IMP

Process View

Homo sapiens

17 genes annotated in human

regulation of transcription from rna polymerase ii promoter in response to stress

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of transcription from rna polymerase ii promoter in response to stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of transcription from rna polymerase ii promoter in response to stress" (in gray)

Name	Description	Probability	Func Analog Organism
JUN	jun proto-oncogene	1.000
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.994
EP300	E1A binding protein p300	0.991
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.983
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.917	Human
DUSP1	dual specificity phosphatase 1	0.908
ATF3	activating transcription factor 3	0.900
SMAD3	SMAD family member 3	0.897
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.886
SP1	Sp1 transcription factor	0.858
JUNB	jun B proto-oncogene	0.854	Human
CREBBP	CREB binding protein	0.823
NCOR2	nuclear receptor corepressor 2	0.666
ZFYVE9	zinc finger, FYVE domain containing 9	0.579
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.566
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.550
YY1	YY1 transcription factor	0.550
KLF4	Kruppel-like factor 4 (gut)	0.463	Human
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.441
EPAS1	endothelial PAS domain protein 1	0.439	Human Mouse
ATF2	activating transcription factor 2	0.412	Human
KAT2B	K(lysine) acetyltransferase 2B	0.386
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.342	Human
IER2	immediate early response 2	0.321
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.312
MAPK14	mitogen-activated protein kinase 14	0.294	Yeast
KLF6	Kruppel-like factor 6	0.262	Human
DDIT3	DNA-damage-inducible transcript 3	0.261	Mouse Rat
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.238
HDAC4	histone deacetylase 4	0.216
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.194
SMAD2	SMAD family member 2	0.188
MAP2K4	mitogen-activated protein kinase kinase 4	0.177
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.158
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.142
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.136
SMAD4	SMAD family member 4	0.135
CHD8	chromodomain helicase DNA binding protein 8	0.121	Human
TRIB3	tribbles homolog 3 (Drosophila)	0.120
EGLN1	egl nine homolog 1 (C. elegans)	0.107
AHR	aryl hydrocarbon receptor	0.106
TGIF1	TGFB-induced factor homeobox 1	0.098
JAG1	jagged 1	0.078
RFWD2	ring finger and WD repeat domain 2	0.072
HIPK2	homeodomain interacting protein kinase 2	0.071
PML	promyelocytic leukemia	0.068
EGLN3	egl nine homolog 3 (C. elegans)	0.063
ING2	inhibitor of growth family, member 2	0.060	Yeast
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.060
RNF11	ring finger protein 11	0.058
WDR5	WD repeat domain 5	0.055
HDAC1	histone deacetylase 1	0.053
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.052
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.051
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.044
ARNT	aryl hydrocarbon receptor nuclear translocator	0.044
KEAP1	kelch-like ECH-associated protein 1	0.043
TTR	transthyretin	0.043
DAXX	death-domain associated protein	0.043
CHD7	chromodomain helicase DNA binding protein 7	0.043	Human
FBXL15	F-box and leucine-rich repeat protein 15	0.042
ZFAND5	zinc finger, AN1-type domain 5	0.040
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.040
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.040
CLOCK	clock homolog (mouse)	0.038
CREB1	cAMP responsive element binding protein 1	0.038
FOSL2	FOS-like antigen 2	0.038
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.037	Human
RB1	retinoblastoma 1	0.037
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.037
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.034
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.033
NRP1	neuropilin 1	0.032
UBC	ubiquitin C	0.031
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.031
ESR1	estrogen receptor 1	0.030
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.030
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.029
SOCS3	suppressor of cytokine signaling 3	0.029
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.029
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.028
RUNX1	runt-related transcription factor 1	0.028
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.027
SNX9	sorting nexin 9	0.027
ARID1A	AT rich interactive domain 1A (SWI-like)	0.026
EGR1	early growth response 1	0.026	Mouse
SMAD5	SMAD family member 5	0.026
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.026
CDAN1	congenital dyserythropoietic anemia, type I	0.026
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.025	Human
BCL3	B-cell CLL/lymphoma 3	0.025
SMAD1	SMAD family member 1	0.024
VEGFA	vascular endothelial growth factor A	0.024
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.023
TLK1	tousled-like kinase 1	0.023
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.023
JUND	jun D proto-oncogene	0.022	Human
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.022
JDP2	Jun dimerization protein 2	0.021
PPARA	peroxisome proliferator-activated receptor alpha	0.020
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.020	Yeast
MAP2K5	mitogen-activated protein kinase kinase 5	0.019
RUVBL1	RuvB-like 1 (E. coli)	0.019
CYLD	cylindromatosis (turban tumor syndrome)	0.019
RYBP	RING1 and YY1 binding protein	0.018
YAF2	YY1 associated factor 2	0.018
ARRB1	arrestin, beta 1	0.018
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.018
RHOA	ras homolog gene family, member A	0.017
KDM6B	lysine (K)-specific demethylase 6B	0.017
XIAP	X-linked inhibitor of apoptosis	0.017
BTG2	BTG family, member 2	0.017
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.017
MEF2C	myocyte enhancer factor 2C	0.016	Yeast
MMS22L	MMS22-like, DNA repair protein	0.016
RHOB	ras homolog gene family, member B	0.016
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.016	Human
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.016	Human
INO80D	INO80 complex subunit D	0.016
TSC22D3	TSC22 domain family, member 3	0.016
BHLHE40	basic helix-loop-helix family, member e40	0.015
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.015
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.015
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.015
SIRT1	sirtuin 1	0.015
CPNE6	copine VI (neuronal)	0.015
SMAD7	SMAD family member 7	0.014
TP73	tumor protein p73	0.014
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.014
HDAC9	histone deacetylase 9	0.014
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.014
DDIT4	DNA-damage-inducible transcript 4	0.013
POU2F1	POU class 2 homeobox 1	0.013
NCOA2	nuclear receptor coactivator 2	0.013
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.013
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.013
AFF4	AF4/FMR2 family, member 4	0.013
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.013
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.013
CLSPN	claspin	0.012
POU5F1	POU class 5 homeobox 1	0.012
HDAC6	histone deacetylase 6	0.012
TRAF4	TNF receptor-associated factor 4	0.012
NBR1	neighbor of BRCA1 gene 1	0.012
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.012
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.012
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.012
BCL6	B-cell CLL/lymphoma 6	0.012
ADRBK1	adrenergic, beta, receptor kinase 1	0.011
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.011
TIMELESS	timeless homolog (Drosophila)	0.011
PARP1	poly (ADP-ribose) polymerase 1	0.011
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.011
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.011
SAP30	Sin3A-associated protein, 30kDa	0.011
ARRDC3	arrestin domain containing 3	0.011
VHL	von Hippel-Lindau tumor suppressor	0.011
PDGFA	platelet-derived growth factor alpha polypeptide	0.011	Human
OCIAD1	OCIA domain containing 1	0.011
MAML1	mastermind-like 1 (Drosophila)	0.011
EGR2	early growth response 2	0.011
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.011
NQO1	NAD(P)H dehydrogenase, quinone 1	0.010
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.010	Human
CUL7	cullin 7	0.010
ANKRD13A	ankyrin repeat domain 13A	0.010
DTX1	deltex homolog 1 (Drosophila)	0.010
PDGFC	platelet derived growth factor C	0.010
CNOT4	CCR4-NOT transcription complex, subunit 4	0.010
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.010
TNIP2	TNFAIP3 interacting protein 2	0.010
RBBP5	retinoblastoma binding protein 5	0.010
EIF1	eukaryotic translation initiation factor 1	0.010
GNAS	GNAS complex locus	0.010