The network for 'retina layer formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

retina layer formation

The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.884
Neurod1 neurogenic differentiation 1 0.869
Pax6 paired box gene 6 0.854
Otx2 orthodenticle homolog 2 (Drosophila) 0.794
Pitx2 paired-like homeodomain transcription factor 2 0.770
Neurog2 neurogenin 2 0.534
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.417
Isl1 ISL1 transcription factor, LIM/homeodomain 0.394
Neurod4 neurogenic differentiation 4 0.317
Pax3 paired box gene 3 0.312
Gbx2 gastrulation brain homeobox 2 0.267
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.234
Foxc1 forkhead box C1 0.183
Vegfa vascular endothelial growth factor A 0.174
Gli3 GLI-Kruppel family member GLI3 0.154
Fgf8 fibroblast growth factor 8 0.148
Hand2 heart and neural crest derivatives expressed transcript 2 0.147
Sox11 SRY-box containing gene 11 0.145
Tcfap2a transcription factor AP-2, alpha 0.144
Dnmt3a DNA methyltransferase 3A 0.130
Emx2 empty spiracles homolog 2 (Drosophila) 0.120
Pou4f2 POU domain, class 4, transcription factor 2 0.112
Atoh7 atonal homolog 7 (Drosophila) 0.111
Fgfr2 fibroblast growth factor receptor 2 0.107
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.101
Bmp4 bone morphogenetic protein 4 0.100
Hoxd13 homeobox D13 0.098
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.097
Lhx9 LIM homeobox protein 9 0.093
Gata4 GATA binding protein 4 0.093
Foxc2 forkhead box C2 0.091
Ptf1a pancreas specific transcription factor, 1a 0.087
Plxnd1 plexin D1 0.084
Hand1 heart and neural crest derivatives expressed transcript 1 0.082
Kiss1 KiSS-1 metastasis-suppressor 0.080
Neurog3 neurogenin 3 0.072
Onecut1 one cut domain, family member 1 0.071
Pitx1 paired-like homeodomain transcription factor 1 0.069
Lhx3 LIM homeobox protein 3 0.069
Insm1 insulinoma-associated 1 0.069
Msx1 homeobox, msh-like 1 0.065
Lhx1 LIM homeobox protein 1 0.063
Hoxa1 homeobox A1 0.058
Msx2 homeobox, msh-like 2 0.055
Gdnf glial cell line derived neurotrophic factor 0.054
En1 engrailed 1 0.054
Dab1 disabled homolog 1 (Drosophila) 0.054
Mdm2 transformed mouse 3T3 cell double minute 2 0.051
Sox2 SRY-box containing gene 2 0.047
Pax2 paired box gene 2 0.045
Tctn1 tectonic family member 1 0.042
Nhlh1 nescient helix loop helix 1 0.040
Mks1 Meckel syndrome, type 1 0.039
Hoxd11 homeobox D11 0.038
Zic1 zinc finger protein of the cerebellum 1 0.037
Ret ret proto-oncogene 0.036
Prph2 peripherin 2 0.035
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.034
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.034
Tlx3 T-cell leukemia, homeobox 3 0.034
Mab21l2 mab-21-like 2 (C. elegans) 0.034
Tbx3 T-box 3 0.034
Bmpr1a bone morphogenetic protein receptor, type 1A 0.033
Arx aristaless related homeobox 0.033
Lhx4 LIM homeobox protein 4 0.033
Pdx1 pancreatic and duodenal homeobox 1 0.030
Acvr1 activin A receptor, type 1 0.030
Tbx1 T-box 1 0.028
Hoxa11 homeobox A11 0.028
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.027
Gdf11 growth differentiation factor 11 0.025
Sox9 SRY-box containing gene 9 0.025
Mecom MDS1 and EVI1 complex locus 0.025
Fgfr3 fibroblast growth factor receptor 3 0.025
Srrm4 serine/arginine repetitive matrix 4 0.025
Foxg1 forkhead box G1 0.025
Tal1 T-cell acute lymphocytic leukemia 1 0.025
Meox2 mesenchyme homeobox 2 0.024
Prox1 prospero-related homeobox 1 0.023
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.023
Sox3 SRY-box containing gene 3 0.023
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.023
Neurog1 neurogenin 1 0.023
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.023
T brachyury 0.022
Pou4f3 POU domain, class 4, transcription factor 3 0.022
Pou3f3 POU domain, class 3, transcription factor 3 0.022
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.022
Sim2 single-minded homolog 2 (Drosophila) 0.022
Sall3 sal-like 3 (Drosophila) 0.022
Mmp24 matrix metallopeptidase 24 0.022
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.022
Fgf9 fibroblast growth factor 9 0.021
Phox2b paired-like homeobox 2b 0.021
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.021
Runx2 runt related transcription factor 2 0.021
Foxh1 forkhead box H1 0.021
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.021
Msi1 Musashi homolog 1(Drosophila) 0.021
Pkd1 polycystic kidney disease 1 homolog 0.020
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
atoh7 atonal homolog 7 0.990
pax6b paired box gene 6b 0.989
rx3 retinal homeobox gene 3 0.967
otx2 orthodenticle homolog 2 0.915
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.911
rx2 retinal homeobox gene 2 0.900
ptf1a pancreas specific transcription factor, 1a 0.885
met met proto-oncogene (hepatocyte growth factor receptor) 0.865
pax2a paired box gene 2a 0.814
tfap2a transcription factor AP-2 alpha 0.810
ahctf1 AT hook containing transcription factor 1 0.804
atoh1b atonal homolog 1b 0.799
cdh2 cadherin 2, neuronal 0.744
fgf8a fibroblast growth factor 8 a 0.729
gdf6a growth differentiation factor 6a 0.711
isl1 islet1 0.699
pax6a paired box gene 6a 0.696
irx1a iroquois homeobox protein 1, a 0.692
dctn1a dynactin 1a 0.674
mych myelocytomatosis oncogene homolog 0.577
gbx2 gastrulation brain homeo box 2 0.576
mab21l2 mab-21-like 2 0.558
vsx1 visual system homeobox 1 homolog, chx10-like 0.546
sox9a SRY-box containing gene 9a 0.527
bhlhe22 basic helix-loop-helix family, member e22 0.523
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.495
ahi1 Abelson helper integration site 1 0.494
irx7 iroquois homeobox protein 7 0.476
neurod4 neurogenic differentiation 4 0.469
six3b sine oculis homeobox homolog 3b 0.468
dnmt3 DNA (cytosine-5-)-methyltransferase 3 0.466
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.461
stil TAL1 (SCL) interrupting locus 0.451
zgc:158643 zgc:158643 0.451
sox11a SRY-box containing gene 11a 0.441
neurod neurogenic differentiation 0.414
ascl1a achaete-scute complex-like 1a (Drosophila) 0.410
irx1b iroquois homeobox protein 1, b 0.361
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.360
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.333
gc3 guanylyl cyclase 3 0.314
otx1b orthodenticle homolog 1b 0.312
crb2a crumbs homolog 2a 0.306
pxn paxillin 0.301
zgc:162213 zgc:162213 0.299
irx4b iroquois homeobox protein 4b 0.288
atoh1a atonal homolog 1a 0.285
fezf2 FEZ family zinc finger 2 0.283
rx1 retinal homeobox gene 1 0.281
foxn4 forkhead box N4 0.271
eng2a engrailed 2a 0.262
barhl2 BarH-like 2 0.258
lhx2b LIM homeobox 2b 0.257
dbx1a developing brain homeobox 1a 0.255
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.247
meis2.2 myeloid ecotropic viral integration site 2.2 0.240
msgn1 mesogenin 1 0.237
foxi1 forkhead box I1 0.237
tbx24 T-box 24 0.230
gdnf glial cell derived neurotrophic factor 0.213
lhx1a LIM homeobox 1a 0.212
chaf1b chromatin assembly factor 1, subunit B 0.210
six3a sine oculis homeobox homolog 3a 0.209
otpb orthopedia homolog b 0.208
lmo2 LIM domain only 2 (rhombotin-like 1) 0.200
lhx1b LIM homeobox 1b 0.186
tbx2b T-box 2b 0.182
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.170
vsx2 visual system homeobox 2 0.158
her1 hairy-related 1 0.156
her7 hairy and enhancer of split related-7 0.154
gbx1 gastrulation brain homeobox 1 0.153
irx4a iroquois homeobox protein 4a 0.145
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.144
dmrt3a doublesex and mab-3 related transcription factor 3a 0.142
dla deltaA 0.140
tpp1 tripeptidyl peptidase I 0.139
crx cone-rod homeobox 0.135
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.133
otx5 orthodenticle homolog 5 0.132
pou3f2 POU class 3 homeobox 2 0.125
im:7138239 im:7138239 0.122
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.122
clrn1 clarin 1 0.121
olfm2 olfactomedin 2 0.119
rb1 retinoblastoma 1 0.116
pcna proliferating cell nuclear antigen 0.115
olig2 oligodendrocyte lineage transcription factor 2 0.113
neurod6a neurogenic differentiation 6a 0.109
dnmt6 DNA (cytosine-5-)-methyltransferase 6 0.103
eng2b engrailed 2b 0.101
her3 hairy-related 3 0.094
sox2 SRY-box containing gene 2 0.094
large like-glycosyltransferase 0.094
pcdh8 protocadherin 8 0.093
slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 0.092
tbx16 T-box gene 16 0.089
her8a hairy-related 8a 0.086
prom1a prominin 1a 0.084
atoh1c atonal homolog 1c 0.083
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.915
DCAF7 DDB1 and CUL4 associated factor 7 0.811
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.523
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.520
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.397
RB1 retinoblastoma 1 0.338
EP300 E1A binding protein p300 0.326
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.298
RUNX1 runt-related transcription factor 1 0.271
DAXX death-domain associated protein 0.218
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.195
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.172
MECP2 methyl CpG binding protein 2 (Rett syndrome) 0.131
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.125
BCAR1 breast cancer anti-estrogen resistance 1 0.116
ELK1 ELK1, member of ETS oncogene family 0.096
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.096
HDAC2 histone deacetylase 2 0.088
TIMP2 TIMP metallopeptidase inhibitor 2 0.076
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.070
SEC31A SEC31 homolog A (S. cerevisiae) 0.068
CDK5 cyclin-dependent kinase 5 0.066
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.066
SFN stratifin 0.065
PARP1 poly (ADP-ribose) polymerase 1 0.063
PML promyelocytic leukemia 0.058
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.056
HDAC1 histone deacetylase 1 0.054
TRIM27 tripartite motif containing 27 0.052
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.046
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.046
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.045
CABLES1 Cdk5 and Abl enzyme substrate 1 0.043
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.043
SH3BP4 SH3-domain binding protein 4 0.042
CAV1 caveolin 1, caveolae protein, 22kDa 0.041
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.041
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.040
SIRT1 sirtuin 1 0.039
KCTD1 potassium channel tetramerisation domain containing 1 0.036
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.034
FIBP fibroblast growth factor (acidic) intracellular binding protein 0.034
SKIL SKI-like oncogene 0.033
MYB v-myb myeloblastosis viral oncogene homolog (avian) 0.031
SMAD4 SMAD family member 4 0.031
PIAS2 protein inhibitor of activated STAT, 2 0.031
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 0.031
LUM lumican 0.029
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.029
TP53 tumor protein p53 0.028
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.028
ALAS1 aminolevulinate, delta-, synthase 1 0.027
HIPK2 homeodomain interacting protein kinase 2 0.027
FURIN furin (paired basic amino acid cleaving enzyme) 0.025
CAV2 caveolin 2 0.025
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.024
ZBTB4 zinc finger and BTB domain containing 4 0.024
CHD4 chromodomain helicase DNA binding protein 4 0.023
TAL1 T-cell acute lymphocytic leukemia 1 0.023
LIMK1 LIM domain kinase 1 0.022
CTBP1 C-terminal binding protein 1 0.022
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.021
FAM160A2 family with sequence similarity 160, member A2 0.020
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.020
PTK2 PTK2 protein tyrosine kinase 2 0.019
LZTS2 leucine zipper, putative tumor suppressor 2 0.019
RANGAP1 Ran GTPase activating protein 1 0.018
ING2 inhibitor of growth family, member 2 0.018
GLUL glutamate-ammonia ligase 0.018
ATN1 atrophin 1 0.016
RSBN1 round spermatid basic protein 1 0.016
GADD45G growth arrest and DNA-damage-inducible, gamma 0.016
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.016
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.015
CABLES2 Cdk5 and Abl enzyme substrate 2 0.015
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.015
YY1 YY1 transcription factor 0.015
SRCIN1 SRC kinase signaling inhibitor 1 0.015
SNIP1 Smad nuclear interacting protein 1 0.014
AATK apoptosis-associated tyrosine kinase 0.014
EED embryonic ectoderm development 0.014
CDK6 cyclin-dependent kinase 6 0.014
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.014
GOLGB1 golgin B1 0.014
ZMYM2 zinc finger, MYM-type 2 0.014
S100A4 S100 calcium binding protein A4 0.013
PTPRN protein tyrosine phosphatase, receptor type, N 0.013
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.013
PTPRD protein tyrosine phosphatase, receptor type, D 0.013
MEF2A myocyte enhancer factor 2A 0.013
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.013
TUBB2A tubulin, beta 2A 0.013
RNF4 ring finger protein 4 0.013
CTBP2 C-terminal binding protein 2 0.013
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.013
STK4 serine/threonine kinase 4 0.013
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.013
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.013
NLK nemo-like kinase 0.012
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism