IMP

Process View

Mus musculus

15 genes annotated in mouse

negative regulation of kidney development

Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of kidney development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of kidney development" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Fgfr2	fibroblast growth factor receptor 2	0.995
Hand1	heart and neural crest derivatives expressed transcript 1	0.990
Gli3	GLI-Kruppel family member GLI3	0.985
Pax2	paired box gene 2	0.982
Msx1	homeobox, msh-like 1	0.967
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.963
Sall4	sal-like 4 (Drosophila)	0.952	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.886
Bmp7	bone morphogenetic protein 7	0.868
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.862
Fgf8	fibroblast growth factor 8	0.817
Bmp4	bone morphogenetic protein 4	0.798
Lhx1	LIM homeobox protein 1	0.787
Eya1	eyes absent 1 homolog (Drosophila)	0.762
Tbx1	T-box 1	0.761
C1qc	complement component 1, q subcomponent, C chain	0.740	Mouse
Sall1	sal-like 1 (Drosophila)	0.699
Dlx5	distal-less homeobox 5	0.677
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.666
Emx2	empty spiracles homolog 2 (Drosophila)	0.630
Hand2	heart and neural crest derivatives expressed transcript 2	0.630
Fgfr3	fibroblast growth factor receptor 3	0.586
Hoxd11	homeobox D11	0.556
Hoxa1	homeobox A1	0.538
Msx2	homeobox, msh-like 2	0.492
Foxc2	forkhead box C2	0.491
Hoxa11	homeobox A11	0.468
Foxc1	forkhead box C1	0.458
Chrd	chordin	0.439
Gata4	GATA binding protein 4	0.363	Mouse
Foxf1a	forkhead box F1a	0.356
Gli2	GLI-Kruppel family member GLI2	0.356
Sox9	SRY-box containing gene 9	0.352
Prrx2	paired related homeobox 2	0.337
Pbx1	pre B-cell leukemia transcription factor 1	0.324
Fgfr1	fibroblast growth factor receptor 1	0.319
Pitx2	paired-like homeodomain transcription factor 2	0.315
Ar	androgen receptor	0.293
Prrx1	paired related homeobox 1	0.282
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.281
Nab2	Ngfi-A binding protein 2	0.271
Tbx3	T-box 3	0.265
Gata6	GATA binding protein 6	0.259	Mouse
Zeb1	zinc finger E-box binding homeobox 1	0.245
Fgf3	fibroblast growth factor 3	0.239
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.236
Tgfb2	transforming growth factor, beta 2	0.231
Sox2	SRY-box containing gene 2	0.218
Pax3	paired box gene 3	0.215
Otx2	orthodenticle homolog 2 (Drosophila)	0.213
Smo	smoothened homolog (Drosophila)	0.209
Lhx9	LIM homeobox protein 9	0.204
Gdf5	growth differentiation factor 5	0.203	Mouse
Hoxd13	homeobox D13	0.194
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.192
Tcfap2a	transcription factor AP-2, alpha	0.188
Hoxa13	homeobox A13	0.187
Nanog	Nanog homeobox	0.186
Gas1	growth arrest specific 1	0.183
Tcf21	transcription factor 21	0.173
Nodal	nodal	0.171	Mouse
Pax8	paired box gene 8	0.170
Fgf10	fibroblast growth factor 10	0.170
Foxh1	forkhead box H1	0.160
Hoxb3	homeobox B3	0.157
Tbx2	T-box 2	0.153
Pou5f1	POU domain, class 5, transcription factor 1	0.148
Lef1	lymphoid enhancer binding factor 1	0.145
Tyrobp	TYRO protein tyrosine kinase binding protein	0.134
Runx2	runt related transcription factor 2	0.129
Col2a1	collagen, type II, alpha 1	0.127
Wt1	Wilms tumor 1 homolog	0.124
Smad6	MAD homolog 6 (Drosophila)	0.117
T	brachyury	0.110
Meox2	mesenchyme homeobox 2	0.109
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.106	Mouse
Lmx1a	LIM homeobox transcription factor 1 alpha	0.102
Twist2	twist homolog 2 (Drosophila)	0.101
Bnc1	basonuclin 1	0.097
Npr2	natriuretic peptide receptor 2	0.094
Gdnf	glial cell line derived neurotrophic factor	0.084
Kiss1	KiSS-1 metastasis-suppressor	0.084
Ctss	cathepsin S	0.083
Tbx15	T-box 15	0.083
Pitx1	paired-like homeodomain transcription factor 1	0.081
Nog	noggin	0.080
Sox7	SRY-box containing gene 7	0.079
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.079
Isl1	ISL1 transcription factor, LIM/homeodomain	0.078
Lhx3	LIM homeobox protein 3	0.076
Hoxa2	homeobox A2	0.073
Lrp2	low density lipoprotein receptor-related protein 2	0.069
Gata5	GATA binding protein 5	0.068	Mouse
Hoxd9	homeobox D9	0.068
Fgf9	fibroblast growth factor 9	0.067
Gsc	goosecoid homeobox	0.063
Rarg	retinoic acid receptor, gamma	0.063
Hoxb6	homeobox B6	0.062
Esrrb	estrogen related receptor, beta	0.061
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.061	Mouse
Hoxa10	homeobox A10	0.058
Gpc3	glypican 3	0.056
Ptch1	patched homolog 1	0.055
Hoxb4	homeobox B4	0.055
Emid2	EMI domain containing 2	0.054
Ly86	lymphocyte antigen 86	0.053
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.053
C1qb	complement component 1, q subcomponent, beta polypeptide	0.052	Mouse
Pax7	paired box gene 7	0.051
Zfp503	zinc finger protein 503	0.050
Pax9	paired box gene 9	0.049	Mouse
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.048
Wnt3a	wingless-related MMTV integration site 3A	0.048
Hoxa5	homeobox A5	0.046
Wnt5a	wingless-related MMTV integration site 5A	0.045
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.044
Pthlh	parathyroid hormone-like peptide	0.044
Fgf15	fibroblast growth factor 15	0.044
Hoxc8	homeobox C8	0.044
Hoxb9	homeobox B9	0.044
Alx4	aristaless-like homeobox 4	0.044
Foxd2	forkhead box D2	0.042
Igl	immunoglobulin lambda chain complex	0.042
Tcfcp2l1	transcription factor CP2-like 1	0.040
Uncx	UNC homeobox	0.040
Gucy2e	guanylate cyclase 2e	0.040
Bmp2	bone morphogenetic protein 2	0.039	Mouse
Hoxb5	homeobox B5	0.039
Tcfap2c	transcription factor AP-2, gamma	0.038
Alx3	aristaless-like homeobox 3	0.036
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.036
Wnt9b	wingless-type MMTV integration site 9B	0.035
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.035
Hoxc4	homeobox C4	0.035
Tal1	T-cell acute lymphocytic leukemia 1	0.033
Zic3	zinc finger protein of the cerebellum 3	0.033
Dusp9	dual specificity phosphatase 9	0.033
Efna2	ephrin A2	0.032
Gdf3	growth differentiation factor 3	0.031	Mouse
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.031
Klf1	Kruppel-like factor 1 (erythroid)	0.030
Plac1	placental specific protein 1	0.030
Alx1	ALX homeobox 1	0.030
Rxra	retinoid X receptor alpha	0.030
Adra2b	adrenergic receptor, alpha 2b	0.029
Fosb	FBJ osteosarcoma oncogene B	0.029
Otx1	orthodenticle homolog 1 (Drosophila)	0.029
Ret	ret proto-oncogene	0.028
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.028
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.028
Foxa2	forkhead box A2	0.027
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.027
Hoxd3	homeobox D3	0.027
Ihh	Indian hedgehog	0.025	Mouse
Col4a3	collagen, type IV, alpha 3	0.025
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.025	Mouse
Gbx2	gastrulation brain homeobox 2	0.025
Foxf2	forkhead box F2	0.024
Fgf4	fibroblast growth factor 4	0.024
Jun	Jun oncogene	0.024
Hoxa3	homeobox A3	0.024
Wnt1	wingless-related MMTV integration site 1	0.024
Sox3	SRY-box containing gene 3	0.023
Prr15	proline rich 15	0.023
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.023
Hoxa9	homeobox A9	0.022
Fos	FBJ osteosarcoma oncogene	0.022
Vangl2	vang-like 2 (van gogh, Drosophila)	0.022
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.022
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.022
Wnt4	wingless-related MMTV integration site 4	0.021
Fbln1	fibulin 1	0.021
Sall3	sal-like 3 (Drosophila)	0.021	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.021
Rarb	retinoic acid receptor, beta	0.020
Hmx3	H6 homeobox 3	0.020
Csf1r	colony stimulating factor 1 receptor	0.020
Cd68	CD68 antigen	0.019
Hoxd10	homeobox D10	0.019
Pkdcc	protein kinase domain containing, cytoplasmic	0.019
Wnt6	wingless-related MMTV integration site 6	0.018
En2	engrailed 2	0.018
Fgf18	fibroblast growth factor 18	0.018
Gpr50	G-protein-coupled receptor 50	0.018
Cldn6	claudin 6	0.017
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.017
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.017
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.017
Pnliprp2	pancreatic lipase-related protein 2	0.017
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.017
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.017
Fnip1	folliculin interacting protein 1	0.017
Hoxd8	homeobox D8	0.017
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.017
Csf3	colony stimulating factor 3 (granulocyte)	0.017
Bicc1	bicaudal C homolog 1 (Drosophila)	0.016
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.016
Npr3	natriuretic peptide receptor 3	0.016
Trp63	transformation related protein 63	0.016
Kiss1r	KISS1 receptor	0.016
Amhr2	anti-Mullerian hormone type 2 receptor	0.016
Edn3	endothelin 3	0.016
Hoxa4	homeobox A4	0.016
Matn3	matrilin 3	0.015
Aif1	allograft inflammatory factor 1	0.015
Eomes	eomesodermin homolog (Xenopus laevis)	0.015
Ptgs2	prostaglandin-endoperoxide synthase 2	0.015
Gdf9	growth differentiation factor 9	0.015
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.014
Wnt10b	wingless related MMTV integration site 10b	0.014
Sox11	SRY-box containing gene 11	0.014
Lyz1	lysozyme 1	0.014
Foxe1	forkhead box E1	0.014
Grem1	gremlin 1	0.014
Gfi1b	growth factor independent 1B	0.014
Wnt2b	wingless related MMTV integration site 2b	0.014
Amh	anti-Mullerian hormone	0.013
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.013
Bcl2	B-cell leukemia/lymphoma 2	0.013
Gm13290	predicted gene 13290	0.013
Hoxc5	homeobox C5	0.013
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.013
Egr1	early growth response 1	0.013	Mouse
Thbd	thrombomodulin	0.013
Tcf15	transcription factor 15	0.013
Tmprss2	transmembrane protease, serine 2	0.013
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.012
Igfbp6	insulin-like growth factor binding protein 6	0.012
Itga8	integrin alpha 8	0.012
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.012
Rem1	rad and gem related GTP binding protein 1	0.012
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.012
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.012
Efna4	ephrin A4	0.012
Mrc1	mannose receptor, C type 1	0.012
Dll1	delta-like 1 (Drosophila)	0.012
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.012
Igfbp5	insulin-like growth factor binding protein 5	0.012
Twist1	twist homolog 1 (Drosophila)	0.012
Nacc1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.012
Osr1	odd-skipped related 1 (Drosophila)	0.012
Apc	adenomatosis polyposis coli	0.011
Myl7	myosin, light polypeptide 7, regulatory	0.011
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.011
En1	engrailed 1	0.011
Sult5a1	sulfotransferase family 5A, member 1	0.011
Stra8	stimulated by retinoic acid gene 8	0.011
Epx	eosinophil peroxidase	0.011
Ntf3	neurotrophin 3	0.011
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.011
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.011
She	src homology 2 domain-containing transforming protein E	0.011
Mn1	meningioma 1	0.011
Guca2b	guanylate cyclase activator 2b (retina)	0.011
Gdf6	growth differentiation factor 6	0.011	Mouse
Tac2	tachykinin 2	0.011
Dlx2	distal-less homeobox 2	0.011
Sfrp2	secreted frizzled-related protein 2	0.011
Sim1	single-minded homolog 1 (Drosophila)	0.011
Fzd4	frizzled homolog 4 (Drosophila)	0.011
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.011
Gata2	GATA binding protein 2	0.011	Mouse
Aebp1	AE binding protein 1	0.011
Mpeg1	macrophage expressed gene 1	0.010
Cdx1	caudal type homeobox 1	0.010
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.010
Fzd8	frizzled homolog 8 (Drosophila)	0.010
Btbd17	BTB (POZ) domain containing 17	0.010
Barx1	BarH-like homeobox 1	0.010
Tead3	TEA domain family member 3	0.010