The network for 'lung development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgf8 fibroblast growth factor 8 1.000
Foxc1 forkhead box C1 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Bmp4 bone morphogenetic protein 4 1.000
Pten phosphatase and tensin homolog 1.000
Fgfr1 fibroblast growth factor receptor 1 0.999
Fgfr2 fibroblast growth factor receptor 2 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.997
Gli3 GLI-Kruppel family member GLI3 0.997
Ednra endothelin receptor type A 0.997
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.996
Tcf21 transcription factor 21 0.996
Tgfbr2 transforming growth factor, beta receptor II 0.996
Nodal nodal 0.996
Sox2 SRY-box containing gene 2 0.994
Vangl2 vang-like 2 (van gogh, Drosophila) 0.994
Col1a1 collagen, type I, alpha 1 0.993
Pax2 paired box gene 2 0.992
Tgfb2 transforming growth factor, beta 2 0.991
Rarg retinoic acid receptor, gamma 0.988
Meox2 mesenchyme homeobox 2 0.986
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.985
Ece1 endothelin converting enzyme 1 0.985
Prrx1 paired related homeobox 1 0.983
Hand1 heart and neural crest derivatives expressed transcript 1 0.980
Hand2 heart and neural crest derivatives expressed transcript 2 0.980
Gata6 GATA binding protein 6 0.978
Nkx2-1 NK2 homeobox 1 0.977
Foxc2 forkhead box C2 0.972
Gata4 GATA binding protein 4 0.972
Tbx3 T-box 3 0.969
Nos3 nitric oxide synthase 3, endothelial cell 0.967
Foxa2 forkhead box A2 0.965
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.964
Nog noggin 0.964
Fgfr3 fibroblast growth factor receptor 3 0.959
Tbx2 T-box 2 0.959
Pbx1 pre B-cell leukemia transcription factor 1 0.957
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.955
Twist2 twist homolog 2 (Drosophila) 0.954
Tbx1 T-box 1 0.951
Hoxa3 homeobox A3 0.950
Smad4 MAD homolog 4 (Drosophila) 0.945
Rarb retinoic acid receptor, beta 0.942
Flt4 FMS-like tyrosine kinase 4 0.942
Hoxa1 homeobox A1 0.939
Pax8 paired box gene 8 0.938
Prrx2 paired related homeobox 2 0.929
Sox9 SRY-box containing gene 9 0.928
Fgf10 fibroblast growth factor 10 0.928
Chrd chordin 0.927
Gdf1 growth differentiation factor 1 0.921
Pitx1 paired-like homeodomain transcription factor 1 0.918
Pax3 paired box gene 3 0.915
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.913
Smad6 MAD homolog 6 (Drosophila) 0.912
Jag1 jagged 1 0.907
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.898
Foxh1 forkhead box H1 0.897
Zic3 zinc finger protein of the cerebellum 3 0.894
Foxg1 forkhead box G1 0.894
Bmp7 bone morphogenetic protein 7 0.893
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.890
Mesp1 mesoderm posterior 1 0.878
Msx1 homeobox, msh-like 1 0.864
Ptk7 PTK7 protein tyrosine kinase 7 0.864
Mapk8 mitogen-activated protein kinase 8 0.857
Hoxb3 homeobox B3 0.852
Pthlh parathyroid hormone-like peptide 0.850
Hoxa2 homeobox A2 0.847
Hoxd9 homeobox D9 0.840
Hoxd13 homeobox D13 0.828
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.824
Vegfa vascular endothelial growth factor A 0.819
Foxf1a forkhead box F1a 0.815
Pou5f1 POU domain, class 5, transcription factor 1 0.812
Hes1 hairy and enhancer of split 1 (Drosophila) 0.809
Nfib nuclear factor I/B 0.806
Hoxc6 homeobox C6 0.798
Hoxb6 homeobox B6 0.791
Hoxb5 homeobox B5 0.789
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.788
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.775
Ptch1 patched homolog 1 0.766
Tcfap2a transcription factor AP-2, alpha 0.765
Sall4 sal-like 4 (Drosophila) 0.759
Fbn1 fibrillin 1 0.756
Smad3 MAD homolog 3 (Drosophila) 0.755
Mmp2 matrix metallopeptidase 2 0.754
Hoxa9 homeobox A9 0.754
Eya1 eyes absent 1 homolog (Drosophila) 0.748
Gsc goosecoid homeobox 0.745
Gli1 GLI-Kruppel family member GLI1 0.737
Smo smoothened homolog (Drosophila) 0.734
Sox4 SRY-box containing gene 4 0.733
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.728
Emx1 empty spiracles homolog 1 (Drosophila) 0.724
Zeb1 zinc finger E-box binding homeobox 1 0.723
Epas1 endothelial PAS domain protein 1 0.721
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.998
FGF1 fibroblast growth factor 1 (acidic) 0.978
FHL2 four and a half LIM domains 2 0.899
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.897
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.814
NRP1 neuropilin 1 0.606
TBX5 T-box 5 0.559
SMAD2 SMAD family member 2 0.517
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.471
BMPR1A bone morphogenetic protein receptor, type IA 0.469
SMAD3 SMAD family member 3 0.467
VEGFA vascular endothelial growth factor A 0.456
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.413
ENG endoglin 0.326
JAG1 jagged 1 0.325
FGFR1 fibroblast growth factor receptor 1 0.315
BMP2 bone morphogenetic protein 2 0.289
FGF10 fibroblast growth factor 10 0.270
GH1 growth hormone 1 0.257
SRSF4 serine/arginine-rich splicing factor 4 0.222
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.204
FLNA filamin A, alpha 0.187
SREBF2 sterol regulatory element binding transcription factor 2 0.154
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.150
NCOR2 nuclear receptor corepressor 2 0.140
NCOA6 nuclear receptor coactivator 6 0.136
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.131
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.118
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.108
KAT2B K(lysine) acetyltransferase 2B 0.108
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.107
ACVR1 activin A receptor, type I 0.104
PAX8 paired box 8 0.102
GH2 growth hormone 2 0.098
NLRC4 NLR family, CARD domain containing 4 0.093
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.092
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.087
POLA2 polymerase (DNA directed), alpha 2 (70kD subunit) 0.082
UTRN utrophin 0.082
ARNT aryl hydrocarbon receptor nuclear translocator 0.081
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.080
RPTOR regulatory associated protein of MTOR, complex 1 0.078
ATXN1 ataxin 1 0.077
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.075
STK3 serine/threonine kinase 3 0.075
TTR transthyretin 0.073
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.071
FN1 fibronectin 1 0.069
CYR61 cysteine-rich, angiogenic inducer, 61 0.065
JAG2 jagged 2 0.065
PSEN1 presenilin 1 0.062
FADS1 fatty acid desaturase 1 0.061
FGF8 fibroblast growth factor 8 (androgen-induced) 0.057
FHL3 four and a half LIM domains 3 0.054
AR androgen receptor 0.051
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.050
CSH2 chorionic somatomammotropin hormone 2 0.049
ITGB4 integrin, beta 4 0.048
SIRT1 sirtuin 1 0.048
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.046
FGF18 fibroblast growth factor 18 0.044
PDZD11 PDZ domain containing 11 0.042
NKX3-1 NK3 homeobox 1 0.042
CSHL1 chorionic somatomammotropin hormone-like 1 0.041
MAML1 mastermind-like 1 (Drosophila) 0.040
FLNB filamin B, beta 0.039
EGLN1 egl nine homolog 1 (C. elegans) 0.039
SPEN spen homolog, transcriptional regulator (Drosophila) 0.038
FGF4 fibroblast growth factor 4 0.037
NUMA1 nuclear mitotic apparatus protein 1 0.037
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.035
ATXN1L ataxin 1-like 0.035
SORBS3 sorbin and SH3 domain containing 3 0.034
COL2A1 collagen, type II, alpha 1 0.034
PUM1 pumilio homolog 1 (Drosophila) 0.034
GATA4 GATA binding protein 4 0.033
BMP4 bone morphogenetic protein 4 0.033
SEC23A Sec23 homolog A (S. cerevisiae) 0.032
SRSF6 serine/arginine-rich splicing factor 6 0.032
HSPG2 heparan sulfate proteoglycan 2 0.031
SRPK1 SRSF protein kinase 1 0.031
PXN paxillin 0.031
TGFB3 transforming growth factor, beta 3 0.031
FKBP4 FK506 binding protein 4, 59kDa 0.030
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.029
SPRY4 sprouty homolog 4 (Drosophila) 0.028
GPSM2 G-protein signaling modulator 2 0.028
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.028
SKI v-ski sarcoma viral oncogene homolog (avian) 0.027
EBP emopamil binding protein (sterol isomerase) 0.027
PLCG1 phospholipase C, gamma 1 0.027
PGR progesterone receptor 0.026
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.026
CACYBP calcyclin binding protein 0.026
WNT1 wingless-type MMTV integration site family, member 1 0.026
FSTL1 follistatin-like 1 0.025
KLF13 Kruppel-like factor 13 0.025
POU5F1 POU class 5 homeobox 1 0.025
ARL4D ADP-ribosylation factor-like 4D 0.025
CREBBP CREB binding protein 0.025
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Rattus norvegicus
Name Description Probability Func Analog Organism
Sc4mol sterol-C4-methyl oxidase-like 0.136
Fn1 fibronectin 1 0.092
Fdps farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) 0.091
Sox17 SRY (sex determining region Y)-box 17 0.069
Aebp1 AE binding protein 1 0.067
Id3 inhibitor of DNA binding 3 0.063
Loxl1 lysyl oxidase-like 1 0.059
Lyz2 lysozyme 2 0.057
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.050
Lamc1 laminin, gamma 1 0.043
Hyal2 hyaluronoglucosaminidase 2 0.043
Ednra endothelin receptor type A 0.042
Prrx1 paired related homeobox 1 0.041
Psgb1 pregnancy-specific beta 1-glycoprotein 0.040
Pawr PRKC, apoptosis, WT1, regulator 0.040
Prl3c1 Prolactin family 3, subfamily c, member 1 0.040
Lepr leptin receptor 0.039
Col8a1 collagen, type VIII, alpha 1 0.038
Il11 interleukin 11 0.037
Stx2 syntaxin 2 0.036
Sod3 superoxide dismutase 3, extracellular 0.036
Cd40lg CD40 ligand 0.036
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.036
Pmp22 peripheral myelin protein 22 0.035
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.035
Scpep1 serine carboxypeptidase 1 0.034
Smad7 SMAD family member 7 0.033
A3galt2 alpha 1,3-galactosyltransferase 2 0.032
Serpini2 serine (or cysteine) peptidase inhibitor, clade I, member 2 0.031
Il1r1 interleukin 1 receptor, type I 0.031
Lox lysyl oxidase 0.030
Sult1a1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.030
Fgfr1 Fibroblast growth factor receptor 1 0.030
Rab7a RAB7A, member RAS oncogene family 0.029
Pip prolactin induced protein 0.029
Hoxb8 homeo box B8 0.029
Prl prolactin 0.028
Sc65 synaptonemal complex protein SC65 0.028
Adam10 ADAM metallopeptidase domain 10 0.028
Wisp1 WNT1 inducible signaling pathway protein 1 0.028
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.028
Cpxm2 carboxypeptidase X (M14 family), member 2 0.028
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.027
Adarb2 adenosine deaminase, RNA-specific, B2 0.027
Mfrp membrane frizzled-related protein 0.027
Kitlg KIT ligand 0.026
Smcp sperm mitochondria-associated cysteine-rich protein 0.026
Pth parathyroid hormone 0.026
Cfb complement factor B 0.026
Gpx3 glutathione peroxidase 3 0.026
Hist1h1d histone cluster 1, H1d 0.026
Foxs1 forkhead box S1 0.026
Fgf10 fibroblast growth factor 10 0.025
Chrnb3 cholinergic receptor, nicotinic, beta 3 0.025
Fcgrt Fc fragment of IgG, receptor, transporter, alpha 0.025
Omd osteomodulin 0.025
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.025
Cdk2 cyclin dependent kinase 2 0.024
Ccr1 chemokine (C-C motif) receptor 1 0.024
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.024
Fgl2 fibrinogen-like 2 0.024
Megf6 multiple EGF-like-domains 6 0.024
Mark2 MAP/microtubule affinity-regulating kinase 2 0.024
Gpr116 G protein-coupled receptor 116 0.023
Slc30a1 solute carrier family 30 (zinc transporter), member 1 0.023
Foxo1 forkhead box O1 0.023
Scgb1a1 secretoglobin, family 1A, member 1 (uteroglobin) 0.023
Tpc1808 tropic 1808 0.023
Prl7a4 prolactin family 7, subfamily a, member 4 0.023
Map3k3 mitogen activated protein kinase kinase kinase 3 0.023
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.023
Vcan versican 0.022
Foxe3 forkhead box E3 0.022
Mmp3 matrix metallopeptidase 3 0.022
Eln elastin 0.022
Sfrp4 secreted frizzled-related protein 4 0.022
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.022
Zfx zinc finger protein X-linked 0.022
Snrpb small nuclear ribonucleoprotein polypeptides B and B1 0.022
Nfia nuclear factor I/A 0.022
Wnt5a wingless-type MMTV integration site family, member 5A 0.021
Chrna10 cholinergic receptor, nicotinic, alpha 10 0.021
Oprk1 opioid receptor, kappa 1 0.021
Six1 SIX homeobox 1 0.021
Fgfr3 fibroblast growth factor receptor 3 0.021
Frzb frizzled-related protein 0.021
Plac1 placenta-specific 1 0.021
Kcns1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 0.021
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.021
Clph casein-like phosphoprotein 0.021
Olfml2b olfactomedin-like 2B 0.021
Tgfb2 transforming growth factor, beta 2 0.020
Otx1 orthodenticle homeobox 1 0.020
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.020
Slc7a12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 0.020
Col11a1 collagen, type XI, alpha 1 0.020
Gp5 glycoprotein V (platelet) 0.020
Rgs4 regulator of G-protein signaling 4 0.020
F2rl3 coagulation factor II (thrombin) receptor-like 3 0.020
Tcp11 t-complex protein 11 0.020
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism