The network for 'heart development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 1.000
tbx5a T-box 5a 1.000
bmp2b bone morphogenetic protein 2b 0.999
kdrl kinase insert domain receptor like 0.999
ttna titin a 0.997
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.997
bmp4 bone morphogenetic protein 4 0.996
tmem2 transmembrane protein 2 0.994
fn1 fibronectin 1 0.994
notch1b notch homolog 1b 0.993
tal1 T-cell acute lymphocytic leukemia 1 0.993
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.993
pcdh8 protocadherin 8 0.990
wnt11r wingless-type MMTV integration site family, member 11, related 0.987
bmp2a bone morphogenetic protein 2a 0.986
wnt5b wingless-type MMTV integration site family, member 5b 0.985
tbx20 T-box 20 0.983
isl1 islet1 0.983
myod1 myogenic differentiation 1 0.980
wnt11 wingless-type MMTV integration site family, member 11 0.978
gata3 GATA-binding protein 3 0.978
tbx16 T-box gene 16 0.977
acvr1l activin A receptor, type I like 0.977
fgf8a fibroblast growth factor 8 a 0.976
vmhc ventricular myosin heavy chain 0.975
fgf10a fibroblast growth factor 10a 0.973
tnni1b troponin I, skeletal, slow b 0.970
myl7 myosin, light polypeptide 7, regulatory 0.968
prkci protein kinase C, iota 0.967
wt1a wilms tumor 1a 0.960
tbx2b T-box 2b 0.960
foxi1 forkhead box I1 0.959
tnnc1b troponin C type 1b (slow) 0.959
tbx18 T-box 18 0.958
ccm2 cerebral cavernous malformation 2 0.953
tpm4 tropomyosin 4 0.950
actc1a actin, alpha, cardiac muscle 1a 0.950
lef1 lymphocyte enhancer binding factor 1 0.945
hnf1ba HNF1 homeobox Ba 0.943
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.942
six4b sine oculis homeobox homolog 4b 0.941
fzd7b frizzled homolog 7b 0.937
tnnt2a troponin T2a, cardiac 0.936
fgfr1b fibroblast growth factor receptor 1b 0.934
pdlim7 PDZ and LIM domain 7 0.933
crip2 cysteine-rich protein 2 0.933
fbn2b fibrillin 2b 0.932
fgfr2 fibroblast growth factor receptor 2 0.926
crabp2a cellular retinoic acid binding protein 2, a 0.925
oep one-eyed pinhead 0.925
vcana versican a 0.923
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.922
shha sonic hedgehog a 0.922
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.921
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.919
lrrc6 leucine rich repeat containing 6 0.918
twist1a twist1a 0.907
pkd2 polycystic kidney disease 2 0.906
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.905
eya1 eyes absent homolog 1 0.901
tbx2a T-box gene 2a 0.898
hoxb5a homeo box B5a 0.894
neo1 neogenin 1 0.891
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.891
fzd10 frizzled homolog 10 0.888
ephb4b eph receptor B4b 0.883
unc45b unc-45 homolog B (C. elegans) 0.879
synpo2lb synaptopodin 2-like b 0.876
notch2 notch homolog 2 0.873
hspb1 heat shock protein, alpha-crystallin-related, 1 0.872
cacnb4a calcium channel, voltage-dependent, beta 4a subunit 0.872
tgfb3 transforming growth factor, beta 3 0.872
spns2 spinster homolog 2 (Drosophila) 0.868
notch3 notch homolog 3 0.868
itgav integrin, alpha V 0.864
prdm16 PR domain containing 16 0.859
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.856
etv2 ets variant gene 2 0.854
fzd7a frizzled homolog 7a 0.849
rarga retinoic acid receptor gamma a 0.848
foxn4 forkhead box N4 0.842
fgf3 fibroblast growth factor 3 0.839
atp1b2b ATPase, Na+/K+ transporting, beta 2b polypeptide 0.832
tp53 tumor protein p53 0.831
sulf1 sulfatase 1 0.829
gro1 groucho 1 0.829
her3 hairy-related 3 0.825
actn3b actinin alpha 3b 0.821
ntla no tail a 0.810
yap1 Yes-associated protein 1 0.807
lama4 laminin, alpha 4 0.802
sall4 sal-like 4 (Drosophila) 0.801
egr2b early growth response 2b 0.800
actn2 actinin, alpha 2 0.796
epas1b endothelial PAS domain protein 1b 0.794
smad5 MAD homolog 5 (Drosophila) 0.789
gli2a GLI-Kruppel family member GLI2a 0.788
prrx1a paired related homeobox 1a 0.788
wnt9a wingless-type MMTV integration site family, member 9A 0.787
hoxc8a homeo box C8a 0.784
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Egfr Epidermal growth factor receptor 1.000
Mad Mothers against dpp 0.999
wg wingless 0.997
en engrailed 0.992
kuz kuzbanian 0.988
emc extra macrochaetae 0.973
tin tinman 0.971
twi twist 0.967
dally division abnormally delayed 0.967
LanA Laminin A 0.959
Mrtf Myocardin-related transcription factor 0.956
slmb supernumerary limbs 0.953
dpp decapentaplegic 0.951
robo roundabout 0.941
slp1 sloppy paired 1 0.934
Mhc Myosin heavy chain 0.933
LanB1 CG7123 gene product from transcript CG7123-RA 0.930
stumps CG31317 gene product from transcript CG31317-RC 0.929
ci cubitus interruptus 0.927
shn schnurri 0.925
Nrg Neuroglian 0.925
Ras85D Ras oncogene at 85D 0.921
htl heartless 0.906
LanB2 Laminin B2 0.897
Rac1 CG2248 gene product from transcript CG2248-RA 0.897
Ggamma1 G protein gamma 1 0.892
sd scalloped 0.873
arm armadillo 0.870
bin biniou 0.864
hipk homeodomain interacting protein kinase 0.852
vg vestigial 0.846
dm diminutive 0.844
Atg1 Autophagy-specific gene 1 0.843
kn knot 0.835
zfh1 Zn finger homeodomain 1 0.820
srp serpent 0.818
Atpalpha Na pump alpha subunit 0.808
hth homothorax 0.802
da daughterless 0.797
abd-A abdominal A 0.787
eve even skipped 0.783
nrv2 nervana 2 0.781
Dll Distal-less 0.775
put punt 0.752
smo smoothened 0.747
HLH54F CG5005 gene product from transcript CG5005-RA 0.743
mam mastermind 0.741
gsb gooseberry 0.738
ush u-shaped 0.738
hpo hippo 0.737
mys myospheroid 0.720
G-oalpha47A G protein oalpha 47A 0.709
hkb huckebein 0.698
mid midline 0.693
noc no ocelli 0.685
gig gigas 0.683
tll tailless 0.672
Dl Delta 0.672
Hand CG18144 gene product from transcript CG18144-RA 0.648
zip zipper 0.645
lea leak 0.635
klu klumpfuss 0.633
pnt pointed 0.603
Wnt2 Wnt oncogene analog 2 0.602
wupA wings up A 0.576
InR Insulin-like receptor 0.572
Kr Kruppel 0.557
Ubx Ultrabithorax 0.550
Akt1 CG4006 gene product from transcript CG4006-RA 0.545
Smox Smad on X 0.537
eya eyes absent 0.534
spdo sanpodo 0.529
pyr pyramus 0.525
tsh teashirt 0.520
fng fringe 0.511
sog short gastrulation 0.506
how held out wings 0.495
bab2 CG9102 gene product from transcript CG9102-RA 0.491
Doc2 Dorsocross2 0.482
pnr pannier 0.474
coro CG9446 gene product from transcript CG9446-RC 0.466
svp seven up 0.466
kni knirps 0.463
Sema-1a CG18405 gene product from transcript CG18405-RD 0.457
mew multiple edematous wings 0.456
Dhc64C Dynein heavy chain 64C 0.434
Moe Moesin 0.432
gcm glial cells missing 0.431
slp2 sloppy paired 2 0.428
CG9894 CG9894 gene product from transcript CG9894-RB 0.422
Gap1 GTPase-activating protein 1 0.413
nej nejire 0.400
fz frizzled 0.399
Hsc70-4 Heat shock protein cognate 4 0.396
rap retina aberrant in pattern 0.396
pdm2 POU domain protein 2 0.395
rho rhomboid 0.369
ex expanded 0.366
Sos Son of sevenless 0.364
vkg viking 0.358
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Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 1.000
SMAD3 SMAD family member 3 0.997
EGFR epidermal growth factor receptor 0.993
TRIM63 tripartite motif containing 63 0.993
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.988
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.982
NOTCH1 notch 1 0.976
RXRA retinoid X receptor, alpha 0.974
TTN titin 0.973
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.971
EP300 E1A binding protein p300 0.963
RARA retinoic acid receptor, alpha 0.961
SP1 Sp1 transcription factor 0.958
XIAP X-linked inhibitor of apoptosis 0.954
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.944
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.929
CAV1 caveolin 1, caveolae protein, 22kDa 0.928
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.924
SMAD4 SMAD family member 4 0.884
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.872
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.872
MAPK14 mitogen-activated protein kinase 14 0.867
RB1 retinoblastoma 1 0.849
SMAD2 SMAD family member 2 0.833
CREBBP CREB binding protein 0.828
TNNI1 troponin I type 1 (skeletal, slow) 0.827
FGFR2 fibroblast growth factor receptor 2 0.824
TNNC1 troponin C type 1 (slow) 0.811
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.803
NCOR1 nuclear receptor corepressor 1 0.801
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.771
VEGFA vascular endothelial growth factor A 0.760
FLNA filamin A, alpha 0.760
ATF2 activating transcription factor 2 0.750
NCOR2 nuclear receptor corepressor 2 0.744
JAG1 jagged 1 0.737
PBX1 pre-B-cell leukemia homeobox 1 0.732
MYOD1 myogenic differentiation 1 0.725
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.712
GSK3B glycogen synthase kinase 3 beta 0.694
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.685
ATN1 atrophin 1 0.676
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.664
DSP desmoplakin 0.658
COL4A1 collagen, type IV, alpha 1 0.656
COL3A1 collagen, type III, alpha 1 0.648
AXIN1 axin 1 0.648
CTGF connective tissue growth factor 0.631
PABPC1 poly(A) binding protein, cytoplasmic 1 0.625
NCOA3 nuclear receptor coactivator 3 0.616
POU3F2 POU class 3 homeobox 2 0.614
NOTCH3 notch 3 0.605
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.605
NRP1 neuropilin 1 0.575
GRB2 growth factor receptor-bound protein 2 0.575
SMAD7 SMAD family member 7 0.573
PAX3 paired box 3 0.564
YY1 YY1 transcription factor 0.558
EPAS1 endothelial PAS domain protein 1 0.551
GATA4 GATA binding protein 4 0.544
FGF1 fibroblast growth factor 1 (acidic) 0.543
TPM1 tropomyosin 1 (alpha) 0.532
HDAC4 histone deacetylase 4 0.530
AR androgen receptor 0.530
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.529
NCOA1 nuclear receptor coactivator 1 0.516
MDFI MyoD family inhibitor 0.506
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.492
MSX1 msh homeobox 1 0.492
ZFYVE9 zinc finger, FYVE domain containing 9 0.485
BMP2 bone morphogenetic protein 2 0.479
ACTN2 actinin, alpha 2 0.474
FKBP1A FK506 binding protein 1A, 12kDa 0.470
TAL1 T-cell acute lymphocytic leukemia 1 0.468
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.444
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.425
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.422
FLNC filamin C, gamma 0.418
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.415
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.404
TCAP titin-cap (telethonin) 0.404
SOX2 SRY (sex determining region Y)-box 2 0.400
ACTA1 actin, alpha 1, skeletal muscle 0.395
STK3 serine/threonine kinase 3 0.393
SMAD6 SMAD family member 6 0.367
CALD1 caldesmon 1 0.366
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.365
YBX1 Y box binding protein 1 0.361
MYOZ1 myozenin 1 0.360
PML promyelocytic leukemia 0.355
SIRT1 sirtuin 1 0.351
COL5A1 collagen, type V, alpha 1 0.349
COL1A2 collagen, type I, alpha 2 0.349
FOXD3 forkhead box D3 0.343
RANBP9 RAN binding protein 9 0.340
MED25 mediator complex subunit 25 0.337
SMYD1 SET and MYND domain containing 1 0.336
TNNT3 troponin T type 3 (skeletal, fast) 0.332
TCF4 transcription factor 4 0.330
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.328
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Smad3 SMAD family member 3 0.304
Casq2 calsequestrin 2 (cardiac muscle) 0.271
Chrnb1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.239
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.220
Notch3 Notch homolog 3 (Drosophila) 0.212
Robo1 roundabout homolog 1 (Drosophila) 0.209
Syt8 synaptotagmin VIII 0.193
Hand2 heart and neural crest derivatives expressed 2 0.182
Strn striatin, calmodulin binding protein 0.176
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.170
Dchs1 dachsous 1 (Drosophila) 0.169
Tagln transgelin 0.162
Scn5a sodium channel, voltage-gated, type V, alpha subunit 0.158
