IMP

Process View

Mus musculus

5 genes annotated in mouse

Multi-species View

regulation of mesodermal cell fate specification

GO:0042661

Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of mesodermal cell fate specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of mesodermal cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	1.000	Mouse
Shh	sonic hedgehog	1.000
Pax3	paired box gene 3	1.000
Gli3	GLI-Kruppel family member GLI3	1.000
Bmp4	bone morphogenetic protein 4	1.000
Foxc1	forkhead box C1	1.000
Pax2	paired box gene 2	0.999
Fgf8	fibroblast growth factor 8	0.998
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.998
Eya1	eyes absent 1 homolog (Drosophila)	0.996
Jag1	jagged 1	0.996
Tbx1	T-box 1	0.995
Foxc2	forkhead box C2	0.994
Fgf10	fibroblast growth factor 10	0.991
Pitx2	paired-like homeodomain transcription factor 2	0.990
Vangl2	vang-like 2 (van gogh, Drosophila)	0.986
Ctnnb1	catenin (cadherin associated protein), beta 1	0.979
Tcfap2a	transcription factor AP-2, alpha	0.976
Fgfr1	fibroblast growth factor receptor 1	0.967
Sox9	SRY-box containing gene 9	0.967	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.964
Rarg	retinoic acid receptor, gamma	0.947
Isl1	ISL1 transcription factor, LIM/homeodomain	0.943
Meox2	mesenchyme homeobox 2	0.935
Chd7	chromodomain helicase DNA binding protein 7	0.933
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.932
Hoxa1	homeobox A1	0.930
Wnt3a	wingless-related MMTV integration site 3A	0.916	Human
Tgfb2	transforming growth factor, beta 2	0.897
Acvr1	activin A receptor, type 1	0.891	Mouse
Gbx2	gastrulation brain homeobox 2	0.886
Prrx1	paired related homeobox 1	0.873
Hand2	heart and neural crest derivatives expressed transcript 2	0.860
Foxg1	forkhead box G1	0.830
Sox2	SRY-box containing gene 2	0.822	Mouse
Dlx5	distal-less homeobox 5	0.805
Fgfr3	fibroblast growth factor receptor 3	0.789	Mouse
Pax6	paired box gene 6	0.772
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.757
Smo	smoothened homolog (Drosophila)	0.756
Sfrp2	secreted frizzled-related protein 2	0.734
Hand1	heart and neural crest derivatives expressed transcript 1	0.721
Apc	adenomatosis polyposis coli	0.707
Gli2	GLI-Kruppel family member GLI2	0.696
Gata4	GATA binding protein 4	0.695
Hoxd13	homeobox D13	0.678
Zeb1	zinc finger E-box binding homeobox 1	0.678
Vegfa	vascular endothelial growth factor A	0.572
Hes1	hairy and enhancer of split 1 (Drosophila)	0.545
Nos3	nitric oxide synthase 3, endothelial cell	0.517
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.514
Hoxa3	homeobox A3	0.512
Efnb2	ephrin B2	0.498
Nog	noggin	0.494
Rarb	retinoic acid receptor, beta	0.487
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.478
Msx1	homeobox, msh-like 1	0.450
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.447
Nodal	nodal	0.440
Psen1	presenilin 1	0.387
Alx4	aristaless-like homeobox 4	0.383
Ednra	endothelin receptor type A	0.379
Lmx1a	LIM homeobox transcription factor 1 alpha	0.340
Fgf3	fibroblast growth factor 3	0.333
Hoxa2	homeobox A2	0.313
Hmx3	H6 homeobox 3	0.308	Worm
Sox11	SRY-box containing gene 11	0.284	Mouse
Gata3	GATA binding protein 3	0.274
Dll1	delta-like 1 (Drosophila)	0.254
Bmp7	bone morphogenetic protein 7	0.254
Rxra	retinoid X receptor alpha	0.236
Prrx2	paired related homeobox 2	0.231
Rara	retinoic acid receptor, alpha	0.212
Nf1	neurofibromatosis 1	0.209
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.203
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.169
Mesp1	mesoderm posterior 1	0.165
Pbx1	pre B-cell leukemia transcription factor 1	0.163
Pax8	paired box gene 8	0.159
Pitx1	paired-like homeodomain transcription factor 1	0.157
Ece1	endothelin converting enzyme 1	0.156
Lrp6	low density lipoprotein receptor-related protein 6	0.152
Pten	phosphatase and tensin homolog	0.140
Smad6	MAD homolog 6 (Drosophila)	0.139
Ret	ret proto-oncogene	0.130
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.124
Rb1	retinoblastoma 1	0.123
Ptch1	patched homolog 1	0.122
Gsc	goosecoid homeobox	0.121
Lmx1b	LIM homeobox transcription factor 1 beta	0.121
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.117
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.115
Smad4	MAD homolog 4 (Drosophila)	0.109
Nkx2-1	NK2 homeobox 1	0.106
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.104
Twist2	twist homolog 2 (Drosophila)	0.103
Pou4f3	POU domain, class 4, transcription factor 3	0.087
Bcl6b	B-cell CLL/lymphoma 6, member B	0.087
Eng	endoglin	0.086
Tcf15	transcription factor 15	0.085
Gpc3	glypican 3	0.083
Foxf1a	forkhead box F1a	0.080
Emx1	empty spiracles homolog 1 (Drosophila)	0.077
Hoxa11	homeobox A11	0.075
Tcf21	transcription factor 21	0.074
Lhx1	LIM homeobox protein 1	0.073
Foxd2	forkhead box D2	0.073
Col2a1	collagen, type II, alpha 1	0.070
Wnt6	wingless-related MMTV integration site 6	0.070
Tbx2	T-box 2	0.067
Kitl	kit ligand	0.066
Trp63	transformation related protein 63	0.065
Eda	ectodysplasin-A	0.065
Msx2	homeobox, msh-like 2	0.063
Pax1	paired box gene 1	0.062
Gdnf	glial cell line derived neurotrophic factor	0.061
Notch2	Notch gene homolog 2 (Drosophila)	0.060
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.056
Lrp2	low density lipoprotein receptor-related protein 2	0.055
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.055
Alx3	aristaless-like homeobox 3	0.054
Chrd	chordin	0.053
Smad3	MAD homolog 3 (Drosophila)	0.053
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.051
Egfr	epidermal growth factor receptor	0.050
Tbx3	T-box 3	0.050
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.049
Gata6	GATA binding protein 6	0.048
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.047
Wnt1	wingless-related MMTV integration site 1	0.047
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.047	Human
Hoxa5	homeobox A5	0.047
Phox2b	paired-like homeobox 2b	0.045
Bmp5	bone morphogenetic protein 5	0.045
Hoxb3	homeobox B3	0.044
Tcfap2c	transcription factor AP-2, gamma	0.043
Sox4	SRY-box containing gene 4	0.043	Mouse
Wnt5a	wingless-related MMTV integration site 5A	0.040
Hesx1	homeobox gene expressed in ES cells	0.038
Tgfbr3	transforming growth factor, beta receptor III	0.036
Ihh	Indian hedgehog	0.035
Cdh5	cadherin 5	0.035
Hoxa13	homeobox A13	0.035
T	brachyury	0.035
Efna2	ephrin A2	0.035
Barx1	BarH-like homeobox 1	0.033
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.033
Dll4	delta-like 4 (Drosophila)	0.032
Tbx15	T-box 15	0.031
She	src homology 2 domain-containing transforming protein E	0.031
Dll3	delta-like 3 (Drosophila)	0.030
Sfrp1	secreted frizzled-related protein 1	0.030	Mouse
Sall4	sal-like 4 (Drosophila)	0.029
Otx1	orthodenticle homolog 1 (Drosophila)	0.029
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.029
Sox3	SRY-box containing gene 3	0.028	Mouse
Zic3	zinc finger protein of the cerebellum 3	0.028
Gli1	GLI-Kruppel family member GLI1	0.028
Hoxd11	homeobox D11	0.028
Pou5f1	POU domain, class 5, transcription factor 1	0.028
Sall3	sal-like 3 (Drosophila)	0.027
Npr3	natriuretic peptide receptor 3	0.027
Efna4	ephrin A4	0.026
Wnt9b	wingless-type MMTV integration site 9B	0.025
En1	engrailed 1	0.025
Pkd1	polycystic kidney disease 1 homolog	0.024
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.023
Ntf3	neurotrophin 3	0.023
Mrc2	mannose receptor, C type 2	0.022
Efs	embryonal Fyn-associated substrate	0.022
Hoxd3	homeobox D3	0.022
Ebf3	early B-cell factor 3	0.021
Snai1	snail homolog 1 (Drosophila)	0.021
Grb10	growth factor receptor bound protein 10	0.021
Ptch2	patched homolog 2	0.020
Emx2	empty spiracles homolog 2 (Drosophila)	0.020
Pax9	paired box gene 9	0.019
Wt1	Wilms tumor 1 homolog	0.019
Foxa2	forkhead box A2	0.019
Edar	ectodysplasin-A receptor	0.019
Sox17	SRY-box containing gene 17	0.018
Gas1	growth arrest specific 1	0.018
Fgf17	fibroblast growth factor 17	0.018
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.018
Cldn6	claudin 6	0.017
Tgfbr2	transforming growth factor, beta receptor II	0.017	Mouse
Hoxd9	homeobox D9	0.017
Lhx3	LIM homeobox protein 3	0.017
Bmp2	bone morphogenetic protein 2	0.017
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.016
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.016
Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1	0.016
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.016
Lef1	lymphoid enhancer binding factor 1	0.015
Dhh	desert hedgehog	0.015
Tbx6	T-box 6	0.015
Vax1	ventral anterior homeobox containing gene 1	0.014
Fgf15	fibroblast growth factor 15	0.014
Pitx3	paired-like homeodomain transcription factor 3	0.014
Esr1	estrogen receptor 1 (alpha)	0.014
Bcl2	B-cell leukemia/lymphoma 2	0.013
Onecut1	one cut domain, family member 1	0.013
Nkx6-1	NK6 homeobox 1	0.013
Fzd1	frizzled homolog 1 (Drosophila)	0.013
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.013
Notch1	Notch gene homolog 1 (Drosophila)	0.013	Zebrafish
Odf3	outer dense fiber of sperm tails 3	0.013
Meox1	mesenchyme homeobox 1	0.013
Fgf4	fibroblast growth factor 4	0.013
Pax7	paired box gene 7	0.013
Col13a1	collagen, type XIII, alpha 1	0.013
Gdf5	growth differentiation factor 5	0.012
Pou3f3	POU domain, class 3, transcription factor 3	0.012
Hoxb5	homeobox B5	0.012
Fbn1	fibrillin 1	0.012
Fgf18	fibroblast growth factor 18	0.012
Hoxb1	homeobox B1	0.012
Hhex	hematopoietically expressed homeobox	0.011
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.011
Btbd17	BTB (POZ) domain containing 17	0.011
Ephb2	Eph receptor B2	0.011
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.011
Emid2	EMI domain containing 2	0.011
Ptk7	PTK7 protein tyrosine kinase 7	0.010
Nkx3-2	NK3 homeobox 2	0.010
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.010	Mouse
Aplnr	apelin receptor	0.010
Fzd8	frizzled homolog 8 (Drosophila)	0.010
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.010
Ntn1	netrin 1	0.010
Slc6a2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.010
Barx2	BarH-like homeobox 2	0.010
Ednrb	endothelin receptor type B	0.010
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.010