-1-glycoprotein 4 0.027
NEB nebulin 0.027
ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.027
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.027
PCBP1 poly(rC) binding protein 1 0.024
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.024
PSG5 pregnancy specific beta-1-glycoprotein 5 0.023
AXIN1 axin 1 0.021
KAT2B K(lysine) acetyltransferase 2B 0.021
MSX2 msh homeobox 2 0.021
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.021
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.019
DPP4 dipeptidyl-peptidase 4 0.019
NOTCH2NL notch 2 N-terminal like 0.019
TGFB3 transforming growth factor, beta 3 0.018
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.018
TMOD3 tropomodulin 3 (ubiquitous) 0.017
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 0.017
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.017
FASLG Fas ligand (TNF superfamily, member 6) 0.017
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.017
PSG2 pregnancy specific beta-1-glycoprotein 2 0.016
MEF2A myocyte enhancer factor 2A 0.016
SFN stratifin 0.016
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.015
GFI1B growth factor independent 1B transcription repressor 0.015
SIGLEC7 sialic acid binding Ig-like lectin 7 0.014
HMGA1 high mobility group AT-hook 1 0.014
CXCL11 chemokine (C-X-C motif) ligand 11 0.014
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.014
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.014
HDAC3 histone deacetylase 3 0.013
PPARA peroxisome proliferator-activated receptor alpha 0.013
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.013
ELK1 ELK1, member of ETS oncogene family 0.013
BMP4 bone morphogenetic protein 4 0.013
IRS2 insulin receptor substrate 2 0.013
RAB8B RAB8B, member RAS oncogene family 0.012
FGF5 fibroblast growth factor 5 0.012
PAX3 paired box 3 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism