IMP

Process View

Homo sapiens

17 genes annotated in human

mitotic g1 dna damage checkpoint

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitotic g1 dna damage checkpoint"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mitotic g1 dna damage checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
MDM2	Mdm2 p53 binding protein homolog (mouse)	1.000
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.991	Human
RB1	retinoblastoma 1	0.973
TP53	tumor protein p53	0.969
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.920
XIAP	X-linked inhibitor of apoptosis	0.887
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.862
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.861	Human
CDK6	cyclin-dependent kinase 6	0.748
CDK2	cyclin-dependent kinase 2	0.706
CCND1	cyclin D1	0.690
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.596
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.514
APAF1	apoptotic peptidase activating factor 1	0.484
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.470
LRDD	leucine-rich repeats and death domain containing	0.405
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.375
HIPK2	homeodomain interacting protein kinase 2	0.363
BRCA1	breast cancer 1, early onset	0.350
RPA1	replication protein A1, 70kDa	0.334
CCND3	cyclin D3	0.331	Human
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.324
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.306
DAXX	death-domain associated protein	0.273
FAS	Fas (TNF receptor superfamily, member 6)	0.246
POU3F2	POU class 3 homeobox 2	0.226
RIPK2	receptor-interacting serine-threonine kinase 2	0.219
IER3	immediate early response 3	0.208
POU5F1	POU class 5 homeobox 1	0.199
PAX3	paired box 3	0.179
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.141
CCNE1	cyclin E1	0.139
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.130
SKP2	S-phase kinase-associated protein 2 (p45)	0.127
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.125
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.119
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.115	Human
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.115
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.109
CFLAR	CASP8 and FADD-like apoptosis regulator	0.099
FADD	Fas (TNFRSF6)-associated via death domain	0.094
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.094	Human
RBL2	retinoblastoma-like 2 (p130)	0.078
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.071	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.071
BCL2	B-cell CLL/lymphoma 2	0.065
RBL1	retinoblastoma-like 1 (p107)	0.065
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.064
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.053
NLRC4	NLR family, CARD domain containing 4	0.053
BIRC2	baculoviral IAP repeat containing 2	0.050
WWOX	WW domain containing oxidoreductase	0.048
CABLES1	Cdk5 and Abl enzyme substrate 1	0.045
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.041
ARRB2	arrestin, beta 2	0.039
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.038
MEOX2	mesenchyme homeobox 2	0.037
RAD18	RAD18 homolog (S. cerevisiae)	0.036
KRT5	keratin 5	0.030
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.026
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.026
CCND2	cyclin D2	0.025	Human
SIAH1	seven in absentia homolog 1 (Drosophila)	0.024
MARCKSL1	MARCKS-like 1	0.024
FANCD2	Fanconi anemia, complementation group D2	0.024
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.023
SATB2	SATB homeobox 2	0.022
NBN	nibrin	0.022
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.020
MDC1	mediator of DNA-damage checkpoint 1	0.020
FASLG	Fas ligand (TNF superfamily, member 6)	0.019
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.019
SMAD7	SMAD family member 7	0.019
BRCA2	breast cancer 2, early onset	0.018
ATM	ataxia telangiectasia mutated	0.017
MKRN1	makorin ring finger protein 1	0.017
RPA2	replication protein A2, 32kDa	0.016
PCGF2	polycomb group ring finger 2	0.016
GSK3B	glycogen synthase kinase 3 beta	0.016
NOTCH1	notch 1	0.015
POLH	polymerase (DNA directed), eta	0.014
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.014	Human
MED1	mediator complex subunit 1	0.014
PCNA	proliferating cell nuclear antigen	0.013
E2F3	E2F transcription factor 3	0.013
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.013
ANXA4	annexin A4	0.013
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.013
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.012
NMI	N-myc (and STAT) interactor	0.012
GORAB	golgin, RAB6-interacting	0.012
NUCB2	nucleobindin 2	0.011
RRM2B	ribonucleotide reductase M2 B (TP53 inducible)	0.011
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.011	Human
YY1	YY1 transcription factor	0.011
CCNA1	cyclin A1	0.011
DZIP1	DAZ interacting protein 1	0.011
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.010
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.010
YAP1	Yes-associated protein 1	0.010
UNG	uracil-DNA glycosylase	0.010
PARP1	poly (ADP-ribose) polymerase 1	0.010