IMP

Process View

Homo sapiens

16 genes annotated in human

endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endoplasmic reticulum unfolded protein response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endoplasmic reticulum unfolded protein response" (in gray)

Name	Description	Probability	Func Analog Organism
SYVN1	synovial apoptosis inhibitor 1, synoviolin	1.000	Fly
PDIA3	protein disulfide isomerase family A, member 3	1.000
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.999	Mouse Worm
BCL2	B-cell CLL/lymphoma 2	0.993	Human
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.991
BCL2L1	BCL2-like 1	0.983	Human
VCP	valosin containing protein	0.959	Worm
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.953	Mouse
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.936	Worm
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.928	Human
SELS	selenoprotein S	0.908
DERL1	Der1-like domain family, member 1	0.884
CANX	calnexin	0.849	Worm
BAX	BCL2-associated X protein	0.806
HSPA8	heat shock 70kDa protein 8	0.774
PDIA6	protein disulfide isomerase family A, member 6	0.745	Worm
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.740
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.691
BAD	BCL2-associated agonist of cell death	0.631
ATF3	activating transcription factor 3	0.630
GHR	growth hormone receptor	0.624
PDIA4	protein disulfide isomerase family A, member 4	0.621	Worm
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.455
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.443	Worm
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.430
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.349
BAK1	BCL2-antagonist/killer 1	0.306
VDAC1	voltage-dependent anion channel 1	0.275
ERO1L	ERO1-like (S. cerevisiae)	0.262	Mouse
GRB2	growth factor receptor-bound protein 2	0.245
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.230
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.212
SOS1	son of sevenless homolog 1 (Drosophila)	0.187
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.170
EIF2AK3	eukaryotic translation initiation factor 2-alpha kinase 3	0.114
CALR	calreticulin	0.109	Worm
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.109
CCND3	cyclin D3	0.097
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.086
ATF2	activating transcription factor 2	0.076
C4orf14	chromosome 4 open reading frame 14	0.070
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.067
DBP	D site of albumin promoter (albumin D-box) binding protein	0.064
AMFR	autocrine motility factor receptor	0.062
BAG1	BCL2-associated athanogene	0.061
ENO1	enolase 1, (alpha)	0.057
SSR1	signal sequence receptor, alpha	0.055
STON2	stonin 2	0.055
ERN1	endoplasmic reticulum to nucleus signaling 1	0.051
DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.050
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.050
HSPH1	heat shock 105kDa/110kDa protein 1	0.049
RPN1	ribophorin I	0.048
CDK6	cyclin-dependent kinase 6	0.046
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.045
RABAC1	Rab acceptor 1 (prenylated)	0.041
TUFM	Tu translation elongation factor, mitochondrial	0.039
RNF144B	ring finger protein 144B	0.039
IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2	0.039
FKBP4	FK506 binding protein 4, 59kDa	0.038
NUCB2	nucleobindin 2	0.037
HYOU1	hypoxia up-regulated 1	0.037
ATXN3	ataxin 3	0.037
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.032
LDHA	lactate dehydrogenase A	0.031
CDK4	cyclin-dependent kinase 4	0.030
KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.028
CYCS	cytochrome c, somatic	0.027
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.027
STX8	syntaxin 8	0.027
ERO1LB	ERO1-like beta (S. cerevisiae)	0.027
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.026
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.025
BAG2	BCL2-associated athanogene 2	0.025
BID	BH3 interacting domain death agonist	0.024
RNR2	l-rRNA	0.023
NSFL1C	NSFL1 (p97) cofactor (p47)	0.023
C19orf10	chromosome 19 open reading frame 10	0.023
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.022
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.022
HM13	histocompatibility (minor) 13	0.022
DERL2	Der1-like domain family, member 2	0.021
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.021
EIF1	eukaryotic translation initiation factor 1	0.020
LDLR	low density lipoprotein receptor	0.020
RPN2	ribophorin II	0.020
SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	0.019
GANAB	glucosidase, alpha; neutral AB	0.019
EMD	emerin	0.019
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.018	Worm
SERP1	stress-associated endoplasmic reticulum protein 1	0.018	Mouse
USP46	ubiquitin specific peptidase 46	0.017
ANKRD12	ankyrin repeat domain 12	0.017
PLCG1	phospholipase C, gamma 1	0.017
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.017
DNM1	dynamin 1	0.017
TRAP1	TNF receptor-associated protein 1	0.016	Worm
HSPA13	heat shock protein 70kDa family, member 13	0.016
KEAP1	kelch-like ECH-associated protein 1	0.016
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.016
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.015
BCAR1	breast cancer anti-estrogen resistance 1	0.015
GRB10	growth factor receptor-bound protein 10	0.015
MANF	mesencephalic astrocyte-derived neurotrophic factor	0.014
VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	0.014	Human
NCL	nucleolin	0.014
PRDX4	peroxiredoxin 4	0.014
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.013
HSPA1B	heat shock 70kDa protein 1B	0.013
TMED9	transmembrane emp24 protein transport domain containing 9	0.013
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.013
CALU	calumenin	0.013
SURF4	surfeit 4	0.013
DCBLD1	discoidin, CUB and LCCL domain containing 1	0.013
SLU7	SLU7 splicing factor homolog (S. cerevisiae)	0.012
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.012
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.012
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.012
TRIB3	tribbles homolog 3 (Drosophila)	0.012
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.011
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.011
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.011
XBP1	X-box binding protein 1	0.011
TRIP10	thyroid hormone receptor interactor 10	0.011
FAF1	Fas (TNFRSF6) associated factor 1	0.010
SEC62	SEC62 homolog (S. cerevisiae)	0.010
EIF3CL	eukaryotic translation initiation factor 3, subunit C-like	0.010
EPRS	glutamyl-prolyl-tRNA synthetase	0.010
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.010
KDM6B	lysine (K)-specific demethylase 6B	0.010