IMP

Process View

Homo sapiens

14 genes annotated in human

Multi-species View

positive regulation of neuron death

GO:1901216

Any process that activates or increases the frequency, rate or extent of neuron death.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of neuron death"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of neuron death" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	0.877	Human
CREBBP	CREB binding protein	0.832
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.812	Mouse Rat
TP53	tumor protein p53	0.693	Zebrafish Mouse
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.655
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.618	Mouse
XIAP	X-linked inhibitor of apoptosis	0.558
BCL2L1	BCL2-like 1	0.501	Human
BAD	BCL2-associated agonist of cell death	0.486
BAX	BCL2-associated X protein	0.467
MAPK8	mitogen-activated protein kinase 8	0.381
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.364
AR	androgen receptor	0.215
JUN	jun proto-oncogene	0.207	Rat
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.196
BID	BH3 interacting domain death agonist	0.193
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.167
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.126	Mouse
LDLR	low density lipoprotein receptor	0.119
NCOA3	nuclear receptor coactivator 3	0.104
APAF1	apoptotic peptidase activating factor 1	0.101
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.089
NCOA2	nuclear receptor coactivator 2	0.086
KAT2B	K(lysine) acetyltransferase 2B	0.083
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.072	Mouse
ATF3	activating transcription factor 3	0.065
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.059
APP	amyloid beta (A4) precursor protein	0.054
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.052
S100B	S100 calcium binding protein B	0.050
IER2	immediate early response 2	0.049
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.047	Rat
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.047
BAK1	BCL2-antagonist/killer 1	0.047	Human
HIPK2	homeodomain interacting protein kinase 2	0.046
MEF2A	myocyte enhancer factor 2A	0.045
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.045
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.044	Rat
BAIAP2	BAI1-associated protein 2	0.038
VAC14	Vac14 homolog (S. cerevisiae)	0.036
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.035
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.034
SH3BP4	SH3-domain binding protein 4	0.034
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.033	Mouse
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.033
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.032
WASL	Wiskott-Aldrich syndrome-like	0.032
HP	haptoglobin	0.032
ARRB1	arrestin, beta 1	0.031
A2M	alpha-2-macroglobulin	0.030
DAXX	death-domain associated protein	0.030
ZNF3	zinc finger protein 3	0.029
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.028
HUWE1	HECT, UBA and WWE domain containing 1	0.027
EP300	E1A binding protein p300	0.027
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.026
APOC1	apolipoprotein C-I	0.026
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.026
DIABLO	diablo, IAP-binding mitochondrial protein	0.026
ENG	endoglin	0.026
MAP2K1	mitogen-activated protein kinase kinase 1	0.024
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.024
CCDC6	coiled-coil domain containing 6	0.024
DDIT3	DNA-damage-inducible transcript 3	0.023	Mouse
MAPK9	mitogen-activated protein kinase 9	0.023
FGF1	fibroblast growth factor 1 (acidic)	0.021
ALK	anaplastic lymphoma receptor tyrosine kinase	0.021
TP53BP2	tumor protein p53 binding protein, 2	0.021
NCOA1	nuclear receptor coactivator 1	0.019
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.018
SKA3	spindle and kinetochore associated complex subunit 3	0.018
SNAI1	snail homolog 1 (Drosophila)	0.018
TRIB3	tribbles homolog 3 (Drosophila)	0.017
BIK	BCL2-interacting killer (apoptosis-inducing)	0.017
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.016
TP53BP1	tumor protein p53 binding protein 1	0.016
TCF4	transcription factor 4	0.016
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.016
CHERP	calcium homeostasis endoplasmic reticulum protein	0.016
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.016
FAS	Fas (TNF receptor superfamily, member 6)	0.016
FADD	Fas (TNFRSF6)-associated via death domain	0.015
ATF2	activating transcription factor 2	0.015
LRDD	leucine-rich repeats and death domain containing	0.015
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.015
BECN1	beclin 1, autophagy related	0.015
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.015
TTR	transthyretin	0.015
BBC3	BCL2 binding component 3	0.014
BTRC	beta-transducin repeat containing	0.014
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.014
BIRC2	baculoviral IAP repeat containing 2	0.014
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.014
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.013
TNF	tumor necrosis factor	0.013
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.013
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.013
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.013
KRT8	keratin 8	0.013
RIPK2	receptor-interacting serine-threonine kinase 2	0.013
CCNE1	cyclin E1	0.012
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.012
ARRB2	arrestin, beta 2	0.012
LCAT	lecithin-cholesterol acyltransferase	0.012
FES	feline sarcoma oncogene	0.012
CABLES1	Cdk5 and Abl enzyme substrate 1	0.012
ESR1	estrogen receptor 1	0.012
NCOA6	nuclear receptor coactivator 6	0.012
CAV2	caveolin 2	0.011
ALB	albumin	0.011
C4orf14	chromosome 4 open reading frame 14	0.011
IDE	insulin-degrading enzyme	0.011
KCTD1	potassium channel tetramerisation domain containing 1	0.011
SKA1	spindle and kinetochore associated complex subunit 1	0.011
TRIP10	thyroid hormone receptor interactor 10	0.011
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.010
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.010
DAB2IP	DAB2 interacting protein	0.010
FSTL1	follistatin-like 1	0.010
IRF3	interferon regulatory factor 3	0.010
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.010
ING1	inhibitor of growth family, member 1	0.010
FGFR1	fibroblast growth factor receptor 1	0.010