IMP

Process View

Homo sapiens

1 genes annotated in human

chemokine c c motif ligand 21 signaling pathway

A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "chemokine c c motif ligand 21 signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "chemokine c c motif ligand 21 signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
CCL5	chemokine (C-C motif) ligand 5	1.000
CCR5	chemokine (C-C motif) receptor 5	1.000	Human
IL2RB	interleukin 2 receptor, beta	0.996
IFNG	interferon, gamma	0.993
CCL22	chemokine (C-C motif) ligand 22	0.991
CCR2	chemokine (C-C motif) receptor 2	0.982	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.977
CCL4	chemokine (C-C motif) ligand 4	0.963
CCR4	chemokine (C-C motif) receptor 4	0.938	Human
CXCR6	chemokine (C-X-C motif) receptor 6	0.921	Human
CCR7	chemokine (C-C motif) receptor 7	0.909
CXCR3	chemokine (C-X-C motif) receptor 3	0.901	Human
IRF4	interferon regulatory factor 4	0.880
CD40LG	CD40 ligand	0.877
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.836
CLEC7A	C-type lectin domain family 7, member A	0.830
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.829
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.821
SLAMF7	SLAM family member 7	0.772
IL10RA	interleukin 10 receptor, alpha	0.684
CCR6	chemokine (C-C motif) receptor 6	0.641	Human
GPR171	G protein-coupled receptor 171	0.617
SLAMF1	signaling lymphocytic activation molecule family member 1	0.610
IL10	interleukin 10	0.539
CD2	CD2 molecule	0.493
CCL3	chemokine (C-C motif) ligand 3	0.477
CYBB	cytochrome b-245, beta polypeptide	0.472
CXCL13	chemokine (C-X-C motif) ligand 13	0.439
RNASE6	ribonuclease, RNase A family, k6	0.423
SELL	selectin L	0.386
IL2RG	interleukin 2 receptor, gamma	0.371
CXCR5	chemokine (C-X-C motif) receptor 5	0.338	Human
CXCR4	chemokine (C-X-C motif) receptor 4	0.308	Human
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.296
CD48	CD48 molecule	0.289
CCR8	chemokine (C-C motif) receptor 8	0.263	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.262
ITK	IL2-inducible T-cell kinase	0.252
CXCL10	chemokine (C-X-C motif) ligand 10	0.250
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.249
CCL11	chemokine (C-C motif) ligand 11	0.229
CCL19	chemokine (C-C motif) ligand 19	0.221
CLEC4A	C-type lectin domain family 4, member A	0.206
CD163	CD163 molecule	0.201
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.200
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.198
TNF	tumor necrosis factor	0.193
CXCR2	chemokine (C-X-C motif) receptor 2	0.181	Human
CCL7	chemokine (C-C motif) ligand 7	0.172
IL1B	interleukin 1, beta	0.155
CD86	CD86 molecule	0.155
IL21R	interleukin 21 receptor	0.149
BIN2	bridging integrator 2	0.148
FASLG	Fas ligand (TNF superfamily, member 6)	0.142
GPR18	G protein-coupled receptor 18	0.120
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.113
IL18RAP	interleukin 18 receptor accessory protein	0.107
CCL8	chemokine (C-C motif) ligand 8	0.106
CCL20	chemokine (C-C motif) ligand 20	0.100
CCR9	chemokine (C-C motif) receptor 9	0.098	Human
LGALS2	lectin, galactoside-binding, soluble, 2	0.095
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.090
TRAF1	TNF receptor-associated factor 1	0.087
GZMK	granzyme K (granzyme 3; tryptase II)	0.078
IL1R2	interleukin 1 receptor, type II	0.075
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.074
IL1F5	interleukin 1 family, member 5 (delta)	0.071
IGSF6	immunoglobulin superfamily, member 6	0.067
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.061
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.060
RGS1	regulator of G-protein signaling 1	0.059
SASH3	SAM and SH3 domain containing 3	0.058
LAG3	lymphocyte-activation gene 3	0.058
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.056
IL8	interleukin 8	0.055
RUNX3	runt-related transcription factor 3	0.055
CD83	CD83 molecule	0.053
DPP4	dipeptidyl-peptidase 4	0.052
CD69	CD69 molecule	0.050
IL7R	interleukin 7 receptor	0.046
IL2RA	interleukin 2 receptor, alpha	0.043
ADAMDEC1	ADAM-like, decysin 1	0.042
GPR109B	G protein-coupled receptor 109B	0.042
TAGAP	T-cell activation RhoGTPase activating protein	0.040
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.039
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.038
MSR1	macrophage scavenger receptor 1	0.037
TBX21	T-box 21	0.037
C3AR1	complement component 3a receptor 1	0.037
CD1C	CD1c molecule	0.036
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.035
AQP9	aquaporin 9	0.034
CYTIP	cytohesin 1 interacting protein	0.033
SLAMF6	SLAM family member 6	0.032
LAMP3	lysosomal-associated membrane protein 3	0.032
CXCR1	chemokine (C-X-C motif) receptor 1	0.032	Human
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.031
IRF8	interferon regulatory factor 8	0.031
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.031
UBASH3A	ubiquitin associated and SH3 domain containing A	0.031
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.031
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.031
CCL2	chemokine (C-C motif) ligand 2	0.030
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.030
PTAFR	platelet-activating factor receptor	0.030
CLEC4E	C-type lectin domain family 4, member E	0.029
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.029
IL4	interleukin 4	0.028
FGL2	fibrinogen-like 2	0.027
PVRIG	poliovirus receptor related immunoglobulin domain containing	0.027
SIT1	signaling threshold regulating transmembrane adaptor 1	0.027
CCR3	chemokine (C-C motif) receptor 3	0.026	Human
PRAF2	PRA1 domain family, member 2	0.026
XCR1	chemokine (C motif) receptor 1	0.026	Human
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.025
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.025
SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	0.025
CD1A	CD1a molecule	0.025
IL1A	interleukin 1, alpha	0.025
CD22	CD22 molecule	0.024
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.024
LY9	lymphocyte antigen 9	0.024
AOAH	acyloxyacyl hydrolase (neutrophil)	0.024
CD28	CD28 molecule	0.024
GRAP2	GRB2-related adaptor protein 2	0.024
PRF1	perforin 1 (pore forming protein)	0.024
TRAF3IP3	TRAF3 interacting protein 3	0.023
IL13	interleukin 13	0.023
CD226	CD226 molecule	0.023
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.023
IL6R	interleukin 6 receptor	0.023
FAIM3	Fas apoptotic inhibitory molecule 3	0.022
GPR65	G protein-coupled receptor 65	0.022
SELPLG	selectin P ligand	0.022
PLEK	pleckstrin	0.022
NCF2	neutrophil cytosolic factor 2	0.021
F13A1	coagulation factor XIII, A1 polypeptide	0.021
GPR183	G protein-coupled receptor 183	0.021
EVI2B	ecotropic viral integration site 2B	0.020
CLEC10A	C-type lectin domain family 10, member A	0.019
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.019
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.019
CCR1	chemokine (C-C motif) receptor 1	0.019	Human
CD160	CD160 molecule	0.019
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.019
AIM2	absent in melanoma 2	0.018
CTSS	cathepsin S	0.018
CD1B	CD1b molecule	0.018
CNR2	cannabinoid receptor 2 (macrophage)	0.018
CD4	CD4 molecule	0.017
SIRPB1	signal-regulatory protein beta 1	0.017
TARP	TCR gamma alternate reading frame protein	0.017
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.017
PTPRE	protein tyrosine phosphatase, receptor type, E	0.017
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.017
TRAT1	T cell receptor associated transmembrane adaptor 1	0.017
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.017
EVI2A	ecotropic viral integration site 2A	0.017
CD8A	CD8a molecule	0.016
PDCD1LG2	programmed cell death 1 ligand 2	0.016
GIMAP4	GTPase, IMAP family member 4	0.016
BATF	basic leucine zipper transcription factor, ATF-like	0.016
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.016
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.016
ICOS	inducible T-cell co-stimulator	0.016
KRT1	keratin 1	0.015
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.015
SLA	Src-like-adaptor	0.015
XCL2	chemokine (C motif) ligand 2	0.015
CCL13	chemokine (C-C motif) ligand 13	0.015
CD80	CD80 molecule	0.015
FFAR2	free fatty acid receptor 2	0.015
EBI3	Epstein-Barr virus induced 3	0.014
STAT4	signal transducer and activator of transcription 4	0.014
CLC	Charcot-Leyden crystal protein	0.014
SIGLEC7	sialic acid binding Ig-like lectin 7	0.014
IL18R1	interleukin 18 receptor 1	0.014
IDO1	indoleamine 2,3-dioxygenase 1	0.013
CSF1R	colony stimulating factor 1 receptor	0.013
ZBTB32	zinc finger and BTB domain containing 32	0.013
TLR8	toll-like receptor 8	0.013
BCL2A1	BCL2-related protein A1	0.013
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.013
CCL1	chemokine (C-C motif) ligand 1	0.013
CD1E	CD1e molecule	0.012
IL21	interleukin 21	0.012
CLEC5A	C-type lectin domain family 5, member A	0.012
TLR7	toll-like receptor 7	0.012
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.012
ZBP1	Z-DNA binding protein 1	0.012
CD84	CD84 molecule	0.012
CD3D	CD3d molecule, delta (CD3-TCR complex)	0.012
FPR2	formyl peptide receptor 2	0.012
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.012
IL1RN	interleukin 1 receptor antagonist	0.012
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.011
BLK	B lymphoid tyrosine kinase	0.011
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.011
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.011
EOMES	eomesodermin	0.011
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.011
ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.011
CD53	CD53 molecule	0.011
ZBED2	zinc finger, BED-type containing 2	0.011
UBD	ubiquitin D	0.010
RUNX2	runt-related transcription factor 2	0.010
IL24	interleukin 24	0.010
CCL23	chemokine (C-C motif) ligand 23	0.010
LAX1	lymphocyte transmembrane adaptor 1	0.010
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.010
GPR132	G protein-coupled receptor 132	0.010
CHI3L2	chitinase 3-like 2	0.010
CLEC2B	C-type lectin domain family 2, member B	0.010
P2RY10	purinergic receptor P2Y, G-protein coupled, 10	0.010