IMP

Process View

Homo sapiens

17 genes annotated in human

mitotic g1 s transition checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitotic g1 s transition checkpoint"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mitotic g1 s transition checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.996
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.976
RB1	retinoblastoma 1	0.960
XIAP	X-linked inhibitor of apoptosis	0.923
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.829
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.811	Human
TP53	tumor protein p53	0.641
APAF1	apoptotic peptidase activating factor 1	0.617
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.550
CDK6	cyclin-dependent kinase 6	0.493
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.441
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.438	Human
RPA1	replication protein A1, 70kDa	0.437
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.376
FAS	Fas (TNF receptor superfamily, member 6)	0.376
CCND3	cyclin D3	0.369	Human
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.287
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.265
LRDD	leucine-rich repeats and death domain containing	0.259
CCND1	cyclin D1	0.245
RIPK2	receptor-interacting serine-threonine kinase 2	0.226
IER3	immediate early response 3	0.215
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.198
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.191
CDK2	cyclin-dependent kinase 2	0.190
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.186	Human
PCGF2	polycomb group ring finger 2	0.180
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.147	Human
WWOX	WW domain containing oxidoreductase	0.144
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.142
POU5F1	POU class 5 homeobox 1	0.110
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.109	Human
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.095
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.093
CFLAR	CASP8 and FADD-like apoptosis regulator	0.083
FASLG	Fas ligand (TNF superfamily, member 6)	0.079
POU3F2	POU class 3 homeobox 2	0.066
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.064
SKP2	S-phase kinase-associated protein 2 (p45)	0.053
BCL2	B-cell CLL/lymphoma 2	0.053
PAX3	paired box 3	0.047
HIPK2	homeodomain interacting protein kinase 2	0.046
RBL2	retinoblastoma-like 2 (p130)	0.044
ARRB2	arrestin, beta 2	0.043
PRNP	prion protein	0.039
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.038
BRCA1	breast cancer 1, early onset	0.037
FADD	Fas (TNFRSF6)-associated via death domain	0.037
BIRC2	baculoviral IAP repeat containing 2	0.034
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.033
FOXD3	forkhead box D3	0.033
SKP1	S-phase kinase-associated protein 1	0.033
MKRN1	makorin ring finger protein 1	0.033
SMAD7	SMAD family member 7	0.030
DAXX	death-domain associated protein	0.030
CCND2	cyclin D2	0.030	Human
RBL1	retinoblastoma-like 1 (p107)	0.029
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.027
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.027
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.026
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.022
CCNE1	cyclin E1	0.022
KRT5	keratin 5	0.021
MED1	mediator complex subunit 1	0.021
NOTCH1	notch 1	0.020
NUCB2	nucleobindin 2	0.020
SPRR2A	small proline-rich protein 2A	0.020
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.019	Human
GORAB	golgin, RAB6-interacting	0.018
RYBP	RING1 and YY1 binding protein	0.018
CCNA1	cyclin A1	0.018
PIM1	pim-1 oncogene	0.018
DIABLO	diablo, IAP-binding mitochondrial protein	0.017
CSNK1A1	casein kinase 1, alpha 1	0.016
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.016
GSK3B	glycogen synthase kinase 3 beta	0.015
CABLES1	Cdk5 and Abl enzyme substrate 1	0.014
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.014
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.014
MARCKSL1	MARCKS-like 1	0.014
SATB2	SATB homeobox 2	0.014
YAP1	Yes-associated protein 1	0.014
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.013
ELF4	E74-like factor 4 (ets domain transcription factor)	0.013
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.013
RIOK3	RIO kinase 3 (yeast)	0.013
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.013
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.012	Human
RPS27L	ribosomal protein S27-like	0.012
UNG	uracil-DNA glycosylase	0.011
E2F3	E2F transcription factor 3	0.011
SALL2	sal-like 2 (Drosophila)	0.011
DZIP1	DAZ interacting protein 1	0.011
PML	promyelocytic leukemia	0.011	Mouse
CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.010
CDK14	cyclin-dependent kinase 14	0.010