IMP

Process View

Homo sapiens

14 genes annotated in human

ear development

The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ear development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ear development" (in gray)

Name	Description	Probability	Func Analog Organism
BBS10	Bardet-Biedl syndrome 10	0.618
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.408
NOTCH1	notch 1	0.402	Mouse
TAL1	T-cell acute lymphocytic leukemia 1	0.333
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.292
ZFYVE9	zinc finger, FYVE domain containing 9	0.231
PAX3	paired box 3	0.208
CSNK1E	casein kinase 1, epsilon	0.200
FSTL1	follistatin-like 1	0.181
NOTCH3	notch 3	0.164
FGF1	fibroblast growth factor 1 (acidic)	0.163
POU3F2	POU class 3 homeobox 2	0.160
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.114
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.090
BMPR1A	bone morphogenetic protein receptor, type IA	0.081
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.073	Mouse
JAG1	jagged 1	0.061	Zebrafish Mouse Rat
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.059
COL3A1	collagen, type III, alpha 1	0.057
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.056
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.055	Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.052
COL2A1	collagen, type II, alpha 1	0.050	Mouse
BMP7	bone morphogenetic protein 7	0.046
COL1A1	collagen, type I, alpha 1	0.046
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.046
SMAD3	SMAD family member 3	0.044
HNF4A	hepatocyte nuclear factor 4, alpha	0.043
SOX2	SRY (sex determining region Y)-box 2	0.042
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.042
FZD1	frizzled homolog 1 (Drosophila)	0.042
CAV1	caveolin 1, caveolae protein, 22kDa	0.042
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.041
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.039
NKX2-1	NK2 homeobox 1	0.038
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.037
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.037
FOXA2	forkhead box A2	0.037
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.036
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.035	Mouse
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.031
PTCH1	patched 1	0.031
BCL2L1	BCL2-like 1	0.030
IRS1	insulin receptor substrate 1	0.030
TM4SF1	transmembrane 4 L six family member 1	0.029
VEGFA	vascular endothelial growth factor A	0.029
MEOX2	mesenchyme homeobox 2	0.029
MEOX1	mesenchyme homeobox 1	0.029
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.028	Rat
PLCG1	phospholipase C, gamma 1	0.028
RB1	retinoblastoma 1	0.027
PPARA	peroxisome proliferator-activated receptor alpha	0.027
MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	0.026	Mouse
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.026
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.025
APC	adenomatous polyposis coli	0.025
PLXNB1	plexin B1	0.025
WT1	Wilms tumor 1	0.024
SMAD7	SMAD family member 7	0.024
TBX5	T-box 5	0.024
GFI1B	growth factor independent 1B transcription repressor	0.024
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.022	Rat
HSPB1	heat shock 27kDa protein 1	0.022
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.022
TCF4	transcription factor 4	0.022
PDZK1	PDZ domain containing 1	0.020
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.020
SIX3	SIX homeobox 3	0.020
COL5A1	collagen, type V, alpha 1	0.019
EGFR	epidermal growth factor receptor	0.019
SOX1	SRY (sex determining region Y)-box 1	0.019	Human
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.018
MSX2	msh homeobox 2	0.018
FRS2	fibroblast growth factor receptor substrate 2	0.018
AXIN1	axin 1	0.018
KRT8	keratin 8	0.018
IGF1R	insulin-like growth factor 1 receptor	0.018	Zebrafish
FOXD3	forkhead box D3	0.017
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.017
MSX1	msh homeobox 1	0.017	Zebrafish Mouse
HSF1	heat shock transcription factor 1	0.017
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.017	Zebrafish
USHBP1	Usher syndrome 1C binding protein 1	0.017
PTMA	prothymosin, alpha	0.017
SOX11	SRY (sex determining region Y)-box 11	0.017	Human
PAX6	paired box 6	0.016
TGFB3	transforming growth factor, beta 3	0.016	Rat
PAX2	paired box 2	0.016	Human Mouse
HOXA10	homeobox A10	0.016
HMGA2	high mobility group AT-hook 2	0.016
TBX2	T-box 2	0.016
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.016
SIM2	single-minded homolog 2 (Drosophila)	0.016
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.016
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.016
BCR	breakpoint cluster region	0.015	Mouse
FBN1	fibrillin 1	0.015
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.015
LRRK2	leucine-rich repeat kinase 2	0.015
SOX9	SRY (sex determining region Y)-box 9	0.015	Human Zebrafish Mouse
MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	0.015	Mouse
RET	ret proto-oncogene	0.014
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.014
SIX6	SIX homeobox 6	0.014
HOXC8	homeobox C8	0.014
MAML1	mastermind-like 1 (Drosophila)	0.014
NCOR2	nuclear receptor corepressor 2	0.014
RSBN1	round spermatid basic protein 1	0.013
LRP6	low density lipoprotein receptor-related protein 6	0.013
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.013
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.013	Rat
TCF12	transcription factor 12	0.013
ADAM12	ADAM metallopeptidase domain 12	0.013
TARBP2	TAR (HIV-1) RNA binding protein 2	0.013
WNT10A	wingless-type MMTV integration site family, member 10A	0.013
MCC	mutated in colorectal cancers	0.013
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.013
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.013
USH1C	Usher syndrome 1C (autosomal recessive, severe)	0.013	Mouse
MAPK14	mitogen-activated protein kinase 14	0.013
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.013
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.012
C1QA	complement component 1, q subcomponent, A chain	0.012
OCLN	occludin	0.012
TBC1D10A	TBC1 domain family, member 10A	0.012
OSBPL8	oxysterol binding protein-like 8	0.012
SDC2	syndecan 2	0.012
HES1	hairy and enhancer of split 1, (Drosophila)	0.012	Mouse
LBX1	ladybird homeobox 1	0.012
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.012
HOXD1	homeobox D1	0.012	Human
SNIP1	Smad nuclear interacting protein 1	0.012
GOPC	golgi-associated PDZ and coiled-coil motif containing	0.012
FBXO7	F-box protein 7	0.011
FOXC1	forkhead box C1	0.011
FOXF1	forkhead box F1	0.011
CTNND1	catenin (cadherin-associated protein), delta 1	0.011
VAX2	ventral anterior homeobox 2	0.011
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.011
PECAM1	platelet/endothelial cell adhesion molecule	0.011
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.011
FOXF2	forkhead box F2	0.011
INHBB	inhibin, beta B	0.011
OTP	orthopedia homeobox	0.011
LHX2	LIM homeobox 2	0.011	Human
HOXD13	homeobox D13	0.011
BHLHE23	basic helix-loop-helix family, member e23	0.011
TBX1	T-box 1	0.011
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.010
MDFI	MyoD family inhibitor	0.010
FZD8	frizzled homolog 8 (Drosophila)	0.010
BMI1	BMI1 polycomb ring finger oncogene	0.010
NCK2	NCK adaptor protein 2	0.010
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.010
PAX7	paired box 7	0.010
FOXG1	forkhead box G1	0.010	Mouse
NKX3-2	NK3 homeobox 2	0.010	Mouse