The network for 'hindbrain development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hindbrain development

The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).

Danio rerio
Name Description Probability Func Analog Organism
fgf3 fibroblast growth factor 3 0.998
egr2b early growth response 2b 0.998
crabp2a cellular retinoic acid binding protein 2, a 0.996
foxa2 forkhead box A2 0.978
six3b sine oculis homeobox homolog 3b 0.974
atoh1b atonal homolog 1b 0.939
foxa1 forkhead box A1 0.932
ptf1a pancreas specific transcription factor, 1a 0.928
pax2a paired box gene 2a 0.926
pax6b paired box gene 6b 0.921
raraa retinoic acid receptor, alpha a 0.918
bmp2b bone morphogenetic protein 2b 0.918
otpb orthopedia homolog b 0.909
hnf1ba HNF1 homeobox Ba 0.906
lfng lunatic fringe homolog 0.903
neurod4 neurogenic differentiation 4 0.893
gbx1 gastrulation brain homeobox 1 0.886
pcdh19 protocadherin 19 0.881
sox2 SRY-box containing gene 2 0.877
lft1 lefty1 0.877
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.875
sp5l Sp5 transcription factor-like 0.870
tal1 T-cell acute lymphocytic leukemia 1 0.865
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.863
spry2 sprouty homolog 2 0.857
msxe muscle segment homeobox E 0.856
ephb3a eph receptor B3a 0.852
sox1a SRY-box containing gene 1a 0.828
fzd3a frizzled homolog 3a 0.827
neurod neurogenic differentiation 0.822
wnt4a wingless-type MMTV integration site family, member 4a 0.822
eng2b engrailed 2b 0.810
pea3 ETS-domain transcription factor pea3 0.799
sox9a SRY-box containing gene 9a 0.792
hoxb1b homeo box B1b 0.790
sall4 sal-like 4 (Drosophila) 0.784
tp53 tumor protein p53 0.783
shha sonic hedgehog a 0.768
gata3 GATA-binding protein 3 0.768
sema3aa semaphorin 3aa 0.760
fgfr1a fibroblast growth factor receptor 1a 0.759
dld deltaD 0.755
otx5 orthodenticle homolog 5 0.754
fgf8a fibroblast growth factor 8 a 0.746
irx4a iroquois homeobox protein 4a 0.742
mecom MDS1 and EVI1 complex locus 0.732
irx7 iroquois homeobox protein 7 0.729
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.728
atoh1a atonal homolog 1a 0.727
pitx3 paired-like homeodomain transcription factor 3 0.725
wnt8b wingless-type MMTV integration site family, member 8b 0.720
otx2 orthodenticle homolog 2 0.719
mnx1 motor neuron and pancreas homeobox 1 0.711
lhx1a LIM homeobox 1a 0.704
itgb1b.2 integrin, beta 1b.2 0.688
gbx2 gastrulation brain homeo box 2 0.685
egr1 early growth response 1 0.679
fgf10a fibroblast growth factor 10a 0.678
ptch1 patched 1 0.676
fn1 fibronectin 1 0.662
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.660
dlc deltaC 0.646
meis2.1 myeloid ecotropic viral integration site 2.1 0.644
fgfr4 fibroblast growth factor receptor 4 0.624
sox3 SRY-box containing gene 3 0.622
egr2a early growth response 2a 0.621
gata5 GATA-binding protein 5 0.618
barhl2 BarH-like 2 0.598
dkk1b dickkopf 1b 0.592
fgfr2 fibroblast growth factor receptor 2 0.591
tgfbi transforming growth factor, beta-induced 0.589
gli2a GLI-Kruppel family member GLI2a 0.588
pax6a paired box gene 6a 0.584
foxd3 forkhead box D3 0.583
irx1b iroquois homeobox protein 1, b 0.576
scrib scribbled homolog (Drosophila) 0.566
olig2 oligodendrocyte lineage transcription factor 2 0.558
nkx1.2la NK1 transcription factor related 2-like,a 0.556
efnb1 ephrin B1 0.551
tbx1 T-box 1 0.547
rx3 retinal homeobox gene 3 0.547
wnt3 wingless-type MMTV integration site family, member 3 0.539
zgc:101606 zgc:101606 0.528
ephb4b eph receptor B4b 0.526
map2k4a mitogen-activated protein kinase kinase 4a 0.523
tfap2a transcription factor AP-2 alpha 0.520
hmx3 homeo box (H6 family) 3 0.517
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.516
epha4b eph receptor A4b 0.510
rarga retinoic acid receptor gamma a 0.502
odz4 odd Oz/ten-m homolog 4 0.499
eya1 eyes absent homolog 1 0.498
alcama activated leukocyte cell adhesion molecule a 0.486
fzd7a frizzled homolog 7a 0.485
ascl1a achaete-scute complex-like 1a (Drosophila) 0.484
six4b sine oculis homeobox homolog 4b 0.483
lhx2b LIM homeobox 2b 0.481
wnt3a wingless-type MMTV integration site family, member 3A 0.478
hapln1a hyaluronan and proteoglycan link protein 1a 0.477
pax3a paired box gene 3a 0.473
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
HLHm7 E(spl) region transcript m7 0.957
spen split ends 0.939
Mad Mothers against dpp 0.937
ci cubitus interruptus 0.893
E(spl) Enhancer of split 0.884
trx trithorax 0.859
malpha E(spl) region transcript malpha 0.714
sd scalloped 0.701
HLHmbeta E(spl) region transcript mbeta 0.677
shi shibire 0.665
hth homothorax 0.661
oc ocelliless 0.633
ss spineless 0.612
Sema-1a CG18405 gene product from transcript CG18405-RD 0.581
Atg1 Autophagy-specific gene 1 0.566
Ubx Ultrabithorax 0.541
ash2 absent, small, or homeotic discs 2 0.530
ato atonal 0.517
HLHm5 E(spl) region transcript m5 0.512
HLHmgamma E(spl) region transcript mgamma 0.508
klu klumpfuss 0.460
SoxN SoxNeuro 0.450
Su(H) Suppressor of Hairless 0.443
aop anterior open 0.423
Syx1A Syntaxin 1A 0.392
al aristaless 0.387
Vang Van Gogh 0.377
wg wingless 0.347
gek genghis khan 0.343
HLHmdelta E(spl) region transcript mdelta 0.309
ewg erect wing 0.299
sbb scribbler 0.277
eyg eyegone 0.272
gig gigas 0.264
HLHm3 E(spl) region transcript m3 0.260
Peb Protein ejaculatory bulb 0.252
put punt 0.252
Antp Antennapedia 0.248
emc extra macrochaetae 0.247
sc scute 0.241
Ser Serrate 0.233
elav embryonic lethal abnormal vision 0.231
norpA no receptor potential A 0.226
opa odd paired 0.223
esg escargot 0.220
hyd hyperplastic discs 0.220
l(2)gl lethal (2) giant larvae 0.213
brat brain tumor 0.212
DAAM Dishevelled Associated Activator of Morphogenesis 0.211
lid little imaginal discs 0.210
sens senseless 0.208
bowl brother of odd with entrails limited 0.206
lz lozenge 0.205
ro rough 0.201
tup tailup 0.199
ems empty spiracles 0.196
amos absent MD neurons and olfactory sensilla 0.196
hh hedgehog 0.188
Gug Grunge 0.186
l(2)k16918 lethal (2) k16918 0.185
kuz kuzbanian 0.176
ft fat 0.172
en engrailed 0.166
Ric Ras which interacts with Calmodulin 0.161
bsk basket 0.161
ush u-shaped 0.154
spi spitz 0.152
hipk homeodomain interacting protein kinase 0.150
Myo31DF Myosin 31DF 0.149
vvl ventral veins lacking 0.148
Stat92E Signal-transducer and activator of transcription protein at 92E 0.147
osa CG7467 gene product from transcript CG7467-RD 0.146
Ca-alpha1D Ca[2+]-channel protein alpha[[1]] subunit D 0.145
ttk tramtrack 0.145
fz frizzled 0.143
sno strawberry notch 0.142
cdi center divider 0.141
hpo hippo 0.137
Med Medea 0.136
dy dusky 0.135
hep hemipterous 0.134
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.133
repo reversed polarity 0.133
argos CG4531 gene product from transcript CG4531-RA 0.130
Tollo CG6890 gene product from transcript CG6890-RA 0.130
sca scabrous 0.130
CG10631 CG10631 gene product from transcript CG10631-RA 0.129
stan starry night 0.127
dm diminutive 0.127
numb CG3779 gene product from transcript CG3779-RB 0.127
Dfd Deformed 0.126
sev sevenless 0.124
tll tailless 0.123
vg vestigial 0.123
Adar Adenosine deaminase acting on RNA 0.122
so sine oculis 0.121
Tsc1 CG6147 gene product from transcript CG6147-RA 0.121
CkIIalpha Casein kinase II alpha subunit 0.121
slp1 sloppy paired 1 0.118
dpp decapentaplegic 0.117
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Homo sapiens
Name Description Probability Func Analog Organism
EP300 E1A binding protein p300 0.999
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.999
JAG1 jagged 1 0.995
ESR1 estrogen receptor 1 0.993
EGFR epidermal growth factor receptor 0.993
AR androgen receptor 0.989
NCOA1 nuclear receptor coactivator 1 0.977
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.973
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.970
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.967
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.954
SKI v-ski sarcoma viral oncogene homolog (avian) 0.945
FGFR1 fibroblast growth factor receptor 1 0.932
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.908
SETD8 SET domain containing (lysine methyltransferase) 8 0.899
INADL InaD-like (Drosophila) 0.897
HNF4A hepatocyte nuclear factor 4, alpha 0.848
APC adenomatous polyposis coli 0.831
MET met proto-oncogene (hepatocyte growth factor receptor) 0.828
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.811
PDZD11 PDZ domain containing 11 0.810
GSK3B glycogen synthase kinase 3 beta 0.809
ATXN1 ataxin 1 0.802
PDX1 pancreatic and duodenal homeobox 1 0.784
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.782
SMAD3 SMAD family member 3 0.781
TAL1 T-cell acute lymphocytic leukemia 1 0.756
MPDZ multiple PDZ domain protein 0.737
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.732
TRRAP transformation/transcription domain-associated protein 0.717
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.708
ARID1A AT rich interactive domain 1A (SWI-like) 0.705
RPL18A ribosomal protein L18a 0.703
TCF4 transcription factor 4 0.698
TP53 tumor protein p53 0.692
BCOR BCL6 corepressor 0.692
ASB2 ankyrin repeat and SOCS box containing 2 0.688
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.679
CHDH choline dehydrogenase 0.667
QKI quaking homolog, KH domain RNA binding (mouse) 0.656
RBPMS RNA binding protein with multiple splicing 0.644
GATA2 GATA binding protein 2 0.642
RUNX1 runt-related transcription factor 1 0.634
PBX1 pre-B-cell leukemia homeobox 1 0.611
EGR1 early growth response 1 0.605
ARID1B AT rich interactive domain 1B (SWI1-like) 0.596
NCOR1 nuclear receptor corepressor 1 0.582
PTCH1 patched 1 0.581
GATA4 GATA binding protein 4 0.581
SNTG2 syntrophin, gamma 2 0.580
LMO4 LIM domain only 4 0.564
TESK1 testis-specific kinase 1 0.537
SH3KBP1 SH3-domain kinase binding protein 1 0.536
SOX1 SRY (sex determining region Y)-box 1 0.522
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.508
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.503
SOX11 SRY (sex determining region Y)-box 11 0.478
SIX6 SIX homeobox 6 0.467
MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 0.467
SIRT1 sirtuin 1 0.450
GRB7 growth factor receptor-bound protein 7 0.449
SUFU suppressor of fused homolog (Drosophila) 0.447
HTT huntingtin 0.442
EGR3 early growth response 3 0.439
P4HB prolyl 4-hydroxylase, beta polypeptide 0.439
ONECUT1 one cut homeobox 1 0.423
ATN1 atrophin 1 0.419
MYOD1 myogenic differentiation 1 0.408
NEUROD1 neurogenic differentiation 1 0.383
PAX6 paired box 6 0.377
NRXN1 neurexin 1 0.376
GLIS2 GLIS family zinc finger 2 0.375
TRIP6 thyroid hormone receptor interactor 6 0.373
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.366
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.366
FOXA2 forkhead box A2 0.365
HNF1A HNF1 homeobox A 0.363
CREBBP CREB binding protein 0.359
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.356
FHL2 four and a half LIM domains 2 0.351
RAX retina and anterior neural fold homeobox 0.344
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.341
SP1 Sp1 transcription factor 0.340
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.336
SESN2 sestrin 2 0.335
ERBB2IP erbb2 interacting protein 0.326
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.323
POU4F2 POU class 4 homeobox 2 0.323
RXRA retinoid X receptor, alpha 0.321
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.320
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.319
TUBB2B tubulin, beta 2B 0.319
RIN1 Ras and Rab interactor 1 0.318
BMP7 bone morphogenetic protein 7 0.311
RANBP9 RAN binding protein 9 0.311
APLP1 amyloid beta (A4) precursor-like protein 1 0.310
HOXD12 homeobox D12 0.309
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.306
SIX3 SIX homeobox 3 0.306
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.304
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Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 1.000
Fgf8 fibroblast growth factor 8 1.000
Tbx1 T-box 1 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Pax3 paired box gene 3 0.999
Tbx3 T-box 3 0.999
Rarg retinoic acid receptor, gamma 0.999
Fgfr1 fibroblast growth factor receptor 1 0.998
Hoxa1 homeobox A1 0.998
En1 engrailed 1 0.998
Fgf10 fibroblast growth factor 10 0.998
Dlx5 distal-less homeobox 5 0.997
Emx2 empty spiracles homolog 2 (Drosophila) 0.996
Fgfr2 fibroblast growth factor receptor 2 0.996
Foxc1 forkhead box C1 0.996
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.995
Eya1 eyes absent 1 homolog (Drosophila) 0.995
Hand2 heart and neural crest derivatives expressed transcript 2 0.995
Sox2 SRY-box containing gene 2 0.994
Ctnnb1 catenin (cadherin associated protein), beta 1 0.994
Smo smoothened homolog (Drosophila) 0.994
Gli2 GLI-Kruppel family member GLI2 0.994
Lmx1a LIM homeobox transcription factor 1 alpha 0.993
Isl1 ISL1 transcription factor, LIM/homeodomain 0.993
Lef1 lymphoid enhancer binding factor 1 0.992
Msx2 homeobox, msh-like 2 0.989
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.988
Nog noggin 0.988
Lhx1 LIM homeobox protein 1 0.987
Emx1 empty spiracles homolog 1 (Drosophila) 0.986
Rara retinoic acid receptor, alpha 0.985
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.984
Lhx3 LIM homeobox protein 3 0.982
Chd7 chromodomain helicase DNA binding protein 7 0.981
Hoxa2 homeobox A2 0.981
Pten phosphatase and tensin homolog 0.979
Gbx2 gastrulation brain homeobox 2 0.975
Sox9 SRY-box containing gene 9 0.975
Foxc2 forkhead box C2 0.970
Vegfa vascular endothelial growth factor A 0.966
Phox2b paired-like homeobox 2b 0.965
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.965
Lmx1b LIM homeobox transcription factor 1 beta 0.964
Otx1 orthodenticle homolog 1 (Drosophila) 0.964
Gsc goosecoid homeobox 0.964
Pax6 paired box gene 6 0.959
Bmp4 bone morphogenetic protein 4 0.959
Msx1 homeobox, msh-like 1 0.957
Chrd chordin 0.957
Wnt1 wingless-related MMTV integration site 1 0.956
Hes1 hairy and enhancer of split 1 (Drosophila) 0.955
Prrx1 paired related homeobox 1 0.950
Hmx3 H6 homeobox 3 0.939
Gdnf glial cell line derived neurotrophic factor 0.937
Rarb retinoic acid receptor, beta 0.937
Trp63 transformation related protein 63 0.936
Pax8 paired box gene 8 0.930
Ednra endothelin receptor type A 0.926
Zeb1 zinc finger E-box binding homeobox 1 0.916
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.904
Smad6 MAD homolog 6 (Drosophila) 0.903
Kit kit oncogene 0.900
Smad1 MAD homolog 1 (Drosophila) 0.899
Tgfb2 transforming growth factor, beta 2 0.895
Vangl2 vang-like 2 (van gogh, Drosophila) 0.894
Prrx2 paired related homeobox 2 0.887
Bdnf brain derived neurotrophic factor 0.886
Smad3 MAD homolog 3 (Drosophila) 0.884
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.882
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.875
Tlx3 T-cell leukemia, homeobox 3 0.874
Lhx5 LIM homeobox protein 5 0.870
Pou3f3 POU domain, class 3, transcription factor 3 0.867
Hoxd3 homeobox D3 0.866
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.859
Wnt6 wingless-related MMTV integration site 6 0.854
Lepr leptin receptor 0.852
Twist2 twist homolog 2 (Drosophila) 0.850
Tcfap2a transcription factor AP-2, alpha 0.848
Neurod1 neurogenic differentiation 1 0.846
Ptf1a pancreas specific transcription factor, 1a 0.845
Pitx1 paired-like homeodomain transcription factor 1 0.839
Bcl2 B-cell leukemia/lymphoma 2 0.830
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.828
Zic3 zinc finger protein of the cerebellum 3 0.822
Fgf15 fibroblast growth factor 15 0.819
Insm1 insulinoma-associated 1 0.806
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.805
Drd2 dopamine receptor D2 0.798
Hoxd11 homeobox D11 0.796
Gsk3b glycogen synthase kinase 3 beta 0.796
Fzd7 frizzled homolog 7 (Drosophila) 0.789
Acvr1 activin A receptor, type 1 0.784
Dll1 delta-like 1 (Drosophila) 0.783
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.782
Mecom MDS1 and EVI1 complex locus 0.776
Ret ret proto-oncogene 0.775
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Rattus norvegicus
Name Description Probability Func Analog Organism
ND1 NADH dehydrogenase subunit 1 0.022
Bcl2 B-cell CLL/lymphoma 2 0.019
CYTB cytochrome b 0.019
ATP6 ATPase subunit 6 0.015
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.015
Kcnk3 potassium channel, subfamily K, member 3 0.014
Grid2 glutamate receptor, ionotropic, delta 2 0.013
Omp olfactory marker protein 0.013
Prlhr prolactin releasing hormone receptor 0.012
Prph2 peripherin 2 0.012
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.012
Epor erythropoietin receptor 0.011
Adarb2 adenosine deaminase, RNA-specific, B2 0.011
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.011
Accn2 amiloride-sensitive cation channel 2, neuronal 0.011
Galr3 galanin receptor 3 0.011
Grm2 glutamate receptor, metabotropic 2 0.011
Ncan neurocan 0.011
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.011
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.011
Shox2 short stature homeobox 2 0.011
Sdc3 syndecan 3 0.011
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.011
Glra1 glycine receptor, alpha 1 0.011
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.011
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.011
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.010
Gata6 GATA binding protein 6 0.010
Tnr tenascin R 0.010
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.010
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.010
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.010
Npy5r neuropeptide Y receptor Y5 0.010
Gad1 glutamate decarboxylase 1 0.010
Fgfr2 fibroblast growth factor receptor 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism