The network for 'mitotic g1 s transition checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic g1 s transition checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle.

Homo sapiens
Name Description Probability Func Analog Organism
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.996
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.976
RB1 retinoblastoma 1 0.960
XIAP X-linked inhibitor of apoptosis 0.923
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.829
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.811
TP53 tumor protein p53 0.641
APAF1 apoptotic peptidase activating factor 1 0.617
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.550
CDK6 cyclin-dependent kinase 6 0.493
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.441
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.438
RPA1 replication protein A1, 70kDa 0.437
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.376
FAS Fas (TNF receptor superfamily, member 6) 0.376
CCND3 cyclin D3 0.369
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.287
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.265
LRDD leucine-rich repeats and death domain containing 0.259
CCND1 cyclin D1 0.245
RIPK2 receptor-interacting serine-threonine kinase 2 0.226
IER3 immediate early response 3 0.215
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.198
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.191
CDK2 cyclin-dependent kinase 2 0.190
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.186
PCGF2 polycomb group ring finger 2 0.180
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.147
WWOX WW domain containing oxidoreductase 0.144
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.142
POU5F1 POU class 5 homeobox 1 0.110
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.109
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.095
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.093
CFLAR CASP8 and FADD-like apoptosis regulator 0.083
FASLG Fas ligand (TNF superfamily, member 6) 0.079
POU3F2 POU class 3 homeobox 2 0.066
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.064
SKP2 S-phase kinase-associated protein 2 (p45) 0.053
BCL2 B-cell CLL/lymphoma 2 0.053
PAX3 paired box 3 0.047
HIPK2 homeodomain interacting protein kinase 2 0.046
RBL2 retinoblastoma-like 2 (p130) 0.044
ARRB2 arrestin, beta 2 0.043
PRNP prion protein 0.039
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.038
BRCA1 breast cancer 1, early onset 0.037
FADD Fas (TNFRSF6)-associated via death domain 0.037
BIRC2 baculoviral IAP repeat containing 2 0.034
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.033
FOXD3 forkhead box D3 0.033
SKP1 S-phase kinase-associated protein 1 0.033
MKRN1 makorin ring finger protein 1 0.033
SMAD7 SMAD family member 7 0.030
DAXX death-domain associated protein 0.030
CCND2 cyclin D2 0.030
RBL1 retinoblastoma-like 1 (p107) 0.029
GADD45A growth arrest and DNA-damage-inducible, alpha 0.027
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 0.027
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.026
CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c 0.022
CCNE1 cyclin E1 0.022
KRT5 keratin 5 0.021
MED1 mediator complex subunit 1 0.021
NOTCH1 notch 1 0.020
NUCB2 nucleobindin 2 0.020
SPRR2A small proline-rich protein 2A 0.020
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.019
GORAB golgin, RAB6-interacting 0.018
RYBP RING1 and YY1 binding protein 0.018
CCNA1 cyclin A1 0.018
PIM1 pim-1 oncogene 0.018
DIABLO diablo, IAP-binding mitochondrial protein 0.017
CSNK1A1 casein kinase 1, alpha 1 0.016
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.016
GSK3B glycogen synthase kinase 3 beta 0.015
CABLES1 Cdk5 and Abl enzyme substrate 1 0.014
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.014
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.014
MARCKSL1 MARCKS-like 1 0.014
SATB2 SATB homeobox 2 0.014
YAP1 Yes-associated protein 1 0.014
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.013
ELF4 E74-like factor 4 (ets domain transcription factor) 0.013
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.013
RIOK3 RIO kinase 3 (yeast) 0.013
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.013
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.012
RPS27L ribosomal protein S27-like 0.012
UNG uracil-DNA glycosylase 0.011
E2F3 E2F transcription factor 3 0.011
SALL2 sal-like 2 (Drosophila) 0.011
DZIP1 DAZ interacting protein 1 0.011
PML promyelocytic leukemia 0.011
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 0.010
CDK14 cyclin-dependent kinase 14 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.786
Mdm4 transformed mouse 3T3 cell double minute 4 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism