IMP

Process View

Homo sapiens

27 genes annotated in human

regulation of release of sequestered calcium ion into cytosol

Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of release of sequestered calcium ion into cytosol"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of release of sequestered calcium ion into cytosol" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	0.994	Human
GSTM1	glutathione S-transferase mu 1	0.954	Human
NCF1	neutrophil cytosolic factor 1	0.946
CCL5	chemokine (C-C motif) ligand 5	0.804	Human
GSTM2	glutathione S-transferase mu 2 (muscle)	0.802
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.788
IL8	interleukin 8	0.758	Human
CCL22	chemokine (C-C motif) ligand 22	0.623	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.606
CCL4	chemokine (C-C motif) ligand 4	0.564	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.397	Human
GSTM4	glutathione S-transferase mu 4	0.389	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.383
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.354	Human
SYK	spleen tyrosine kinase	0.337
DTNA	dystrobrevin, alpha	0.335
CCR7	chemokine (C-C motif) receptor 7	0.319	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.318
IFNG	interferon, gamma	0.317
CCL20	chemokine (C-C motif) ligand 20	0.304	Human
CXCL3	chemokine (C-X-C motif) ligand 3	0.292	Human
DPP4	dipeptidyl-peptidase 4	0.265
CCL8	chemokine (C-C motif) ligand 8	0.246	Human
CXCL5	chemokine (C-X-C motif) ligand 5	0.215	Human
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.215
IL1B	interleukin 1, beta	0.196
TGFBR1	transforming growth factor, beta receptor 1	0.185
CCL7	chemokine (C-C motif) ligand 7	0.169	Human
CCL2	chemokine (C-C motif) ligand 2	0.157	Human
MPDZ	multiple PDZ domain protein	0.150
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.146
KIAA1683	KIAA1683	0.143
CD22	CD22 molecule	0.143
CCR4	chemokine (C-C motif) receptor 4	0.129	Human
CCR2	chemokine (C-C motif) receptor 2	0.122	Human
IL2RB	interleukin 2 receptor, beta	0.122
CCL3	chemokine (C-C motif) ligand 3	0.121	Human
CCL19	chemokine (C-C motif) ligand 19	0.117	Human
CXCL13	chemokine (C-X-C motif) ligand 13	0.116
BLNK	B-cell linker	0.109
CCL13	chemokine (C-C motif) ligand 13	0.106	Human
IL10	interleukin 10	0.104
CXCR3	chemokine (C-X-C motif) receptor 3	0.103
BAK1	BCL2-antagonist/killer 1	0.101
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.083
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.082
CLEC7A	C-type lectin domain family 7, member A	0.081
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.080
ACVR1B	activin A receptor, type IB	0.079
ARRB2	arrestin, beta 2	0.077
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.075	Human
CCL11	chemokine (C-C motif) ligand 11	0.075	Human
ACTB	actin, beta	0.075
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.068
IL6	interleukin 6 (interferon, beta 2)	0.067
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.067
ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	0.064
PSEN2	presenilin 2 (Alzheimer disease 4)	0.063
CD40LG	CD40 ligand	0.062
NCF2	neutrophil cytosolic factor 2	0.062
BCL2L1	BCL2-like 1	0.061
RNR2	l-rRNA	0.061
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.060	Human
SH3BP2	SH3-domain binding protein 2	0.058
SPTBN1	spectrin, beta, non-erythrocytic 1	0.056
TNF	tumor necrosis factor	0.055
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.054
TTN	titin	0.052
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.050
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.046
MATK	megakaryocyte-associated tyrosine kinase	0.046
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.046
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.045
IRF4	interferon regulatory factor 4	0.044
BAD	BCL2-associated agonist of cell death	0.042
PTEN	phosphatase and tensin homolog	0.042
AKAP6	A kinase (PRKA) anchor protein 6	0.041
CCR1	chemokine (C-C motif) receptor 1	0.040	Human
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.040
CXCR6	chemokine (C-X-C motif) receptor 6	0.040	Human
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.039
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.039
NCF4	neutrophil cytosolic factor 4, 40kDa	0.038
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.038
PRKCA	protein kinase C, alpha	0.037
SYNM	synemin, intermediate filament protein	0.036
SOCS3	suppressor of cytokine signaling 3	0.035
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.035
UBD	ubiquitin D	0.034
PF4	platelet factor 4	0.034	Human
THBS1	thrombospondin 1	0.034
IL2RG	interleukin 2 receptor, gamma	0.033
SLAMF7	SLAM family member 7	0.033
IL1RN	interleukin 1 receptor antagonist	0.032
CD79B	CD79b molecule, immunoglobulin-associated beta	0.032
RGS1	regulator of G-protein signaling 1	0.032
SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.031
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.030
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.030
VAV1	vav 1 guanine nucleotide exchange factor	0.030
CXCR2	chemokine (C-X-C motif) receptor 2	0.030	Human
CCR3	chemokine (C-C motif) receptor 3	0.029	Human
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.029
PRKCD	protein kinase C, delta	0.028
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.028	Human
MUC1	mucin 1, cell surface associated	0.028
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.028
FGA	fibrinogen alpha chain	0.028
SELE	selectin E	0.027
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.027
TRPC3	transient receptor potential cation channel, subfamily C, member 3	0.027	Human
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.027
IL18RAP	interleukin 18 receptor accessory protein	0.026
IDO1	indoleamine 2,3-dioxygenase 1	0.026
LAMP3	lysosomal-associated membrane protein 3	0.025
IL1R2	interleukin 1 receptor, type II	0.025
MAPK4	mitogen-activated protein kinase 4	0.024
CFL1	cofilin 1 (non-muscle)	0.024
BCL2A1	BCL2-related protein A1	0.024
IL10RA	interleukin 10 receptor, alpha	0.024
CAV1	caveolin 1, caveolae protein, 22kDa	0.024
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.023
MYO10	myosin X	0.023
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.023
RHAG	Rh-associated glycoprotein	0.023
NOP10	NOP10 ribonucleoprotein homolog (yeast)	0.023
IL21R	interleukin 21 receptor	0.023
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.023
RNF144B	ring finger protein 144B	0.022
ARRB1	arrestin, beta 1	0.022
GSTM3	glutathione S-transferase mu 3 (brain)	0.022	Human
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.022
MAPT	microtubule-associated protein tau	0.022
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.022
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.021
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.021
TRIM9	tripartite motif containing 9	0.021
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.020
SNCAIP	synuclein, alpha interacting protein	0.020
CH25H	cholesterol 25-hydroxylase	0.020
CCR8	chemokine (C-C motif) receptor 8	0.020	Human
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.020
IL1A	interleukin 1, alpha	0.020
SPTB	spectrin, beta, erythrocytic	0.019
SSTR3	somatostatin receptor 3	0.019
CCR6	chemokine (C-C motif) receptor 6	0.019	Human
CD83	CD83 molecule	0.018
CARD11	caspase recruitment domain family, member 11	0.018
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.018	Mouse
SOD2	superoxide dismutase 2, mitochondrial	0.018
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.018
PF4V1	platelet factor 4 variant 1	0.018	Human
AQP9	aquaporin 9	0.018
S100A12	S100 calcium binding protein A12	0.018
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.017
EBI3	Epstein-Barr virus induced 3	0.017
SKIL	SKI-like oncogene	0.017
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.017
CAV2	caveolin 2	0.017
TGFB3	transforming growth factor, beta 3	0.017
ENG	endoglin	0.017
C1orf93	chromosome 1 open reading frame 93	0.017
GRB2	growth factor receptor-bound protein 2	0.017
APP	amyloid beta (A4) precursor protein	0.017
PTPRA	protein tyrosine phosphatase, receptor type, A	0.017
EHD1	EH-domain containing 1	0.016
CXCR5	chemokine (C-X-C motif) receptor 5	0.016	Human
DTNB	dystrobrevin, beta	0.016
IL7R	interleukin 7 receptor	0.016
GPR171	G protein-coupled receptor 171	0.016
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.016
NKG7	natural killer cell group 7 sequence	0.016
CCL1	chemokine (C-C motif) ligand 1	0.016	Human
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.016
ADAMDEC1	ADAM-like, decysin 1	0.016
IRF8	interferon regulatory factor 8	0.016
WNT2	wingless-type MMTV integration site family member 2	0.016
FPR3	formyl peptide receptor 3	0.015
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.015
CCR9	chemokine (C-C motif) receptor 9	0.015	Human
IL1F5	interleukin 1 family, member 5 (delta)	0.015
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.015
DARC	Duffy blood group, chemokine receptor	0.015
CD160	CD160 molecule	0.015
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.015
VCAM1	vascular cell adhesion molecule 1	0.014
PLEK	pleckstrin	0.014
FKBP1A	FK506 binding protein 1A, 12kDa	0.014	Human
PI3	peptidase inhibitor 3, skin-derived	0.014
CLEC10A	C-type lectin domain family 10, member A	0.014
LRRK2	leucine-rich repeat kinase 2	0.014
LGALS2	lectin, galactoside-binding, soluble, 2	0.014
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	0.014
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.014	Human
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.014
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.014	Human
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.014
CXCR1	chemokine (C-X-C motif) receptor 1	0.014	Human
ICAM1	intercellular adhesion molecule 1	0.014
CCL21	chemokine (C-C motif) ligand 21	0.014
CALCOCO2	calcium binding and coiled-coil domain 2	0.014
GPR109B	G protein-coupled receptor 109B	0.014
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.013
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.013
RNASE3	ribonuclease, RNase A family, 3	0.013
PRKCB	protein kinase C, beta	0.013
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.013	Human
GZMK	granzyme K (granzyme 3; tryptase II)	0.013
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.013
IL2RA	interleukin 2 receptor, alpha	0.013
VAV2	vav 2 guanine nucleotide exchange factor	0.013
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.013
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.013
PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	0.013
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.013
CD72	CD72 molecule	0.013
STAT4	signal transducer and activator of transcription 4	0.013
OSMR	oncostatin M receptor	0.013
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.013
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.013
RHOA	ras homolog gene family, member A	0.012
TLR2	toll-like receptor 2	0.012
BCL2	B-cell CLL/lymphoma 2	0.012
DOCK7	dedicator of cytokinesis 7	0.012
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.012
ARF3	ADP-ribosylation factor 3	0.012
INHBA	inhibin, beta A	0.012
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.012
LAG3	lymphocyte-activation gene 3	0.012
EFNA1	ephrin-A1	0.012
TRAPPC1	trafficking protein particle complex 1	0.012
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.012
IL18R1	interleukin 18 receptor 1	0.012
ITPR3	inositol 1,4,5-trisphosphate receptor, type 3	0.012
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.011
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.011
CABP1	calcium binding protein 1	0.011
CCL23	chemokine (C-C motif) ligand 23	0.011	Human
C2	complement component 2	0.011
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.011
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.011
IL1F9	interleukin 1 family, member 9	0.011
CALM3	calmodulin 3 (phosphorylase kinase, delta)	0.011
CFP	complement factor properdin	0.011
HBA2	hemoglobin, alpha 2	0.011
BLK	B lymphoid tyrosine kinase	0.011
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.011
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.011
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.011
TRPC4	transient receptor potential cation channel, subfamily C, member 4	0.011	Human
XCL1	chemokine (C motif) ligand 1	0.011
ARRDC3	arrestin domain containing 3	0.011
GPR18	G protein-coupled receptor 18	0.011	Human
PDE4B	phosphodiesterase 4B, cAMP-specific	0.011
EPB42	erythrocyte membrane protein band 4.2	0.010
BCL10	B-cell CLL/lymphoma 10	0.010
DNASE1L3	deoxyribonuclease I-like 3	0.010
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.010
MSC	musculin	0.010
S100A9	S100 calcium binding protein A9	0.010
RAB5C	RAB5C, member RAS oncogene family	0.010
F3	coagulation factor III (thromboplastin, tissue factor)	0.010
PECAM1	platelet/endothelial cell adhesion molecule	0.010
SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	0.010
SELL	selectin L	0.010
PDCD6IP	programmed cell death 6 interacting protein	0.010
PTPRF	protein tyrosine phosphatase, receptor type, F	0.010
CD80	CD80 molecule	0.010
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.010
EGF	epidermal growth factor	0.010