IMP
Process View
signal transduction involved in cell cycle checkpoint
A signal transduction process that contributes to a cell cycle checkpoint.
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Click on a gene's description to view its network relationships with genes known to be involved in "signal transduction involved in cell cycle checkpoint"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.986 | ||
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.964 | Human | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.926 | Human | |
| XIAP | X-linked inhibitor of apoptosis | 0.858 | ||
| RB1 | retinoblastoma 1 | 0.738 | ||
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.722 | ||
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.685 | ||
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.642 | ||
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.560 | Human | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.463 | Human | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.448 | ||
| TP53 | tumor protein p53 | 0.447 | Mouse | |
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.419 | ||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.326 | ||
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.287 | ||
| IER3 | immediate early response 3 | 0.257 | ||
| POU3F2 | POU class 3 homeobox 2 | 0.256 | ||
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.243 | ||
| LRDD | leucine-rich repeats and death domain containing | 0.225 | ||
| SF3A2 | splicing factor 3a, subunit 2, 66kDa | 0.218 | ||
| FADD | Fas (TNFRSF6)-associated via death domain | 0.212 | ||
| PAX3 | paired box 3 | 0.183 | ||
| NLRC4 | NLR family, CARD domain containing 4 | 0.160 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 0.149 | ||
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.109 | ||
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.100 | ||
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.095 | ||
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | 0.082 | Human | |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.067 | ||
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.066 | ||
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.064 | ||
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.063 | ||
| POU5F1 | POU class 5 homeobox 1 | 0.062 | ||
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.062 | ||
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.058 | ||
| MEOX2 | mesenchyme homeobox 2 | 0.049 | ||
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.048 | Human | |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.047 | Human | |
| SMAD7 | SMAD family member 7 | 0.044 | ||
| CCND1 | cyclin D1 | 0.039 | ||
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.038 | ||
| CDK6 | cyclin-dependent kinase 6 | 0.036 | ||
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.035 | ||
| DZIP1 | DAZ interacting protein 1 | 0.029 | ||
| NOTCH1 | notch 1 | 0.026 | ||
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.024 | ||
| NBN | nibrin | 0.024 | ||
| PLRG1 | pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) | 0.024 | ||
| BCL2 | B-cell CLL/lymphoma 2 | 0.024 | ||
| FOXD3 | forkhead box D3 | 0.022 | ||
| CDK2 | cyclin-dependent kinase 2 | 0.022 | ||
| SP100 | SP100 nuclear antigen | 0.022 | ||
| MARCKSL1 | MARCKS-like 1 | 0.021 | ||
| AXIN1 | axin 1 | 0.021 | ||
| PPP5C | protein phosphatase 5, catalytic subunit | 0.021 | ||
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | 0.020 | ||
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.020 | ||
| NUCB2 | nucleobindin 2 | 0.019 | ||
| EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 | 0.019 | ||
| HIPK2 | homeodomain interacting protein kinase 2 | 0.019 | ||
| CCND3 | cyclin D3 | 0.018 | ||
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.018 | ||
| CUX1 | cut-like homeobox 1 | 0.017 | ||
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.017 | ||
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.017 | ||
| GORAB | golgin, RAB6-interacting | 0.016 | ||
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.016 | Human | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.016 | ||
| HDAC4 | histone deacetylase 4 | 0.015 | ||
| RBL2 | retinoblastoma-like 2 (p130) | 0.014 | ||
| TTI1 | Tel2 interacting protein 1 homolog (S. pombe) | 0.014 | ||
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.014 | ||
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.013 | ||
| SALL2 | sal-like 2 (Drosophila) | 0.013 | ||
| TELO2 | TEL2, telomere maintenance 2, homolog (S. cerevisiae) | 0.013 | ||
| IFI16 | interferon, gamma-inducible protein 16 | 0.013 | ||
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | 0.012 | ||
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.012 | ||
| TP53BP1 | tumor protein p53 binding protein 1 | 0.012 | ||
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.012 | ||
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.012 | ||
| PARP1 | poly (ADP-ribose) polymerase 1 | 0.012 | ||
| CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | 0.011 | ||
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.011 | ||
| RBL1 | retinoblastoma-like 1 (p107) | 0.011 | ||
| ATMIN | ATM interactor | 0.011 | ||
| PRPF8 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) | 0.011 | ||
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.010 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.010 | ||
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.010 | ||
| PPP2R5D | protein phosphatase 2, regulatory subunit B', delta | 0.010 | Human | |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.010 |