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.148
Rara retinoic acid receptor, alpha 0.142
Tgfbr2 transforming growth factor, beta receptor II 0.140
Plb1 phospholipase B1 0.137
Ptgfr prostaglandin F receptor 0.135
Actc1 actin, alpha, cardiac muscle 1 0.131
Tpm3 tropomyosin 3, gamma 0.129
Pkia protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.127
LOC100362824 caveolin 2-like 0.126
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.122
Asph aspartate-beta-hydroxylase 0.122
Emp1 epithelial membrane protein 1 0.119
Obp2b odorant binding protein 2B 0.113
Nos3 nitric oxide synthase 3, endothelial cell 0.112
Ppard peroxisome proliferator-activated receptor delta 0.112
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.106
Tnni1 troponin I type 1 (skeletal, slow) 0.104
Pfn1 profilin 1 0.103
Dcc deleted in colorectal carcinoma 0.103
Cela2a chymotrypsin-like elastase family, member 2A 0.095
Oprm1 opioid receptor, mu 1 0.095
Hspa1l heat shock protein 1-like 0.095
Gata6 GATA binding protein 6 0.094
Cntn5 contactin 5 0.091
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.091
Olr1867 olfactory receptor 1867 0.091
Galr2 galanin receptor 2 0.088
Nfia nuclear factor I/A 0.087
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.087
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.086
Nos1 nitric oxide synthase 1, neuronal 0.082
Cav1 caveolin 1, caveolae protein 0.081
Foxd3 forkhead box D3 0.081
Hspb2 heat shock protein beta 2 0.081
Gja1 gap junction protein, alpha 1 0.079
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.079
Dmd dystrophin 0.077
Sox17 SRY (sex determining region Y)-box 17 0.075
Id3 inhibitor of DNA binding 3 0.075
Fgfr2 fibroblast growth factor receptor 2 0.075
Cd9 CD9 molecule 0.075
Fgf7 fibroblast growth factor 7 0.075
Slc22a6 solute carrier family 22 (organic anion transporter), member 6 0.075
Tpm4 tropomyosin 4 0.073
Vegfa vascular endothelial growth factor A 0.072
Prrx1 paired related homeobox 1 0.072
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.072
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.071
Adrb1 adrenergic, beta-1-, receptor 0.069
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.068
LOC494499 LOC494499 protein 0.068
Ly6b lymphocyte antigen 6 complex, locus B 0.068
Tcfe2a transcription factor E2a 0.067
Efnb1 ephrin B1 0.067
Sstr5 somatostatin receptor 5 0.066
Mrgprf MAS-related GPR, member F 0.066
Marcks myristoylated alanine rich protein kinase C substrate 0.066
RT1-Ba RT1 class II, locus Ba 0.065
Agtr1a angiotensin II receptor, type 1a 0.065
Selp selectin P 0.065
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.065
Cnga1 cyclic nucleotide gated channel alpha 1 0.065
Eef2 eukaryotic translation elongation factor 2 0.064
Bmp6 bone morphogenetic protein 6 0.064
Hoxc4 homeo box C4 0.063
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.063
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.063
Kcnn1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 0.062
Arpc2 actin related protein 2/3 complex, subunit 2 0.062
Acta1 actin, alpha 1, skeletal muscle 0.062
Irs1 insulin receptor substrate 1 0.061
Kcnv2 potassium channel, subfamily V, member 2 0.061
Mc4r melanocortin 4 receptor 0.060
Myl7 myosin, light chain 7, regulatory 0.060
Il1r1 interleukin 1 receptor, type I 0.060
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.060
Col10a1 collagen, type X, alpha 1 0.059
Mmp10 matrix metallopeptidase 10 0.059
Dpysl3 dihydropyrimidinase-like 3 0.057
Hnf1b HNF1 homeobox B 0.057
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.057
Nfib nuclear factor I/B 0.057
Tagln2 transgelin 2 0.056
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.056
Klk1c10 T-kininogenase 0.056
Gja5 gap junction protein, alpha 5 0.055
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.055
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism