The network for 'negative regulation of metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

Danio rerio
Name Description Probability Func Analog Organism
fgf3 fibroblast growth factor 3 0.887
gata6 GATA-binding protein 6 0.849
dlx3b distal-less homeobox gene 3b 0.793
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.738
fgf8a fibroblast growth factor 8 a 0.651
otpb orthopedia homolog b 0.586
ndr2 nodal-related 2 0.559
foxi1 forkhead box I1 0.558
tp53 tumor protein p53 0.549
dusp6 dual specificity phosphatase 6 0.506
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.495
pkd2 polycystic kidney disease 2 0.474
etv5b ets variant 5b 0.458
pax8 paired box gene 8 0.451
ncl nucleolin 0.443
dlx1a distal-less homeobox gene 1a 0.439
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.438
gli1 GLI-Kruppel family member 1 0.433
ins preproinsulin 0.423
sall1a sal-like 1a (Drosophila) 0.420
tgfb3 transforming growth factor, beta 3 0.417
fzd8a frizzled homolog 8a 0.415
spry4 sprouty (Drosophila) homolog 4 0.403
gro1 groucho 1 0.402
sox9b SRY-box containing gene 9b 0.399
ntla no tail a 0.395
tbx18 T-box 18 0.392
gata5 GATA-binding protein 5 0.392
klf4 Kruppel-like factor 4 0.389
cav1 caveolin 1 0.380
socs3a suppressor of cytokine signaling 3a 0.363
tfap2a transcription factor AP-2 alpha 0.362
pou3f3a POU class 3 homeobox 3a 0.359
fgf19 fibroblast growth factor 19 0.358
igf1rb insulin-like growth factor 1b receptor 0.344
jag1b jagged 1b 0.341
snai1b snail homolog 1b (Drosophila) 0.337
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.336
pou3f2 POU class 3 homeobox 2 0.336
ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.334
tfeb transcription factor EB 0.323
robo3 roundabout homolog 3 0.318
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.309
sox19a SRY-box containing gene 19a 0.308
ascl1a achaete-scute complex-like 1a (Drosophila) 0.303
her8a hairy-related 8a 0.301
runx1 runt-related transcription factor 1 0.297
jun jun proto-oncogene 0.296
bmp2b bone morphogenetic protein 2b 0.294
dag1 dystroglycan 1 0.292
lhx1a LIM homeobox 1a 0.292
boc brother of CDO 0.292
tal1 T-cell acute lymphocytic leukemia 1 0.287
dct dopachrome tautomerase 0.282
runx2b runt-related transcription factor 2b 0.277
srsf2 serine/arginine-rich splicing factor 2 0.276
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.274
mchr1b melanin-concentrating hormone receptor 1b 0.273
pcna proliferating cell nuclear antigen 0.269
furina furin (paired basic amino acid cleaving enzyme) a 0.266
tbx1 T-box 1 0.263
satb2 SATB homeobox 2 0.261
tbx6 T-box gene 6 0.250
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.243
eomesa eomesodermin homolog a 0.241
gdnf glial cell derived neurotrophic factor 0.239
hp1bp3 heterochromatin protein 1, binding protein 3 0.233
fgf20a fibroblast growth factor 20a 0.232
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.230
pparg peroxisome proliferator activated receptor gamma 0.229
notch1a notch homolog 1a 0.228
her7 hairy and enhancer of split related-7 0.227
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.227
supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.226
fzd7a frizzled homolog 7a 0.225
sox11b SRY-box containing gene 11b 0.223
nkx2.3 NK2 transcription factor related 3 0.222
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.221
hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.217
tll1 tolloid-like 1 0.216
alcamb activated leukocyte cell adhesion molecule b 0.215
smo smoothened homolog (Drosophila) 0.213
rad21 RAD21 homolog (S. pombe) 0.212
acvr1l activin A receptor, type I like 0.209
jag2 jagged 2 0.208
birc5b baculoviral IAP repeat-containing 5B 0.207
flot2a flotillin 2a 0.207
tshz1 teashirt family zinc finger 1 0.204
met met proto-oncogene (hepatocyte growth factor receptor) 0.203
wnt5b wingless-type MMTV integration site family, member 5b 0.197
tardbp TAR DNA binding protein 0.197
zff9 zinc finger protein 9 0.197
emx3 empty spiracles homeobox 3 0.196
cry1a cryptochrome 1a 0.194
nfe2l2 nuclear factor (erythroid-derived 2)-like 2 0.193
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.193
junb jun B proto-oncogene 0.191
hnrnpk heterogeneous nuclear ribonucleoprotein K 0.189
sox4a SRY-box containing gene 4a 0.188
robo1 roundabout homolog 1 0.187
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
pha-4 Protein PHA-4 0.889
egl-18 Protein EGL-18 0.805
vab-3 Protein VAB-3 0.770
lmn-1 Protein LMN-1 0.718
egl-13 Protein EGL-13 0.589
npp-7 Protein NPP-7 0.547
nhr-67 Protein NHR-67 0.527
zip-7 Protein ZIP-7 0.497
cacn-1 Protein CACN-1 0.477
his-16 Protein HIS-16 0.451
lin-66 Protein LIN-66 0.436
snr-2 Protein SNR-2 0.427
hcp-3 Protein HCP-3 0.423
fkb-6 Protein FKB-6 0.421
elt-6 Protein ELT-6 0.417
kle-2 Protein KLE-2 0.412
CELE_C17E4.6 Protein C17E4.6 0.411
hlh-11 Protein HLH-11 0.406
unc-62 Protein UNC-62 0.400
nhr-6 Protein NHR-6 0.394
his-5 Protein HIS-5 0.392
lsy-2 Protein LSY-2 0.389
rsp-1 Protein RSP-1 0.382
sma-6 Protein SMA-6 0.376
hlh-2 Protein HLH-2 0.370
oma-2 Protein OMA-2 0.366
his-1 Protein HIS-1 0.364
CELE_C24H12.5 Protein C24H12.5 0.362
glp-1 Protein GLP-1 0.359
unc-37 Protein UNC-37 0.359
jmjd-2 Protein JMJD-2 0.357
csn-4 Protein CSN-4 0.342
atn-1 Protein ATN-1 0.338
lin-53 Protein LIN-53 0.338
his-31 Protein HIS-31 0.333
npp-4 Protein NPP-4 0.332
his-45 Protein HIS-45 0.325
egg-6 Protein EGG-6 0.325
hlh-1 Protein HLH-1 0.324
mom-4 Protein MOM-4 0.323
unc-59 Protein UNC-59 0.317
hrp-1 Protein HRP-1 0.311
F22B3.4 Protein F22B3.4 0.310
hum-5 Protein HUM-5 0.310
pry-1 Protein PRY-1 0.310
CELE_C25A1.4 Protein C25A1.4 0.306
zyg-1 Protein ZYG-1 0.304
CELE_C23G10.8 Protein C23G10.8 0.301
CELE_F58A4.2 Protein F58A4.2 0.298
F33D11.10 Protein F33D11.10 0.297
C32D5.11 Protein C32D5.11 0.296
egl-46 Protein EGL-46 0.290
asb-2 Protein ASB-2 0.290
mdf-2 Protein MDF-2 0.289
tam-1 Protein TAM-1 0.289
klp-19 Protein KLP-19 0.289
uaf-1 Protein UAF-1 0.287
dpf-3 Protein DPF-3 0.285
tbx-8 Protein TBX-8 0.284
plk-1 Protein PLK-1 0.283
spc-1 Protein SPC-1 0.282
his-52 Protein HIS-52 0.277
B0336.3 Protein B0336.3 0.276
cids-2 Protein CIDS-2 0.272
F25H5.5 Protein F25H5.5 0.269
gls-1 Protein GLS-1 0.268
madf-5 Protein MADF-5 0.267
F21A10.2 Protein F21A10.2 0.267
ceh-22 Protein CEH-22 0.264
his-50 Protein HIS-50 0.260
atg-2 Protein ATG-2 0.259
zyg-9 Protein ZYG-9 0.259
his-42 Protein HIS-42 0.257
dlc-1 Protein DLC-1 0.257
eat-4 Protein EAT-4 0.253
swsn-3 Protein SWSN-3 0.253
ima-3 Protein IMA-3 0.252
egl-15 Protein EGL-15 0.250
sea-2 Protein SEA-2 0.248
brc-1 Protein BRC-1 0.245
Y17G7B.20 Protein Y17G7B.20 0.245
D1081.8 Protein D1081.8 0.243
mcm-4 Protein MCM-4 0.242
mab-5 Protein MAB-5 0.235
age-1 Protein AGE-1 0.235
lin-11 Protein LIN-11 0.232
F56C9.10 Protein F56C9.10 0.231
vps-33.2 Protein VPS-33.2 0.230
aap-1 Protein AAP-1 0.228
rnp-7 Protein RNP-7 0.228
his-3 Protein HIS-3 0.226
his-39 Protein HIS-39 0.221
rad-26 Protein RAD-26 0.220
CELE_C17H12.13 Protein C17H12.13 0.220
alg-2 Protein ALG-2 0.220
T28C6.7 Protein T28C6.7 0.220
egl-44 Protein EGL-44 0.219
F11E6.7 Protein F11E6.7 0.215
Y42H9AR.4 Protein Y42H9AR.4 0.215
oac-46 Protein OAC-46 0.214
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Jun Jun oncogene 0.665
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.548
Tgfbr2 transforming growth factor, beta receptor II 0.543
Cd9 CD9 molecule 0.536
Zfp36 zinc finger protein 36 0.516
Hand2 heart and neural crest derivatives expressed 2 0.514
Nfya nuclear transcription factor-Y alpha 0.513
Fos FBJ osteosarcoma oncogene 0.463
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.459
Creb1 cAMP responsive element binding protein 1 0.456
Sfrs1 splicing factor, arginine/serine-rich 1 0.455
Vim vimentin 0.436
Dlg1 discs, large homolog 1 (Drosophila) 0.432
Ifitm3 interferon induced transmembrane protein 3 0.423
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.422
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.419
Mapk3 mitogen activated protein kinase 3 0.414
Eif4h eukaryotic translation initiation factor 4H 0.414
Casp2 caspase 2 0.398
Cd63 Cd63 molecule 0.394
S100a10 S100 calcium binding protein A10 0.392
Rhoc ras homolog gene family, member C 0.391
Met met proto-oncogene 0.389
Btg2 BTG family, member 2 0.386
Dusp1 dual specificity phosphatase 1 0.378
Hoxc4 homeo box C4 0.375
Errfi1 ERBB receptor feedback inhibitor 1 0.372
Junb jun B proto-oncogene 0.372
Calcrl calcitonin receptor-like 0.371
Hspb1 heat shock protein 1 0.369
Tcfe2a transcription factor E2a 0.368
Dchs1 dachsous 1 (Drosophila) 0.368
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.363
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.358
Gja1 gap junction protein, alpha 1 0.357
LOC100363106 LRRG00130-like 0.350
Hnrpd heterogeneous nuclear ribonucleoprotein D 0.343
Synpo synaptopodin 0.340
Ptms parathymosin 0.336
Pim1 pim-1 oncogene 0.328
Kdm6b lysine (K)-specific demethylase 6B 0.328
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.326
Stat3 signal transducer and activator of transcription 3 0.324
Prrx1 paired related homeobox 1 0.323
Klf9 Kruppel-like factor 9 0.320
Anxa4 annexin A4 0.320
Phkg1 phosphorylase kinase, gamma 1 0.316
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.311
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.310
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.310
Fga fibrinogen alpha chain 0.309
Stat5b signal transducer and activator of transcription 5B 0.306
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.305
Dynll1 dynein light chain LC8-type 1 0.300
Foxd3 forkhead box D3 0.300
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.300
Nras neuroblastoma ras oncogene 0.298
Myo1b myosin Ib 0.296
Gfi1 growth factor independent 1 transcription repressor 0.295
Klf6 Kruppel-like factor 6 0.295
Hes1 hairy and enhancer of split 1 (Drosophila) 0.293
Top2a topoisomerase (DNA) II alpha 0.290
Smad7 SMAD family member 7 0.288
Rhob ras homolog gene family, member B 0.287
Hspd1 heat shock protein 1 (chaperonin) 0.285
Lig3 ligase III, DNA, ATP-dependent 0.281
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.279
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.279
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.276
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.275
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.275
Anxa5 annexin A5 0.270
Ier2 immediate early response 2 0.268
Ahr aryl hydrocarbon receptor 0.267
Hoxd3 homeo box D3 0.265
Siah1a seven in absentia 1A 0.265
Pou3f2 POU class 3 homeobox 2 0.264
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.263
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.262
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.261
Fgf18 fibroblast growth factor 18 0.260
Ncan neurocan 0.256
Proc protein C 0.255
Serpinb7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.255
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.254
Asgr1 asialoglycoprotein receptor 1 0.253
Metap2 methionyl aminopeptidase 2 0.251
Smad3 SMAD family member 3 0.248
Bcl2 B-cell CLL/lymphoma 2 0.248
Hnrnpr heterogeneous nuclear ribonucleoprotein R 0.247
Anxa2 annexin A2 0.247
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.244
Tef thyrotrophic embryonic factor 0.243
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.243
Irs1 insulin receptor substrate 1 0.242
Pcna proliferating cell nuclear antigen 0.239
Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.239
Pzp pregnancy-zone protein 0.237
Faslg Fas ligand (TNF superfamily, member 6) 0.237
S100a6 S100 calcium binding protein A6 0.237
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism