IMP

Process View

Homo sapiens

4 genes annotated in human

tricarboxylic acid metabolic process

The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "tricarboxylic acid metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "tricarboxylic acid metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	1.000
HDAC2	histone deacetylase 2	1.000
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.990
INSR	insulin receptor	0.802
PDHB	pyruvate dehydrogenase (lipoamide) beta	0.793
HDAC3	histone deacetylase 3	0.639
MDH2	malate dehydrogenase 2, NAD (mitochondrial)	0.617
NCAPD2	non-SMC condensin I complex, subunit D2	0.591
ADRBK1	adrenergic, beta, receptor kinase 1	0.538
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.517
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.510
EGFR	epidermal growth factor receptor	0.459
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.430	Rat
DLAT	dihydrolipoamide S-acetyltransferase	0.406
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.320
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.279
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.269
ACO2	aconitase 2, mitochondrial	0.246
AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	0.225
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.224
PFDN1	prefoldin subunit 1	0.222
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.212
JAK2	Janus kinase 2	0.199
CTTN	cortactin	0.191
PRKCA	protein kinase C, alpha	0.190
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.188
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.183
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.148
PTPRB	protein tyrosine phosphatase, receptor type, B	0.142
GLUD1	glutamate dehydrogenase 1	0.137	Mouse
TOM1L1	target of myb1 (chicken)-like 1	0.131
ESR1	estrogen receptor 1	0.129
USPL1	ubiquitin specific peptidase like 1	0.126
PARP1	poly (ADP-ribose) polymerase 1	0.126
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.121
CHD4	chromodomain helicase DNA binding protein 4	0.118
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.113
BCAR1	breast cancer anti-estrogen resistance 1	0.109
RCOR1	REST corepressor 1	0.109
C3orf15	chromosome 3 open reading frame 15	0.089
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.088
EPOR	erythropoietin receptor	0.086
IL2RB	interleukin 2 receptor, beta	0.084
STAP2	signal transducing adaptor family member 2	0.083
SUCLG1	succinate-CoA ligase, alpha subunit	0.083
MTA3	metastasis associated 1 family, member 3	0.082
NCOR2	nuclear receptor corepressor 2	0.076
IDH3G	isocitrate dehydrogenase 3 (NAD+) gamma	0.076	Rat
GLUD2	glutamate dehydrogenase 2	0.072	Mouse
IRS1	insulin receptor substrate 1	0.068
GATAD2A	GATA zinc finger domain containing 2A	0.066
RBBP4	retinoblastoma binding protein 4	0.066
MBD2	methyl-CpG binding domain protein 2	0.063
PDHX	pyruvate dehydrogenase complex, component X	0.062
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.059
MTA2	metastasis associated 1 family, member 2	0.057
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.055
NCAPH2	non-SMC condensin II complex, subunit H2	0.053
IDH3B	isocitrate dehydrogenase 3 (NAD+) beta	0.052	Rat
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.052
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.051
CAV1	caveolin 1, caveolae protein, 22kDa	0.051
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.050
CUX1	cut-like homeobox 1	0.049
LAT	linker for activation of T cells	0.046
ALAS1	aminolevulinate, delta-, synthase 1	0.046
GPI	glucose-6-phosphate isomerase	0.045
IGF1R	insulin-like growth factor 1 receptor	0.043
MTA1	metastasis associated 1	0.042
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.042
PTPN9	protein tyrosine phosphatase, non-receptor type 9	0.036
STAT5A	signal transducer and activator of transcription 5A	0.035	Mouse
SAP30	Sin3A-associated protein, 30kDa	0.034
FH	fumarate hydratase	0.032
SENP1	SUMO1/sentrin specific peptidase 1	0.032
C21orf33	chromosome 21 open reading frame 33	0.032
SH2B1	SH2B adaptor protein 1	0.031
SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	0.031
STAT5B	signal transducer and activator of transcription 5B	0.030	Mouse
DLD	dihydrolipoamide dehydrogenase	0.029
GATAD2B	GATA zinc finger domain containing 2B	0.029
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.029
NFS1	NFS1 nitrogen fixation 1 homolog (S. cerevisiae)	0.026
GRB10	growth factor receptor-bound protein 10	0.025
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.025
GHITM	growth hormone inducible transmembrane protein	0.025
OXA1L	oxidase (cytochrome c) assembly 1-like	0.025
PRMT2	protein arginine methyltransferase 2	0.025
MECR	mitochondrial trans-2-enoyl-CoA reductase	0.025
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.024
ACAD8	acyl-CoA dehydrogenase family, member 8	0.024
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.024
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.024
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.023
DLST	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	0.023
DUSP7	dual specificity phosphatase 7	0.022
TH1L	TH1-like (Drosophila)	0.021
RBBP7	retinoblastoma binding protein 7	0.021
TXN2	thioredoxin 2	0.021
BRE	brain and reproductive organ-expressed (TNFRSF1A modulator)	0.020
PGR	progesterone receptor	0.020
ING2	inhibitor of growth family, member 2	0.020
SUCLA2	succinate-CoA ligase, ADP-forming, beta subunit	0.020
MFN2	mitofusin 2	0.019
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.019
HADH	hydroxyacyl-CoA dehydrogenase	0.019
TSC22D1	TSC22 domain family, member 1	0.018
C14orf1	chromosome 14 open reading frame 1	0.018
JAK1	Janus kinase 1	0.018
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.018
FRZB	frizzled-related protein	0.018
KAT2B	K(lysine) acetyltransferase 2B	0.017
NONO	non-POU domain containing, octamer-binding	0.017
SIRT2	sirtuin 2	0.017
SUDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.017
SOCS2	suppressor of cytokine signaling 2	0.017
BCKDHA	branched chain keto acid dehydrogenase E1, alpha polypeptide	0.017
UQCRC1	ubiquinol-cytochrome c reductase core protein I	0.016
IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.016	Human Yeast
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.016
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.015
LTK	leukocyte receptor tyrosine kinase	0.015
ATP5SL	ATP5S-like	0.015
CTNNBL1	catenin, beta like 1	0.015
CDK2AP1	cyclin-dependent kinase 2 associated protein 1	0.015
TUBA1A	tubulin, alpha 1a	0.015
EXT2	exostosin 2	0.014
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.014
NSFL1C	NSFL1 (p97) cofactor (p47)	0.014
TSR2	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	0.014
IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	0.013
MAPK14	mitogen-activated protein kinase 14	0.013
ACAT1	acetyl-CoA acetyltransferase 1	0.013
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.013
PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	0.013
C20orf43	chromosome 20 open reading frame 43	0.013
HEMGN	hemogen	0.013
KDM1A	lysine (K)-specific demethylase 1A	0.013
MMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	0.013
SEPHS2	selenophosphate synthetase 2	0.013
ZHX1	zinc fingers and homeoboxes 1	0.013
PRDX6	peroxiredoxin 6	0.013
E2F3	E2F transcription factor 3	0.013
SFXN4	sideroflexin 4	0.013
NCAPG	non-SMC condensin I complex, subunit G	0.012
CYLD	cylindromatosis (turban tumor syndrome)	0.012
C16orf87	chromosome 16 open reading frame 87	0.012
GHR	growth hormone receptor	0.012	Mouse
PQBP1	polyglutamine binding protein 1	0.012
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.012
RSAD1	radical S-adenosyl methionine domain containing 1	0.012
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.012
ETFB	electron-transfer-flavoprotein, beta polypeptide	0.012
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.012
ASCC2	activating signal cointegrator 1 complex subunit 2	0.012
MIPEP	mitochondrial intermediate peptidase	0.012
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.012
BCR	breakpoint cluster region	0.012
C3orf10	chromosome 3 open reading frame 10	0.011
ECI2	enoyl-CoA delta isomerase 2	0.011
ALDH9A1	aldehyde dehydrogenase 9 family, member A1	0.011
H2AFY	H2A histone family, member Y	0.011
ZMYM3	zinc finger, MYM-type 3	0.011
DHRS11	dehydrogenase/reductase (SDR family) member 11	0.011
E2F2	E2F transcription factor 2	0.011
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.011
PRKAG1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.011
GPD1L	glycerol-3-phosphate dehydrogenase 1-like	0.010
LRRC47	leucine rich repeat containing 47	0.010
C14orf43	chromosome 14 open reading frame 43	0.010
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.010
FRK	fyn-related kinase	0.010
DOCK7	dedicator of cytokinesis 7	0.010
UBAC1	UBA domain containing 1	0.010
USP53	ubiquitin specific peptidase 53	0.010